Article
Rheumatology
Marc Scherlinger, Johanna Lutz, Gael Galli, Christophe Richez, Jacques-Eric Gottenberg, Jean Sibilia, Laurent Arnaud, Patrick Blanco, Thierry Schaeverbeke, Emmanuel Chatelus, Marie-Elise Truchetet
Summary: This study found significant differences in clinical characteristics and prognosis in patients with systemic sclerosis who have concomitant autoimmune diseases. Patients with overlap SgS/SSc had a higher risk of mortality, while those with RA/SSc received more medication treatments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Immunology
Kaan Yilmaz, Stefanie Haeberle, Yong Ook Kim, Marvin J. Fritzler, Shih-Yen Weng, Benjamin Goeppert, Verena K. Raker, Kerstin Steinbrink, Detlef Schuppan, Alexander Enk, Eva N. Hadaschik
Summary: Our study demonstrates that Treg-deficient scurfy mice spontaneously develop clinical, serological, and immunopathological characteristics of autoimmune liver diseases (AILD), with overlapping features of primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Ezgi Deniz Batu, Aybuke Gunalp, Sezgin Sahin, Semanur Ozdel, Zehra Kizildag, Aysenur Pac Kisaarslan, Ilknur Bagrul, Muserref Kasap Cuceoglu, Ayse Tanatar, Hafize Emine Sonmez, Erdal Sag, Selcan Demir, Elif Celikel, Sengul Caglayan, Banu Celikel Acar, Betul Sozeri, Nuray Aktay Ayaz, Yelda Bilginer, M. Hakan Poyrazoglu, Erbil Unsal, Oezgur Kasapcopur, Seza Ozen
Summary: This study compared the characteristics and outcomes of pediatric MCTD and other overlap syndromes, finding differences in disease phenotype and prognosis. MCTD may be considered a more severe disease. Analyzing these patients could pave the way for early and effective treatment.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Immunology
Isabelle Paggioli, Jeremy Moss
Summary: Alopecia Areata is an autoimmune disease that results in rapid hair loss and is associated with psychological disorders and decreased quality of life. There are currently no effective treatments, but JAK inhibitors may be a promising option.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Gastroenterology & Hepatology
Jaimy Villavicencio Kim, George Y. Wu
Summary: Elevated aminotransferases in celiac disease patients can normalize with a strict gluten-free diet, especially in those with cryptogenic liver disease. The relationship between liver damage and intestinal permeability may play a role in the elevation of aminotransferases in celiac disease. Routine monitoring of liver enzymes and adherence to a gluten-free diet is recommended for celiac disease patients, with further investigation needed if there is no improvement despite strict compliance with the diet.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Psychology, Clinical
Dominique Endres, Viktoria Maier, Frank Leypoldt, Klaus-Peter Wandinger, Belinda Lennox, Thomas A. Pollak, Kathrin Nickel, Simon Maier, Bernd Feige, Katharina Domschke, Harald Pruss, Karl Bechter, Rick Dersch, Ludger Tebartz van Elst
Summary: Autoimmune encephalitis can mimic predominant psychiatric and neurocognitive disorders, such as schizophreniform psychoses or neurodegenerative dementia. Patients can be successfully treated with immunomodulatory drugs.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Immunology
Rui Wang, Ruqi Tang, Bo Li, Xiong Ma, Bernd Schnabl, Herbert Tilg
Summary: The delicate interaction between the gut microbiota and liver is crucial in preventing accidental immune activation against harmless antigens, also aiding in understanding and treating various liver diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Cristiana Bianco, Elena Coluccio, Daniele Prati, Luca Valenti
Summary: Anemia is a common feature of liver and bowel diseases, and autoimmune hemolytic anemia should be considered in differential diagnosis. Prompt treatment based on direct antiglobulin test results is crucial, while drug-induced immune-mediated hemolytic anemia should be ruled out. Maintaining a high clinical suspicion for timely diagnosis and appropriate treatment is essential due to the adverse impact of anemia on clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Cumali Efe, Anand V. Kulkarni, Benedetta Terziroli Beretta-Piccoli, Bianca Magro, Albert Friedrich Staettermayer, Mustafa Cengiz, Daniel Clayton-Chubb, Craig Lammert, Christine Bernsmeier, Ozlem Gul, Fatima Higuera-de la Tijera, Margarita Anders, Ellina Lytvyak, Mete Akin, Tugrul Purnak, Rodrigo Liberal, Mirta Peralta, Berat Ebik, Serkan Duman, Nurhan Demir, Yasemin Balaban, Alvaro Urzua, Fernando Contreras, Maria Grazia Venturelli, Yilmaz Bilgic, Adriana Medina, Marcos Girala, Fulya Guensar, Maria-Carlota Londono, Theodoros Androutsakos, Ayelen Kisch, Alper Yurci, Fatih Guezelbult, Yasir Furkan Cagin, Enver Avci, Murat Guezelbulut, Emine Kubra Dindar-Demiray, Murat Harputluoglu, Rahul Kumar, Sanjaya K. Satapathy, Manuel Mendizabal, Marcelo Silva, Stefano Fagiuoli, Stuart K. Roberts, Nese Karadag Soylu, Ramazan Idilman, Eric M. Yoshida, Aldo J. Montano-Loza, George N. Dalekos, Ezequiel Ridruejo, Thomas D. Schiano, Staffan Wahlin
Summary: This study evaluated the clinical features, treatment response, and outcomes of liver injury following SARS-CoV-2 vaccination. The liver injury was predominantly hepatocellular and some patients showed features of immune-mediated hepatitis. Corticosteroid therapy may be beneficial for patients with immune-mediated features or severe hepatitis. The overall outcome was generally favorable, but a few patients experienced vaccine-associated liver failure.
Review
Immunology
Xinhe Zhang, Xuyong Lin, Xuedan Li, Lin Guan, Yiling Li, Ningning Wang
Summary: This case report describes a patient with ulcerative colitis, primary biliary cholangitis, and autoimmune hepatitis, ultimately diagnosed with overlap syndrome. The accurate diagnosis of overlap syndrome requires multiple laboratory tests and pathological examinations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Bruno Fattizzo, Fabio Serpenti, Wilma Barcellini, Chiara Caprioli
Summary: Hypoplastic myelodysplastic syndromes (hMDS) pose a diagnostic challenge, blending features of both MDS (dysplasia, genetic lesions, cytopenias) and aplastic anemia (low cellularity, autoimmunity). There are two potential hMDS phenotypes: one proinflammatory and autoimmune, resembling AA and responding to immunosuppression; the other MDS-like, dominated by genetic lesions and prone to leukemic evolution. Personalized treatment and monitoring based on the predominant hMDS phenotype may be beneficial for patient management.
Review
Psychiatry
Aaron J. Hauptman, Vladimir Ferrafiat
Summary: This review summarizes recent literature on autoimmune and post-infectious encephalitis, discusses special considerations in children with neurodevelopmental conditions, and presents a paradigm for evaluation and management.
CURRENT OPINION IN PSYCHIATRY
(2023)
Review
Immunology
Monika Peshevska-Sekulovska, Plamena Bakalova, Violeta Snegarova, Snezhina Lazova, Tsvetelina Velikova
Summary: The SARS-CoV-2 pandemic has posed challenges for patients with chronic conditions and autoimmune diseases. Vaccination is considered an effective strategy for pandemic control, but patients with autoimmune gut and liver diseases have been excluded from vaccine clinical trials. Real-world data are needed to understand the long-term safety and efficacy of COVID-19 vaccines in these patients. Despite current recommendations, vaccine hesitancy remains high among autoimmune disease patients.
Review
Cell Biology
Luiz Eduardo Baggio Savio, Simon C. Robson, Maria Serena Longhi
Summary: Imbalance between regulatory and effector T lymphocytes, governed by CD39 ectonucleotidase, contributes to chronic inflammatory diseases and autoimmune disorders. Innovative therapeutic strategies to boost CD39 levels and activity have translational and clinical implications for the treatment of chronic inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Alan Bonder, Albert Pares, Laura Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
Summary: Recurrence of autoimmune hepatitis (AIH) is common after liver transplantation, and it is associated with younger age at transplantation, the use of mycophenolate mofetil post-transplant, sex mismatch, and high pre-transplant IgG levels. Recurrent AIH is associated with impaired graft and overall survival. Better characterization, prevention, and treatment strategies are needed for the management of recurrent AIH.
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Palak J. Trivedi, Stefan G. Hubscher, Michael Heneghan, Dermot Gleeson, Gideon M. Hirschfield
JOURNAL OF HEPATOLOGY
(2019)
Editorial Material
Medicine, General & Internal
Evaggelia Liaskou, Gideon M. Hirschfield
Editorial Material
Gastroenterology & Hepatology
Maya Deeb, Tom H. Karlsen, Gideon M. Hirschfield
JOURNAL OF HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Ulrich Beuers, Limas Kupcinskas, Peter Ott, Annika Bergquist, Martti Faerkkilae, Michael P. Manns, Albert Pares, Ulrich Spengler, Michael Stiess, Roland Greinwald, Markus Prols, Dominique Wendum, Uta Drebber, Raoul Poupon
Summary: Budesonide did not improve liver histology in patients with PBC who had insufficient response to UDCA, but demonstrated significant improvements in biochemical markers of disease activity.
JOURNAL OF HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Surain B. Roberts, Amol A. Verma, Gideon M. Hirschfield
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Surain B. Roberts, Bettina E. Hansen, Saeha Shin, Lusine Abrahamyan, Lauren Lapointe-Shaw, Harry L. A. Janssen, Fahad Razak, Amol A. Verma, Gideon M. Hirschfield
Summary: Liver disease is a growing burden on population health globally, with liver disease patients in Toronto-area hospitals having higher mortality rates and resource use compared to common cardio-respiratory conditions such as heart failure, COPD, and pneumonia. Re-evaluation of approaches to caring for inpatients with liver disease is necessary.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Palak J. Trivedi, Gideon M. Hirschfield
Summary: Autoimmune liver diseases, including primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis, show meaningful changes in disease epidemiology with increasing incidence and prevalence in Europe, North America, and the Asia-Pacific region. Global variations exist in contemporary incidence rates, with age, sex, and race impacting clinical outcomes and the need for gastroenterology, hepatology, and organ transplant services.
Article
Gastroenterology & Hepatology
Kristel K. Leung, Audrey Kim, Bettina E. Hansen, Les Lilly, Nazia Selzner, Keyur Patel, Mamatha Bhat, Gideon M. Hirschfield, Zita Galvin
Summary: This study analyzed the impact of organ allocation in liver transplantation, finding that patient social determinants and primary liver disease etiology continue to be significantly associated with ultimate transplantation.
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Alan Bonder, Albert Pares, Laura Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
Summary: Recurrence of autoimmune hepatitis (AIH) is common after liver transplantation, and it is associated with younger age at transplantation, the use of mycophenolate mofetil post-transplant, sex mismatch, and high pre-transplant IgG levels. Recurrent AIH is associated with impaired graft and overall survival. Better characterization, prevention, and treatment strategies are needed for the management of recurrent AIH.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Christopher L. Bowlus, Michael R. Galambos, Richard J. Aspinall, Gideon M. Hirschfield, David E. J. Jones, Yvonne Doerffel, Stuart C. Gordon, Stephen A. Harrison, Andreas E. Kremer, Marlyn J. Mayo, Paul J. Thuluvath, Cynthia Levy, Mark G. Swain, Guy W. Neff, David A. Sheridan, Carmen M. Stanca, Christoph P. Berg, Aparna Goel, Mitchell L. Shiffman, John M. Vierling, Pol Boudes, Alexandra Steinberg, Yun-Jung Choi, Charles A. McWherter
Summary: This study examined the efficacy and safety of seladelpar in patients with primary biliary cholangitis (PBC). The results showed that seladelpar significantly improved biochemical markers of cholestasis and inflammation, and the improvements were maintained or improved after dose escalation at 52 weeks. The treatment was safe and not associated with worsening pruritus.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Mitchell L. Shiffman, Aliya Gulamhusein, Kris Kowdley, John M. Vierling, Cynthia Levy, Andreas E. Kremer, Ehud Zigmond, Pietro Andreone, Stuart C. Gordon, Christopher L. Bowlus, Eric J. Lawitz, Richard J. Aspinall, Daniel S. Pratt, Karina Raikhelson, Maria S. Gonzalez-Huezo, Michael A. Heneghan, Sook-Hyang Jeong, Alma L. Ladron de Guevara, Marlyn J. Mayo, George N. Dalekos, Joost P. H. Drenth, Ewa Janczewska, Barbara A. Leggett, Frederik Nevens, Victor Vargas, Eli Zuckerman, Christophe Corpechot, Eduardo Fassio, Holger Hinrichsen, Pietro Invernizzi, Palak J. Trivedi, Lisa Forman, David E. J. Jones, Stephen D. Ryder, Mark G. Swain, Alexandra Steinberg, Pol F. Boudes, Yun-Jung Choi, Charles A. McWherter
Summary: This study evaluated the efficacy and safety of seladelpar in patients with primary biliary cholangitis who had inadequate response or intolerance to ursodeoxycholic acid. The results showed that seladelpar significantly improved liver biochemistry and pruritus in these patients, and it was well tolerated.
Article
Gastroenterology & Hepatology
Amanda Ricciuto, Binita M. Kamath, Gideon M. Hirschfield, Palak J. Trivedi
Summary: Autoimmune liver diseases are classified into three syndromes, but they are challenging due to variant presentations and lack of definable disease aetiologies. This article argues that "autoimmune sclerosing cholangitis" and "PSC/AIH-overlap" in young patients represent inflammatory phases of primary sclerosing cholangitis and should be considered as the same entity to facilitate unified care and collaborative studies.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laura Martinez-Gili, Alexandros Pechlivanis, Julie A. K. McDonald, Sofina Begum, Jonathan Badrock, Jessica K. Dyson, Rebecca Jones, Gideon Hirschfield, Stephen D. Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor-Robinson, Mary M. E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Summary: A study on patients with primary biliary cholangitis (PBC) showed that there is variation in response to ursodeoxycholic acid (UDCA) treatment. Responders exhibited high levels of secondary and tertiary bile acids, while non-responders had lower urinary bile acid levels and higher levels of 12-dehydrocholic acid. Additionally, non-responders showed lower gut microbiota diversity and lower capacity for bile acid deconjugation.
Review
Medicine, General & Internal
Georg Beyer, Aida Habtezion, Jens Werner, Markus M. Lerch, Julia Mayerle
Review
Gastroenterology & Hepatology
Kristel K. Leung, Maya Deeb, Gideon M. Hirschfield
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)