Article
Immunology
Andreas Koerner, David Koehler, Mariella Schneider, Judith M. Roth, Tiago F. Granja, Claudia Eggstein, Valbona Mirakaj, Peter Rosenberger
Summary: The study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. The results reveal that SEMA7A has a multifaceted role in inflammatory responses, with differential effects in peritonitis and intestinal inflammation. The expression and distribution of SEMA7A target receptors within different organ systems significantly influence SEMA7A's function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Nan Zhao, Xiaoxun Zhang, Jingjing Ding, Qiong Pan, Ming-Hua Zheng, Wen-Yue Liu, Gang Luo, Jiaquan Qu, Mingqiao Li, Ling Li, Ying Cheng, Ying Peng, Qiaoling Xie, Qinglin Wei, Qiao Li, Lingyun Zou, Xinshou Ouyang, Shi-Ying Cai, James L. Boyer, Jin Chai
Summary: The SEMA7AR(148W) mutation is identified as a potentially strong genetic determinant of NAFLD, promoting intrahepatic lipid accumulation and NAFLD by enhancing PKC-alpha-stimulated fatty acid and triglyceride synthesis and fatty acid uptake.
Article
Biochemistry & Molecular Biology
Ping Hu, Andrew E. Miller, Chiuan-Ren Yeh, Grace C. Bingham, Mete Civelek, Thomas H. Barker
Summary: Integrin is a crucial cellular receptor that mediates the interaction between cells and the extracellular matrix, converting environmental cues into cellular responses. It plays a vital role in wound healing by regulating fibroblast behavior and tissue homeostasis. Semaphorin 7A (SEMA7a) has been found to modulate integrin signaling, enhancing fibroblast adhesion and migration, and promoting normal tissue repair.
Article
Pharmacology & Pharmacy
Hai-Yan Lou, Hai-Peng Yan, Long-Gui Yang, Jiang-hua Fan, William C. Cho, Zheng-hui Xiao, Shuang-Jie Li
Summary: Red blood cells may contribute to immune response and inflammation through the interaction mediated by integrin alpha 4 beta 1, impacting cell adhesion, migration, and T cell proliferation for adaptive immunity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiaoyan Yu, Feiyu Tang, Fuyang Cao, Xiyan Tan, Liang Weng, Lunquan Sun
Summary: This study demonstrated the critical role of Drebrin in LUAD and the associated mechanism. Drebrin can promote migration and invasion of LUAD cells, and its high expression predicts poor prognosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Eddie A. James, Alok V. Joglekar, Amelia K. Linnemann, Holger A. Russ, Sally C. Kent
Summary: In this article, the authors discuss the interface between islet beta cells and immune infiltrates, with a focus on T cells, in the context of T1D. They emphasize the importance of studying pancreatic and immune cell phenotypes and their impact on cell function to gain a comprehensive understanding of T1D disease etiology in humans. They also highlight the active role of beta cells and the critical axis of the T cell-beta cell interface in autoimmune responses.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Elias Rackl, Lin Li, Lara Kristina Klauer, Selda Ugur, Elena Pepeldjiyska, Corinna L. Seidel, Carina Gunsilius, Melanie Weinmann, Fatemeh Doraneh-Gard, Nina Reiter, Caroline Plett, Daniel Christoph Amberger, Peter Bojko, Doris Kraemer, Joerg Schmohl, Andreas Rank, Christoph Schmid, Helga Maria Schmetzer
Summary: This study analyzed whether the stimulation of immune cells by dendritic cells would lead to increased expression of Integrin beta 7 (β7) and improved antileukemic cytotoxicity. The results showed that specific treatment methods can increase the expression of β7 in immune cells and it is associated with leukemia cell lysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Martina Vargovic, Neven Papic, Lara Samadan, Mirjana Balen Topic, Adriana Vince
Summary: This study found that serum semaphorin concentrations are associated with the severity and outcomes of COVID-19. SEMA3C, SEMA3F, and SEMA7A levels are increased in COVID-19 patients, while SEMA3A levels are decreased. Serum semaphorin levels have better predictive value than other markers for distinguishing COVID-19 severity.
Article
Cell Biology
Minhee Kim, Jingjing Lin, Jeong-Eun Huh, Jin Hee Park, Miyeon Go, Hana Lee, Donghyun Hwang, Han Sung Kim, Taesoo Kim, Daekee Lee, Soo Young Lee
Summary: The study revealed that TSPAN7 plays a crucial role in regulating the bone-resorbing function of osteoclasts by modulating actin ring formation. Deletion of Tm4sf2 led to significant defects in integrin-mediated actin ring formation, resulting in decreased bone resorption. The findings suggest that TSPAN7 acts as a novel modulator in osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Angelo Corti, Giulia Anderluzzi, Flavio Curnis
Summary: In this review, the research on the interaction between CgA and its fragments with receptors is discussed. The structural requirements, biological effects, mechanisms, and potential therapeutic applications of the interactions between CgA-related peptides and neuropilin-1 and integrins are reviewed.
Article
Biology
Jia C. Wang, Yang-In Yim, Xufeng Wu, Valentin Jaumouille, Andrew Cameron, Clare M. Waterman, John H. Kehrl, John A. Hammer
Summary: This study found that LFA-1:ICAM-1 interactions promote the formation of a contractile actomyosin arc network, which plays a dominant role in B-cell immune synapse (IS) formation. This network is created by mDia1, organized into concentric, contractile arcs by myosin 2A, and flows inward at the same rate as B-cell receptor (BCR):antigen clusters. The results demonstrate that integrin is crucial for synapse formation and inhibiting myosin impairs synapse formation and BCR signaling.
Article
Biochemistry & Molecular Biology
Gianni Colotti, Cristina Maria Failla, Pedro Miguel Lacal, Mariangela Ungarelli, Federica Ruffini, Patrizio Di Micco, Angela Orecchia, Veronica Morea
Summary: NRP-1 is a semaphorin receptor involved in neuron guidance and a co-receptor for certain VEGF isoforms, playing a critical role in angiogenesis and endothelial cell adhesion. Additionally, the interaction between NRP-1 and sVEGFR-1 has been investigated, with potential implications for developing novel anti-angiogenic compounds.
Article
Chemistry, Analytical
Yangyang Zhang, Xinhuan Chen, Yan Qiao, Shuang Yang, Zhaoting Wang, Mengmeng Ji, Kai Yin, Jimin Zhao, Kangdong Liu, Baoyin Yuan
Summary: In this study, DNA aptamers were developed to specifically bind to esophageal squamous cell carcinoma (ESCC) cells. The aptamer A2 was found to strongly bind to multiple cancer cells, including ESCC cell lines. Tissue imaging confirmed the specific recognition of clinical ESCC tissues by A2. The binding target of A2 was identified as integrin beta 1. In addition, A2-induced targeted therapy using DNA nanoassemblies carrying antitumor agents showed inhibition of tumor cell growth in vitro and in vivo.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudia Paindelli, Stefano Casarin, Feng Wang, Luis Diaz-Gomez, Jianhua Zhang, Antonios G. Mikos, Christopher J. Logothetis, Peter Friedl, Eleonora Dondossola
Summary: In this study, targeting beta 1 integrin (beta 1I) was shown to significantly improve the outcome of Ra-223 treatment for bone metastatic prostate cancer (PCa), particularly in tumors with high beta 1I expression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Yi Zhou, Zi-xiang Li, Yuan-ting Liu, Ze-Cheng Xu, Yan Hu, Wen Lv, Zheng-yu Yang, Yan-mei Sheng, Sha Liu
Summary: The study demonstrated that NITyr could protect neurons against A beta 1-40-induced cytotoxicity by inducing autophagy, which might involve the CB2/AMPK/mTOR/ULK1 pathway.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biology
Bin Wu, Francois G. C. Blot, Aaron Benson Wong, Catarina Osorio, Youri Adolfs, R. Jeroen Pasterkamp, Jana Hartmann, Esther B. E. Becker, Henk-Jan Boele, Chris De Zeeuw, Martijn Schonewille
Article
Biochemistry & Molecular Biology
Daniel Rozbesky, Marieke G. Verhagen, Dimple Karia, Gergely N. Nagy, Luis Alvarez, Ross A. Robinson, Karl Harlos, Sergi Padilla-Parra, R. Jeroen Pasterkamp, Edith Yvonne Jones
Review
Biochemistry & Molecular Biology
Vamshidhar R. Vangoor, Andreia Gomes-Duarte, R. Jeroen Pasterkamp
Summary: Long non-coding RNAs play crucial roles in the expression and development of motor neurons in the nervous system, and disruptions in their effects may contribute to motor neuron diseases. Research on the expression and functions of lncRNAs in motor neurons is shedding light on potential therapeutic targets for various motor neuron diseases.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Rianne de Jongh, Xandor M. Spijkers, Svetlana Pasteuning-Vuhman, Paul Vulto, R. Jeroen Pasterkamp
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease with no cure available, affecting upper and lower motor neurons. Studies suggest that neuromuscular junction (NMJ) defects may occur early in the disease, but the mechanistic insight into how NMJ dysfunction relates to ALS onset and progression is incomplete. Microfluidic technology combined with iPSC technology provides a new approach for studying ALS phenotypes, enhancing our understanding of NMJ pathology and offering potential future directions for therapy development.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Ruud van Zessen, Jacques P. Flores-Dourojeanni, Timon Eekel, Siem van den Reijen, Bart Lodder, Azar Omrani, Marten P. Smidt, Geert M. J. Ramakers, Geoffrey van der Plasse, Garret D. Stuber, Roger A. H. Adan
Summary: Recent research shows that calcium activity and dopamine signals from VTA play important roles in the process of learning reward associations. Optogenetic inhibition during reward delivery disrupts learned behavior, while continued interference with these signals leads to impaired learning behavior. Cue-induced dopamine signals play a crucial role in driving learned behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Ruediger Klein, Ronald Jeroen Pasterkamp
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Ramin Raoof, Christian Martin Gil, Floris P. J. G. Lafeber, Huub de Visser, Judith Prado, Sabine Versteeg, Mirte N. Pascha, Anne L. P. Heinemans, Youri Adolfs, Jeroen Pasterkamp, John N. Wood, Simon C. Mastbergen, Niels Eijkelkamp
Summary: This study reveals the crucial role of macrophages in maintaining OA pain independently from joint damage. Sensory neurons innervate damaged knee joints, shaping DRG macrophages into an M1 phenotype. Inhibiting M1-like macrophages in the DRG can resolve persistent OA pain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Valeria Bonapersona, Heike Schuler, Ruth Damsteegt, Youri Adolfs, R. Jeroen Pasterkamp, Martijn P. van den Heuvel, Marian Joels, R. Angela Sarabdjitsingh
Summary: Acute stress leads to sequential activation of functional brain networks, resulting in changes in cellular activity. The study found that areas such as the hypothalamus, amygdala, prefrontal cortex, hippocampus, and thalamus are most affected by acute stress. The cellular activity patterns also shift over time, and the strategy of some brain areas changes after stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
News Item
Clinical Neurology
Elly M. Hol, R. Jeroen Pasterkamp
Summary: The study combined genome-wide association data with microglial transcriptomes to identify functional variants underlying brain disorders. This information will contribute to further mechanistic studies into disease-associated microglial changes.
NATURE REVIEWS NEUROLOGY
(2022)
Correction
Clinical Neurology
Elly M. Hol, R. Jeroen Pasterkamp
NATURE REVIEWS NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Vanessa Donega, Astrid T. van der Geest, Jacqueline A. Sluijs, Roland E. van Dijk, Chi Chiu Wang, Onur Basak, R. Jeroen Pasterkamp, Elly M. Hol
Summary: This study identifies CD271(+) progenitors from the aged subventricular zone (SVZ) as late oligodendrocyte progenitor cells and suggests SFRP1 as a potential signal for maintaining quiescence of progenitors from the aged SVZ. Furthermore, the administration of WAY-316606, an SFRP1 inhibitor, stimulates activation of neural stem cells both in vitro and in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Amber Berdenis van Berlekom, Raphael Kubler, Jeske W. Hoogeboom, Danielle Vonk, Jacqueline A. Sluijs, R. Jeroen Pasterkamp, Jinte Middeldorp, Aletta D. Kraneveld, Johan Garssen, Rene S. Kahn, Elly M. Hol, Lot D. de Witte, Marco P. Boks
Summary: There is compelling evidence that nutrition has a significant impact on human brain development. Previous studies have shown that three specific amino acids, histidine, lysine, and threonine, can synergistically inhibit mTOR activity and behavior. In this pioneering study, human cerebral organoids were used to investigate the impact of amino acid supplementation on neurodevelopment. The results showed that exposure to threonine, histidine, and lysine led to decreased mTOR activity, reduced organoid size, and altered gene expression, supporting findings from previous rodent studies.
Article
Neurosciences
Marloes Verkerke, Amber Berdenis van Berlekom, Vanessa Donega, Danielle Vonk, Jacqueline A. Sluijs, Nayab F. Butt, Lois Kistemaker, Lot D. de Witte, R. Jeroen Pasterkamp, Jinte Middeldorp, Elly M. Hol
Summary: This study investigates the development and maturation of astrocytes in cerebral organoids derived from human induced pluripotent stem cells. Based on morphological and transcriptomic analysis, it is found that the optimal time to study matured astrocytes is after 19 weeks in culture.
Article
Multidisciplinary Sciences
Francois G. C. Blot, Joshua J. White, Amy van Hattem, Licia Scotti, Vaishnavi Balaji, Youri Adolfs, R. Jeroen Pasterkamp, Chris I. De Zeeuw, Martijn Schonewille
Summary: The classification of neuronal subpopulations has advanced, but its impact on behavior is uncertain. The flocculus of the cerebellum is a suitable model for studying neuronal subpopulations. Through genetic targeting, the study demonstrates separate micromodules within the flocculus that involve distinct subpopulations of Purkinje cells. Furthermore, optogenetic excitation of these subpopulations produces movements with different kinematic profiles. These findings highlight the importance of subpopulations in mediating specific aspects of cerebellar behavior.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Francois G. C. Blot, Joshua J. White, Amy van Hattem, Licia Scotti, Vaishnavi Balaji, Youri Adolfs, R. Jeroen Pasterkamp, Chris I. De Zeeuw, Martijn Schonewille
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
