Article
Cell Biology
Yunki Lim, Brandon Berry, Stephanie Viteri, Matthew McCall, Eun Chan Park, Christopher Rongo, Paul S. Brookes, Keith Nehrke
Summary: This study demonstrates that FNDC-1 plays a role in non-hypoxic mitochondrial quality control, with its loss leading to stress responses and metabolic remodeling dependent on atfs-1. These changes are prophylactic against subsequent HR injury.
Article
Biochemistry & Molecular Biology
Mohammad Khoonkari, Dong Liang, Marina Trombetta Lima, Tjitze van der Land, Yuanke Liang, Jianwu Sun, Amalia Dolga, Marleen Kamperman, Patrick van Rijn, Frank A. E. Kruyt
Summary: Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults, and ECM stiffening plays a significant role in its progression. This study identifies a novel mechano-adaptive mechanism involving PERK/FLNA/F-Actin and provides new insights into the cellular adaptation to ECM stiffening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Fang Liu, Zhun Liu, Weisheng Cheng, Qingquan Zhao, Xinyu Zhang, He Zhang, Miao Yu, He Xu, Yichen Gao, Qianrui Jiang, Guojun Shi, Likun Wang, Shanshan Gu, Jia Wang, Nan Cao, Zhongyan Chen
Summary: This study reveals the importance of protein quality control in cardiac development and demonstrates how the PERK-ATF4-WARS1 axis is activated to cope with differentiation-induced proteotoxic stress in human pluripotent stem cells.
Review
Physiology
Khan Sadia, Mohammad Zahid Ashraf, Aastha Mishra
Summary: Hypoxia disrupts endothelial cell integrity, leading to an imbalance in coagulation proteins. Sirtuins play a crucial role in reducing ER stress and inflammation, offering a novel therapeutic approach for hypoxia-induced thrombosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yong Zhou, Yang Jin, Yuan Wang, Ruijin Wu
Summary: Endometriosis is a chronic gynecological disease with an unclear cause. Hypoxia is closely related to the occurrence and development of the disease, with hypoxia-inducible factor-1 alpha playing a key role and the unfolded protein response supplementing cell survival under hypoxic stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wencheng Wei, Yunfei Li, Chuanxi Wang, Yan Zhao, Zhenyu Yang, Hao Wang, Ziying Gao, Yanxiang Jiang, Yuan He, Li Zhao, Hao Gao, Xinsheng Yao, Yuhui Hu
Summary: The study conducted a comprehensive functional prediction of Vinigrol, revealing its broad anti-cancer function and the underlying mechanisms, which provide insights for further exploration of the structure-efficacy relationship of the compound family.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Yan Zhao, Zhenyu Yang, Hao Wang, Ziying Gao, Yanxiang Jiang, Yuan He, Li Zhao, Hao Gao, Xinsheng Yao, Yuhui Hu
Summary: Vinigrol is a natural diterpenoid with a unique chemical structure, and its total synthesis has been a subject of great interest in the past decades. In this study, we conducted a comprehensive functional prediction of Vinigrol using a transcriptome-based strategy and identified its prominent anti-cancer effect. Further investigations revealed the underlying targets and regulatory mechanisms of Vinigrol's anti-cancer function. This study provides insights into the structure-efficacy relationship of Vinigrol and its potential applications in experimental and clinical settings.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Neurosciences
Chiara Lanzillotta, Ilaria Zuliani, Antonella Tramutola, Eugenio Barone, Carla Blarzino, Valentina Folgiero, Matteo Caforio, Diletta Valentini, Alberto Villani, Franco Locatelli, D. Allan Butterfield, Elizabeth Head, Marzia Perluigi, Jose F. Abisambra, Fabio Di Domenico
Summary: Abnormal activation of the PERK pathway in neurodegenerative disorders is associated with reduced protein synthesis, cell death, and altered antioxidant response. In Down syndrome, PERK activation is linked to the early development of Alzheimer's disease, suggesting that dysregulation of the PERK pathway may play a key role in DS pathology.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Garrett Dalton Smedley, Keenan E. Walker, Shauna H. Yuan
Summary: Neurodegenerative diseases are a growing concern for the aging population, and errors within the PERK pathway have been linked to a variety of pathologies. However, conflicting narratives exist due to the wide array of methodological approaches in genetic and clinical studies. As PERK is connected to pathology, it has become a valuable target for research in understanding and potentially treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jinlong Tan, Yinju Liu, Fan Yang, Guohua Chen, Yongxiang Fang, Xiaobing He, Zhongzi Lou, Huaijie Jia, Zhizhong Jing, Weike Li
Summary: This study demonstrates that infection with lumpy skin disease virus (LSDV) causes endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR). It also shows that an unbalanced ER environment hampers LSDV replication and that PERK-eIF2a and IRE1-XBP1 signaling cascades contribute to LSDV replication.
Article
Oncology
Xufeng Pu, Li Li, Zhenhui Chen, Aihua Gong, Jiao Lei, Lirong Zhang, Hsiang- Tsai
Summary: Potassium (K+) is a vital intracellular cation that regulates various cellular processes. Recent studies have shown that dying cancer cells release potassium into the tumor microenvironment (TME), affecting cell survival-related events. This study demonstrates that a high-potassium environment can reverse ferroptosis, a type of cell death. It also reveals the mechanisms through which high potassium levels attenuate endoplasmic reticulum (ER) stress and activate the unfolded protein response. This research provides insights into the roles of potassium and the TME in cancer cell ferroptosis, offering potential therapeutic strategies.
Article
Multidisciplinary Sciences
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Summary: Axial length is the primary determinant of eye size and is elongated in myopia. This study reveals that endoplasmic reticulum (ER) stress in the sclera and the PERK/ATF6 pathway are involved in the axial elongation during myopia development. The researchers also demonstrate that 4-PBA eye drops show promise as a drug for myopia suppression/treatment.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Summary: In this study, the effectiveness of a mitochondrial-targeted NADPH oxidase inhibitor in reducing oxidative stress and inflammation in rats exposed to organophosphates (OP) was examined. The inhibitor showed promising results in decreasing markers of oxidative stress and inflammation in the serum, but had limited effects in the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shaoqun Shu, Hui Wang, Jiefu Zhu, Ying Fu, Juan Cai, Anqun Chen, Chengyuan Tang, Zheng Dong
Summary: This study found that endoplasmic reticulum (ER) stress contributes to the development of chronic kidney disease (CKD) following cisplatin chemotherapy through the PERK-PKC delta pathway.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valerie Perea, Christian Cole, Justine Lebeau, Vivian Dolina, Kelsey R. Baron, Aparajita Madhavan, Jeffery W. Kelly, Danielle A. Grotjahn, R. Luke Wiseman
Summary: Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are interconnected in the development of various diseases. The PERK signaling pathway, an arm of the unfolded protein response (UPR), plays a significant role in regulating mitochondrial biology during ER stress. This study reveals that PERK activity promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA), leading to protective mitochondrial elongation in response to acute ER stress. These findings highlight a novel role for PERK in modulating mitochondrial phospholipids and demonstrate its involvement in adapting organellar shape during ER stress.