The unfolded protein response and gastrointestinal disease

The Unfolded Protein Response and Chemical Chaperones Reduce Protein Misfolding and Colitis in Mice

(2013) Stewart Siyan Cao et al.   GASTROENTEROLOGY

Potential for therapeutic manipulation of the UPR in disease

(2013) Sang Won Park et al.   Seminars in Immunopathology

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

The Unfolded Protein Response: A Multifaceted Regulator of Lipid and Lipoprotein Metabolism

(2012) Edward A. Fisher et al.   Cell Metabolism

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

(2012) Shiyu Wang et al.   Cell Metabolism

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium

(2012) Read Pukkila-Worley et al.   CURRENT OPINION IN IMMUNOLOGY

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice

(2012) Michael E. Rothenberg et al.   GASTROENTEROLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic Reticulum Stress Response Promotes Cytotoxic Phenotype of CD8  + Intraepithelial Lymphocytes in a Mouse Model for Crohn's Disease-like Ileitis

(2012) J.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Glutamine Treatment Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis

(2012) Irene Crespo et al.   PLoS One

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What is the role of HLA-B27 in spondyloarthropathies?

(2011) Anthoula Chatzikyriakidou et al.   AUTOIMMUNITY REVIEWS

Structure–function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells

(2011) Emanuel Berger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding

(2011) J. Jasper Deuring et al.   BIOCHEMICAL JOURNAL

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications

(2011) Marcelo G. Roma et al.   CLINICAL SCIENCE

Role of mucus layers in gut infection and inflammation

(2011) Gunnar C Hansson   CURRENT OPINION IN MICROBIOLOGY

Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress

(2011) Ferdinand Maingat et al.   FASEB JOURNAL

Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis

(2011) Xavier Tréton et al.   GASTROENTEROLOGY

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals

(2011) Caroline M Hodin et al.   JOURNAL OF PATHOLOGY

Spondyloarthritis

(2011) Maxime Dougados et al.   LANCET

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Survive an innate immune response through XBP1

(2010) Arthur Kaser et al.   CELL RESEARCH

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion

(2010) Joep Grootjans et al.   GASTROENTEROLOGY

Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion

(2010) N. Rolhion et al.   GUT

Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis

(2010) T. Werner et al.   GUT

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serological Markers for Inflammatory Bowel Disease in AIDS Patients with Evidence of Microbial Translocation

(2010) Anupa Kamat et al.   PLoS One

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis

(2009) Takushi Namba et al.   AMERICAN JOURNAL OF PATHOLOGY

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

HIV Protease Inhibitors Induce Endoplasmic Reticulum Stress and Disrupt Barrier Integrity in Intestinal Epithelial Cells

(2009) Xudong Wu et al.   GASTROENTEROLOGY

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

Tissue Distribution of Murine Muc19/Smgc Gene Products

(2009) Biswadip Das et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

(2009) K. Brandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

The Adenocarcinoma-Associated Antigen, AGR2, Promotes Tumor Growth, Cell Migration, and Cellular Transformation

(2008) Z. Wang et al.   CANCER RESEARCH

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

(2008) Jahangir Iqbal et al.   Cell Metabolism

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules

(2008) Arthur Kaser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE