Article
Clinical Neurology
Amanda Almacellas Barbanoj, Robert T. Graham, Benito Maffei, Jenna C. Carpenter, Marco Leite, Justin Hoke, Felisia Hardjo, James Scott-Solache, Christos Chimonides, Stephanie Schorge, Dimitri M. Kullmann, Vincent Magloire, Gabriele Lignani
Summary: Focal cortical dysplasias are a common type of cortical development abnormality that often leads to cognitive and behavioral abnormalities as well as drug-resistant epilepsy. A gene therapy approach targeting the overexpression of the Kv1.1 potassium channel has shown promising results in reducing seizures in a mouse model of frontal lobe focal cortical dysplasia.
Article
Clinical Neurology
Krasimir Minkin, Kaloyan Gabrovski, Petar Karazapryanov, Yoana Milenova, Stanimir Sirakov, Vasil Karakostov, Kiril Romanski, Petia Dimova
Summary: The study demonstrated that awake craniotomy may be beneficial for patients with drug-resistant epilepsy caused by focal cortical dysplasia involving eloquent areas, potentially changing the preoperative plan and leading to good seizure control outcomes postoperatively.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Hossein Shahabi, Kenneth Taylor, Tugba Hirfanoglu, Shreekanth Koneru, William Bingaman, Katsuya Kobayashi, Masako Kobayashi, Anand Joshi, Richard M. Leahy, John C. Mosher, Juan Bulacio, Dileep Nair
Summary: This study compared brain connectivity differences between FCD types I and II, revealing that type I patients exhibit greater cortical hyperexcitability while type II patients display a more restricted zone of hyperexcitability. These differences may contribute to different post-surgical seizure outcomes between the two pathological substrates.
Article
Behavioral Sciences
Yunling Wang, Chenmin He, Cong Chen, Zhongjin Wang, Wenjie Ming, Jingjing Qiu, Meiping Ying, Wei Chen, Bo Jin, Hong Li, Meiping Ding, Shuang Wang
Summary: The study found that focal cortical dysplasia (FCD) is a significantly independent risk factor associated with sleep-related epilepsy (SRE), with the highest incidence of SRE in the FCD group. A small lesion size of FCD further increased the risk of SRE.
EPILEPSY & BEHAVIOR
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Horst Urbach, Marcel Heers, Dirk-Matthias Altenmueller, Andreas Schulze-Bonhage, Anke Maren Staack, Thomas Bast, Marco Reisert, Ralf Schwarzwald, Christoph P. Kaller, Hans-Juergen Huppertz, Theo Demerath
Summary: Automated MRI postprocessing tool was evaluated for enhanced and rapid detection of focal cortical dysplasia (FCD). The results showed effective identification of FCD within a minute, with a need for careful comparison with conventional MRI images to reduce false positives.
Article
Clinical Neurology
Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Guttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefania Conde-Blanco, Jose Carlos Pariente, Saul Pascual-Diaz, Ignacio Delgado-Martinez, Carmen Perez-Enriquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Eugenia Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane G. Kloster, Giske Opheim, Leticia Ribeiro, Clarissa Yasuda, Camilla Rossi-Espagnet, Khalid Hamandi, Anna Tietze, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofia Gonzalez-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terence O'Brien, Jay Shetty, Graeme Jackson, John S. Duncan, Gavin P. Winston, Lars H. Pinborg, Fernando Cendes, Fabian J. Theis, Russell T. Shinohara, J. Helen Cross, Torsten Baldeweg, Sophie Adler, Konrad Wagstyl
Summary: One of the challenges in applying machine learning to diagnostic biomedical imaging is the interpretability of algorithms. This study developed an open-source and interpretable machine-learning algorithm to automatically identify FCDs from structural MRI data, improving the confidence of physicians in identifying subtle MRI lesions in individuals with epilepsy.
Article
Clinical Neurology
Imad Najm, Dennis Lal, Mario Alonso Vanegas, Fernando Cendes, Iscia Lopes-Cendes, Andre Palmini, Eliseu Paglioli, Harvey B. Sarnat, Christopher A. Walsh, Samuel Wiebe, Eleonora Aronica, Stephanie Baulac, Roland Coras, Katja Kobow, J. Helen Cross, Rita Garbelli, Hans Holthausen, Karl Rossler, Maria Thom, Assam El-Osta, Jeong Ho Lee, Hajime Miyata, Renzo Guerrini, Yue-Shan Piao, Dong Zhou, Ingmar Bluemcke
Summary: Ongoing challenges in diagnosing focal cortical dysplasia (FCD) require continuous research and consensus agreement to improve disease definition and classification. An International League Against Epilepsy (ILAE) Task Force has reviewed the FCD classification of 2011 and identified existing gaps. They conducted surveys, literature reviews, and clinico-pathological studies to update the classification and propose new categories. This update may contribute to a better understanding of FCD and the development of targeted treatments.
Article
Behavioral Sciences
Kazuki Sakakura, Ayataka Fujimoto, Yoshifumi Arai, Naoki Ichikawa, Keishiro Sato, Shimpei Baba, Chikanori Inenaga, Akira Matsumura, Eiichi Ishikawa, Hideo Enoki, Tohru Okanishi
Summary: This study revealed neuropathological differences between patients with posttrauma epilepsy and those with traumatic brain injury without epilepsy, with focal cortical dysplasia being a key factor in distinguishing the two groups.
EPILEPSY & BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Jie Yu, Ming Zhou, Jian Li, Tingting Long, Yulai Li, Li Feng, Dengming Chen, Zhiquan Yang, Yiyun Huang, Shuo Hu
Summary: In this study, the SV2A abnormalities in patients with FCD II were evaluated using F-18-SynVesT-1 PET and compared with F-18-FDG PET. The results showed that F-18-SynVesT-1 PET had a higher accuracy for the localization of FCD II lesions than MRI and a more restricted pattern of abnormality than F-18-FDG PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Shaoping Zhong, Zhihao Zhao, Wanjing Xie, Yiying Cai, Yiying Zhang, Jing Ding, Xin Wang
Summary: This study confirmed a profound disturbance in GABAergic interneurons and synaptic transmission in patients with type II FCD, which is related to the activation status of mTOR. Postnatal mTOR inhibition can partially rescue this disturbance. The results also suggest that postsynaptic mechanisms independent of interneuron reduction or altered expression of GABA synapse genes might be responsible for the impaired GABAergic neurotransmission in type II FCD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Mengyi Guo, Jing Zhang, Jing Wang, Xiongfei Wang, Qing Gao, Chongyang Tang, Jiahui Deng, Zhonghua Xiong, Xiangru Kong, Yuguang Guan, Jian Zhou, Detlev Boison, Guoming Luan, Tianfu Li
Summary: In this study, the adenosine signaling in FCD type I and type II patients was analyzed, revealing upregulation of adenosine-metabolizing enzymes ADK and ADA, as well as adenosine-producing enzyme CD73 in BCs. Moreover, an increase in A(2A)R density, a decrease in GLT-1 levels, and an increase in mTOR levels were observed in FCD specimens. These findings suggest that dysregulation of the adenosine system is a common pathological feature of both FCD type I and type II, and may serve as a therapeutic target for epilepsy associated with FCD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Ariane Lewis, Steven Galetta
Summary: In their research article, Chassoux et al. conducted a retrospective review on 60 patients with focal cortical dysplasia type 2 (FCD2) in the central region who underwent surgical resection. They found that 88% of patients achieved seizure freedom after surgery, and although 87% experienced early transitory postoperative deficits, 40% of them fully recovered. It was also observed that patients with FCD2 can have preoperative and postoperative neurologic deficits, and some patients showed improvement after surgery.
Article
Pharmacology & Pharmacy
Jinha Park, Se Hee Kim, Jongsung Hahn, Hoon-Chul Kang, Sang-Guk Lee, Heung Dong Kim, Min Jung Chang
Summary: Based on a population pharmacokinetic model of everolimus in FCD patients, this study recommends an optimal dose regimen for FCD patients. The recommended dose ranges from 7 mg/m2 or higher for patients with BSA 0.5 m2, to 6 mg/m2 or higher for patients with BSA 0.7 m2. A dose of 4.5 mg/m2 is sufficient for patients with BSA higher than 1.5 m2 to achieve the target trough range of 5-15 ng/mL.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Alexander G. Weil, Evan C. Lewis, George M. Ibrahim, Olivia Kola, Chi-Hong Tseng, Xinkai Zhou, Kao-Min Lin, Li-Xin Cai, Qing-Zhu Liu, Jiu-Luan Lin, Wen-Jing Zhou, Gary W. Mathern, Matthew D. Smyth, Brent R. O'Neill, Roy Dudley, John Ragheb, Sanjiv Bhatia, Daniel Delev, Georgia Ramantani, Josef Zentner, Jeffrey Ojemann, Anthony C. Wang, Christian Dorfer, Martha Feucht, Thomas Czech, Robert J. Bollo, Galymzhan Issabekov, Hongwei Zhu, Mary Connelly, Paul Steinbok, Jian-Guo Zhang, Kai Zhang, Eveline Teresa Hidalgo, Howard L. Weiner, Lily Wong-Kisiel, Samuel Lapalme-Remis, Manjari Tripathi, Poodipedi Sarat Chandra, Walter Hader, Feng-Peng Wang, Yi Yao, Pierre Olivier Champagne, Qiang Guo, Shao-Chun Li, Marcelo Budke, Maria Angeles Perez-Jimenez, Christian Raftapoulos, Patrice Finet, Pauline Michel, Karl Schaller, Martin N. Stienen, Valentina Baro, Christian Cantillano Malone, Juan Pociecha, Noelia Chamorro, Valeria L. Muro, Marec von Lehe, Silvia Vieker, Chima Oluigbo, William D. Gaillard, Mashael Al Khateeb, Faisal Al Otaibi, Niklaus Krayenbuhl, Jeffrey Bolton, Phillip L. Pearl, Aria Fallah
Summary: A predictive model for seizure freedom in children undergoing cerebral hemispheric surgery was developed and validated using data from 1267 surgeries across multiple centers and countries. Factors such as age, age at seizure onset, metabolic factors were found to be predictive of seizure freedom after surgery. The Hemispheric Surgery Outcome Prediction Scale (HOPS) may be useful for clinical decision-making.
Review
Biochemistry & Molecular Biology
Matthias Simon, Alexander Grote
Summary: IL-6 is a proinflammatory cytokine that may serve as a potential biomarker in SAH patients, although discrepancies in research findings and lack of defined clinical endpoints hinder its routine clinical use. Further research is needed to better understand the role of IL-6 and neuroinflammation in the pathophysiology of SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Sandra Schmuhl-Giesen, Astrid Rollenhagen, Bernd Walkenfort, Rachida Yakoubi, Kurt Satzler, Dorothea Miller, Marec von Lehe, Mike Hasenberg, Joachim H. R. Luebke
Summary: Synapses play a crucial role in the computational properties of brain networks. However, the quantitative morphology of synapses, especially in humans, is still largely unknown. In this study, researchers used transmission electron microscopy and 3D-volume reconstructions to generate quantitative models of synaptic boutons in the temporal lobe neocortex. They found that these synaptic boutons were of medium size and had different pools of synaptic vesicles. The results suggest that these synaptic boutons in layer 6 play a reliable role in synaptic transmission and may act as amplifiers, integrators, and discriminators for sensory information processing.
Article
Oncology
Tunc Faik Ersoy, Neda Mokhtari, Daniel Brainman, Bjoern Berger, Attila Salay, Philipp Schuett, Florian Weissinger, Alexander Grote, Matthias Simon
Summary: Cerebellar metastases patients have varying prognoses and individualized decision-making is crucial. Chemotherapy has a positive impact on survival, while extracerebral metastases do not significantly influence overall survival.
Article
Surgery
Sami Ridwan, Mario Ganau, Cesare Zoia, Marike Broekman, Alexander Grote, Hans Clusmann
Summary: This study investigated the impact of COVID-19 on international neurosurgeons, revealing a significant decrease in surgical activity due to the pandemic. While most neurosurgeons expressed concerns about personal and family health, private practitioners faced uncertain financial outlooks during the ongoing crisis.
FRONTIERS IN SURGERY
(2021)
Editorial Material
Clinical Neurology
Friedhelm C. Schmitt, Marec von Lehe, Martin Holtkamp
ZEITSCHRIFT FUR EPILEPTOLOGIE
(2022)
Article
Oncology
Nancy Ann Oberheim-Bush, Wenyin Shi, Michael W. McDermott, Alexander Grote, Julia Stindl, Leonardo Lustgarten
Summary: This study evaluated the safety of TTFields therapy in patients with GBM and a VP shunt. Results showed that TTFields therapy was well tolerated and had a favorable safety profile in this population. There was no evidence of disruption to VP shunt effectiveness with TTFields therapy.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Eric Goulin Lippi Fernandes, Sami Ridwan, Isabell Greeve, Wolf-Ruediger Schaebitz, Alexander Grote, Matthias Simon
Summary: This study analyzed the clinical and imaging data of 49 patients who underwent posterior fossa decompression surgery for cerebellar infarction. The results showed that rapid recovery of consciousness after surgery does not necessarily lead to good functional outcomes. While many patients died during follow-up, long-term functional impairment was rare. Surgical intervention should focus primarily on pressure relief, and the removal of infarcted tissue may have limited impact on outcomes. Patients with a Glasgow Coma Scale (GCS) of 14-15 may be able to postpone surgery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Alexander Grote, Dieter-Henrik Heiland, Julia Taube, Christoph Helmstaedter, Vidhya M. Ravi, Paulina Will, Elke Hattingen, Jan-Ruediger Schuere, Juri-Alexander Witt, Annika Reimers, Christian Elger, Johannes Schramm, Albert J. Becker, Daniel Delev
Summary: This study identifies a distinct mesial-temporal lobe epilepsy syndrome called "innate inflammatory gliosis only" characterized by chronic inflammation associated with astrocytes. Patients with this syndrome have poor seizure and neuropsychological outcomes after surgery compared to patients with hippocampus sclerosis. The findings suggest that this syndrome requires innovative pharmacotreatment strategies.
Article
Biochemistry & Molecular Biology
Juergen Serth, Inga Peters, Olga Katzendorn, Tu N. Dang, Joana Moog, Zarife Balli, Christel Reese, Joerg Hennenlotter, Alexander Grote, Marcel Lafos, Hossein Tezval, Markus A. Kuczyk
Summary: Recent studies have shown that DNA methylation of the NKX6-2 gene can be used to predict the risk of metastatic disease in RCC patients, with NKX6-2 found to be hypermethylated in primary metastatic RCC. Analysis of methylation data from different tissue samples reveals similarities between metastatic tissues and primary metastatic RCC tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Julia Taube, Juri-Alexander Witt, Alexander Grote, Daniel Delev, Jonas Enkirch, Elke Hattingen, Albert J. Becker, Christian Erich Elger, Christoph Helmstaedter
Summary: This study compared the pre- and postoperative memory performance of patients with gliosis only (GO) and hippocampal sclerosis (HS). The results showed that GO patients had a later onset of epilepsy, less severe and non-specific memory impairments before surgery, less successful surgical outcome, and a more significant memory decline after surgery compared to HS patients. These findings provide further evidence that GO and HS are distinct clinical entities.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Antonia Knoellner, Daniel Memmert, Marec von Lehe, Johannes Jungilligens, Hans-Erik Scharfen
Summary: This study examined the relationship between visual skills and executive functions in elite soccer players. The results showed a strong correlation between visual abilities and executive functions, especially in the areas of near-far quickness, selective attention, and cognitive flexibility. Visual clarity and contrast sensitivity also had moderate correlations with cognitive functions.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Clinical Neurology
Sami Obaid, Jia-Shu Chen, George M. Ibrahim, Alain Bouthillier, Evan Dimentberg, Werner Surbeck, Elena Guadagno, Tristan Brunette-Clement, Nathan A. Shlobin, Aidan Shulkin, Andrew T. Hale, Luke D. Tomycz, Marec Von Lehe, Michael Scott Perry, Francine Chassoux, Viviane Bouilleret, Delphine Taussig, Martine Fohlen, Georg Dorfmuller, Koichi Hagiwara, Jean Isnard, Chima O. Oluigbo, Naoki Ikegaya, Dang K. Nguyen, Aria Fallah, Alexander G. Weil
Summary: Insular epilepsy is a type of drug-resistant epilepsy that can be treated with surgery. The surgery has a good success rate and is generally safe, with most patients experiencing seizure freedom and temporary neurological deficits. However, younger patients and those requiring invasive monitoring or stereotactic ablation procedures have lower rates of seizure freedom.
Article
Clinical Neurology
Kanjana Unnwongse, Stefan Rampp, Tim Wehner, Annika Kowoll, Yaroslav Parpaley, Marec von Lehe, Benjamin Lanfer, Mateusz Rusiniak, Carsten Wolters, Joerg Wellmer
Summary: This study evaluated the spatial accuracy of electrical source imaging for known sources and identified factors determining the localization error. The results showed that increasing source depth and decreasing skull conductivity led to higher localization errors. Optimizing the selected skull conductivity minimized the localization error.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Nancy Ann Oberheim-Bush, Wenyin Shi, Michael McDermott, Alexander Grote, Julia Stindl, Leonardo Lustgarten
