BIM, PUMA, and the Achilles' Heel of Oncogene Addiction

PUMA and BIM Are Required for Oncogene Inactivation-Induced Apoptosis

(2013) G. R. Bean et al.   Science Signaling

Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors

(2012) Dorte L. Nielsen et al.   BREAST

Genomic Predictors of Outcome and Treatment Response in Breast Cancer

(2012) Lara Dunn et al.   Molecular Diagnosis & Therapy

The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival

(2011) Antònia Obrador-Hevia et al.   BRITISH JOURNAL OF HAEMATOLOGY

A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation

(2011) Xianwang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

(2011) Mario Campone et al.   Molecular Cancer

Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression

(2011) Stefano Amente et al.   NUCLEIC ACIDS RESEARCH

Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

(2010) Aditi Pandya Martin et al.   CANCER BIOLOGY & THERAPY

FOXO3 Encodes a Carcinogen-Activated Transcription Factor Frequently Deleted in Early-Stage Lung Adenocarcinoma

(2010) O. R. Mikse et al.   CANCER RESEARCH

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shifting paradigms: the seeds of oncogene addiction

(2009) Charles L Sawyers   NATURE MEDICINE

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

(2009) Saskia M. Brachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition

(2009) A. C. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

(2008) Qing-Bai She et al.   PLoS One

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY