Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications

Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations

(2015) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

(2015) Alice Nomura et al.   Oncotarget

DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition

(2015) Parthasarathy Chandrakesan et al.   Oncotarget

Colorectal cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA

(2014) C. Kantara et al.   CANCER RESEARCH

The recently suggested intestinal cancer stem cell markerDCLK1is an epigenetic biomarker for colorectal cancer

(2014) Hege Marie Vedeld et al.   Epigenetics

The novel colorectal cancer biomarkersCDO1, ZSCAN18andZNF331are frequently methylated across gastrointestinal cancers

(2014) Hege Marie Vedeld et al.   INTERNATIONAL JOURNAL OF CANCER

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis

(2014) Carla Kantara et al.   LABORATORY INVESTIGATION

Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin

(2013) Angelo Pietro Femia et al.   BMC CANCER

Therapeutic strategies targeting cancer stem cells

(2013) Xiaoyan Ning et al.   CANCER BIOLOGY & THERAPY

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis

(2013) Keun Hur et al.   GUT

DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

(2013) Erling A. Hoivik et al.   PLoS One

Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

(2013) Carla S. Verissimo et al.   PLoS One

Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury

(2013) Randal May et al.   STEM CELLS

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation

(2013) Euikyung Shin et al.   Nature Communications

DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer

(2013) Christina Grimm et al.   PLoS Genetics

Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia

(2012) Miho Kikuchi et al.   BMC GASTROENTEROLOGY

A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps

(2012) C. Do et al.   Cancer Prevention Research

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: Phenotypic differences between transformed and nontransformed stem cells

(2012) Shubhashish Sarkar et al.   INTERNATIONAL JOURNAL OF CANCER

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Immunolocalization of DCAMKL-1, a putative intestinal stem cell marker, in normal colonic tissue

(2012) Giuseppe Gagliardi et al.   PATHOLOGY RESEARCH AND PRACTICE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

(2012) Kristel Kemper et al.   STEM CELLS

Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development

(2011) Sharmistha Pal et al.   GENOME RESEARCH

shRNA against CD44 inhibits cell proliferation, invasion and migration, and promotes apoptosis of colon carcinoma cells

(2011) Hyeong Kim   ONCOLOGY REPORTS

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

(2011) Sripathi M Sureban et al.   JOURNAL OF NANOBIOTECHNOLOGY

Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas

(2010) Randal May et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells

(2010) Carla S Verissimo et al.   ENDOCRINE-RELATED CANCER

Annexin A2 Mediates Up-regulation of NF-κB, β-catenin, and Stem Cell in Response to Progastrin in Mice and HEK-293 Cells

(2010) Shubhashish Sarkar et al.   GASTROENTEROLOGY

DCAMKL-1 Expression Identifies Tuft Cells Rather Than Stem Cells in the Adult Mouse Intestinal Epithelium

(2009) François Gerbe et al.   GASTROENTEROLOGY

Functional Cross-talk between β-Catenin and NFκB Signaling Pathways in Colonic Crypts of Mice in Response to Progastrin

(2009) Shahid Umar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice

(2009) Guangchun Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model

(2009) Scott C. Borinstein et al.   MOLECULAR CARCINOGENESIS

Variants in Doublecortin- and Calmodulin Kinase Like 1, a Gene Up-Regulated by BDNF, Are Associated with Memory and General Cognitive Abilities

(2009) Stéphanie Le Hellard et al.   PLoS One

Doublecortin and CaM Kinase-like-1 and Leucine-Rich-Repeat-Containing G-Protein-Coupled Receptor Mark Quiescent and Cycling Intestinal Stem Cells, Respectively

(2009) Randal May et al.   STEM CELLS

Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo

(2008) S Umar et al.   ONCOGENE

Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase-Like-1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple Intestinal Neoplasia Mice

(2007) Randal May et al.   STEM CELLS