Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Meng-Shan Tsai, Shun-Hua Chen, Chih-Peng Chang, Yi-Ling Hsiao, Li-Chiu Wang
Summary: ILK reduces the accumulation of H3K9me3 on HSV-1 DNA by reducing SUV39H1 and TRIM28 binding, enhancing virus replication. ILK knockdown decreases TRIM28 phosphorylation, weakening its inhibition on lytic gene transcription. ILK inhibitor suppresses HSV-1 replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Matylda Barbara Mielcarska, Katarzyna Skowronska, Zbigniew Wyzewski, Felix Ngosa Toka
Summary: Current data strongly indicate that herpes simplex virus type 1 (HSV-1) infection is a contributing factor to Alzheimer's disease (AD). HSV-1 infection causes damage to neurons and glial cells, as well as modifications in their environment, leading to impaired signal transmission and homeostatic and immune functions. This review discusses the pathological alterations in central nervous system (CNS) cells following HSV-1 infection, including inflammatory responses, oxidative damage, and cellular dysfunctions associated with AD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zipora Tietel, Sarit Melamed, Noy Eretz-Kdosha, Ami Guetta, Raanan Gvirtz, Navit Ogen-Shtern, Arnon Dag, Guy Cohen
Summary: Jojoba wax does not affect the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Malassezia furfur, but significantly attenuates HSV-1 plaque formation. Different varieties of Jojoba wax show a high potency anti-viral effect against HSV-1 infection.
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Noemie Berry, Rodolphe Suspene, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stephane Rigaud, Herve Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Summary: HSV-1 impairs the mitochondrial network and releases mtDNA, leading to the upregulation of type I interferon and APOBEC3A expression. The RNA polymerase III/RIG-I pathway is crucial for interferon production. Released mtDNA causes mutations induced by APOBEC3A, resulting in DNA catabolism.
Article
Virology
Anita Felicitas Meier, Kurt Tobler, Kevin Michaelsen, Bernd Vogt, Els Henckaerts, Cornel Fraefel
Summary: The study shows that HSV-1 modulates AAV genome end recombination, potentially through mechanisms involving the ICP8 protein. Despite changes in the type of end recombination, no significant alteration in circular AAV genome abundance was observed.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Nabil El Bilali, Bita Khadivjam, Eric Bonneil, Pierre Thibault, Roger Lippe
Summary: The study investigated the composition of HSV-1 A, B, and C nuclear capsids, identifying host proteins specific to C-capsids. By purifying viral particles using a novel method, it aims to uncover the differences and functional relevance of these viral capsids. This innovative approach opens up new research avenues to clarify the biology of herpesviruses.
JOURNAL OF VIROLOGY
(2021)
Review
Infectious Diseases
Daniele Roberto Giacobbe, Stefano Di Bella, Antonio Lovecchio, Lorenzo Ball, Andrea De Maria, Antonio Vena, Bianca Bruzzone, Giancarlo Icardi, Paolo Pelosi, Roberto Luzzati, Matteo Bassetti
Summary: The clinical implications of HSV-1 reactivations in critically ill patients with COVID-19 remain controversial, especially for those without symptomatic manifestations.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Microbiology
Jesse H. Arbuckle, Jodi L. Vogel, Stacey Efstathiou, Thomas M. Kristie
Summary: Herpes simplex virus is a significant global disease burden. It establishes a lifelong persistent infection in sensory neurons. Transcription of the viral immediate early (IE) genes is regulated by the cellular transcriptional coactivator HCF-1, which is also involved in viral reactivation from latency. A study using an HCF-1 conditional knockout mouse model demonstrated that the deletion of HCF-1 in sensory neurons reduces the number of latently infected neurons that initiate viral reactivation. This is due to a defect in the removal of repressive chromatin associated with latent viral genomes. HCF-1 is therefore a critical regulatory factor for the initiation of HSV reactivation.
Article
Biochemistry & Molecular Biology
Dmitry S. Karpov, Natalia A. Demidova, Kirill A. Kulagin, Anastasija I. Shuvalova, Maxim A. Kovalev, Ruslan A. Simonov, Vadim L. Karpov, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Regina R. Klimova, Alla A. Kushch
Summary: Almost all people are infected with herpes viruses at some point in their lives. These viruses can persist in a dormant form and reactivate under certain conditions, causing disease. Drug-resistant strains have also emerged. Using CRISPR/Cas systems for treatment shows promise in controlling herpesvirus infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Malgorzata Krzyzowska, Martyna Janicka, Marcin Chodkowski, Magdalena Patrycy, Oliwia Obuch-Woszczatynska, Emilia Tomaszewska, Katarzyna Ranoszek-Soliwoda, Grzegorz Celichowski, Jaroslaw Grobelny
Summary: This study investigated the therapeutic effects of EGCG-AgNPs on herpes virus infections and their role in immune response. The results showed that EGCG-AgNPs effectively inhibited the attachment and entry of HSV viruses and significantly increased the infiltration of immune cells and the expression of IFN and CXCL proteins during treatment.
Article
Virology
Eric E. Abrahamson, Wenxiao Zheng, Vaishali Muralidaran, Milos D. Ikonomovic, David C. Bloom, Vishwajit L. Nimgaonkar, Leonardo D'Aiuto
Summary: The study suggests that HSV-1 infection in the brain may lead to the accumulation of A beta 42, thus contributing to the onset of Alzheimer's disease. Additionally, by comparing 2D and 3D neuronal cultures, different patterns of accumulation were observed, emphasizing the importance of 3D cultures in modeling host-pathogen interactions.
JOURNAL OF VIROLOGY
(2021)
