Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity

Solulin increases clot stability in whole blood from humans and dogs with hemophilia

(2012) J. H. Foley et al.   BLOOD

Development of high-throughput HILIC-MS/MS methodology for plasma citrulline determination in multiple species

(2011) Prem K. Gupta et al.   Analytical Methods

Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis

(2011) Deyan Luo et al.   INFECTION AND IMMUNITY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model

(2011) E. J. SU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

(2010) H. Iwasaki et al.   BLOOD

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose  -irradiation

(2010) H. Yu et al.   BLOOD

Regulation of Ceramide Synthase-Mediated Crypt Epithelium Apoptosis by DNA Damage Repair Enzymes

(2010) J. A. Rotolo et al.   CANCER RESEARCH

Regulation of inflammation by the protein C system

(2010) Hartmut Weiler   CRITICAL CARE MEDICINE

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice

(2010) Edward Kerschen et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

(2010) Søren M. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

(2010) Thijs van Iersel et al.   THROMBOSIS AND HAEMOSTASIS

Determination of Sample Sizes for Demonstrating Efficacy of Radiation Countermeasures

(2009) Ralph L. Kodell et al.   BIOMETRICS

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

(2009) D. G. Kent et al.   BLOOD

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Cell-intrinsic and Vector-related Properties Cooperate to Determine the Incidence and Consequences of Insertional Mutagenesis

(2009) Olga S Kustikova et al.   MOLECULAR THERAPY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

(2008) Stephanie T. Yerkovich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inactivation of Thrombomodulin by Ionizing Radiation in a Cell-Free System: Possible Implications for Radiation Responses in Vascular Endothelium

(2008) Christopher C. Ross et al.   RADIATION RESEARCH

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE