Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid

Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats

(2015) Gokhan Cuce et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway

(2015) Beatriz Garcia-Diaz et al.   HUMAN MOLECULAR GENETICS

Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC/MS Q-TOF

(2015) M.S. Rofiee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice

(2015) Daniel J. Conklin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

(2015) Galvin Vredenburg et al.   TOXICOLOGY LETTERS

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

(2015) Cong Lin et al.   Oncotarget

Metabolomics integrated elementary flux mode analysis in large metabolic networks

(2015) Matthias P. Gerstl et al.   Scientific Reports

A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma

(2015) Weijian Zhang et al.   Scientific Reports

Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes

(2015) Bahram Sanjabi et al.   Scientific Reports

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

(2015) Dong-Gun Kim et al.   Oncotarget

Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity

(2014) Aiming Liu et al.   ARCHIVES OF TOXICOLOGY

How I treat Burkitt lymphoma in adults

(2014) C. Jacobson et al.   BLOOD

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid

(2014) Aizhen Xiong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative study on intestinal metabolism and absorptionin vivoof ginsenosides in sulphur-fumigated and non-fumigated ginseng by ultra performance liquid chromatography quadruple time-of-flight mass spectrometry based chemical profiling approach

(2014) He Zhu et al.   Drug Testing and Analysis

Not all (bile acids) who wander are lost: The first report of a patient with an isolated NTCP defect

(2014) Saul J. Karpen et al.   HEPATOLOGY

Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines

(2014) Mousa O. Germoush et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Simultaneous Determination of Original, Degraded Ginsenosides and Aglycones by Ultra High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry for Quantitative Evaluation of Du-Shen-Tang, the Decoction of Ginseng

(2014) Shan-Shan Zhou et al.   MOLECULES

Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures

(2014) Jie Liu et al.   TOXICOLOGICAL SCIENCES

Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice

(2014) Swetha Rudraiah et al.   TOXICOLOGY

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

(2014) Haw-Wen Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone

(2014) Yasmin Ohana Haim et al.   Scientific Reports

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats

(2013) Sung-Hwan Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

The metabolomic window into hepatobiliary disease

(2013) Diren Beyoğlu et al.   JOURNAL OF HEPATOLOGY

Cyclophosphamide as a first-line therapy in LGL leukemia

(2013) A Moignet et al.   LEUKEMIA

Therapeutic options for patients with lymphoma and liver dysfunction or failure during mechlorethamine shortage

(2013) Mohamad Bassam Sonbol et al.   LEUKEMIA & LYMPHOMA

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

(2013) April D. Lake et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Herbal Medicines as Adjuvants for Cancer Therapeutics

(2012) Chong-Zhi Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies

(2012) D. Wang et al.   BLOOD

Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide

(2012) Tareisha Dunlap et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice

(2012) Xiaojie Wei et al.   FITOTERAPIA

Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids

(2012) Fan Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: The role of ginsenoside Rg3, a protopanaxadiol

(2012) Sang Il Gum et al.   LIVER INTERNATIONAL

Xenobiotic Metabolomics: Major Impact on the Metabolome

(2011) Caroline H. Johnson et al.   Annual Review of Pharmacology and Toxicology

The effects of acrolein on the thioredoxin system: Implications for redox-sensitive signaling

(2011) Charles R. Myers et al.   MOLECULAR NUTRITION & FOOD RESEARCH

U.S. Food and Drug Administration Approval: Rituximab in Combination with Fludarabine and Cyclophosphamide for the Treatment of Patients with Chronic Lymphocytic Leukemia

(2011) S. J. Casak et al.   ONCOLOGIST

Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

(2011) Kees Meijer et al.   PLoS One

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

(2011) Jingtao Lu et al.   TOXICOLOGICAL SCIENCES

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC–ESI-QTOFMS-based metabolomics

(2010) Fei Li et al.   BIOCHEMICAL PHARMACOLOGY

Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity

(2009) D. J. Conklin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells

(2008) Charles R. Myers et al.   TOXICOLOGY

Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells

(2007) Qiu Hua Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY