Article
Chemistry, Multidisciplinary
Tomoko Inose, Shuichi Toyouchi, Shinnosuke Hara, Shoji Sugioka, Peter Walke, Rikuto Oyabu, Beatrice Fortuni, Wannes Peeters, Yuki Usami, Kenji Hirai, Steven De Feyter, Hiroshi Uji-i, Yasuhiko Fujita, Hirofumi Tanaka
Summary: Graphene nanoribbons (GNRs) have attracted tremendous attention for their potential in next-generation nanoelectronic devices. The authors recently discovered that unzipping from double-walled carbon nanotubes (DWNTs) can produce crystalline single-layered GNRs (sGNRs) with high yield. By using silver nanowire-based tip-enhanced Raman spectroscopy (TERS), the authors analyzed the single GNRs and found heterogeneity in defect density and edge structure, which provides deeper insights into the structure and reaction mechanism of unzipped GNRs.
Article
Biophysics
Xiaohui Lu, Chanyu Yao, Linlin Sun, Zheng Li
Summary: MicroRNAs are reliable biomarkers for noninvasive detection of diseases, including cancers. Plasmon-enhanced biosensors are promising tools for miRNA analysis, using enhanced optical output to detect and analyze miRNA.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Haining Li, Bing Yang, Biao Yu, Nan Huang, Lusheng Liu, Jiaqi Lu, Xin Jiang
Summary: Treatment of hydrogen plasma on silicon nanowires, followed by coatings of nanocrystalline diamond and multilayer graphene, enables enhanced Raman signals with reduced fluorescent background. The graphene-coated nanowires show lower fluorescent background than diamond-coated ones, with a minimum detection limit of 10(7) mol/L and an enhancement factor exceeding 10(4). The stable Raman enhancement is attributed to hydrogen-terminated graphene and the nanowire structure, independent of graphene layers and maintaining stability after exposure to the atmosphere for a month.
APPLIED SURFACE SCIENCE
(2021)
Article
Materials Science, Ceramics
Thi Ha Tran, Thi Mai Anh Nguyen, Vu Phuong Thao Dao, Cong Doanh Sai, Thanh Cong Bach, Nguyen Hai Pham, An Bang Ngac, Van Thanh Pham, Thi Kim Chi Tran, Hyeonsik Cheong, Viet Tuyen Nguyen
Summary: This study reports a facile process to fabricate CuO/Au core/shell nanowires, which show high sensitivity as SERS substrates capable of detecting methylene blue at concentrations as low as 10(-13) M. The major advantages of these SERS substrates are their sensitivity, uniformity, and purity without the presence of organic surfactants in the synthesis process.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Linchangqing Yang, Junfang Li, Meng Yin, Qingkong Kong, Guangcheng Xi
Summary: Due to its layered structure, graphdiyne has a strong tendency to form 2D materials, and most of the current research is based on GDY 2D structures. However, the synthesis of ultrathin nanowires with a high aspect ratio has not been reported. In this study, ultrathin GDY nanowires with diameters below 3 nm were successfully synthesized using a two-phase interface method, exhibiting excellent crystallinity and an aspect ratio of over 2500. The formation of GDY ultrathin nanowires is believed to follow the oriented-attachment mechanism of nanoparticles. These nanowires demonstrate significant quantum confinement effect, enhanced photoelectric effect, and promising applications in surface-enhanced Raman sensing.
Article
Chemistry, Physical
Lulu Yu, Liu Lu, Linghui Zeng, Xiaohong Yan, Xifeng Ren, Judy Z. Wu
Summary: Surface-enhanced Raman spectroscopy (SERS) of rhodamine 6G (R6G) was investigated on a hybrid nanostructure of double-aligned Ag nanowires (AgNWs) on a bilayer triangular MoS2 flake under excitation of polarized light. Enhanced R6G Raman signatures were achieved on the hybrid AgNWs-MoS2 SERS substrates, with the largest (lowest) enhancement observed when the polarization is perpendicular (parallel) to the axial direction of the aligned AgNWs. The SERS enhancement by the MoS2 in the hybrid AgNWs-MoS2 SERS substrates is primarily attributed to the enhanced evanescent electric field of the hot spot at the interface between AgNWs and MoS2, as revealed by theoretical simulation.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Engineering, Electrical & Electronic
Guijiang Yang, Hao Wu, Zi Liang, Liang Wang, Changjian Ke, Zhenggang Lian, Qianqing Yu, Zuming Xia, Ming Tang, Deming Liu
Summary: A single-mode Raman gain fiber was designed and fabricated for a Raman distributed temperature sensor with high-precision temperature measurement and low power consumption. The use of fluorine-doped inner cladding was shown to improve acoustic field control and suppress stimulated Brillouin scattering. By utilizing the high Raman gain of the fiber, a significant improvement in signal-to-noise ratio and reduction in temperature uncertainty were achieved, with the sensor consuming only half the power compared to traditional single-mode fiber sensors.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Yu Fukunaga, Makoto Harada, Tetsuo Okada
Summary: Freezing is proposed as an efficient way to enhance sensitivity and reproducibility in SERS measurements, maximizing signal intensity and preparing a high-performance SERS platform through simple methods.
Article
Engineering, Environmental
Seung Mo Kong, Dongha Shin, Jeong-Wook Oh, Hyungseok Park, Jea Seung Lee, Nam-Il Won, Yang Ho Na
Summary: The study demonstrates the potential of flexible surface-enhanced Raman scattering (SERS) substrates for detecting single polymer nanoparticles. The use of polydimethylsiloxane (PDMS) membranes as flexible substrates, Ag nanowires (AgNWs) to create nanopores, and PDMS-polyethylene glycol (PEG) block copolymer (BCP) for solvent application improvement was investigated. The SERS substrates showed a limit of detection (LOD) of 7.06 x 10-11 M for rhodamine 6G (R6G) probes and exhibited mechanical stability under various conditions. Additionally, the substrates were able to separate polystyrene (PS) particles from a solution and visually distinguish them from AgNWs. The flexibility of the SERS substrates allowed for swab sampling of irregular surfaces and successful detection of crystal violet (CV) in contaminated scallops and PS in stainless-steel structures covered with PS particles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Puran Pandey, Siela Vongphachanh, Jongwon Yoon, Bokyoung Kim, Chel-Jong Choi, Jung Inn Sohn, Woong-Ki Hong
Summary: This study demonstrated the use of AgNWNF-coated stretchable PDMS substrates as SERS sensors with strong effects. The adhesion strength of AgNWNEs on UVO-treated PDMS substrates was significantly stronger than that of AgNWNFs on untreated PDMS.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Multidisciplinary
Yalambaku Rajesh, M. S. S. Bharati, S. Venugopal Rao, M. Ghanashyam Krishna
Summary: This study demonstrates the potential of ZnO nanowire arrays decorated with TiN nanoparticles as SERS substrates, achieving enhancement in Raman signals. The research presents a simple, cost-effective and facile method for the fabrication of TiN-based SERS substrates.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Biophysics
Jinyoung Kim, Joowon Park, Jisun Ki, Hyun Wook Rho, Yong-Min Huh, Eunjung Kim, Hye Young Son, Seungjoo Haam
Summary: Breast cancer is a common global cancer, and early detection is crucial for improving the 5-year survival rate. In this study, the combination of seed-mediated grown silver nanopillars and surface-enhanced Raman spectroscopy was used for rapid and sensitive detection of circulating miRNA in breast cancer.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Myoung Gyu Kim, Miyeon Jue, Kwan Hee Lee, Eun Yeong Lee, Yeonjeong Roh, Minju Lee, Hyo Joo Lee, Sanghwa Lee, Huifang Liu, Bonhan Koo, Yoon Ok Jang, Eui Yeon Kim, Qiao Zhen, Sung-Han Kim, Jun Ki Kim, Yong Shin
Summary: The study introduces a deep learning assisted ZnO-Au-SERS-based direct amplification (ZADA) system for rapid, sensitive molecular diagnostics. The system can amplify target nucleic acids directly on the SERS surface, eliminating the need for post-amplification hybridization and Raman reporters. Clinical validation with COVID-19 samples yielded high sensitivity and specificity. The integration of a deep learning program further enhanced sensitivity and specificity to 100%.
Article
Nanoscience & Nanotechnology
Hiroki Makanai, Tatsuya Nishihara, Kazuhito Tanabe
Summary: In this study, a purification-free method based on surface-enhanced Raman scattering (SERS) using functionalized gold nanoparticles was developed for the detection of specific nucleic acids. The robust Raman signal of an acetylene-tagged Hoechst molecule (AH) was identified through SERS, and the target nucleic acids were detected through strand displacement and dissociation processes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Yifan Wang, Zhiming Chen, Pan Zeng, An Cao, Tao Zhang, Yue Li
Summary: The inappropriate usage of biochemical molecules has resulted in serious environmental problems. To address this, there is a need for low-cost biochemical sensors. Surface-enhanced Raman scattering (SERS) has shown potential, but has limitations of low utilization and high cost. In this study, researchers developed a high-throughput and highly sensitive NIR-SERS biochemical sensor by combining inkjet printing technology with plasmonic metallic nanoparticles. This new sensor showed the ability to detect multiple biochemical molecules with high sensitivity.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Geonhyeong Park, Yun-Seok Choi, S. Joon Kwon, Dong Ki Yoon
Summary: The planar spin glass pattern, known for its randomness due to geometrical frustration, holds potential as a physical unclonable function (PUF) for advanced security systems in the digitalized society. Traditional magnetic spin glass patterns face obstacles in detection, posing challenges for authentication in security systems. A solution is introduced using a topologically protected maze pattern in chiral liquid crystals, exhibiting comparable randomness to magnetic spin glass. The maze can be identified through optical microscopy and machine learning-based object detection, offering a next-generation security system through microscopically controlled structures.
ADVANCED MATERIALS
(2023)
Article
Biophysics
Jayeon Song, Younseong Song, Hyowon Jang, Jeong Moon, Hyunju Kang, Yong-Min Huh, Hye Young Son, Hyun Wook Rho, Mirae Park, Eun-Kyung Lim, Juyeon Jung, Yongwon Jung, Hyun Gyu Park, Kyoung G. Lee, Sung Gap Im, Taejoon Kang
Summary: Accurate and efficient DNA detection is crucial for disease diagnosis and health monitoring. This study presents a one-step elution-free DNA analysis method based on the combination of CRISPR/Cas9-mediated CLAT assay and a DNA-capturing pDMAMS-coated tube. The combination simplifies DNA detection in a single tube without the need for complicated extraction steps, improving sensitivity. The platform demonstrates attomolar sensitivity in various samples and shows potential applications in tissue and liquid biopsies.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Sanghyeok Park, Dongha Kim, Yun-Seok Choi, Arthur Baucour, Donghyeong Kim, Sangho Yoon, Kenji Watanabe, Takashi Taniguchi, Jonghwa Shin, Jonghwan Kim, Min-Kyo Seo
Summary: Researchers developed a meta-mirror platform to customize the radiative decay rate and polarization correlation of excitons in TMDCs. By altering the optical layout, the radiative decay rate could be reduced by two orders of magnitude and a statistical correlation between emission intensity and spectral line width was observed. This platform shows great potential for tailoring the two-dimensional distributions of lifetime, density, diffusion, and polarization of TMDC excitons in advanced opto-excitonic applications.
Article
Chemistry, Multidisciplinary
Ba Thong Trinh, Hanjun Cho, Deunchan Lee, Oleksii Omelianovych, Taehun Kim, Sy Khiem Nguyen, Ho-Suk Choi, Hongki Kim, Ilsun Yoon
Summary: A simple in situ method is introduced to fabricate Au nanoparticles on cellulose filter papers as dual-functional substrates for solar-to-steam (STS) generation and surface-enhanced Raman spectroscopy (SERS) sensing. The substrates exhibit high solar absorption and achieve a stable evaporation rate under sunlight illumination. Enriched SERS hotspots between AuNPs endow the substrates with the ability to detect chemical contamination in water, and the purified water can be analyzed using SERS for confirmation.
Article
Nanoscience & Nanotechnology
Younseong Song, Nahyun Park, Da Ae Jo, Jueun Kim, Dongeun Yong, Jayeon Song, Yoo Min Park, Seok Jae Lee, Yong Tae Kim, Sung Gap Im, Bong Gill Choi, Taejoon Kang, Kyoung G. Lee
Summary: Sensitive and accurate capture, enrichment, and identification of drug-resistant bacteria on human skin are achieved using a three-dimensional hierarchically structured polyaniline nanoweb (3D HPN). This nanoweb enhances bacteria capture efficiency and helps severely deform the bacteria surface. The recovered bacteria can be successfully identified by real-time polymerase chain reaction (PCR) analysis. The assay exhibits excellent sensitivity to detect target bacteria concentrations without any signal interruption and can be extended to on-site pathogen detection systems.
Article
Infectious Diseases
Sun-Woo Yoon, Kristin Widyasari, Jieun Jang, Seungjun Lee, Taejoon Kang, Sunjoo Kim
Summary: A single dose of mRNA-based COVID-19 vaccines can enhance immune responses in individuals who had previously contracted SARS-CoV-2, including levels of IFN-gamma and neutralizing antibodies. However, T-cell and B-cell levels did not significantly increase in the infected group following the second vaccine dose.
BMC INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Niclas S. Mueller, Rakesh Arul, Gyeongwon Kang, Ashley P. Saunders, Amalya C. Johnson, Ana Sanchez-Iglesias, Shu Hu, Lukas A. Jakob, Jonathan Bar-David, Bart de Nijs, Luis M. Liz-Marzan, Fang Liu, Jeremy J. Baumberg
Summary: This study demonstrates the activation of anti-Stokes photoluminescence (PL) in WSe2 monolayers through plasmonic nano-cavities, with a near hundred-fold enhancement of the upconverted PL intensity. It also highlights the significance of precise nanoparticle geometry and shows the selective and reversible switching of upconverted PL via electrochemical gating.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Joochan Kim, Jaehyung Jeon, Hyowon Jang, Youngkwang Moon, Abdurhaman Teyib Abafogi, Danny van Noort, Jinkee Lee, Taejoon Kang, Sungsu Park
Summary: The current standard method for diagnosing COVID-19 involves uncomfortable and invasive sampling. This study introduces a 3D printed fluidic swab (3DPFS) that enables easy and efficient nasal wash sampling, resulting in higher sensitivity for detecting SARS-CoV-2 compared to cotton swabs. Users also reported greater comfort when using the 3DPFS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing.
Article
Chemistry, Multidisciplinary
Younseong Song, Jayeon Song, Seongeun Kim, Hyowon Jang, Hogi Kim, Booseok Jeong, Nahyun Park, Sunjoo Kim, Dongeun Yong, Eun-Kyung Lim, Kyoung G. Lee, Taejoon Kang, Sung Gap Im
Summary: This study presents a charge-shifting polyplex as an RNA extraction carrier for rapid and user-friendly nucleic acid testing. The polyplex can rapidly bind with viral RNA to efficiently capture a substantial amount of RNA. The captured RNA can be released quickly through hydrolysis, streamlining the entire process from RNA extraction to analysis. The method requires only 5 minutes of centrifugation and can detect RNA in a one-pot setup. It is compatible with high-speed qRT-PCR kits and can identify clinical samples within 1 hour, including the extraction to detection procedure. The method successfully detected influenza viruses, SARS-CoV-2, and their variants in clinical samples with high sensitivity and specificity. This polyplex-based approach represents a significant breakthrough in molecular diagnostics.
MATERIALS HORIZONS
(2023)
Article
Biochemical Research Methods
Ji Wook Choi, Won Ho Seo, Taejoon Kang, Taewook Kang, Bong Geun Chung
Summary: Since the outbreak of COVID-19, detection technologies in molecular diagnosis applications, particularly droplet digital PCR (ddPCR), have gained significant attention. The combination of isothermal amplification strategies with ddPCR has made it a popular method for on-site testing. However, non-specific amplification still poses a challenge. In this study, a multiplexed droplet digital recombinase polymerase amplification (MddRPA) assay was developed, offering rapid detection, precise quantification, and multiplexing capability for viral infections.
Article
Chemistry, Applied
Kyeonghye Guk, Soyeon Yi, Hyeran Kim, Suhyeon Kim, Eun-Kyung Lim, Taejoon Kang, Juyeon Jung
Summary: The PoreGlow system based on split green fluorescent protein (GFP) was developed and assessed for the rapid and accurate detection of L. monocytogenes. It showed high sensitivity and specificity, with no cross-reactivity with other bacteria. This system is promising for the early detection of L. monocytogenes in food products, which is crucial for preventing outbreaks and protecting public health.
Article
Chemistry, Multidisciplinary
Juri Kim, Yun-Seok Choi, Geonhyeong Park, Mingeun Kim, Jin Suk Myung, Woo Jin Choi, Soon Mo Park, Dong Ki Yoon
Summary: This article introduces a method for fabricating anisotropic DNA hydrogels and demonstrates the potential of directionally controlled DNA hydrogels as smart materials.
Article
Biophysics
Sehun Jeong, Jingyu Kim, Seong-In Cho, Taejoon Kang, Sunjoo Kim, Eun-Kyung Lim, Sang-Hee Ko Park
Summary: This study presents the development of a multiplex immunosensor based on dual-gate oxide TFT for rapid and accurate detection of influenza A pH1N1 virus, SARS-CoV-2, and RSV. The sensor demonstrates high sensitivity and can detect multiple viruses simultaneously, making it a potential point-of-care test for future pandemics.
BIOSENSORS & BIOELECTRONICS
(2023)
