Article
Biology
Fangrui Chen, Jingchao Wu, Malina K. Iwanski, Daphne Jurriens, Arianna Sandron, Milena Pasolli, Gianmarco Puma, Jannes Z. Kromhout, Chao Yang, Wilco Nijenhuis, Lukas C. Kapitein, Florian Berger, Anna Akhmanova
Summary: This study reveals the self-assembly properties of interphase PCM in animal cells and its sensitivity to motor- and microtubule-based rearrangement.
Review
Cell Biology
Jianhang Jia, Jin Jiang
Summary: This review focuses on the essential role of Smoothened (Smo) protein in Hedgehog (Hh) signal transduction, as well as the regulatory mechanisms of Smo endocytosis and degradation in both insects and vertebrates. It discusses how Hh inhibits Smo ubiquitination and promotes Smo surface/ciliary accumulation through ubiquitin-specific protease 8 (USP8) in Drosophila, and also highlights the induction of sumoylation by Hh in regulating Smo trafficking and abundance in both Drosophila and mammalian cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Manyue Zhang, Na Xu, Wenxin Xu, Guixia Ling, Peng Zhang
Summary: With the development of nanotechnology, organelle-targeted nano drug delivery systems have emerged as a potential method to transport drugs specifically to subcellular compartments. Golgi-targeted nano drug delivery systems can alter the morphology of the Golgi apparatus and offer high specificity, low-dose administration, and decreased side effects. This review introduces Golgi-targeted nano drug delivery systems and their applications in disease therapies and diagnosis, including cancer, metastasis, fibrosis, and neurological diseases. It also discusses modifications and strategies to achieve targeting, Golgi-disturbing agents, and special endocytosis for endosomal/lysosomal escape.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Daniela Spano, Antonino Colanzi
Summary: The Golgi Complex, as the central hub in the endomembrane system, plays important roles not only in biosynthesis and processing, but also in trafficking, sorting, and signaling. Its dysregulation is involved in various cellular processes and contributes to the onset of pathological conditions, including cancer.
Article
Cell Biology
Shaozhong Yang, Franco K. C. Au, Gefei Li, Jianwei Lin, Xiang David Li, Robert Z. Qi
Summary: Yang et al. uncover a mechanism by which the centrosomin motif 1 (CM1) regulates microtubule nucleation and cellular organization. This regulation is achieved through an autoinhibitory mechanism and can be relieved by phosphorylation. This study provides valuable insights into the control of microtubule formation in cells.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Developmental Biology
Hiroyuki Yamaguchi, Matthew D. Meyer, Li He, Lakmini Senavirathna, Sheng Pan, Yoshihiro Komatsu
Summary: Intramembranous ossification is a characteristic process in skull development, where ciliary and golgin proteins play a crucial role in regulating collagen trafficking. The molecular complex of IFT20 and GMAP210 is essential for proper intramembranous ossification during skull development, as shown through mutant mouse models.
Article
Cell Biology
Friederike Hantel, Huaize Liu, Lisa Fechtner, Herbert Neuhaus, Jie Ding, Danilo Arlt, Peter Walentek, Pablo Villavicencio-Lorini, Christoph Gerhardt, Thomas Hollemann, Thorsten Pfirrmann
Summary: Cilia play an important role in embryonic development, and the GID complex is involved in primary cilia-dependent signal transduction and protein homeostasis. GID subunits may be candidate genes for human ciliopathies associated with defects in Hedgehog signaling.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jie Wang, Qihang Jiang, Roman Pleskot, Peter Grones, Elmehdi Bahafid, Gregoire Denay, Carlos Galvan-Ampudia, Xiangyu Xu, Michael Vandorpe, Evelien Mylle, Ive De Smet, Teva Vernoux, Ruediger Simon, Moritz K. Nowack, Daniel Van Damme
Summary: Endocytosis is important for plant response to stimuli and TPC plays an essential role in endocytosis in Arabidopsis plants. Knockout or knockdown of TPC subunits cause severe phenotypes, but partially functional alleles cause mild deviations. Reduced TPC-dependent endocytosis leads to hypersensitivity to CLAVATA3 peptide signaling.
Article
Plant Sciences
Deepanksha Arora, Daniel Van Damme
Summary: Endomembrane trafficking allows proteins and lipids to flow between different endomembrane compartments in eukaryotic cells, largely through vesicle-mediated transport. This process involves packaging transmembrane proteins into vesicles, followed by vesicle scission, uncoating, and fusion at the target membrane. Three major trafficking pathways (anterograde, retrograde, endocytic) operate inside cells, each involving specific machinery and coat proteins for packaging and delivery along the pathways.
Article
Biochemistry & Molecular Biology
Charlotte H. Hurst, Dionne Turnbull, Kaltra Xhelilaj, Sally Myles, Robin L. Pflughaupt, Michaela Kopischke, Paul Davies, Susan Jones, Silke Robatzek, Cyril Zipfel, Julien Gronnier, Piers A. Hemsley
Summary: Plant receptor kinases play a crucial role in transducing extracellular stimuli and are regulated by post-translational modifications. This study demonstrates the essential role of S-acylation in plant receptor kinases FLS24 and EFR for their function in immune signaling and resistance to bacterial infection. S-acylation stabilizes and promotes retention of activated receptor kinase complexes at the plasma membrane to increase signaling efficiency.
Article
Biochemistry & Molecular Biology
Wenxin Tang, Wenwei Lin, Xiang Zhou, Jingzhe Guo, Xie Dang, Binqi Li, Deshu Lin, Zhenbiao Yang
Summary: Mechanical signaling, based on the FER kinase, regulates cortical MT reorganization in Arabidopsis. FER mutations impair cell response to mechanical perturbations and ROP6 activation. Reduction in pectin content also impacts mechanical induction of MT reorganization.
Review
Cell Biology
Federica Liccardo, Alberto Luini, Rosaria Di Martino
Summary: G-protein-coupled receptors (GPCRs) and G-proteins play important roles in various physiological and pathological processes, and can elicit intracellular responses through different signaling pathways. Recent research suggests that they may not only exist on the plasma membrane, but also on endomembranes, initiating or propagating signaling pathways through these organelles. However, further investigation is needed to understand how these alternative intracellular signaling pathways of GPCRs and G-proteins impact the physiological and pathological function of endomembranes.
Article
Environmental Studies
Amol Paithankar, Snehamoy Chatterjee, Ryan Goodfellow
Summary: The study introduces a global optimization model that effectively addresses the mining complex problem, helping to enhance the economic value of the entire mining project and reduce risks.
Article
Plant Sciences
Peng Wang, Wei Siao, Xiuyang Zhao, Deepanksha Arora, Ren Wang, Dominique Eeckhout, Jelle Van Leene, Rahul Kumar, Anaxi Houbaert, Nancy De Winne, Evelien Mylle, Michael Vandorpe, Ruud A. Korver, Christa Testerink, Kris Gevaert, Steffen Vanneste, Geert De Jaeger, Daniel Van Damme, Eugenia Russinova
Summary: Adaptor protein (AP) complexes play a crucial role in vesicle transport regulation. In plants, the AP complexes are involved in sorting cargoes and regulating endocytosis and post-Golgi trafficking routes. A comprehensive interactome analysis identified several hub proteins, including a previously unknown adaptin binding-like protein called P34, which interacts with AP complexes and controls their stability. This study provides important insights into the regulation of endomembrane trafficking in plant cells.
Article
Chemistry, Multidisciplinary
Zhao Zhang, Hujun Cao, Zhitao Xiong, Joshua Adedeji Bolarin, Weijin Zhang, Ping Chen
Summary: A nitrogen-based complex hydride was investigated for hydrogen isotope separation, showing a positive isotope effect with a separation factor of 1.42. The H-D exchange process in this system occurs at 373 K and can be accelerated with temperature increase.
CHEMICAL COMMUNICATIONS
(2021)
Article
Clinical Neurology
Chu Cheng, Masaki Kobayashi, Jose A. Martinez, Hilarie Ng, Joanna J. Moser, Xiuling Wang, Vandana Singh, Marvin J. Fritzler, Douglas W. Zochodne
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2015)
Article
Oncology
Joanna J. Moser, Marvin J. Fritzler, Jerome B. Rattner
Article
Cell Biology
Joanna J. Moser, Marvin J. Fritzler, Jerome B. Rattner
Article
Oncology
Young Ou, Yibing Ruan, Min Chen, Joanna J. Moser, Jerome B. Rattner, Frans A. van der Hoorn
EXPERIMENTAL CELL RESEARCH
(2009)
Review
Biochemistry & Molecular Biology
Joanna J. Moser, Marvin J. Fritzler
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2010)
Article
Cell Biology
Songqing Li, Shang L. Lian, Joanna J. Moser, Mark L. Fritzler, Marvin J. Fritzler, Minoru Satoh, Edward K. L. Chan
JOURNAL OF CELL SCIENCE
(2008)
Article
Biochemical Research Methods
Joanna J. Moser, Edward K. L. Chan, Marvin J. Fritzler
Review
Anesthesiology
Joanna J. Moser, Pamela M. Veale, Debbie L. McAllister, David P. Archer
PEDIATRIC ANESTHESIA
(2013)
Article
Multidisciplinary Sciences
Joanna J. Moser, Marvin J. Fritzler
Article
Anesthesiology
J. J. Moser, A. M. Walker, A. O. Spencer
BRITISH JOURNAL OF ANAESTHESIA
(2017)
Review
Anesthesiology
David P. Archer, Andrew M. Walker, Sarah K. McCann, Joanna J. Moser, Ramana M. Appireddy
Article
Neurosciences
Joanna J. Moser, Theophany Eystathioy, Edward K. L. Chan, Marvin J. Fritzler
JOURNAL OF NEUROSCIENCE RESEARCH
(2007)
Article
Medicine, General & Internal
Joanna J. Moser, Marvin J. Fritzler, Jerome B. Rattner
BMC CLINICAL PATHOLOGY
(2014)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
