MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma

MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: In vitro and in vivo studies

(2015) Kuan-Lin Kuo et al.   CANCER LETTERS

Chemotherapeutic and targeted biological agents for metastatic bladder cancer: A comprehensive review

(2014) Terence T Sio et al.   INTERNATIONAL JOURNAL OF UROLOGY

Protein Phosphatase 6 Controls BCR-Induced Apoptosis of WEHI-231 Cells by Regulating Ubiquitination of Bcl-xL

(2014) R. Kajihara et al.   JOURNAL OF IMMUNOLOGY

Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways

(2014) K. Garcia et al.   MOLECULAR CANCER THERAPEUTICS

BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells

(2013) Ayano Watanabe et al.   EXPERIMENTAL DERMATOLOGY

Development of Therapeutic Combinations Targeting Major Cancer Signaling Pathways

(2013) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924

(2013) A. A. Jazaeri et al.   MOLECULAR CANCER THERAPEUTICS

2-Methoxyestradiol Induces Mitotic Arrest, Apoptosis, and Synergistic Cytotoxicity with Arsenic Trioxide in Human Urothelial Carcinoma Cells

(2013) Kuan-Lin Kuo et al.   PLoS One

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

The Proto-oncogene PKC  Regulates the Alternative Splicing of Bcl-x Pre-mRNA

(2012) J. C. Shultz et al.   MOLECULAR CANCER RESEARCH

Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

(2012) Y. Kee et al.   MOLECULAR CANCER RESEARCH

The Role of Bcl-xL in Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia on Human Colon Cancer

(2012) X. Song et al.   MOLECULAR CANCER RESEARCH

Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS

(2011) Jen-Hao Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Transcriptional up-regulation of SOD1 by CEBPD: A potential target for cisplatin resistant human urothelial carcinoma cells

(2010) Tzyh-Chyuan Hour et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells

(2009) Ku-Chung Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

Nucleolin Stabilizes Bcl-XL Messenger RNA in Response to UVA Irradiation

(2008) J. Zhang et al.   CANCER RESEARCH

Optimizing therapeutic strategies in advanced bladder cancer: Update on chemotherapy and the role of targeted agents

(2008) J. Bellmunt et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes

(2008) L JI et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY