Article
Engineering, Electrical & Electronic
James A. Covington, Santiago Marco, Krishna C. Persaud, Susan S. Schiffman, H. Troy Nagle
Summary: The human olfactory system is difficult to replicate and poses challenges for real-time detection and analysis of odors. Artificial olfaction has stimulated interdisciplinary research and commercial development for various applications. Engineers and scientists have been working on solving odor measurement and control problems over the past century.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Chemical
Kang Qian, Yin Bao, Jianxi Zhu, Jun Wang, Zhenbo Wei
Summary: In this study, a portable e-nose equipped with a smartphone was developed to identify different grades of Chinese dry-cured ham using GC-IMS technology and a hybrid filter-wrapper method for feature optimization. SVM algorithm yielded the best prediction results, with an accuracy of 96.06% and a time consumption of 17.32 s. The filter-wrapper method performed well in optimizing feature data and enabling clear identification of ham grades.
JOURNAL OF FOOD ENGINEERING
(2021)
Review
Chemistry, Analytical
Stefano Robbiani, Beatrice Julia Lotesoriere, Raffaele L. Dellaca, Laura Capelli
Summary: This review paper discusses the application and challenges of electronic nose technology, including the influence of factors such as temperature, humidity, and gas flow on the response of gas sensors. Software and hardware approaches to address these issues are analyzed, and the importance of tailoring e-nose design to the target application is emphasized.
Article
Chemistry, Analytical
Sayed A. M. Marzouk, Abdallah J. Abu Namous
Summary: This paper describes an experimental system for simultaneous permeation of different gases through gas permeable membranes and provides a proof of concept for gas identification. The system records the rate of gas pressure accumulation behind each membrane as a measure of gas permeation rate. The results show promising potential for using simultaneous permeation rates through different membranes as characteristic fingerprints for gas identification.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Shengming Li, Lin Feng, Yunfei Ge, Li Zhu, Liang Zhao
Summary: The novel electronic nose with active perception and ensemble learning method can differentiate the smell of different objects effectively. Experimental results show that the accuracy of active odor perception can reach over 90%, even with only 30% training data.
Article
Chemistry, Analytical
Zhifang Liang, Lei Zhang, Fengchun Tian, Congzhe Wang, Liu Yang, Tan Guo, Lian Xiong
Summary: Sensor drift caused by aging components and environmental factors seriously affects the performance and lifespan of electronic nose (E-nose). Existing research mainly uses offline compensation techniques, but the dynamic and uncertainty of sensor drift make offline techniques unsuitable for practical applications. A semi-supervised online method based on the WWH problem is proposed to address when, which, and how to update the prediction model for drift compensation. Experiment results demonstrate that sensor drift can be effectively compensated online using this method.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Food Science & Technology
Qi Wang, Xueying Chen, Chen Zhang, Xiaohui Li, Ning Yue, Hua Shao, Jing Wang, Fen Jin
Summary: Aroma is important for the market value and consumer satisfaction of fresh oriental melon, but there is limited research on its volatile flavor and the impact of forchlorfenuron application. This study used E-nose and HS-GC-IMS to characterize the volatile profile of fresh oriental melon after forchlorfenuron application. The analysis showed distinct differences in volatile compounds between the application and pollination groups, with 13 critical different compounds identified in the application group. These findings provide valuable insights for evaluating the flavor quality of oriental melon after forchlorfenuron treatment.
Article
Automation & Control Systems
Pierre Maho, Cyril Herrier, Thierry Livache, Pierre Comon, Simon Barthelme
Summary: Gas sensors lack repeatability over time due to drift. We propose a model-based correction method that does not require calibration samples over time, improving the reliability of electronic noses.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2022)
Article
Chemistry, Analytical
Tharatorn Rungreungthanapol, Chishu Homma, Ken-ichi Akagi, Masayoshi Tanaka, Jun Kikuchi, Hideyuki Tomizawa, Yoshiaki Sugizaki, Atsunobu Isobayashi, Yuhei Hayamizu, Mina Okochi
Summary: Researchers designed an olfactory receptor mimetic peptide-modified graphene field-effect transistor (gFET) to address the low specificity challenge of graphene-based sensors for volatile organic compound (VOC) sensing. Peptides mimicking a fruit fly olfactory receptor were designed using a high-throughput analysis method and successfully achieved sensitive and selective detection of limonene. The peptide probe was bifunctionalized and facilitated facile sensor functionalization. This study demonstrates the advancement of a precise VOC detection system using a target-specific peptide selection and functionalization strategy for gFET sensors.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Silvano Dragonieri, Vitaliano Nicola Quaranta, Andrea Portacci, Madiha Ahroud, Marcin Di Marco, Teresa Ranieri, Giovanna Elisiana Carpagnano
Summary: Exhaled breath analysis using an e-nose is a groundbreaking tool that has shown its applicability in respiratory and systemic diseases. This study aimed to assess whether food intake can be considered a confounder in exhaled breath analysis and found that the exhaled VOC-profile is influenced by recent food intake, with two hours being sufficient to avoid food-induced alterations.
Article
Engineering, Electrical & Electronic
Eli G. Pale-Ramon, Jorge A. Ortega-Contreras, Karen J. Uribe-Murcia, Yuriy S. Shmaliy
Summary: This paper investigates the effect of sampling time jitter on the robust H-2 optimal finite impulse response (OFIR) filter in discrete-time processes. By comparing with other filters, the results show that the robust H-2-OFIR filter performs better in resisting time jitter.
Article
Polymer Science
Bo Zhao, Li Guo, Mingze Han, Yunhong Liang, Mo Li, Shuli Ma, Tianjian Tong, Zhiyong Chang
Summary: In this study, electrospun filters were developed as pre-filters for electronic nose (PFEN) to mitigate the disturbance on gas detection in dusty environments. The results showed that all filters did not affect the response of sensors to the detecting gas, and the PCL/GO-3 filter exhibited the best performance in terms of removal efficiency, pressure drop, and quality factor. These results indicate that electrospun filters can be an excellent option for mitigating PM deposition for gas detection in dusty environments.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alexander L. R. M. Augustini, Christopher Borg, Stefanie Sielemann, Ursula Telgheder
Summary: The analysis of aerosol from tobaccoless electronic cigarettes is important for understanding their impact on human health. This study presents a setup using standard lab equipment for quickly collecting a quantitative sample from e-cigarettes aerosol. The setup allows for simple and sensitive identification of unknown substances and degradation products in the aerosols.
Article
Chemistry, Applied
Huaixiang Tian, Juanjuan Xiong, Shuang Chen, Haiyan Yu, Chen Chen, Juan Huang, Haibin Yuan, Xinman Lou
Summary: In this study, electronic nose and headspace-gas chromatography ion-mobility spectrometry were used to detect adulteration of soymilk in raw bovine milk. The obtained data from these techniques can distinguish the adulterated samples and a quantitative model was established to accurately determine the adulteration levels. This research provides scientific information for rapid, non-destructive and effective detection of adulteration in milk.
Article
Chemistry, Applied
Mohammad Reza Zarezadeh, Mohammad Aboonajmi, Mahdi Ghasemi-Varnamkhasti
Summary: In this research, fraud samples of olive oil were detected using six different classification models by combining the methods of E-nose and ultrasound. The results showed that the ultrasound system's data was more effective than the E-nose system, with the ANN method achieving the highest accuracy of 95.51%.
Article
Immunology
Colin P. D. Birch, Mark A. Chambers, Sandrine Lesellier
Summary: An oral vaccine is being considered as a potential tool to combat Mycobacterium bovis in European badgers. A robust scoring system for tuberculous lesions, known as the disease burden score (DBS), has been developed and found to be the most accurate and reliable. Covariates such as sex, weight, and immunological evidence play a significant role in disease severity and should be considered in experimental studies.
Article
Veterinary Sciences
Roland T. Ashford, Paul Anderson, Laura Waring, Dipesh Dave, Freya Smith, Richard J. Delahay, Eamonn Gormley, Mark A. Chambers, Jason Sawyer, Sandrine Lesellier
PREVENTIVE VETERINARY MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Jordan Pascoe, Charlotte L. Hendon-Dunn, Colin P. D. Birch, Gareth A. Williams, Mark A. Chambers, Joanna Bacon
Article
Pharmacology & Pharmacy
Sandrine Lesellier, Colin P. D. Birch, Dipesh Dave, Deanna Dalley, Sonya Gowtage, Simonette Palmer, Claire McKenna, Gareth A. Williams, Roland Ashford, Ute Weyer, Sarah Beatham, Julia Coats, Alex Nunez, Pedro Sanchez-Cordon, John Spiropoulos, Stephen Powell, Jason Sawyer, Jordan Pascoe, Charlotte Hendon-Dunn, Joanna Bacon, Mark A. Chambers
Article
Veterinary Sciences
Mary-Anne Frank, William S. M. Justice, Roberto La Ragione, Mark A. Chambers
JOURNAL OF ZOO AND WILDLIFE MEDICINE
(2020)
Article
Immunology
Frederika Dicks, Tatjana Marks, Emilie Karafillakis, Mark A. Chambers
Summary: Vaccine hesitancy not only affects human vaccines, but also extends to One Health policies such as vaccination of cattle and badgers in England's bovine tuberculosis eradication strategy. Monitoring social media is crucial in understanding real-time public perceptions and addressing misinformation to improve support for such policies.
Review
Microbiology
Rebecca Thomas, Mark Chambers
Summary: This study reviewed diagnostics for TB in non-bovid species, with a focus on immunity-based tests. The P22 complex emerged as a reliable and accurate antigenic target with high sensitivity and specificity values. Meerkats and African wild dogs were reported to be diagnosed for TB for the first time, and suid species showed the most consistent immunological responses.
Article
Chemistry, Analytical
Janella Marie de Jesus, Catia Costa, Amy Burton, Vladimir Palitsin, Roger Webb, Adam Taylor, Chelsea Nikula, Alex Dexter, Firat Kaya, Mark Chambers, Veronique Dartois, Richard J. A. Goodwin, Josephine Bunch, Melanie J. Bailey
Summary: Elemental and molecular imaging are important in understanding disease pathogenesis, and performing sequential elemental and molecular imaging poses challenges and successes. While compromises may be involved, research shows that correlating sulfur, iron, and lipid markers in a single tissue section at the 50 μm scale is feasible with sequential DESI-ME imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Winifred C. Akwani, Arnoud H. M. van Vliet, Jordan O. Joel, Soenke Andres, Margo Diricks, Florian P. Maurer, Mark A. Chambers, Suzanne M. Hingley-Wilson
Summary: Comparative genomics was used to design MABC subspecies-specific PCR assays, successfully distinguishing M. abscessus, M. bolletii, and M. massiliense subspecies. The analysis showed high sensitivity and specificity, and experimental validation confirmed the effectiveness of the PCR assays.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mahado Ismail, Catia Costa, Katherine Longman, Mark A. Chambers, Sarah Menzies, Melanie J. Bailey
Summary: This study found that fingerprint samples can be used to monitor therapeutic drug use with high accuracy. Detection of metabolites can determine sample volume and reduce intradonor variability.
Article
Veterinary Sciences
Graham C. Smith, Ann Barber, Philip Breslin, Colin Birch, Mark Chambers, Dipesh Dave, Phil Hogarth, Eamonn Gormley, Sandrine Lesellier, Ana Balseiro, Richard Budgey
Summary: In wildlife disease management, vaccination is not a common option. However, the use of the human vaccine BCG for bovine tuberculosis in badgers has been increasing since 2010. A workshop was held with experts in the field to determine the pathways of partial protection in badgers and these were simulated using a model. The simulation showed that some individuals receive no benefit from the vaccine, while others have delayed disease progression. However, overall the vaccine can still eradicate the disease in isolated populations, although its effectiveness is reduced due to partial protection. Further investigation is needed to identify potential vaccination failures.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Veterinary Sciences
Andrew Robertson, Kate L. Palphramand, Robbie A. McDonald, Sonya Middleton, Mark A. Chambers, Richard J. Delahay, Stephen P. Carter
Summary: This study investigated the factors influencing the uptake of candidate oral vaccine baits in wild badger populations. The results showed that cubs had a higher uptake rate than adults, and placing the baits directly into sett entrances resulted in a higher uptake rate. Season, bait type, and packaging did not affect uptake, while increasing the quantity of bait available increased uptake in cubs but not in adults. Additionally, levels of badger activity at setts were positively associated with bait uptake.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Environmental Sciences
Brian Gardner, Martha Betson, Adriana Cabal Rosel, Manuela Canica, Mark A. Chambers, Francesca M. Contadini, Laura C. Gonzalez Villeta, Marwa M. Hassan, Roberto M. La Ragione, Alexandre de Menezes, Davide Messina, Gordon Nichols, Daniel Olivenca, Revati Phalkey, Joaquin M. Prada, Werner Ruppitsch, Lorenzo A. Santorelli, Nick Selemetas, Mukunthan Tharmakulasingam, Arnoud H. M. van Vliet, Markus Woegerbauer, Inaki Deza-Cruz, Giovanni Lo Iacono
Summary: Human, animal, and environmental health are threatened by antibiotic resistance. In addition to inappropriate use of antibiotics, other environmental factors also play a significant role. This study aims to collect and categorize evidence on the effects of environmental factors on antibiotic resistance in the outdoor environment and explore the relationship with natural or anthropogenic conditions.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
K. Longman, C. Frampas, H. Lewis, C. Costa, R. Nilforooshan, M. Chambers, M. Bailey
Summary: This study explores the collection of finger sweat as a rapid and convenient method for monitoring patient adherence to antipsychotic drugs. The finger sweat test was found to be 100% effective in monitoring adherence within commonly prescribed dosing ranges and could differentiate between contact and administration of the drugs. Furthermore, a significant correlation was observed between the mass of parent drug in finger sweat and plasma concentration in a subgroup of patients. The finger sweat technology shows promise as a dignified and noninvasive method for monitoring treatment adherence in patients taking antipsychotics.
FRONTIERS IN CHEMISTRY
(2023)
Article
Art
Alastair S. Macdonald, Mark A. Chambers, Roberto La Ragione, Kayleigh Wyles, Matthieu Poyade, Andrew Wales, Naomi Klepacz, Tom R. Kupfer, Fraje Watson, Shona Noble
Summary: This study used visualization methods to enhance awareness of infection-related behaviors during veterinary surgery preparation, leading to behavior change and implementation of infection control measures. The approach also improved the delivery of training content by making complex contamination concepts easier to understand.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)