Article
Chemistry, Analytical
Melanie Welden, Arshak Poghossian, Farnoosh Vahidpour, Tim Wendlandt, Michael Keusgen, Christina Wege, Michael J. Schoening
Summary: Utilizing tobacco mosaic virus particles as nanoscaffolds, a bi-enzyme EISCAP biosensor was developed for sequential detection of penicillin and urea. The biosensor exhibited high sensitivity and precision, and could also mimic an enzyme logic gate.
Review
Materials Science, Multidisciplinary
Svetlana N. Khonina, Grigory S. Voronkov, Elizaveta P. Grakhova, Nikolay L. Kazanskiy, Ruslan V. Kutluyarov, Muhammad A. Butt
Summary: In the field of photonic integrated devices, polymers play a crucial role due to their compatibility with patterning techniques, affordability, and tunability. Polymer waveguides provide a viable platform for optical connectivity with low propagation losses and high flexibility. They have gained attention in optical sensing applications, especially in challenging environments such as power facilities. This review discusses the commonly used polymer materials in integrated photonics and highlights their significant applications in biosensing, gas sensing, temperature sensing, and mechanical sensing.
Article
Engineering, Electrical & Electronic
Jinze Li, Xin Liu, Hao Sun, Liming Wang, Jianqi Zhang, Xi Huang, Li Deng, Jiawei Xi, Tianhong Ma
Summary: The immobilization of enzymes is a key factor in biosensor development. This study successfully used the electrospinning method to immobilize enzymes on optical fiber sensors, demonstrating high sensitivity in detecting glucose with promising potential for further development.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Analytical
Didem Nur Unal, Selenay Sadak, Bengi Uslu
Summary: There has been an increasing interest in the field of sensors for ionic liquids due to their unique properties, such as electrochemical and radiolytic stability, and the ability to synthesize a large number of variations with different anions and cations. Ionic liquids are preferred for fabricating electrochemical, optical sensors, and biosensors, as well as for use in electrolyte solutions. They offer advantages such as increased conductivity, optical properties, and stability, lower detection limits, enhanced electron transfer, and increased effective surface area of electrodes and sensor platforms. The use of nanomaterials in sensor modification further enhances these properties.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Qi Li, Siji Xu, Liangyu He, Kun Huang, Xiangyu Zhang, Dabin Qin
Summary: The Zn-MOF is a highly selective and sensitive Al3+ fluorescent sensor with a detection limit of 0.69μM via ratiometric fluorescence signal changes. Furthermore, the Zn-MOF demonstrates good recyclability in the sensing of Al3+ with at least 5 cycles and can construct an INHIBIT logic gate.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Analytical
Tamara Lazarevic-Pasti
Summary: Organophosphates are extensively used pesticides to protect crops, thus accurate monitoring of their concentrations in the environment and food is crucial. Portable sensors, specifically based on carbon materials, need to be developed for routine analysis. This review focuses on the selectivity, sensitivity, stability, and reusability of electrochemical and optical sensors based on carbon materials.
Article
Chemistry, Analytical
Eun-Ki Hong, Won-Ju Cho
Summary: This study presents a high sensitivity IGZO nanofiber channel double gate field-effect transistor (FET) based chemical sensor. Compared to IGZO film channels, the nanofiber channels demonstrated higher sensitivity and stability in pH sensing applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Wenfang Du, Jie Liu, Hong Li, Chenyi Deng, Jie Luo, Qianqian Feng, Yan Tan, Shengyuan Yang, Zhaoyang Wu, Fubing Xiao
Summary: In this study, a two-dimensional photonic crystal dually cross-linked supramolecular hydrogel was constructed for the colorimetric and fluorescent dual-mode sensing of bisphenol A (BPA) using a host-guest pair of beta-cyclodextrin and tert-butyl. The proposed method provides a sensitive, selective, cost-effective, and regenerative dual-mode approach for BPA analysis, and offers new insights for the design of diversified sensing platforms.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
David C. Magri
Summary: This article critically reviews the evolution of fluorescence sensing at the University of Malta in the context of molecular logic-based computation. It showcases the design principle of photoinduced electron transfer (PET) and discusses redox-driven switching alongside traditional acid-base and ion-binding phenomena. The cross-pollination with internal charge transfer (ICT) further provides intelligent molecules with interesting and enhanced properties.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Spectroscopy
Malabika Ghosh, Uddipan Dasgupta, Sumanta Nayek, Abhijit Saha, Rama Ranjan Bhattacharjee, Ankan Dutta Chowdhury
Summary: Carbon quantum dot-PSS fluorescent nanocomposites have been developed for specific Fe3+ detection, with a low detection limit of 1 ppm, rapid sensing process, simple instrumentation, and excellent performance in the presence of biological samples. It shows great potential for diagnostic applications in the near future.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Haifeng Sha, Bing Yan
Summary: In this study, a series of mixed lanthanide metal-organic frameworks (Ln-MOFs) probes were synthesized using a simple method of in situ doping. The luminous color of the probes can be finely modulated by changing the molar ratio of Tb3+ and Eu3+ during synthesis. The probes have the continuous detection capability of zinc ions and fluoride ions due to the unique energy transfer modulation mechanism. The detection of Zn2+ and F- in a real environment shows that the probes have a good practical application prospect. The designed sensor can sequentially detect Zn2+ concentrations ranging from 10-8 to 10-3 M (LOD = 4.2 nM) and F- levels ranging from 10-5 to 10-3 M (LOD = 3.6 mu M) with high selectivity. Additionally, a simple Boolean logic gate device is constructed based on different output signals to realize intelligent visualization of Zn2+ and F- monitoring.
Article
Chemistry, Analytical
Dengfeng Qu, Zongli Gu, Jialiang Wu, Li Wang, Shufeng Liu
Summary: In this study, a simple and multifunctional electrochemical sensing platform was constructed using a DNA junction scaffold structure as the immobilization probe. The platform enabled amplified and controllable signal responses for the analysis of two nucleic acid targets, and could be flexibly used for target assays based on different signal response behaviors. The platform also demonstrated the operation of logic devices with different target inputs. The low detection limit of 10 fM was achieved for both individual and simultaneous target analysis in buffer or serum. This DNA junction scaffold-based sensing platform features easy fabrication and operation, sensitive and selective analysis of multiple targets, controllable and multilevel signal response behaviors, and expandable logic operation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Jaydeep Singh Parmar, Nawaz Shafi, Chitrakant Sahu
Summary: In this paper, a novel triple gate (TG) cavity based, polysilicon junctionless (JL) ion-sensitive field-effect transistor (ISFET) architecture is proposed for the first time, and its performance is compared with conventionally doped ISFET. The study investigates the effect of pH on the device for different parameters, and measures the threshold voltage sensitivity for various configurations. The simulations are conducted using the ATLAS device simulator.
Article
Chemistry, Analytical
Xue Wang, Yingying Sun, Zhe Liu, Weiwei Chen, Tingting Meng, Huanyuan Wang
Summary: In this research, a novel liquid crystal biosensor using Fe3O4 nanospheres as signal amplifiers was constructed to improve the ability of nanomaterials to interfere with liquid crystal orientation. This biosensor showed highly selective and sensitive detection of HCG. By utilizing the large spatial structure of Fe3O4 nanospheres, b-hCG antibodies were immobilized on the glass substrate, and the antigen-antibody formed a specific immune response to disrupt the orientation of the liquid crystal in the presence of HCG antigens. This strategy resulted in an amplified optical signal and greatly increased the sensitivity of detection. The prepared LC biosensor demonstrated excellent specificity and sensitivity and is expected to provide a sensitive detection platform for HCG and other molecular monitors.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Applied
Yangyu Yang, Xia Tong, Yuxia Chen, Rongrong Zhou, Guihan Cai, Tongtao Wang, Shuihan Zhang, Shuyun Shi, Ying Guo
Summary: A dual-emission carbon dots-based nonenzymatic fluorescent sensing platform has been developed for simultaneous and high-performance detection of parathion-methyl and glyphosate. The carbon dots with emissions at 440 nm and 660 nm were prepared from mulberry leaves and sodium hydroxide. The sensing platform showed excellent sensitivity and selectivity, and could be applied in food/herbal samples with acceptable recoveries and high selectivity. Moreover, an OR logic gate was achieved for estimating food, herbal, or environmental safety.
Article
Chemistry, Multidisciplinary
Sofiene Abdellaoui, Florika C. Macazo, Rong Cai, Antonio L. De lacey, Marcos Pita, Shelley D. Minteer
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Multidisciplinary
Isabel Fuentes, Tania Garcia-Mendiola, Shinichi Sato, Marcos Pita, Hiroyuki Nakamura, Encarnacion Lorenzo, Francesc Teixidor, Fernanda Marques, Clara Vinas
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Electrochemistry
Carmen Jarne, Logan Paul, Jose Carlos Conesa, Sergey Shleev, Antonio L. De Lacey, Marcos Pita
Article
Chemistry, Physical
Julian Szczesny, Adrian Ruff, Ana R. Oliveira, Marcos Pita, Ines A. C. Pereira, Antonio L. De Lacey, Wolfgang Schuhmann
ACS ENERGY LETTERS
(2020)
Article
Chemistry, Physical
Sandra Alonso, Gerard Santiago, Isabel Cea-Rama, Laura Fernandez-Lopez, Cristina Coscolin, Jan Modregger, Anna K. Ressmann, Monica Martinez-Martinez, Helena Marrero, Rafael Bargiela, Marcos Pita, Jose L. Gonzalez-Alfonso, Manon L. Briand, David Rojo, Coral Barbas, Francisco J. Plou, Peter N. Golyshin, Patrick Shahgaldian, Julia Sanz-Aparicio, Victor Guallar, Manuel Ferrer
Article
Biochemistry & Molecular Biology
Gabriel Garcia-Molina, Paolo Natale, Laura Valenzuela, Julia Alvarez-Malmagro, Cristina Gutierrez-Sanchez, Ana Iglesias-Juez, Ivan Lopez-Montero, Marisela Velez, Marcos Pita, Antonio L. De Lacey
BIOELECTROCHEMISTRY
(2020)
Review
Chemistry, Analytical
Melisa del Barrio, Gabriel Luna-Lopez, Marcos Pita
Article
Nanoscience & Nanotechnology
Julia Alvarez-Malmagro, Ana R. Oliveira, Cristina Gutierrez-Sanchez, Beatriz Villajos, Ines A. C. Pereira, Marisela Velez, Marcos Pita, Antonio L. De Lacey
Summary: This study investigates the covalent bonding of Desulfovibrio vulgaris Hildenborough FdhAB formate dehydrogenase to gold and graphite electrodes, showing a compact enzyme layer anchored to the electrode surface for the reduction of CO2 to formic acid via direct electron transfer. The operational stability of CO2 electroreduction to formate by direct electron transfer is demonstrated with approximately 100% Faradaic yield.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Electrochemistry
Melisa del Barrio, Moumita Rana, Juan Jose Vilatela, Encarnacion Lorenzo, Antonio L. De Lacey, Marcos Pita
Summary: A semiconductor combined with carbon nanotube fibers has been proposed as a photoelectrode for the quantification of NADH with high sensitivity. This system may serve as a biosensing platform for detection and quantification of dehydrogenases' activity.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Physical
Jose M. Abad, Marcos Pita, Antonio L. De Lacey
Summary: Monolayer-Protected Gold Clusters (AuMPCs) have attracted great interest as nanoscale capacitors in aqueous media for various nanobiotechnological applications. However, achieving subattofarad double-layer capacitance and single-electron charging has been challenging. In this study, we successfully synthesized Thioctic Acid Monolayer-Protected Au Clusters (TA-AuMPCs) that exhibited electrochemical single electron quantized capacitance charging in both organic and aqueous solutions. The functional carboxylic groups present in TA-AuMPCs provide a simple strategy for interfacing nanoparticles with biomolecules for biological electron transfer reactions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Melisa del Barrio, Emiliano Martinez-Perinan, Cristina Gutierrez-Sanchez, Eva Mateo-Marti, Marcos Pita, Antonio L. De Lacey, Felix Pariente, Encarnacion Lorenzo
Summary: The determination of cholesterol is important for heart disease detection and as a fuel for enzymatic fuel cells. A cholesterol biosensor and peroxide-free biofuel cell was developed using electrocatalytic oxidation of NADH generated during cholesterol dehydrogenase (ChDH) reaction. This alternative method avoids the use of H2O2 biosensing strategies.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Luna-Lopez, Melisa del Barrio, Jennifer Fize, Vincent Artero, Ana Margarida Coito, Ines A. C. Pereira, Jose Carlos Conesa, Ana Iglesias-Juez, Antonio L. De Lacey, Marcos Pita
Summary: Clean energy vectors are required to achieve a fossil fuel-free society, reducing both greenhouse effect and pollution. Electrochemical water splitting provides a clean method to obtain green hydrogen, but efficient electrocatalysts are needed to avoid high overpotentials. The combination of inorganic semiconductors with biocatalysts offers an alternative approach for photoelectrochemical H2 production.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Physical
Mihai-Cristian Fera, Rita R. Manuel, Ines A. C. Pereira, Jose M. Abad, Antonio L. De Lacey, Marcos Pita
Summary: The electrochemical reduction of CO2 through redox enzymes is a promising method to reduce global CO2 concentrations. In this study, the enzyme Desulfovibrio vulgaris Hildenborough FdhAB formate dehydrogenase was effectively immobilized on MWCNTs-modified low density graphite electrodes using electrostatic interactions and protected with polyethyleneimine (PEI) polymer. The synergistic effect of MWCNTs and PEI resulted in high catalytic current densities and long-term operational stability.
Article
Nanoscience & Nanotechnology
Keyvan Jodeiri, Aleksandra Foerster, Gustavo F. Trindade, Jisun Im, Diego Carballares, Roberto Fernandez-Lafuente, Marcos Pita, Antonio L. De Lacey, Christopher Parmenter, Christopher Tuck
Summary: The drive for miniaturization in enzyme-based bioelectronics has led to the development of 3D microstructured electrodes. Additive manufacturing combined with electroless metal plating allows the production of these electrodes with high surface area. The challenge lies in ensuring strong adhesion between the metal layer and polymer structure, which has been achieved in this study through the introduction of an interfacial adhesion layer.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Laura Fernandez-Lopez, Isabel Cea-Rama, Julia Alvarez-Malmagro, Anna K. Ressmann, Jose L. Gonzalez-Alfonso, Cristina Coscolin, Patrick Shahgaldian, Francisco J. Plou, Jan Modregger, Marcos Pita, Julia Sanz-Aparicio, Manuel Ferrer
Summary: Metal complexes introduced into protein scaffolds can generate versatile biomimetic catalysts with various catalytic properties. In this study, we synthesized and covalently bound a bipyridinyl derivative to the active site of an esterase, resulting in a biomimetic catalyst that exhibits catecholase activity and enantioselective catalytic oxidation of (+)-catechin.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
