Article
Developmental Biology
Alyssa C. Lesko, Raymond Keller, Ping Chen, Ann Sutherland
Summary: Formation of the vertebrate neural tube involves cell level processes such as polarized cell intercalation and shape changes, which are driven by gene expression and cytoskeletal dynamics. Mutations in the Scribble gene have been linked to neural tube defects in mice, affecting cell behavior at the molecular level. This study shows that Scribble plays a central role in regulating the molecular complexes and morphomechanical behaviors underlying neural tube formation in mammals.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Gessica de Oliveira Lopes, Walessa Alana Braganca Aragao, Priscila Cunha Nascimento, Leonardo Oliveira Bittencourt, Ana Carolina Alves Oliveira, Luana Ketlen Reis Leao, Sergio Melo Alves-Junior, Joao de Jesus Viana Pinheiro, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Summary: The study showed that chronic lead exposure induces oxidative stress in the blood and glands, causing cellular, morphological, and biochemical damage in both parotid and submandibular glands. This was evidenced by increased MT I/II expression, decreased CK-19 expression, and decreased α-SMA immunostaining in both glands.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Quentin Laurichesse, Blandine Moucaud, Lilia Laddada, Yoan Renaud, Krzysztof Jagla, Cedric Soler
Summary: The study reveals the critical role of the Kruppel-like factor Dar1 in Drosophila leg tendon development, shedding light on the formation of the unique structure of tendons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Robert J. Huebner, Shinuo Weng, Chanjae Lee, Sena Sarikaya, Ophelia Papoulas, Rachael M. Cox, Edward M. Marcotte, John B. Wallingford
Summary: This article investigates the role of the Arvcf protein in controlling head-to-tail axis extension in Xenopus. It is found that Arvcf is necessary for axis extension in the intact organism, but not in isolated tissues. The study also reveals that the force defect is a result of the dampening of pulsatile recruitment of cell adhesion and cytoskeletal proteins.
DEVELOPMENTAL CELL
(2022)
Article
Biology
Eduardo Pulgar, Cornelia Schwayer, Nestor Guerrero, Loreto Lopez, Susana Marquez, Steffen Hartel, Rodrigo Soto, Carl-Philipp Heisenberg, Miguel L. Concha
Summary: The study uncovers a mechanism where progenitor cells coordinate their movement with adjacent tissues by incomplete delamination during development. This process ensures the collective fate and allocation of cells at the site of differentiation.
Article
Biochemistry & Molecular Biology
Clinton H. Durney, James J. Feng
Summary: This study explores the roles of cellular forces during the formation of the salivary gland in Drosophila embryos using a novel three-dimensional vertex model. Different myosin pools were found to play distinct roles in the invagination process, leading to the formation of a model that agrees with experimental observations.
Article
Cell Biology
Arthur Marivin, Rachel Xi-Yeen Ho, Mikel Garcia-Marcos
Summary: This study reveals a mechanism by which the PAR polarity complex recruits the protein DAPLE to apical cell junctions, leading to the efficient assembly of the apical actomyosin network. DAPLE recruits the actin-stabilizing protein CD2AP and activates heterotrimeric G protein signaling to favor RhoA-myosin activation, thereby maintaining epithelial cell shape.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Lauren Meeks, Diogo De Oliveira Pessoa, Jessica A. Martinez, Kirsten H. Limesand, Megha Padi
Summary: This study investigated the metabolic phenotype of radiation-induced damage in parotid salivary glands by integrating transcriptomic and metabolomic data. The findings suggest that radiation therapy induces a mitochondrial dysfunction phenotype, impacting energy metabolism.
PHYSIOLOGICAL GENOMICS
(2021)
Article
Multidisciplinary Sciences
Silvia Meyer-Nava, Mario Zurita, Viviana Valadez-Graham
Summary: Drosophila melanogaster is a useful model for studying heterochromatin formation and maintenance, with polytenized cells providing a tool for observing amplified chromatin. Direct visualization of heterochromatin in cells complements observation in polytene chromosome preparations but protein localization may be altered by treatment severity. Immunostaining techniques, fluorescent antibodies, and confocal microscopy are used for precise observation of heterochromatin aggregates.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Cell Biology
Alphy John, Matteo Rauzi
Summary: In the Drosophila embryo, mesoderm cells fold and extend simultaneously under the synergistic control of anterior-posterior and dorsal-ventral gene patterning, driving tissue growth and shape changes.
DEVELOPMENTAL CELL
(2021)
Article
Pathology
Asterios Triantafyllou, Nikita Ruggles
Summary: Little attention has been paid to immunohistochemically assessed lysosomal activities in salivary neoplasia. In an attempt to address this, the study examined CD63 and HSP27 expression in 101 benign and malignant epithelial salivary tumors, finding that CD63 expression is associated with differentiated or simple luminal cell phenotypes, possibly reflecting autophagy of secretory granules, while HSP27 expression is associated with non-luminal cells, possibly reflecting cytoskeleton remodeling.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Hui Miao, Timothy E. Vanderleest, Rashmi Budhathoki, Dinah Loerke, J. Todd Blankenship
Summary: Force generation in epithelial tissues is pulsatile, with actomyosin networks generating contractile forces before cyclically disassembling. PIP3 is identified as a critical lipid cue for ratcheting engagement, and disruption of PIP3 leads to dramatic shape switches in epithelial cells. Additionally, PIP3 enrichments and JAK/STAT signaling jointly regulate Sbf/Rab35 recruitment, elucidating a complex lipid-dependent regulatory machinery in directing ratcheting engagement in epithelial tissues.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Tran Duy Binh, Yen D. H. Nguyen, Tuan L. A. Pham, Kenichi Komori, Thanh Q. C. Nguyen, Masahide Taninaka, Kaeko Kamei
Summary: The lipid storage droplet-2 (LSD-2) protein plays a critical role in promoting lipid accumulation and droplet formation in Drosophila. It also functions as a regulator of lipolysis. In addition, LSD-2 is involved in the control of the endoreplication cell cycle and cell death programs in the salivary glands.
SCIENTIFIC REPORTS
(2022)
Article
Physics, Multidisciplinary
Guo-Jie J. Gao, Michael C. Holcomb, Jeffrey H. Thomas, Jerzy Blawzdziewicz
Summary: Communication via mechanical stress feedback is important for coordinating collective cellular movements. The researchers have improved their model by introducing progressive constrictions and fluctuation of particle radii, successfully capturing the dynamics of collective cells.
FRONTIERS IN PHYSICS
(2022)
Article
Cell Biology
Kia Z. Perez-Vale, Kristi D. Yow, Noah J. Gurley, Melissa Greene, Mark Peifer
Summary: This passage discusses the changes in cell shape and arrangement during embryonic morphogenesis and their relationship with the cytoskeleton and adherens junctions. It is found that Rap1 is a crucial regulator of cell adhesion, controlling both cadherin-mediated and integrin-mediated processes. Canoe/Afadin, one of the effectors of Rap1, plays multiple roles in morphogenesis. Another Rap1 guanine nucleotide exchange factor (GEF) regulator, Dizzy, is also involved in regulating Rap1's action via Canoe.
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Cell Biology
Gemma C. Girdler, Derek A. Applewhite, Wick M. G. Perry, Stephen L. Rogers, Katja Roeper
JOURNAL OF CELL SCIENCE
(2016)
Editorial Material
Cell Biology
Clara Sidor, Katja Roper
JOURNAL OF CELL BIOLOGY
(2017)
Article
Cell Biology
Zsanett Takacs, Ferenc Jankovics, Peter Vilmos, Peter Lenart, Katja Roper, Miklos Erdelyi
JOURNAL OF CELL SCIENCE
(2017)
Article
Developmental Biology
Mary K. Pines, Ben E. Housden, Fred Bernard, Sarah J. Bray, Katja Roeper
Article
Cell Biology
Katja Roeper
DEVELOPMENTAL CELL
(2012)
Article
Cell Biology
Alexander J. R. Booth, Guy B. Blanchard, Richard J. Adams, Katja Roeper
DEVELOPMENTAL CELL
(2014)
Article
Genetics & Heredity
Vanessa Maybeck, Katja Roeper
Review
Cell Biology
Barry J. Thompson, Franck Pichaud, Katja Roeper
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2013)
Article
Cell Biology
Katja Roper
JOURNAL OF CELL SCIENCE
(2007)
Article
Cell Biology
K Röper, YL Mao, NH Brown
JOURNAL OF CELL SCIENCE
(2005)
Article
Biochemistry & Molecular Biology
Y Kosodo, K Röper, W Haubensak, AM Marzesco, D Corbeil, WB Huttner
Article
Biochemistry & Molecular Biology
K Röper, NH Brown
Article
Cell Biology
K Röper, NH Brown
JOURNAL OF CELL BIOLOGY
(2003)
Article
Cell Biology
K Röper, SL Gregory, NH Brown
JOURNAL OF CELL SCIENCE
(2002)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
