Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Rui-Lin Xie, Rui Liang, Yuan-Yuan Luo, Zhuo-Hao Ruan, Yi-Fu Li, Wen-Sheng Liu
Summary: This study investigates the effects of growth hormone changes on the genes and regulatory roles of the turtle. The results show that the injection of recombinant human growth hormone promotes the growth of the turtle by affecting the expression of SS, GHR, and IGF-1 genes.
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Rianne Nederlof, Sophia Reidel, Andre Spychala, Stefanie Goedecke, Andre Heinen, Tobias Lautwein, Patrick Petzsch, Karl Koehrer, Axel Goedecke
Summary: IGF1 treatment induces an anti-inflammatory phenotype in bone marrow derived neutrophils and attenuates inflammation after myocardial infarction (MI). The effect of IGF1 is mediated through the JAK2/STAT6 pathway rather than the canonical Ras/Raf/ERK or PI3K/AKT pathway. Single cell sequencing analysis shows that IGF1 treatment downregulates pro-inflammatory genes and upregulates anti-inflammatory genes in neutrophils and macrophages after MI.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Bowen Hu, Hongmei Li, Xiquan Zhang
Summary: Mitochondria play a crucial role in cellular energy homeostasis and metabolism, generating ATP through oxidative phosphorylation among other functions. The GH-GHR-IGF1 axis influences somatic growth processes such as cell proliferation and survival. This axis has a significant impact on mitochondrial biogenesis, mitophagy, and function under various physiological conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kangkang Chen, Xiaoyi Dou, Jai Hoon Eum, Ruby E. Harrison, Mark R. Brown, Michael R. Strand
Summary: This study assessed the expression of insulin-like peptides (ILPs) and ovary ecdysteroidogenic hormone (OEH) in Aedes aegypti during a gonadotrophic cycle and further functionally characterized these peptides to understand their roles in regulating egg formation. The results showed that all ILPs and OEH were expressed during the cycle, and there were differences in their biological activities and insulin- insulin growth factor signaling (IIS) phosphorylation levels.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Lianbin Xu, Mark D. Hanigan, Xueyan Lin, Xiuli Li, Mengmeng Li, Wei Liu, Zhiyong Hu, Qiuling Hou, Yun Wang, Zhonghua Wang
Summary: The study indicated that several circulating amino acids mediate the effects of dietary protein supply on concentrations of IGF-I, GH, and PRL, thereby altering the metabolism status in peripheral tissues including the lactating mammary glands.
JOURNAL OF ANIMAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Genetics & Heredity
Weronika Strozewska, Magdalena Durda-Masny, Anita Szwed
Summary: This review aims to summarize the mutations in the GHR and IGF1R genes that have been discovered so far and their impact on body height, as well as their relationship with catch-up growth in children born small for gestational age (SGA).
Article
Biology
Jie Li, Jiayi Wu, Catherine Hall, Xiao-chen Bai, Eunhee Choi, Emily J. Gallagher
Summary: The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) play crucial roles in metabolic homeostasis and cell growth. This study reveals that the structural rigidity of the disulfide-linked alpha CTs is critical for optimal IR and IGF1R signaling activation.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yang Xu, Chang Yong Han, Mi Jung Park, Myung Chan Gye
Summary: This study investigated the mechanism of precocious sexual maturation following prepubertal rhGH therapy. The results showed that rhGH can promote gonadal maturation by activating the steroidogenic pathway of LCs and increasing testicular IGF1 levels.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Ecology
Aude Lalis, Stefano Mona, Emmanuelle Stoetzel, Francois Bonhomme, Karim Souttou, Ali Ouarour, Stephane Aulagnier, Christiane Denys, Violaine Nicolas
Article
Ecology
Ahmed Souissi, Francois Bonhomme, Manuel Manchado, Lilia Bahri-Sfar, Pierre-Alexandre Gagnaire
Article
Multidisciplinary Sciences
Maud Duranton, Francois Allal, Christelle Fraisse, Nicolas Bierne, Francois Bonhomme, Pierre-Alexandre Gagnaire
NATURE COMMUNICATIONS
(2018)
Article
Microbiology
Kelly Brener-Raffalli, Camille Clerissi, Jeremie Vidal-Dupiol, Mehdi Adjeroud, Francois Bonhomme, Marine Pratlong, Didier Aurelle, Guillaume Mitta, Eve Toulza
Biographical-Item
Zoology
Christiane Denys, Francois Bonhomme, Boris Krystufek, Marjan Mashkour, Jean Denis Vigne, Roohollah Siahsarvie
Correction
Multidisciplinary Sciences
Maud Duranton, Francois Allal, Christelle Fraisse, Nicolas Bierne, Francois Bonhomme, Pierre-Alexandre Gagnaire
NATURE COMMUNICATIONS
(2018)
Article
Ecology
Oxala Garcia-Rodriguez, Demetra Andreou, Jeremy S. Herman, George P. Mitsainas, Jeremy B. Searle, Francois Bonhomme, Eleftherios Hadjisterkotis, Holger Schutkowski, Richard Stafford, John R. Stewart, Emilie A. Hardouin
JOURNAL OF BIOGEOGRAPHY
(2018)
Article
Evolutionary Biology
Maud Duranton, Francois Bonhomme, Pierre-Alexandre Gagnaire
EVOLUTIONARY APPLICATIONS
(2019)
Article
Multidisciplinary Sciences
Thomas Cucchi, Katerina Papayianni, Sophie Cersoy, Laetitia Aznar-Cormano, Antoine Zazzo, Regis Debruyne, Remi Berthon, Adrian Balasescu, Alan Simmons, Francois Valla, Yannis Hamilakis, Fanis Mavridis, Marjan Mashkour, Jamshid Darvish, Roohollah Siahsarvi, Fereidoun Biglari, Cameron A. Petrie, Lloyd Weeks, Alireza Sardari, Sepideh Maziar, Christiane Denys, David Orton, Emma Jenkins, Melinda Zeder, Jeremy B. Searle, Greger Larson, Francois Bonhomme, Jean-Christophe Auffray, Jean-Denis Vigne
SCIENTIFIC REPORTS
(2020)
Article
Genetics & Heredity
Carine Rey, Audrey Darnaude, Franck Ferraton, Bruno Guinand, Francois Bonhomme, Nicolas Bierne, Pierre-Alexandre Gagnaire
Article
Evolutionary Biology
Maud Duranton, Francois Allal, Sophie Valiere, Olivier Bouchez, Francois Bonhomme, Pierre-Alexandre Gagnaire
Article
Multidisciplinary Sciences
Dariusz Czernecki, Frederic Bonhomme, Pierre-Alexandre Kaminski, Marc Delarue
Summary: Cyanophage S-2L incorporates 2-aminoadenine into its DNA, altering its biophysical properties. Through investigation of the genes and synthesis pathways involved, the researchers successfully incorporated 2-aminoadenine into the bacterial genome, opening up possibilities for studying synthetic organisms containing ZTGC-DNA.
NATURE COMMUNICATIONS
(2021)
Article
Fisheries
Francois Bonhomme, Laura Meyer, Christine Arbiol, Daniela Banaru, Lilia Bahri-Sfar, Karima Fadhlaoui-Zid, Petr Strelkov, Marco Arculeo, Laurent Soulier, Jean-Pierre Quignard, Pierre-Alexandre Gagnaire
Summary: The study reveals that coastal anchovies in the Mediterranean share a common ancestor, despite limited gene flow, there is still significant genetic differentiation. Therefore, it is proposed that coastal anchovies should have their own species status and emphasize the need for a unified taxonomical framework for future research and management.
JOURNAL OF FISH BIOLOGY
(2022)
Article
Microbiology
Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frederic Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B. Arimondo, Peter Dedon, Peter Preiser, Artur Scherf
Summary: This study identified a novel epitranscriptomic mechanism in malaria parasites, involving the cytosine methylation of a specific tRNA site, which regulates the translation of a subset of parasite proteins involved in various metabolic pathways.
Article
Biochemistry & Molecular Biology
Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser, Marcel Hollenstein
Summary: Ruthenium complexes and aptamers can be used as photosensitizers in photodynamic therapy, but their lack of inherent targeting to disease sites may lead to side effects and the need for higher doses. This study presents the first direct conjugation of a Ru(ii) polypyridyl complex-based photosensitizer to an aptamer, and evaluates its in vitro cancer cell specific photosensitization.
RSC CHEMICAL BIOLOGY
(2022)