Article
Chemistry, Applied
Ines F. A. Mariz, Sebastian Raja, Tiago Silva, Suzete Almeida, Erica Torres, Carlos Baleizao, Ermelinda Macoas
Summary: This study explores the enhancement of nonlinear optical response in small organic molecules by examining the two-photon absorption (TPA) properties of perylene-3,4,9,10-tetracarboxylic acid diimides (PDIs) with different substituents. The research finds that tetra-phenoxy bay-substituted PDIs with an A-PDI-A architecture exhibit significantly higher TPA cross-section compared to planar unsubstituted PDIs, despite their distortion from planarity.
Article
Materials Science, Multidisciplinary
Erisa Ferasat, Marzieh Golshan, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: PTCDA was modified to PTCDI with ethylenediamine, followed by bonding coumarin derivatives onto PTCDI. The transparent and fluorescent properties of the synthesized dye in the near-infrared region were evaluated, showing high absorption on a white background and high reflection on a black background.
MATERIALS RESEARCH BULLETIN
(2021)
Article
Materials Science, Multidisciplinary
M. I. Alonso, M. Garriga, J. O. Osso, F. Schreiber, R. Scholz
Summary: In this study, the complex dielectric tensor of single crystalline 3,4,9,10-perylene tetracarboxylic dianhydride (alpha-PTCDA) was determined as a function of energy in the range between 1.4 and 5.0 eV. The results showed monoclinic symmetry of the crystal, with the principal axes of the real and imaginary parts of the tensor not coinciding and exhibiting chromatic dispersion. The experimental findings indicated resonances occurring at energies close to electronic excitations, such as the optical gap and the HOMO-LUMO peak-to-peak gap, due to coupling with the stronger component of the tensor.
Article
Biotechnology & Applied Microbiology
Arash Kamal, Majid Abdouss, Majid Mazhar
Summary: This study investigated factors affecting the near-infrared reflectance of perylene-bisimide derivatives, validating some and rejecting others. The NIR properties of the synthesized pigments show a correlation with the imide substitution structure, but a direct relationship cannot be established.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Marzieh Golshan, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: Poly(amidoamine) (PAMAM) dendrimers up to 4th generation were successfully designed and synthesized using perylene-3,4,9,10-tetracarboxylic diimide (PTCDI) as a luminescent core. The synthesis success was confirmed by various analyses, and the thermal stability and fluorescence properties of the dendrimers were improved with generation progression.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Applied
Marzieh Golshan, Farnaz Amani, Mehdi Salami-Kalajahi
Summary: This study focused on the synthesis of a highly fluorescence colorant PTCDI-Rh6 G and characterized its optical properties using various techniques. The PTCDI showed better performance in cold colors compared to the PTCDI-Rh6 G hybrid, as demonstrated by its higher reflection rate in the NIR range of 700-1000 nm.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Physical
Qijing Bu, Haoran Wang, Shu Li, Guang Lu, Xixi Zhu, Qingyun Liu
Summary: Integrating the extraction layer and cocatalyst with semiconductor is important for improving the photoelectrochemical water oxidation performance by facilitating the transfer of photogenerated holes.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Qiaoxia Zhang, Xiangwei Liu, Haoran Wang, Qing Liu, Qingyun Liu, Xianxi Zhang
Summary: In this work, a thrombin photoelectrochemical aptasensor was developed using PTCA and Au nanoparticles to enhance the photocurrent response of ZnO NRs, and Ag@Ag2S for signal-off detection of thrombin with a detection limit of 33 fM.
Article
Chemistry, Multidisciplinary
Yitao Lou, Xianfa Rao, Jianjun Zhao, Jun Chen, Baobao Li, Lei Kuang, Qiangzhong Wang, Shengwen Zhong, Hua Wang, Lijue Wu
Summary: The organic hard carbon material PTCDA-1100 prepared by high temperature calcination of PTCDA shows superior cyclic stability and rate capability in Lithium-ion batteries compared to commercial graphite materials.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dong Liu, Shuyun Meng, Xiuli Shen, Yuye Li, Xiaohong Yan, Tianyan You
Summary: This work presents a dual-ratiometric aptasensor for streptomycin detection, utilizing the in-situ coupling of photoelectrochemical and electrochemical assays. The use of methylene blue as a bifunctional probe enables the simultaneous generation of photocurrent and redox current, resulting in enhanced analytical performances compared to single-signal or single-ratiometric assays. The MB-based dual-mode sensing offers a promising tool for studying interactions between PEC and EC behaviors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
T. G. U. Ghobadi, A. Ghobadi, M. Demirtas, M. Buyuktemiz, K. N. Ozvural, E. A. Yildiz, E. Erdem, H. G. Yaglioglu, E. Durgun, Y. Dede, E. Ozbay, F. Karadas
Summary: The cover of this issue features an utopic city in the Iron Age powered by an iron photosensitizer, bridging semiconductor buildings and a catalyst.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
T. Gamze Ulusoy Ghobadi, Amir Ghobadi, Merve Demirtas, Muhammed Buyuktemiz, Kubra N. Ozvural, Elif Akhuseyin Yildiz, Emre Erdem, H. Gul Yaglioglu, Engin Durgun, Yavuz Dede, Ekmel Ozbay, Ferdi Karadas
Summary: The study successfully constructed a stable iron-sensitized photoanode with exceptional photosensitizing ability and connectivity to cobalt water oxidation catalytic sites via cyanide linkers. This breakthrough in chromophore-catalyst assemblies will inspire interest in dye-sensitization with robust bulk systems for photoconversion applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Xiaodi Zhu, Qiuyu Huang, Xiaoyu Sun, Yong Hao, Huan Wang, Dan Wu, Hongmin Ma, Huangxian Ju, Qin Wei
Summary: In this study, robust PTA nanoassemblies were used to form type II heterojunctions with In2O3, leading to the construction of high-performance PEC immunosensing platforms. Ag@CeO2 nanoparticles were employed as energy level matching nanolabels for a signal-on PEC immunosensing method, achieving the detection of the typical protein biomarker CEA.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Materials Science, Multidisciplinary
Dongpo Su, Enyu Chen
Summary: Perylene derivatives are good candidates for preparing fluorescent anodic aluminum oxide due to their strong fluorescence and high quantum yields. However, their poor water solubility hampers their application as a fluorescent dye. In this study, a fabrication process for preparation of fluorescent films was presented using a water-soluble PTC4- potassium salt as the fluorescent dye. The factors influencing the fabrication process were discussed to avoid fluorescence quenching. The research also proposed a possible fluorescence quenching mechanism. This method shows potential for mass industrial production due to its similarity to existing methods and the availability of easily accessible and inexpensive raw materials.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Haonan Wang, Yan Li, Bo Yao, Haitao Xu, Shiyan Liu, Yongsheng Tan, Xiao Luo, Cuilu Xi, Xinfei Wu, Yifan Zhang, Jie Deng, Zebo Fang
Summary: This paper demonstrates a high-performance red light sensor based on a PTCDI-C8 organic phototransistor with an optimized gold nanoparticles modified layer, which exhibits superior optical properties. The introduction of AuNPs leads to high photosensitivity, photoresponsivity, and external quantum efficiency at 660nm, as well as a significant improvement under 532nm green light illumination compared to single PTCDI-C8 layer OPT. The photophysical mechanisms of introducing AuNPs to improve device performance were explored in this study.
Article
Nanoscience & Nanotechnology
Yali Yuan, Tao Hu, Xia Zhong, Minghui Zhu, Yaqin Chai, Ruo Yuan
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biophysics
Qiao Ding, Minghui Zhu, Hanmei Deng, Ruo Yuan, Yali Yuan
Summary: A novel self-enhanced photoelectric active material, Na+, K+-codoped carbon nitride (NaKCN), was synthesized for constructing a sensitive photoelectrochemical (PEC) biosensor to detect target miRNA-182-5p. The NaKCN displayed glucose oxidase (GOx)-mimicking photocatalytic property and Na+, K+ co-doping effectively improved the optical absorptivity and photocatalytic efficiency. The PEC biosensor achieved high sensitivity with a low detection limit, providing a new avenue for improving sensitivity of bioanalysis and diagnosis of diseases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Han-Mei Deng, Ming-Jun Xiao, Ya-Qin Chai, Ruo Yuan, Ya-Li Yuan
Summary: In this study, P3HT-PbS nanocomposites and target-trigger generated hemin/G-quadruplex nanotail were integrated as dual enhancers to develop an ultrasensitive photocathodic biosensor for the detection of beta 2-microglobulin (beta 2-MG). The combination of the two enhancements significantly amplified the photocurrent, allowing for a good detection range of 0.1 pg/mL to 100 ng/mL.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Minghui Zhu, Yaqin Chai, Ruo Yuan, Bo Zu, Yali Yuan
Summary: The dual-mode biosensor constructed in this study utilized dual CHA and enzyme cascade catalysis amplification to achieve sensitive and accurate detection of miRNA-21. It effectively addressed the low sensitivity and accuracy issues in traditional biosensors, providing a wide detection range and potential as an efficient and universal biosensing avenue.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Mingrui Zhang, Qiao Ding, Minghui Zhu, Ruo Yuan, Yali Yuan
Summary: A novel electrochemical biosensor with highly efficient triple-recycle catalytic hairpin assembly (CHA) and tetris hybridization chain reaction (THCR) was designed for ultrasensitive detection of target ATP. The biosensor showed a linear range from 100 fM to 100 nM and a detection limit down to 30 fM, providing a new approach for achieving highly sensitive and selective analysis using a simple and effective amplifying strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Qingyuan Dong, Qiao Ding, Ruo Yuan, Yali Yuan
Summary: A novel ternary nanocomposite (AuNPs/CdS QDs/CeO2) with excellent photoelectrochemical performance was synthesized and combined with a scrollable three-dimensional DNA walker mechanism to construct a near-zero background biosensor for miRNA-182-5p detection. The biosensor showed high sensitivity and could be used for constructing sensing platforms with excellent sensitivity and ultra-low background.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Rui Zhang, Mingrui Zhang, Qiao Ding, Ruo Yuan, Yali Yuan
Summary: In this study, a novel label-free and signal-off electrochemical biosensor based on efficient target-trigger T-structure recycling with dual strand displacement amplification (T-DSDA) was constructed for the sensitive detection of miRNA-155 related to cardiovascular diseases. The sensor demonstrated rapid and sensitive detection capability with a low detection limit, and showed strong anti-interference ability in bovine whole blood. This research provides a foundation for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Juan Xing, Qing-Yuan Dong, Qiao Ding, Xiao Yang, Ruo Yuan, Ya-Li Yuan
Summary: A novel conjugated microporous polymer on carbon nanotube composite (CMP-CNTs) was synthesized as a photoelectrochemical (PEC) signal probe for constructing a sensitive PEC biosensor to detect the N gene of COVID-19. By integrating with target-triggered T-junction recycling dual-strand displacement amplification (T-DSDA), CMP-CNTs composites exhibited ideal photoelectrical conversion efficiency due to effective electron-hole pairs separation and accelerated carrier migration. The proposed PEC biosensor showed high sensitivity towards the N-Gene of COVID-19 with a detection limit of 33 aM, providing a new way for simple, sensitive, and reliable sensing platform in biological analysis and early clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Qingyuan Dong, Qiao Ding, Ruo Yuan, Yali Yuan
Summary: In this study, a TPAPP-Fe/Cu material was prepared, and a highly sensitive photoelectrochemical biosensor was constructed for the detection of colon cancer-related miRNA-182-5p. The biosensor showed a detection limit as low as 0.2 fM, demonstrating great potential in early clinical diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Mingjun Xiao, Minghui Zhu, Ruo Yuan, Yali Yuan
Summary: In this work, an ultrasensitive PEC biosensor based on dual-sensitized PDA/ZnO@MoS2 QDs photoactive material was proposed for detection of miRNA-182-5p. The DSN-assisted target recycling amplification triggered a multilocus domino-like DNA cascade reaction on DNA nanonet, which significantly enhanced the detection sensitivity. The developed biosensor exhibited a low detection limit of 0.17 fM, providing a new avenue for sensitive, fast and reliable sensing of various DNA/RNA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Chou Wu, Hanmei Deng, Qiao Ding, Ruo Yuan, Yali Yuan
Summary: In this study, a novel reduction-accelerated quenching strategy using Au nano-flower/organic polymer heterojunction was proposed for ultrasensitive detection of Hg2+. The biosensor exhibited excellent sensitivity and selectivity to Hg2+ in the range of 1 fM-10 nM, with a detection limit of 0.48 fM. The proposed biosensor has great potential for routine detection of Hg2+ in various samples.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Mingjun Xiao, Qian Xiong, Chaoju Yang, Hanmei Deng, Ruo Yuan, Yali Yuan
Summary: In this study, a high-performance inorganic organic nanosphere with cascade energy band arrangement was synthesized for sensitive photocathodic biosensing. The biosensor showed a wide detection range and low detection limit for p53, demonstrating its potential in early disease diagnosis and biological analysis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Han-Mei Deng, Mei-Ling Cheng, Ya-Li Yuan, Ruo Yuan, Ya-Qin Chai
Summary: This study successfully prepared a nanocomposite of polymer/phthalocyanine zinc, which exhibited high photoelectric conversion efficiency under long-wavelength illumination and was suitable for ultra-sensitive detection of microRNA-21. Additionally, this composite material demonstrated anti-interference capability and could effectively avoid damage to biological activity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qingyuan Dong, Juan Xing, Ruo Yuan, Yali Yuan
Summary: In this study, a novel porphyrinic covalent organic polymer (TPAPP-PTCA PCOP) was synthesized to construct a polarity-switchable dual-wavelength photoelectrochemical (PEC) biosensor. The PCOP exhibited both n-type and p-type semiconductor characteristics, allowing for the generation of dual-polarity photocurrent at two different excitation wavelengths. The photocurrent of the PCOP could be switched to the cathode and anode by ferrocene and hydrogen peroxide, respectively. A PCOP-based PEC biosensor integrating dual wavelengths, reliable accuracy, and polarity switch with high sensitivity was developed, achieving a low detection limit for aflatoxin M1.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bei-Bei Kou, Ya-Qin Chai, Ya-Li Yuan, Ruo Yuan
Summary: This study utilized a rigid 3D DNA nanopillar to investigate the influence of spatial organization on cascade activity in multienzyme systems, achieving controllable regulation of mimic enzyme ratio and spacing. The results demonstrate that the optimal mimic enzyme ratio can be obtained by adjusting the DNA polyhedron structure, and the constructed DNA nanopillar supports directional movement of a bipedal DNA walker for continuous enzyme spacing regulation.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
