Article
Polymer Science
Canan Altunbas, Ahmet Aslan, Kevser Kusat, Mehtap Sahiner, Sinan Akgol, Nurettin Sahiner
Summary: Cryogels offer advantages such as mechanical and chemical stability, ease of production, superior porosity, and low cost for enzyme immobilization applications. By altering parameters such as pH, enzyme concentration, and flow rate, the best reaction conditions for immobilizing catalase onto cryogel matrices were determined. Repeated useability tests showed that the cryogel matrix remained stable and maintained its adsorption capacity with a high recovery ratio. Therefore, cryogels have promising potential for various industrial applications.
Article
Biotechnology & Applied Microbiology
Raquel A. Rocha, Lygie Esquirol, Vivien Rolland, Philip Hands, Robert E. Speight, Colin Scott
Summary: Enzyme immobilization provides advantages for biocatalysis, but current methods often require surface modification and incur associated costs. This study investigated cellulose and silica carriers for immobilization, using fluorescent proteins as models. Two binding tags were tested and successfully fused to various proteins, but immobilization resulted in loss of enzymatic activity.
ENZYME AND MICROBIAL TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
X. Wan, H. Zhang, Q. Yan, H. Hu, W. Pan, Y. Chai, Y. Gao, N. Li, B. Tang
Summary: This study reported a porphyrin-based three-dimensional covalent organic framework as an enzyme nanoprotector to maintain the activity of catalase under acidic tumor microenvironment. The nanoprotector can efficiently generate reactive oxygen species and realize photodynamic therapy of cancer, greatly enhancing the efficacy of cancer therapy.
MATERIALS TODAY NANO
(2022)
Article
Biotechnology & Applied Microbiology
Chunzhi Li, Xuezhen Feng, Lixia Sun, Liqin Zhou, Jianhua Sun, Zefen Wang, Dankui Liao, Ping Lan, Xiongdiao Lan
Summary: This study investigated the immobilization of papain on Ti3C2 MXene nanosheets and its performance. The results showed that the immobilized papain exhibited improved stability and reusability, making it suitable for enzyme immobilization studies in other support systems.
ENZYME AND MICROBIAL TECHNOLOGY
(2021)
Review
Immunology
Rula Zain, Mauno Vihinen
Summary: Low-molecular weight chemical compounds have a long history as drugs, but target specificity and binding efficiency remain major obstacles for their clinical relevance. Protein kinases, with their structural similarities and large protein families, present challenges as attractive cellular targets. Bruton tyrosine kinase (BTK), a promising target for B-cell malignancies and autoimmune diseases, has received significant attention. The focus of this review is on the structural properties and binding modes of small-molecule BTK inhibitors, including irreversible and reversible inhibitors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Abri-Mehraban, Seyed Jalal Zargar, Navvabeh Salarizadeh
Summary: The study investigated the structural changes of Hb induced by DOX in the presence of different concentrations of Glc using spectroscopic techniques. Results showed that the presence of Glc alleviated the hyperchromic effect of DOX on Hb, influenced the intrinsic fluorescence and alpha-helix structure of Hb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Ryan S. Czarny, Alexander N. Ho, P. Shing Ho
Summary: Classical hydrogen bonds have long been the main non-covalent interaction used by chemists and chemical engineers to design and control compound structures, but recently non-classical non-covalent interactions such as halogen bonds have also emerged as important tools. Research is focused on understanding the role of halogen bonds in biological systems and utilizing them to control the structures, stabilities, and activities of biomolecules.
Article
Nanoscience & Nanotechnology
Christopher P. Horoszko, Peter J. Schnatz, Januka Budhathoki-Uprety, Rahul Rao-Pothuraju, Ronald L. Koder, Daniel A. Heller
Summary: This study demonstrates the importance of dye binding location in efficient carbon nanotube-based donor-acceptor devices, with the coating layer affecting dye binding. The results suggest that considering the impact of the coating interface in application and assay design is necessary.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Medicinal
Florencio Zaragoza
Summary: An increasing number of drugs that combine therapeutic peptides or proteins with albumin-binding structures are being approved. This article presents the pharmacokinetic data of currently marketed drugs of this type. Acylation with fatty acids or fatty α,β-dicarboxylic acids has been successful in preparing long-acting analogs of insulin, GLP-1, and other peptides, but not larger proteins. However, with the use of a tetrazole-sulfonylamide fatty acid bioisostere, a long-acting analog of human growth hormone (191 amino acids) suitable for once-weekly administration has been developed.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Florencio Zaragoza
Summary: An increasing number of drugs that consist of a therapeutic peptide or protein linked to an albumin-binding structure are being approved. In this perspective, the pharmacokinetic data of currently marketed drugs of this type will be presented. Acylation with fatty acids or fatty a,?-dicarboxylic acids has been used successfully to prepare long-acting analogs of insulin, GLP-1, and other peptides but not of larger proteins. With a tetrazole-sulfonylamide fatty acid bioisostere, it has now been possible to prepare a long-acting analog of human growth hormone (191 amino acids), which is suitable for once-weekly administration.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Gregory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Summary: This study identifies noncovalent TGR inhibitors that are effective against schistosome infections in mice, surpassing praziquantel in treating juvenile worms.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Anthony C. Yu, Huada Lian, Xian Kong, Hector Lopez Hernandez, Jian Qin, Eric A. Appel
Summary: Studies suggest that entropy-driven physical networks exhibit invariant mechanical properties at elevated temperatures, in contrast to enthalpy-dominated crosslinking networks. By connecting thermodynamics and temperature-dependent viscoelasticity in a mathematical framework, the temperature dependence of crosslinking interactions is explored.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Hao Cheng, Chao Qin, Bing Yang, Xiaojie Hu, Michael Gatheru Waigi, Galina K. Vasilyeva, Yanzheng Gao
Summary: The interaction between phthalic acid esters (PAEs) and DNA is responsible for disrupting endocrine functions and causing teratogenic and carcinogenic effects. This study confirmed this binding interaction through a fluorescence titration quenching experiment. PAEs were found to predominantly interact with thymines in the DNA minor groove through hydrogen bonding and van der Waals forces.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Physical
Alhadji Malloum, Jeanet Conradie
Summary: This study thoroughly explores the potential energy surfaces of DMSO clusters and analyzes the non-covalent interactions in these clusters using quantum theory. The strongest and weakest non-covalent interactions in DMSO clusters are found to be CH center dot center dot center dot O hydrogen bonding and H center dot center dot center dot H bonding, respectively. Additionally, the temperature-dependent isomer distribution of the investigated clusters is reported, and the performance of ten density functional theory functionals in calculating the binding energies of DMSO clusters is assessed.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Pui Ching Lan, Yin Zhang, Weijie Zhang, Xueying Ge, Shengqian Ma
Summary: Covalent organic frameworks are used to create an ideal reaction environment for hydrolysis, improving stability and efficiency.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Environmental Sciences
Songwen Tan, Zhenxing Chi, Ye Shan, Zhengzhong Wen, Weiguo Li
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2017)
Article
Environmental Sciences
Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li, Ye Shan
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2017)
Article
Spectroscopy
Zhenxing Chi, Shixuan Li, Zhengzhong Wen, Ye Shan
SPECTROSCOPY LETTERS
(2017)
Article
Environmental Sciences
Zhenxing Chi, Songwen Tan, Xu Tan, Lin Zhong, Weiguo Li
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Spectroscopy
Zhenxing Chi, Bowen Hong, Xiulian Ren, Kunyu Cheng, Yuqian Lu, Xinning Liu
SPECTROSCOPY LETTERS
(2018)
Article
Environmental Sciences
Zhenxing Chi, Hongwei Lin, Weiguo Li, Xunuo Zhang, Qiang Zhang
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Wenxu Fang, Zhenxing Chi, Weiguo Li, Xunuo Zhang, Qiang Zhang
JOURNAL OF NANOBIOTECHNOLOGY
(2019)
Article
Environmental Sciences
Shixuan Li, Zhenxing Chi, Weiguo Li
ENVIRONMENTAL POLLUTION
(2019)
Article
Environmental Sciences
Hanyong Zhang, Wenhu Zhou, Xuehui Zhan, Zhenxing Chi, Weiguo Li, Binsheng He, Songwen Tan
Summary: This study developed a halophilic biocarrier-MBR for treating saline pharmaceutical wastewaters. The system performed well at low ampicillin concentrations but showed decreased performance at high concentrations.
Article
Engineering, Environmental
Zhenxing Chi, Bowen Hong, Songwen Tan, Yanchao Wu, Huijing Li, Chih-Hao Lu, Weiguo Li
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Environmental Sciences
Zhenxing Chi, Jia Liu, Songwen Tan, Hongwei Lin, Weilin Wu, Weiguo Li
Summary: Phthalic acid esters pose harm to human health by affecting the oxygen-carrying function of red blood cells. High doses of DMP were found to reduce Hb content and increase granulocyte content, while in vitro experiments demonstrated an increase in iron release with DMP concentration. Vitamin C and E were observed to reduce iron release induced by DMP through oxidative stress.
Article
Engineering, Environmental
Zhenxing Chi, Ling Weng, Xunuo Zhang
Summary: This study investigated the interaction and quenching mechanism between Ag+ and BHb using spectroscopic methods, revealing that the binding of Ag+ with BHb occurs at one site through van der Waals interactions and hydrogen bonds. Additionally, Ag+ was found to alter the conformation of BHb, potentially impacting protein functions.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2021)
Article
Environmental Sciences
Zhenxing Chi, Hongwei Lin, Xiaodan Wang, Xuanlin Meng, Jieqiong Zhou, Li Xiang, Guodong Cao, Pengfei Wu, Zongwei Cai, Xingchen Zhao
Summary: This study aims to investigate the immunotoxic effect and mechanism of dimethyl phthalate (DMP) on blood immune system. The results showed that DMP caused oxidative damage in rats, suppressed immune defense, and disrupted inflammatory regulation, leading to significantly decreased blood cell counts and disordered antibody and cytokine secretion. Flow cytometry revealed a positive correlation between DMP exposure level and apoptosis/necrosis in lymphocytes, especially CD3(+)CD4(+)T cells. Transcriptomics uncovered an oxidative stress-related mechanism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Zhenxing Chi, Jing Zhao, Weiguo Li, Arash Araghi, Songwen Tan
Article
Environmental Sciences
Zhenxing Chi, Songwen Tan, Weiguo Li, Zhengzhong Wen, Xuemei Song, Mingjing Wang
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)