Article
Chemistry, Medicinal
Bruno Pessoa, Mar Collado-Gonzalez, Giuseppina Sandri, Antonio Ribeiro
Summary: This study aimed to optimize a nanoparticle formulation for orally delivered insulin by assessing the relationship between design parameters and experimental data using response surface methodology. The results showed that a nanoparticle formulation with 0.03% PEG, 0.047% chitosan, and 1.20% albumin provided an optimal solution for insulin oral delivery, maintaining insulin bioactivity in simulated intestinal media.
Article
Pharmacology & Pharmacy
C. Reboredo, C. J. Gonzalez-Navarro, C. Martinez-Oharriz, A. L. Martinez-Lopez, J. M. Irache
Summary: The study aimed to produce PEG-coated nanoparticles with mucus-permeating properties for oral drug delivery using simple procedures and regulatory-approved compounds. The nanoparticles were successfully coated with PEG 35,000, reducing their hydrophobic surface and increasing their hydrophilicity. This coating allowed the nanoparticles to have increased mobility in mucus, potentially enhancing the oral bioavailability of biomacromolecules and other biologically active compounds.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Hajar A. Asal, Kamel R. Shoueir, Maha A. El-Hagrasy, Elshahat A. Toson
Summary: Chitosan-based nanoparticles were developed as nanocarriers for insulin to enhance its oral uptake. Among them, chitosan gold nanoparticles functionalized with poly lactic-co-glycolic acid (PLGA) showed high insulin retention in an acidic medium, resulting in reduced blood glucose levels and improved pharmacological availability and bioavailability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Amani Elsayed, Mayyas Al-Remawi, Nisrein Jaber, Khalid M. Abu-Salah
Summary: Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia. Insulin therapy is crucial for its management, with subcutaneous administration being the most common route. To improve oral insulin absorption, novel approaches in the field of nanoscience and nanotechnology have been explored, including the use of nanoparticles, nano-platforms, and nanocarriers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ya-Wen Zhang, Ling-Lan Tu, Zhan Tang, Qiao Wang, Gao-Li Zheng, Li-Na Yin
Summary: The use of chitosan-conjugated deoxycholic acid/sodium alginate nanoparticles loaded with insulin can improve intestinal permeability and enhance insulin absorption, leading to a significant hypoglycemic effect in diabetic rat models.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Nisreen M. Abdulsalam, Najla A. Khateeb, Mona S. Binkadem, Nahlah A. Alhadhrami, Abdalla M. Khedr, Rehab Abdelmonem, Kamel R. Shoueir, Eman Hassan Nadwa
Summary: Chitosan was modified and functionalized to improve oral insulin delivery. The Cs-DNS NPs had a particle size of 33.29 ± 5.08 nm and positive zeta potential. In vitro experiments showed high insulin entrapment efficiency and gradual release at different pH levels. In vivo experiments demonstrated that insulin-incorporated Cs-DNS NPs effectively lowered serum glucose levels, with a bioavailability of 17.5 ± 0.31% and pharmacological availability of 8.6 ± 0.8%.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Hongbo Cheng, Zhixiang Cui, Shuang Guo, Xin Zhang, Yingnan Huo, Shirui Mao
Summary: Mucoadhesive and mucopenetrating nanoparticles have different absorption mechanisms in enhancing oral insulin absorption. Mucopenetrating nanoparticles have a faster onset of action, while mucoadhesive nanoparticles show a sustained hypoglycemic effect. Overall, there is no significant difference in pharmacological availability between the two types of nanoparticles.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Melbha Starlin Chellathurai, Chung Lip Yong, Zarif Mohamed Sofian, Shariza Sahudin, Najihah Binti Mohd Hasim, Syed Mahmood
Summary: Chitosan is a natural polysaccharide that is biodegradable, bioadhesive, and biocompatible. It has been extensively studied for oral insulin drug delivery systems. Electrostatic interaction between chitosan and insulin leads to the formation of self-assembled nanoparticles, which can protect insulin from degradation and improve intestinal uptake. Functionalized chitosan nanoparticles also offer opportunities for targeted and prolonged delivery. This review provides a comprehensive guide for formulating stable insulin-chitosan nanoparticles using mild ionic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Gayatri Iyer, Sathish Dyawanapelly, Ratnesh Jain, Prajakta Dandekar
Summary: This review examines the barriers and formulation strategies for oral insulin delivery, as well as recent advancements and clinical trials in this field. Oral insulin delivery strategies have the potential to greatly improve patient compliance in the treatment of diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Sepideh Khoee, Samaneh Moayeri, Mohammad A. Charsooghi
Summary: This paper synthesized functionalized nanoparticles and investigated their diffusion coefficients and velocities in different solutions, as well as the effects of an external magnetic field and NaCl concentration on their movement direction.
Article
Pharmacology & Pharmacy
Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat, Pranee Rojsitthisak
Summary: In this study, metformin and curcumin were co-encapsulated into chitosan/alginate nanoparticles using response surface methodology. The optimized nanoparticles displayed stability, sustained release of the drugs, enhanced mucoadhesion, and improved cellular uptake. Furthermore, the nanoparticles exhibited better anti-inflammatory effects and pain relief compared to the physical mixture of the drugs, without significant side effects in mice. This study establishes the efficacy and safety of a chitosan/alginate nanodelivery system for the combination of metformin and curcumin against pain.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Lorenzo Bonetti, Alice Caprioglio, Nina Bono, Gabriele Candiani, Lina Altomare
Summary: Mucoadhesive buccal patches are dosage forms with long residence time on the oral mucosa and increased drug bioavailability. In this study, chitosan-based buccal patches were improved with the addition of methylcellulose, resulting in higher stability and superior mucoadhesive properties. The gentamicin sulfate-loaded patches showed no cytotoxic effects and significant antibacterial activity.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Qian Zhang, Ying Li, Shuai Wang, Donghao Gu, Cuihua Zhang, Shihao Xu, Xiaoli Fang, Chenyang Li, Haiqiang Wu, Wei Xiong
Summary: Researchers have developed orally delivered nanoparticles to enhance the effectiveness of kidney-targeted drug for the treatment of renal fibrosis. These nanoparticles showed good stability in the gastrointestinal environment and enhanced transmembrane transport. The oral administration of these nanoparticles resulted in improved bioavailability and higher accumulation in the kidneys, leading to significant improvements in kidney function and pathological changes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Polymer Science
Zhenyu Xu, Long Chen, Xiaoya Duan, Xueming Li, Hao Ren
Summary: A novel oral delivery system of insulin called NiM, based on a three-dimensional system of biocompatible chitosan/alginate/casein, has been developed to overcome the GI barriers. NiM showed stable hydrodynamic parameters and effectively controlled the release of insulin in gastric and intestinal tracts, demonstrating promising results for diabetic patients.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Li Shangyong, Zhang Hui, Chen Kaiwei, Jin Mengfei, Vu Son Hai, Samil Jung, He Ningning, Zheng Zhou, Myeong-Sok Lee
Summary: Oral drug delivery systems have advantages of simplicity and minimal side effects, making them suitable for colon-targeted therapy. Chitosan/alginate nanoparticles (CANPs) show potential in the treatment of intestinal diseases due to their strong electrostatic interaction and intestinal mucosal adhesion.
Article
Pharmacology & Pharmacy
Narges Ajalli, Mehrab Pourmadadi, Fatemeh Yazdian, Majid Abdouss, Hamid Rashedi, Abbas Rahdar
Summary: For the first time, a nano-wound dressing was designed to optimize wound healing. The synthesized nanocomposite showed excellent mechanical properties, biodegradability, antimicrobial activity, and non-toxicity. The scratch test and animal model results demonstrated that this nanocomposite accelerated wound healing, achieving a 92.25% wound healing rate after 14 days. Therefore, it has the potential to replace traditional methods for wound healing.
CURRENT DRUG DELIVERY
(2023)
Review
Materials Science, Multidisciplinary
Mahshid Fallah-Darrehchi, Payam Zahedi, Parmida Harirchi, Majid Abdouss
Summary: This review discusses the dynamic interplay between extracellular matrix with anisotropic structure and biological cells, leading to the development of actuation-responsive biomaterials. Liquid crystalline elastomers (LCEs) are stimuli responsive polymers that can exhibit reversible orientational order due to the attachment of highly anisotropic mesogenic units to amorphous elastomeric chains. The review briefly explains the structures and synthesis methods of LCEs, highlighting their biochemical and biomechanical features from a molecular perspective.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Amin Foroozandeh, Majid Abdouss, Hossein SalarAmoli, Mehrab Pourmadadi, Fatemeh Yazdian
Summary: Early detection is crucial in controlling and treating deadly ovarian cancer among women. Nanobiosensors are being used as a time-saving tool with high selectivity and sensitivity for biomarker detection. This study developed an electrochemical aptasensor using graphitic carbon nitrides, magnetic nanoparticles, and polyaniline to detect ovarian cancer antigen 125 (CA125) biomarkers. The aptasensor showed excellent selectivity, stability, and a broad dynamic linear range for evaluating patients' and healthy individuals' serum.
PROCESS BIOCHEMISTRY
(2023)
Article
Engineering, Chemical
Mohamadreza Shakiba, Majid Abdouss, Saeedeh Mazinani, Mohammad Reza Kalaee
Summary: In this study, PANI was successfully functionalized onto electrospun PAN nanofibers through electrostatic interaction and hydrogen bonding, followed by ultrasound-assisted polymerization. The resulting APAN/PANI-S nanofibrous membrane demonstrated outstanding physical stability and high water flux in oil/water separation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Agricultural Engineering
Mehrab Pourmadadi, Sepehr Darvishan, Majid Abdouss, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A pH-sensitive nanocomposite was synthesized by coating halloysite nanotubes (HNT) with polyacrylic acid (PAA)/carboxymethyl cellulose (CMC) hydrogel for controlled delivery of curcumin (CUR) to MCF-7 cancer cells. Hazelnut oil and Span 80 surfactant were added to minimize the nanocomposite size and increase its uniformity, and to enhance the stability and retention of CUR as an anticancer drug, respectively. The resulting drug delivery system exhibited high drug loading and encapsulation efficiency, pH-sensitivity, and sustained drug release. It also demonstrated strong toxicity against MCF-7 cancer cells and induced apoptosis. These results highlight the potential of PAA/CMC/HNT/CUR hydrogel nanocomposites as smart drug delivery vehicles for breast cancer treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Alireza Tajiki, Majid Abdouss
Summary: A biocompatible and pH-responsive carrier nanoplatform was developed for targeted delivery of curcumin to breast cancer cells. The nanocomposite structure was confirmed and its particle size was found to be suitable for specific entry into cancer cells and minimal damage to healthy cells. In vitro tests showed that the PAA-Starch-TiO2 carrying Cur exhibited increased bioavailability and controlled release, leading to more effective cancer cell death through apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hamidreza Abdouss, Mehrab Pourmadadi, Payam Zahedi, Majid Abdouss, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A novel pH-sensitive nanocarrier was designed using chitosan, polyacrylic acid, and graphitic carbon nitride via water/oil/water emulsification for curcumin drug delivery. The incorporation of g-C3N4 into CS/PAA hydrogel was achieved, providing a high drug loading capacity and pH-sensitive release profile. The nanocarrier showed excellent efficacy in eliminating cancer cells and has great potential for controlled drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Hossein Karami, Mehrab Pourmadadi, Majid Abdouss, Mohammad Reza Kalaee, Omid Moradi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: This study successfully prepared a hydrogel nanocarrier containing chitosan, alumina, and carbon quantum dots for drug delivery of curcumin. The nanocarrier exhibited good stability and drug release profile, and showed anti-tumor activity against breast cancer cells. This finding is significant for tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Ali Aslani, Majid Abdouss
Summary: The field of nanotechnology has opened up new possibilities for drug delivery systems, reducing the side effects of conventional chemotherapy. ZIF-8, a promising porous material, tends to aggregate in water, limiting its usefulness. By incorporating ZIF-8 into hydrogels made of gelatin and carboxymethylcellulose, we improved their mechanical strength and stability without aggregation. We used double emulsions with the hydrogels and biological macromolecules to create drug carriers with precise control over drug release. Characterization techniques confirmed the stability of the nanocarriers, which showed cytotoxicity against cancer cells and potential for further investigation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Mohamadreza Shakiba, Mehdi Sheikhi, Zohreh Pahnavar, Alireza Tajiki, Ashkan Bigham, Amin Foroozandeh, Sepehr Darvishan, Mehrab Pourmadadi, Hamid Emadi, Javad Rezatabar, Hamidreza Abdouss, Majid Abdouss
Summary: Endowing wound dressings with drug delivery capability is an effective strategy for localized transfer of medicinal compounds to damaged skin layers. This study designed and fabricated a wound dressing composed of polyamide 6, hyaluronic acid, and curcumin-loaded halloysite nanotubes (PA6/HA/HNT@Cur) for wound healing applications. The platform exhibited desirable physicochemical properties, antibacterial and antioxidation activities, as well as good cell compatibility. In vivo evaluation showed that the nanocomposite mat significantly reduced wound size after 14 days. This study provides a swift and straightforward method for developing wound dressings in clinical settings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Composites
Mohammad Shadabfar, Morteza Ehsani, Hossein Ali Khonakdar, Majid Abdouss
Summary: This study successfully prepared a novel conducting polymer nanocomposite by chemically modifying carbon nanotubes and using carboxymethyl cellulose. The results showed improved dispersion and electrochemical properties for the nanocomposite containing oxidized carbon nanotubes.
POLYMER COMPOSITES
(2023)
Article
Polymer Science
Neda Rostami, Farzaneh Faridghiasi, Aida Ghebleh, Hadi Noei, Meisam Samadzadeh, Mohammad Mahmoudi Gomari, Alireza Tajiki, Majid Abdouss, Alireza Aminoroaya, Manisha Kumari, Reza Heidari, Vladimir N. Uversky, Bryan R. Smith
Summary: In this study, copolymers PLA-PEG-PLA and PEG-PLA-PEG were synthesized and compared for their delivery capacity of curcumin to MCF-7 breast cancer cells. The results showed that PLA-PEG-PLA had stronger interaction with the cell membrane and lower free energy, making it a better carrier for cell membrane penetration.
Article
Engineering, Environmental
Nafiseh Aghababaei, Majid Abdouss, Hassan Hosseini-Monfared, Farshid Ghanbari
Summary: A novel direct double Z-scheme O-g-C3N4/ZnO/TiO2@halloysite nanotubes (HNTs) photocatalyst was successfully synthesized to degrade and mineralize diclofenac (DCF) using a simple and low-cost method. Under specific conditions, the O-g-C3N4/ZnO/TiO2@HNTs degraded DCF completely, showing 1.66 and 2.4 times higher efficiency compared to other photocatalysts. Additionally, the photocatalyst also exhibited a significant removal rate of DCF from urban wastewater along with the removal of total organic carbon (TOC).
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Mohamadreza Shakiba, Parisa Jahangiri, Erfan Rahmani, Seyede Mahtab Hosseini, Ashkan Bigham, Amin Foroozandeh, Alireza Tajiki, Mehrab Pourmadadi, Shadi Nasiri, Shirzad Jouybar, Majid Abdouss
Summary: A PA6/PVA/CMWCNT-Cur hybrid nanofibrous composite with good antibacterial properties, mechanical properties, and controlled drug release function was successfully prepared for wound healing applications. The sample with a 0.75 wt % CMWCNT-Cur content was chosen as the most suitable sample due to its uniform nanofiber structure and excellent antibacterial features.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Mahshid Fallah-Darrehchi, Parmida Harirchi, Majid Abdouss, Payam Zahedi
Summary: This review provides an overview of liquid crystalline elastomers (LCEs), their structures, synthesis methods, and applications in biology. LCEs have reversible orientational order and are considered as smart mimickers of biological cell topology. The interactions between LCEs and cells can enhance cell growth, and the degree of orientational order varies among different cells.
ACS APPLIED POLYMER MATERIALS
(2023)