A Kinetic Test Characterizes Kinase Intramolecular and Intermolecular Autophosphorylation Mechanisms

Aurora A kinase (AURKA) in normal and pathological cell division

(2012) Anna S. Nikonova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

(2012) Harshani R. Lawrence et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the molecular mechanisms of mitotic kinase activation

(2012) R. Bayliss et al.   Open Biology

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic

(2011) Charlotte A. Dodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

(2010) Charlotte A. Dodson et al.   BIOCHEMICAL JOURNAL

Mechanistic Studies of the Autoactivation of PAK2

(2010) Jue Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells

(2010) Young Jin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation

(2010) V. Joukov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

(2009) Mark W. Richards et al.   MOLECULAR CELL

Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase

(2009) Zhenjian Cai et al.   MOLECULAR CELL

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

(2008) Jinhua Wu et al.   EMBO JOURNAL

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

The challenge of selecting protein kinase assays for lead discovery optimization

(2008) Haiching Ma et al.   Expert Opinion on Drug Discovery

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

(2008) Isaac Westwood et al.   JOURNAL OF MOLECULAR BIOLOGY

Analysis of Protein Kinase Autophosphorylation Using Expressed Protein Ligation and Computational Modeling

(2008) Kerry A. Pickin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY