Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy

Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma

(2015) Hua Zhu et al.   Oncotarget

Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma

(2014) Ji-Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma

(2014) Kateryna Kondratska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer

(2014) Charlotte Dubois et al.   CANCER CELL

Pivotal Role of the Lipid Raft SK3-Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

(2013) A. Chantome et al.   CANCER RESEARCH

Microtubule-Associated Histone Deacetylase 6 Supports the Calcium Store Sensor STIM1 in Mediating Malignant Cell Behaviors

(2013) Y.-T. Chen et al.   CANCER RESEARCH

Emerging roles of store-operated Ca2+entry through STIM and ORAI proteins in immunity, hemostasis and cancer

(2013) Wolfgang Bergmeier et al.   Channels

STIM1 and STIM2-mediated Ca2+influx regulates antitumour immunity by CD8+T cells

(2013) Carl Weidinger et al.   EMBO Molecular Medicine

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

(2013) Sonal Srikanth et al.   MOLECULES AND CELLS

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

(2013) Rajender K. Motiani et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation

(2013) Anne-Sophie Ay et al.   PLoS One

Store-operated Ca2+ entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells

(2012) Natalie Bell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

(2012) Ning Yang et al.   CANCER LETTERS

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Immunodeficiency due to defects in store-operated calcium entry

(2011) Stefan Feske   Annals of the New York Academy of Sciences

T-regulatory cells in primary immune deficiencies

(2011) James W. Verbsky et al.   Current Opinion in Allergy and Clinical Immunology

Orais and STIMs: physiological mechanisms and disease

(2011) A. Berna-Erro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

MS4A12 Is a Colon-Selective Store-Operated Calcium Channel Promoting Malignant Cell Processes

(2008) M. Koslowski et al.   CANCER RESEARCH

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

(2008) Valarie A. Barr et al.   MOLECULAR BIOLOGY OF THE CELL

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY