A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity

(2014) Kea Martin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Microtubules by Natural Agents for Cancer Therapy

(2014) E. Mukhtar et al.   MOLECULAR CANCER THERAPEUTICS

Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins

(2014) Carlos R. Figueiredo et al.   PEPTIDES

Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells

(2014) Andrey S. Dobroff et al.   Translational Oncology

Microtubule-Depolymerizing Agents Used in Antibody-Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells

(2014) P. Muller et al.   Cancer Immunology Research

A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems

(2014) Mariana H. Massaoka et al.   FEBS Open Bio

Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells

(2013) Rebekka Müller et al.   PLoS One

The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior

(2012) Seungwon Yang et al.   BIOMATERIALS

The Role of the PI3K-AKT Pathway in Melanoma

(2012) Michael A. Davies   CANCER JOURNAL

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Melanocortin 1 Receptor Regulates Melanoma Cell Migration by Controlling Syndecan-2 Expression

(2012) Heesung Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Actin-binding Complementarity-determining Region 2 of Variable Heavy Chain from Monoclonal Antibody C7 Induces Apoptosis in Several Human Tumor Cells and Is Protective against Metastatic Melanoma

(2012) Denise C. Arruda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination

(2012) Fabian Benencia et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A Tubulin Binding Peptide Targets Glioma Cells Disrupting Their Microtubules, Blocking Migration, and Inducing Apoptosis

(2012) Raphael Berges et al.   MOLECULAR THERAPY

Jacaranone Induces Apoptosis in Melanoma Cells via ROS-Mediated Downregulation of Akt and p38 MAPK Activation and Displays Antitumor Activity In Vivo

(2012) Mariana H. Massaoka et al.   PLoS One

Antibody Constant Region Peptides Can Display Immunomodulatory Activity through Activation of the Dectin-1 Signalling Pathway

(2012) Elena Gabrielli et al.   PLoS One

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

(2011) Daniela M. Arduino et al.   BMB Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Promises of Apoptosis-Inducing Peptides in Cancer Therapeutics

(2011) David Barras et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Anti-Angiogenic Peptides for Cancer Therapeutics

(2011) Elena V. Rosca et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates

(2011) Xiao-Xiang Zhang et al.   JOURNAL OF CONTROLLED RELEASE

RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis

(2011) T. T. Giang Ho et al.   MOLECULAR BIOLOGY OF THE CELL

Chemotherapeutic Agents Targeting the Tubulin Cytoskeleton Modify LPS-induced Cytokine Secretion by Dendritic Cells and Increase Antigen Presentation

(2010) Viviana Marin-Esteban et al.   JOURNAL OF IMMUNOTHERAPY

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Antibodies as Crypts of Antiinfective and Antitumor Peptides

(2009) W. Magliani et al.   CURRENT MEDICINAL CHEMISTRY

Peptide Inhibitors Targeting Protein Kinases

(2009) Hagit Eldar-Finkelman et al.   CURRENT PHARMACEUTICAL DESIGN

Antibody Complementarity-Determining Regions (CDRs): A Bridge between Adaptive and Innate Immunity

(2009) Elena Gabrielli et al.   PLoS One

The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460

(2008) Chiara Cenciarelli et al.   APOPTOSIS

The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration

(2008) N. Dey et al.   CANCER RESEARCH

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Invasion and Metastasis of Hepatocellular Carcinoma Cells via Targeting RhoC In vitro and In vivo

(2008) W. Wang et al.   CLINICAL CANCER RESEARCH

Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities

(2008) Luciano Polonelli et al.   PLoS One

PPARγInhibitors as Novel Tubulin-Targeting Agents

(2008) Katherine L. Schaefer   PPAR Research