Review
Cardiac & Cardiovascular Systems
Goren Saenz-Pipaon, David A. Dichek
Summary: Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in the pathophysiology of multiple human diseases, including those affecting the cardiovascular system. As such, miRNAs have emerged as promising therapeutic targets for preventing the onset and/or progression of several cardiovascular diseases. The use of antagomirs, such as anti-miRNA antisense oligonucleotides, shows potential in precisely blocking specific miRNAs and treating major cardiovascular diseases. Recent advancements in antisense oligonucleotide chemistry and targeted delivery systems have improved efficacy and safety, providing hope for future clinical applications.
Article
Biochemistry & Molecular Biology
Izabela Zaborniak, Angelika Macior, Pawel Chmielarz
Summary: A series of troxerutin-based macromolecules with polymeric side chains were successfully synthesized using the SARA ATRP approach, exhibiting pH-responsive behavior and thermoresponsive properties. These polymers were investigated for controlled release of quercetin, with the study revealing a strong correlation between polymer chain length and the efficiency of active substance release.
Review
Cell Biology
Peter J. Kennel, P. Christian Schulze
Summary: MiRNA-regulated processes play a crucial role in cardiovascular homeostasis and disease, offering potential as biomarkers and therapeutic targets. Research on miRNA in heart failure diseases provides insight into new directions for heart failure treatment.
Article
Agriculture, Multidisciplinary
Fang Wang, Yuanrong Chen, Kiyoshi Itagaki, Bin Zhu, Yajuan Lin, Haizhao Song, Luanfeng Wang, Ling Xiong, Zebin Weng, Xinchun Shen
Summary: Wheat-germ-derived peptide APEPEPAF (APE) has protective properties against ulcerative colitis by regulating the PKC zeta/NF-kappa B signaling pathway, preserving colon barrier function, and improving intestinal flora imbalance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tao Zheng, Wentao Wang, Mohsen Mohammadniaei, Jon Ashley, Ming Zhang, Ninglin Zhou, Jian Shen, Yi Sun
Summary: This study developed a targeted delivery system for miRNA-21 using ligand-modified nanoparticles, which temporarily opened the blood-tumor barrier to achieve effective transportation and controlled release in glioblastoma treatment, leading to the inhibition of tumor growth and angiogenesis.
Article
Biochemistry & Molecular Biology
Jing Echesabal-Chen, Kun Huang, Lucia Vojtech, Olanrewaju Oladosu, Ikechukwu Esobi, Rakesh Sachdeva, Naren Vyavahare, Hanjoong Jo, Alexis Stamatikos
Summary: This study aimed to test whether lipoparticles targeting proinflammatory endothelial cells can facilitate exosome-mediated transgene delivery to macrophages. The results showed that using this method can decrease miR-33a-5p expression in macrophages and increase ABCA1 expression, thereby promoting cholesterol efflux.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Microbiology
Gokulakannan Venkatesan, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Salfarina Iberahim, Alwi bin Muhd Besari Hashim
Summary: Early disease diagnosis is crucial for effective management and treatment. Diagnostic methods should be accurate, consistent, low-cost, and non-invasive. Exosomal microRNA (miRNA) has shown potential as biomarkers for various diseases, but its application in vector-borne diseases is limited. This review focuses on discussing miRNAs derived from exosomal plasma that may serve as disease biomarkers for early detection of vector-borne diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Javanmardi, Samira Sadat Abolmaali, Mohammad Javad Mehrabanpour, Mahmoud Reza Aghamaali, Ali Mohammad Tamaddon
Summary: This study successfully suppressed the expression of miR-21 and induced tumor cell apoptosis through the delivery of As-21 using nanohydrogels. Additionally, this approach enhanced the cytotoxicity of cisplatin and inhibited angiogenesis, making it a promising neoadjuvant therapy for treating resistant tumors.
Article
Chemistry, Multidisciplinary
Hendrik Schneider, Simon Englert, Arturo Macarron Palacios, Jorge Alberto Lerma Romero, Ataurehman Ali, Olga Avrutina, Harald Kolmar
Summary: The study showcases the design, synthesis, and biological evaluation of integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin on dextran polysaccharides. The constructs demonstrated good binding properties to integrin-overexpressing tumor cells and remarkable antiproliferative activity, suggesting a promising approach for developing tailor-made multimeric molecular hybrids with potential antitumor effects.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Aastha Gupta, Ankita Dhiman, Ankur Sood, Ravi Bharadwaj, Neal Silverman, Garima Agrawal
Summary: In this study, disulfide crosslinked dextran/eudragit S-100 nanoparticles (DEEU NPs) were developed for colorectal cancer treatment. These redox environment sensitive DEEU NPs showed high encapsulation efficiency for the doxorubicin (DOX) model drug and exhibited significant release in the reducing environment. The DOX-DEEU NPs demonstrated enhanced cytotoxicity for cancer cells and the in vivo biodistribution results indicated their potential as a promising platform for colorectal cancer treatment.
Article
Chemistry, Multidisciplinary
Wenfeng Zhu, Rui Chen, Weiheng Wang, Yi Liu, Changgui Shi, Songjun Tang, Guoke Tang
Summary: In this study, we developed an acetylsalicylic acid (ASA)-based double-network (DN) hydrogel with suitable porous structure and favorable mechanical properties. The in situ encapsulated ASA in the DN hydrogel showed sustained release, anti-inflammation, and osteoinductive properties, demonstrating a new strategy for bone tissue regeneration.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell Biology
Kamatham Pushpa Tryphena, Gurpreet Singh, Naitik Jain, Paras Famta, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Summary: Despite extensive research in Parkinson's disease, the burden of the disease remains high and continues to rise. Current treatments only target symptom control, so the focus of research is on identifying new therapeutic targets to slow or halt disease progression. Recent studies have explored the role of microRNAs in regulating Parkinson's disease mechanisms and found many to be dysregulated in patient samples, suggesting they could serve as diagnostic markers and novel therapies. The challenge lies in delivering these microRNAs to the brain due to degradability and poor blood brain barrier permeability, but nanoparticles offer a promising solution.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Cell Biology
Hanhao Dai, Yunlong Yu, Junyong Han, Jun Luo, Chao Song, Zhibo Deng, Yijing Wu, Dianshan Ke, Jie Xu
Summary: Osteoporotic fracture is a major health problem in ageing society, and the treatment for it needs improvement. This study aimed to explore the effectiveness of hierarchical hydrogel and extracellular vesicles (EVs) loaded with miRNA in bone loss. AntagomiRNAs targeting miR-200b-3p and miR-130b-3p were encapsulated in EVs and delivered sequentially using the hierarchical hydrogel. The combination of hierarchical hydrogel and dual EVs effectively ameliorated bone loss by promoting osteoblast precursor proliferation and maturation.
CELL PROLIFERATION
(2023)
Review
Chemistry, Multidisciplinary
Yujie Yang, Zhen Liu, Hongchao Ma, Meiwen Cao
Summary: Gene therapy provides new strategies for treating diseases by modifying abnormal genes, and peptide-based vectors are promising tools for efficient gene delivery. This review discusses the design and application of peptide-based nonviral gene vectors, their role in overcoming biological barriers, and the current challenges and future prospects for the development of such vectors.
Review
Medicine, Research & Experimental
Muhammad Mustafa Abeer, Sanja Trajkovic, David J. Brayden
Summary: This review discusses the prediction methods and challenges of the oral bioavailability of hydrolysates and their bioactive peptides from food proteins. The study found that analytical detection methods for peptides in hydrolysates pose challenges, and mass spectrometry and peptidomics techniques can improve detection capabilities.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Shuting Shi, Haoru Zhu, Xinyu Xia, Zhihui Liang, Xuehu Ma, Bingbing Sun
Review
Nanoscience & Nanotechnology
Haiyang Zhao, Luxin Li, Huilu Zhan, Yanhui Chu, Bingbing Sun
JOURNAL OF NANOMATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Min Li, Fang Cheng, Changying Xue, Hanqi Wang, Chen Chen, Qiqi Du, Dan Ge, Bingbing Sun
Letter
Immunology
Shuting Shi, Zhihui Liang, Bingbing Sun
Article
Engineering, Biomedical
Zhihui Liang, Yun Yang, Ge Yu, Haoru Zhu, Xinyu Xia, Chen Chen, Duo Fu, Min Li, Gang Cheng, Changying Xue, Li Shi, Hao Zeng, Bingbing Sun
Summary: The study demonstrates that engineered amorphous aluminum hydroxyphosphate nanoparticles (AAHPs) with positive charges show significantly enhanced immunostimulation potentials compared to neutral or negatively-charged particles. When used in vaccines, these particles can induce long-lasting and enhanced humoral immunity, providing protection in disease models.
Article
Chemistry, Analytical
Yan Su, Ting Liu, Caiqiao Song, Aiqiao Fan, Nan Zhu, Bingbing Sun, Cheng Yang
Summary: A solid-contact ion-selective electrode (SC-ISE) using MoS2/Fe3O4 composites as the ion-to-electron transducer was developed to determine serum K+ with high sensitivity and stability. The electrode showed a Nernst response with a low detection limit, resistance to interference, and good potential reproducibility and long-term stability.
Article
Chemistry, Analytical
Cheng Yang, Fathimath Abbas, Amina Rhouati, Yingying Sun, Xiaolin Chu, Shengnan Cui, Bingbing Sun, Changying Xue
Summary: This study presents a quencher-free fluorescent aptasensor for the detection of OTA. By monitoring the fluorescence change induced by the conformational change of the aptamer, the presence of OTA can be detected. Two different aptamers were used, with one aptamer showing better sensitivity.
Article
Engineering, Biomedical
Duo Fu, Mengjia Wang, Tao Yang, Min Li, Zhihui Liang, Chen Chen, Lei Zhang, Changying Xue, Bingbing Sun, Chuanbin Mao
Summary: This study investigated the interaction between nanofibers and the mucosal interface, as well as the impact of nanofiber length on immune responses. The results showed that shorter nanofibers had a stronger ability to activate immune responses and enhance mucosal and systematic antibody responses. Additionally, vaccines adjuvanted with shorter nanofibers were able to induce cytotoxic T lymphocyte responses, effectively inhibiting tumor growth.
Article
Chemistry, Multidisciplinary
Yiyang Guo, Yubin Ma, Xin Chen, Min Li, Xuehu Ma, Gang Cheng, Changying Xue, Yi Y. Zuo, Bingbing Sun
Summary: The penetration behavior of nanoparticles in mucous is influenced by the physicochemical properties of the particles and the mucus microenvironment. In this study, the authors prepared a library of silica nanoparticles with different surface modifications and studied their mucus penetration behavior. They found that particle surface properties, such as PEGylation and amine/carboxyl groups, affected the immobilization and movement of the nanoparticles in mucus. The study provides insights for designing efficient transmucosal nanocarriers for pulmonary diseases.
Article
Robotics
Sen Wang, Yongyao Li, Guanyu Ding, Chao Li, Qinglei Zhao, Bingbing Sun, Qi Song
Summary: In this paper, a disinfection robot design based on the UVC radiation mechanism is proposed, using low-computational path optimization to address the issue of virus contamination in the cold-chain warehouse or hospital environment under the influence of COVID-19. By utilizing a graph-based approach to generate a closed-loop disinfection path, the efficiency and smoothness of path planning are enhanced. The improved algorithm is validated through Gazebo simulation and experiments, demonstrating its advantages in disinfection coverage and computation resources.
Article
Engineering, Chemical
Jiahui Yan, Yanwei Sun, Taotao Ji, Nan Zhang, Bingbing Sun, Shengyan Meng, Ben Hang Yin, Mingming Wu, Haoquan Hu, Yi Liu
Summary: In this study, a simple and complete room-temperature (RT) protocol was developed for preparing (111)-oriented UiO-66 membranes on a ZrO2-modified alpha-Al2O3 substrate. The membranes exhibited higher CO2/N2 adsorption selectivity due to the higher missing-linker numbers in the UiO-66 framework and the stronger affinity interaction between CO2 and defective sites in Zr6-oxo cluster nodes. The prepared membrane showed superior CO2/N2 selectivity and stable separation performance under moisture conditions.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Minghui Liu, Shibo Sun, Yao Meng, Ling Wang, Haowen Liu, Wuyang Shi, Qiuyu Zhang, Weiping Xu, Bingbing Sun, Jianqiang Xu
Summary: Targeting TXNRD1, this study investigated the inhibition of three benzophenanthridine alkaloids on the enzyme and revealed their anti-cancer mechanisms in gastric cancer cell lines. Chelerythrine was identified as a novel TXNRD1 inhibitor that targets Sec(498) and induces necroptosis in multiple gastric cancer cell lines.
Article
Chemistry, Multidisciplinary
Yubin Ma, Yiyang Guo, Shan Liu, Yu Hu, Cheng Yang, Gang Cheng, Changying Xue, Yi Y. Zuo, Bingbing Sun
Summary: Zwitterionic polymers with superior antifouling properties are promising trans-mucus nanocarriers. The effect of pH microenvironment on the trans-mucus fate of pH-sensitive zwitterionic polymers is unclear. This study prepared zwitterionic polydopamine-modified silica nanoparticles (SiNPs-PDA) and found that the diffusion of SiNPs-PDA in mucus with a pH value of 5.6 was 3 times faster than in mucus with pH values 3.0 or 7.0. The pH-mediated mucus penetration behavior of SiNPs-PDA was mediated by hydrophobic and electrostatic interactions and hydrogen bonding between mucin and the particles.
Article
Toxicology
Tiancong Ma, Xiang Wang, Liqiao Li, Bingbing Sun, Yifang Zhu, Tian Xia
Summary: The use of e-cigarettes is associated with acute lung injury in the United States, with toxicity partly attributed to reactive oxygen species and aldehydes generated during aerosolization. Cell and animal studies show that e-cigarette samples induce oxidative stress, inflammatory response, and cell death.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Immunology
Zhihui Liang, Haoru Zhu, Xin Wang, Bo Jing, Zifan Li, Xinyu Xia, Hongwu Sun, Yun Yang, Weiting Zhang, Li Shi, Hao Zeng, Bingbing Sun
FRONTIERS IN IMMUNOLOGY
(2020)
