Combating Evolution to Fight Disease

The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens

(2013) Leah E Cowen   CURRENT OPINION IN MICROBIOLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

(2013) Erika Shor et al.   PLoS Genetics

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Two Mechanisms Produce Mutation Hotspots at DNA Breaks in Escherichia coli

(2012) Chandan Shee et al.   Cell Reports

Human Copy Number Variation and Complex Genetic Disease

(2011) Santhosh Girirajan et al.   Annual Review of Genetics

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

(2011) Subhajyoti De et al.   NATURE BIOTECHNOLOGY

High order chromatin architecture shapes the landscape of chromosomal alterations in cancer

(2011) Geoff Fudenberg et al.   NATURE BIOTECHNOLOGY

Transcriptional Infidelity Promotes Heritable Phenotypic Change in a Bistable Gene Network

(2009) Alasdair J. E Gordon et al.   PLOS BIOLOGY