Mechanisms of tissue injury in autoimmune liver diseases

Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms

(2014) Marcial Sebode et al.   JOURNAL OF HEPATOLOGY

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis

(2013) Gideon M. Hirschfield et al.   Annual Review of Pathology-Mechanisms of Disease

Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis

(2013) H. Tanaka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Genetics of Complex Cholestatic Disorders

(2013) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Increased TERC gene copy number and cells in senescence in primary sclerosing cholangitis compared to colitis and control patients

(2013) Ido Laish et al.   GENE

Clonality, activated antigen-specific CD8+T cells, and development of autoimmune cholangitis in dnTGFβRII mice

(2013) Kazuhito Kawata et al.   HEPATOLOGY

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

(2013) Janosch Katt et al.   HEPATOLOGY

Autoimmune hepatitis: the role of environmental risk factors: a population-based study

(2013) Jing H. Ngu et al.   Hepatology International

Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA

(2013) Patrick S.C. Leung et al.   JOURNAL OF AUTOIMMUNITY

Novel insights into autoimmune liver diseases provided by genome-wide association studies

(2013) George F. Mells et al.   JOURNAL OF AUTOIMMUNITY

Mucosal immunity in liver autoimmunity: A comprehensive review

(2013) Palak J. Trivedi et al.   JOURNAL OF AUTOIMMUNITY

Autoimmune liver disease, autoimmunity and liver transplantation

(2013) Marco Carbone et al.   JOURNAL OF HEPATOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

Primary sclerosing cholangitis

(2013) Gideon M Hirschfield et al.   LANCET

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

(2013) Jimmy Z Liu et al.   NATURE GENETICS

Review article: overlap syndromes and autoimmune liver disease

(2012) P. J. Trivedi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population

(2012) Minoru Nakamura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci atGPR35andTCF4

(2012) David Ellinghaus et al.   HEPATOLOGY

Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments

(2012) Palak J. Trivedi et al.   Hepatology International

Role of gut microbiota in liver diseases

(2012) Yasuhiro Miyake et al.   HEPATOLOGY RESEARCH

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

(2012) Brian D. Juran et al.   HUMAN MOLECULAR GENETICS

Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency

(2012) Vladimir K. Bakalov et al.   JOURNAL OF AUTOIMMUNITY

Mechanisms of environmental influence on human autoimmunity: A national institute of environmental health sciences expert panel workshop

(2012) Carlo Selmi et al.   JOURNAL OF AUTOIMMUNITY

Criteria for environmentally associated autoimmune diseases

(2012) Frederick W. Miller et al.   JOURNAL OF AUTOIMMUNITY

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

(2012) Trine Folseraas et al.   JOURNAL OF HEPATOLOGY

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency

(2012) Moritz Peiseler et al.   JOURNAL OF HEPATOLOGY

The dynamic biliary epithelia: Molecules, pathways, and disease

(2012) Steven P. O’Hara et al.   JOURNAL OF HEPATOLOGY

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

(2012) Jimmy Z Liu et al.   NATURE GENETICS

Implication for Functions of the Ectopic Adipocyte Copper Amine Oxidase (AOC3) from Purified Enzyme and Cell-Based Kinetic Studies

(2012) Sam H. Shen et al.   PLoS One

Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis

(2012) Brijesh Srivastava et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Genetics in primary sclerosing cholangitis

(2011) Trine Folseraas et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Pathogenesis of primary sclerosing cholangitis

(2011) Marion J. Pollheimer et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Primary Sclerosing Cholangitis and Disease Distribution in Inflammatory Bowel Disease

(2011) Aoibhlinn O'Toole et al.   Clinical Gastroenterology and Hepatology

Cutting-Edge Issues in Primary Biliary Cirrhosis

(2011) Marco Folci et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Immune-mediated diseases in primary sclerosing cholangitis

(2011) Laetitia E. Lamberts et al.   DIGESTIVE AND LIVER DISEASE

Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis

(2011) Michelle M. Mitchell et al.   Epigenetics

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

(2011) Masanobu Tsuda et al.   HEPATOLOGY

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

(2011) Marcel Janse et al.   HEPATOLOGY

Connecting liver and gut: Murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid

(2011) Katrin Neumann et al.   HEPATOLOGY

Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: A meta-analysis

(2011) Yan Liang et al.   HEPATOLOGY RESEARCH

Cholangiocyte N-Ras Protein Mediates Lipopolysaccharide-induced Interleukin 6 Secretion and Proliferation

(2011) Steven P. O'Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis

(2011) Tobias Mueller et al.   LIVER INTERNATIONAL

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

(2011) George F Mells et al.   NATURE GENETICS

Interleukin-17 Contributes to the Pathogenesis of Autoimmune Hepatitis through Inducing Hepatic Interleukin-6 Expression

(2011) Li Zhao et al.   PLoS One

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Cutting Edge Issues in Primary Sclerosing Cholangitis

(2010) Christopher L. Bowlus   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis

(2010) Silvia Ferri et al.   HEPATOLOGY

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

(2010) Ana Lleo et al.   HEPATOLOGY

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

(2010) Evaggelia Liaskou et al.   HEPATOLOGY

Concurrent Autoimmune Diseases in Patients With Autoimmune Hepatitis

(2010) Andreas Teufel et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis

(2010) Hitoshi Sano et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

(2010) Motoko Sasaki et al.   JOURNAL OF HEPATOLOGY

Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

(2010) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7α-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis

(2010) Yasuaki Takeyama et al.   Medical Molecular Morphology

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

(2010) Gideon M Hirschfield et al.   NATURE GENETICS

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

(2010) Xiangdong Liu et al.   NATURE GENETICS

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

(2010) Espen Melum et al.   NATURE GENETICS

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population

(2009) G. Rong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis

(2009) K. Harada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut Homing Receptors on CD8 T Cells Are Retinoic Acid Dependent and Not Maintained by Liver Dendritic or Stellate Cells

(2009) Bertus Eksteen et al.   GASTROENTEROLOGY

Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

(2009) Tom H. Karlsen et al.   GASTROENTEROLOGY

p-ANCAs in autoimmune liver disorders recognise human  -tubulin isotype 5 and cross-react with microbial protein FtsZ

(2009) B. Terjung et al.   GUT

Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent

(2009) Walee Chamulitrat et al.   HEPATOLOGY

Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells

(2009) Maria Serena Longhi et al.   HEPATOLOGY

A Familial Case of Autoimmune Hepatitis

(2009) Osamu Yoshida et al.   INTERNAL MEDICINE

Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis

(2009) Gerda Rudolph et al.   JOURNAL OF HEPATOLOGY

Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis

(2009) Christoph P. Berg et al.   LIVER INTERNATIONAL

Primary Biliary Cirrhosis Associated withHLA, IL12A,andIL12RB2Variants

(2009) Gideon M. Hirschfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoantibodies and their Antigens in Autoimmune Hepatitis

(2009) Dimitrios Bogdanos et al.   SEMINARS IN LIVER DISEASE

CCL25 and CCL28 promote α4β7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

(2008) Alice Miles et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adoptive transfer of CD8+ T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice

(2008) Guo-Xiang Yang et al.   HEPATOLOGY

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

(2008) Motoko Sasaki et al.   HEPATOLOGY

Lymphocyte homing and its role in the pathogenesis of IBD

(2008) Bertus Eksteen et al.   INFLAMMATORY BOWEL DISEASES

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

(2008) Martin Holdener et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Etiopathogenesis of primary sclerosing cholangitis

(2008) Roger Chapman et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Autoantibodies in primary sclerosing cholangitis

(2008) Johannes Roksund Hov et al.   WORLD JOURNAL OF GASTROENTEROLOGY