Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

(2010) Christophe Mas et al.   BIOCHEMICAL PHARMACOLOGY

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

On hedgehogs and human cancer

(2010) A. Ruiz i Altaba et al.   EMBO Molecular Medicine

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

(2010) B. Stecca et al.   Journal of Molecular Cell Biology

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling

(2009) Sumimasa Arimura et al.   GASTROENTEROLOGY

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

(2009) Frédéric Varnat et al.   MECHANISMS OF DEVELOPMENT

Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?

(2008) Ariel Ruiz i Altaba   CANCER CELL

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

(2008) Y. Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA