Article
Chemistry, Multidisciplinary
Kenichiro Omoto, Menghua Shi, Kazuma Yasuhara, Claire Kammerer, Gwenael Rapenne
Summary: This paper reports the synthesis of ruthenium-based molecular gear prototypes with pentaphenylcyclopentadienyl ligand as an anchoring unit and aryl-functionalized indazoles as a rotating cogwheel. Crystal structures showed that the aryl groups increase the diameter of the cogwheel, making them suitable for intermolecular gearing motions once adsorbed on a surface.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Yohan Gisbert, Seifallah Abid, Claire Kammerer, Gwenael Rapenne
Summary: This review highlights the major efforts in the development of molecular gears over the past 40 years, from covalent bis-triptycyl systems undergoing rotation in solution to gearing systems anchored on surfaces. Different strategies have been devised to control the architecture of molecular gears, aiming at increased efficiency, complexity, and functionality.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Wang Yang, Yan Jingling
Summary: Catalysts, especially rare-earth metal complexes, play a crucial role in the development of the polyolefin industry. The design and synthesis of metal catalysts are key factors in metal-organic chemistry. Rare-earth metal complexes harness unique orbital structure, reactivity, and coordination criteria, making them efficient catalysts in the preparation of polyolefin materials. This review focuses on the development of rare-earth metal catalysts and their applications in polyolefin synthesis, providing new ideas and research methods for the synthesis of high-quality and functionalized polyolefin catalysts.
ACTA CHIMICA SINICA
(2023)
Article
Chemistry, Inorganic & Nuclear
Fen You, Suting Xu, Jixing Wang, Jingjing Zhai, Fei Wang, Li Pan, Yat-Ming So, Xiaochao Shi
Summary: A simple method for accessing new derivatizable bulky-demanding OHF ligands has been developed, leading to the synthesis of a series of half-sandwich rare-earth metal complexes bearing the OHF ancillary ligands, which exhibit high catalytic activity for styrene (co)polymerization.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Alexander A. Vinogradov, Pavel D. Komarov, Lada N. Puntus, Ilya Taydakov, Konstantin A. Lyssenko, Ilya E. Nifant'ev, Evgenia A. Varaksina, Dmitrii M. Roitershtein
Summary: In this study, a series of tetranuclear complexes were synthesized and characterized, with the Tb complex showing a high degree of π-system stacking interaction. Additionally, the luminescent properties of the Nd ion were observed for the first time, and the energy levels of the Cp-Ant ligand were estimated.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Medicinal
Monika Absolonova, Lucie Melounkova, Jaromir Vinklarek, Jan Honzicek, Libor Dostal, Ondrej Mrozek
Summary: Cytotoxic complexes containing molybdenum are studied as potential alternatives to commercial drugs, with different ligands having a significant impact on cytotoxicity. Functionalization of the Cp ring in Mo complexes can improve cytotoxicity against cancer cells, suggesting a potential strategy for designing highly efficient cytotoxic drugs in the future.
Article
Business, Finance
Hans Degryse, Artashes Karapetyan, Sudipto Karmakar
Summary: By utilizing the 2011 EBA Capital exercise, it was found that affected banks tend to require collateral on new loans and partially shield relationship borrowers. The increased collateralization has economically relevant real effects, leading to fund reallocation towards sectors with greater asset tangibility and a tilt towards tangible asset investments by firms and sectors borrowing from treated banks.
JOURNAL OF FINANCIAL ECONOMICS
(2021)
Article
Chemistry, Medicinal
Hang Su, Taiwei Chu
Summary: Hypoxia imaging agents labeled with tricarbonyl technetium-99m were prepared and evaluated for their hypoxic selectivity. The results showed that the agents with different carbon chain lengths and 2-nitroimidazole groups exhibited varying hypoxic selectivity. Compounds with one 2-nitroimidazole group showed decreased hypoxic selectivity as the carbon chain lengthened. However, compounds with two 2-nitroimidazole groups demonstrated better hypoxic selectivity in cell experiments. Further modifications are needed to improve the clearance rate in the blood for these agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Business, Finance
Jianfeng Guo, Xiaojie Liu, Changnan Cui, Fu Gu
Summary: This study finds that private lending interest rate is the most significant influencing factor on the average interest rate of peer-to-peer microloans in China, with other factors also playing a role. Following changes in the Chinese P2P market after June 15, 2018, coefficients of certain influencing factors shifted, resulting in different impacts on interest rates.
FINANCE RESEARCH LETTERS
(2021)
Article
Business, Finance
Asror Nigmonov, Syed Shams, Khorshed Alam
Summary: This study empirically investigates the key macroeconomic factors influencing default risk in the P2P lending market using probit regression analysis. The results show that higher interest rates and inflation increase the probability of default, with a significantly higher impact on loans with lower ratings. This research contributes to informing future market practices for P2P lending platforms and investors in estimating default risk of loans.
RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE
(2022)
Article
Economics
Jeremie Bertrand, Marieke Delanghe, Paul-Olivier Klein
Summary: Relationship lending is commonly known to help SMEs obtain credit, but one of the major obstacles faced by these firms is the initial application process for credit. This study examines how relationship lending affects the demand for credit, specifically the discouragement of borrowers. Through analysis of a cross-country survey of over 2300 firms in Europe in 2010, it is found that firms relying on relationship lending tend to refrain from applying for credit in the first place. This is attributed to a self-rationing mechanism, where riskier firms using relationship lending are more likely to be discouraged. On the other hand, the use of transactional lending reduces discouragement, regardless of firm risk. These findings indicate that firms utilizing relationship lending have a better understanding of their likelihood of rejection and can make informed decisions on whether or not to apply for credit.
ECONOMIC MODELLING
(2023)
Article
Chemistry, Physical
Quannan Wang, Yu-Han Nie, Chen-Xu Liu, Wen-Wen Zhang, Zhi-Jie Wu, Qing Gu, Chao Zheng, Shu-Li You
Summary: In this study, an enantioselective C-H activation/annulation reaction catalyzed by CpRh(III) was reported for the efficient synthesis of planar chiral ferrocene-fused heterocyclic molecules. By finding suitable catalysts, products with high yields and excellent enantioselectivity were obtained. The proposed reaction mechanism was supported by experimental and computational studies.
Article
Chemistry, Inorganic & Nuclear
Emily Y. Tsui, Keaton V. Prather
Summary: Irradiating cobalt metallocenes at specific energies causes the destabilization of the cyclopentadienyl-cobalt bond and the release of radicals. These radicals can be detected by EPR spectroscopy and chemically captured using hydrogen-atom-donating reagents. This reaction offers a new photochemical method for generating cobalt complexes or catalytic cyclopentadienyl cobalt(I) species for [2 + 2 + 2] cyclotrimerization reactions. Additionally, the results highlight that cobaltocene is not a photostable redox reagent under various conditions, including those relevant to photovoltaics or photocatalysis.
INORGANIC CHEMISTRY
(2023)
Article
Business
Suling Feng, Huimin Liu, Yang Yang
Summary: This study utilized the MF-DCCA approach to analyze the lending markets in China and discovered cross-correlations between different markets, highlighting the importance of further regulation on the online lending market.
EMERGING MARKETS FINANCE AND TRADE
(2022)
Article
Emergency Medicine
Jiwoon Kim, Je Hyeok Oh, Kyeongil Min, Du Hwan Kim
Summary: The handedness of the rescuer does not significantly affect the chest compression depth (CCD) during vertical one-handed chest compression (OHCC), although using the dominant hand generates greater force.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Chemistry, Multidisciplinary
Guangying Tan, Frank Glorius
Summary: Stereochemical editing, a recently prominent method, enables direct manipulation of organic molecules with stereocenters to adjust their relative stereochemistry. Various light-driven reactions, such as deracemization and epimerization, have been successfully developed. Wendlandt and colleagues have recently reported a versatile photochemical epimerization of unactivated tertiary stereogenic centers, providing rapid access to challenging stereoisomers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Peter Bellotti, Huan-Ming Huang, Teresa Faber, Frank Glorius
Summary: The emergence of modern photocatalysis has revolutionized late-stage C-H functionalization, offering unprecedented regio- and chemoselectivities. This Review focuses on the strategies of small-molecule drugs, agrochemicals, and natural products, highlighting the main mechanistic scenarios and comparing established ionic chemistry and photocatalyzed radical-based manifolds. The authors aim to provide a comprehensive overview of the current state-of-the-art and address the challenges and future directions in this field.
Article
Chemistry, Multidisciplinary
Johannes E. Erchinger, Reece Hoogesteger, Ranjini Laskar, Subhabrata Dutta, Carla Huempel, Debanjan Rana, Constantin G. Daniliuc, Frank Glorius
Summary: This article presents a new synthetic method that utilizes a photosensitizer to react sulfur fluoride compounds with alkenes, resulting in protected beta-amino sulfonyl fluorides. This method can be used to synthesize peptido sulfonyl fluorides, beta-ammonium sulfonates, and beta-sultams relevant in medicinal chemistry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Guangying Tan, Fritz Paulus, Alessia Petti, Maxim-Aleksa Wiethoff, Anna Lauer, Constantin Daniliuc, Frank Glorius
Summary: A novel radical relay 1,4-carboimination between two distinct olefins with alkyl carboxylic acid-derived bifunctional oxime esters was achieved via energy transfer catalysis. The reaction showed high chemo- and regioselectivity, forming multiple C-C and C-N bonds in a single operation. This mild and metal-free method exhibited a broad substrate scope and excellent tolerance of sensitive functional groups, providing easy access to structurally diverse 1,4-carboiminated products. Furthermore, the obtained imines could be readily converted into valuable biologically relevant free gamma-amino acids.
Article
Chemistry, Multidisciplinary
Akash Kaithal, Himadri Sekhar Sasmal, Subhabrata Dutta, Felix Schafer, Lisa Schlichter, Frank Glorius
Summary: This study reports a catalytic approach to synthesizing cis-selective saturated carbo-and heterocyclic germanium compounds with a 3D framework through the hydrogenation of readily accessible aromatic germanes with a 2D framework. Nishimura's catalyst exhibited the best hydrogenation reactivity, achieving an isolated yield of up to 96%. The synthesized products showed versatile applications in coupling reactions and demonstrated orthogonal reactivity with boranes or silanes, acquiring a three-dimensional structure with high stability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Roman Kleinmans, Subhabrata Dutta, Kristers Ozols, Huiling Shao, Felix Schafer, Rebecca E. Thielemann, Hok Tsun Chan, Constantin G. Daniliuc, Kendall N. Houk, Frank Glorius
Summary: The ortho-selective intermolecular photocycloaddition of bicyclic aza-arenes is reported, utilizing a strain-release approach. This reaction enables the construction of C-(sp(3))-rich bicyclo-[2.1.1]-hexanes directly connected to N-heteroarenes. Photophysical experiments and DFT calculations reveal the mechanism of this selective intermolecular photocycloaddition.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius, Herbert Waldmann, Matthew D. Disney
Summary: Insufficient occupancy of the target, especially for RNA, leads to a lack of biological activity and the difficulty in recognizing RNA structures with small molecules adds to this challenge. By studying the molecular recognition patterns between a small-molecule collection and folded RNA structures, we can map the interaction landscapes across the human transcriptome and define structure-activity relationships. In cases where RNA-binding compounds bind elsewhere and are predicted to be biologically inert, an alternative strategy is to cleave the target through a ribonuclease-targeting chimera, using an RNA-binding molecule appended to a heterocycle that locally activates RNase L-1. Overlaying the substrate specificity of RNase L with the binding landscape of small molecules identifies potential bioactive binders that can be converted into degraders. Proof of concept is provided through the design of selective degraders for pre-miR-155, JUN mRNA, and MYC mRNA, demonstrating the potential of small-molecule RNA-targeted degradation as potent and specific modulators of RNA function.
Article
Multidisciplinary Sciences
Huamin Wang, Huiling Shao, Ankita Das, Subhabrata Dutta, Hok Tsun Chan, Constantin Daniliuc, K. N. Houk, Frank Glorius
Summary: In this study, a photoinduced ring enlargement method of thiophenes was developed, which involves the insertion of bicyclo[1.1.0]butanes to form eight-membered bicyclic rings under mild conditions. The synthetic value, broad functional-group compatibility, and excellent chemo- and regioselectivity were demonstrated by scope evaluation and product derivatization. Experimental and computational studies suggested a photoredox-induced radical pathway.
Review
Chemistry, Multidisciplinary
Lukas Lueckemeier, Marco Pierau, Frank Glorius
Summary: This review aims to present the state-of-the-art in transition-metal catalysed asymmetric hydrogenation of (hetero)arenes, highlighting recent advances and important trends, and providing a broad overview for the reader.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Organic
Chen Zhihao, Fan Qi, Yin Biaolin, Li Qingjiang, Wang Honggen
Summary: Alpha-boryl carbonyl compounds have traditionally been considered thermodynamically unstable and prone to undergo 1,3-boron migration. In recent years, methods for synthesizing stable and separable alpha-boryl carbonyl compounds have been actively developed, thanks to the development and understanding of sp(3)-hybridized boron or tetra-coordinated boron. These methods include the insertion reaction of borane with diazo esters, sulfur ylides and other carbene precursors, the free-radical borylation reaction of alpha,beta-unsaturated carbonyl compounds, and late-stage structural modification reactions of boron-containing compounds. The recent advances in the synthesis of alpha-boryl carbonyl compounds are reviewed based on different reaction types, and the existing challenges and future research directions are discussed.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Tristan Wegner, Anna L. L. Matos, Karine Porte, Kira Mehring, Marco Pierau, Hendrik Horstmeier, Volker Gerke, Frank Glorius
Summary: Cholesterol is a vital lipid in cellular membranes and plays a role in various cellular processes. Diseases like immunological disorders and cancer have been associated with abnormalities in cholesterol homeostasis. Thus, there is a need for molecular tools to study cholesterol distribution and interactions. In this study, a novel bifunctional imidazolium-based cholesterol analog (X-CHIM) was synthesized, which can serve as a versatile tool for investigating cellular cholesterol distributions and cholesterol-protein interactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Robert Zielinski, Mowpriya Das, Canan Kosbab, Mike Thomas Nehring, Mario Daehne, Norbert Esser, Martin Franz, Frank Glorius
Summary: The adsorption behavior of cyclohexyl cyclic (alkyl)(amino)carbene molecules on a silicon surface is investigated, showing a self-limited, well ordered growth of a stable monolayer with large domains, which is surprising on semiconductors. Additionally, the surface defect density strongly influences the grade of ordering, as the initial adsorption takes place on a defect site.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Physical
Yuan Liu, Shuang Lin, Yin Li, Jiang-Hao Xue, Qingjiang Li, Honggen Wang
Summary: This article reports a facile synthesis strategy for bicyclo[2.1.1]hexanes (BCHs) as bioisosteres of benzenoids in medicinal chemistry. The synthesis is achieved through a strain-release-driven [27r + 2o-] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with alkenes using a pyridine-boryl radical catalyst. The mild reaction conditions, wide substrate scope, and good functional group tolerance make this protocol appealing for drug design and synthesis. Theoretical mechanistic studies suggest a radical relay mechanism, and synthetic applications of the products are demonstrated.
Article
Chemistry, Multidisciplinary
Florenz Buss, Mowpriya Das, Daniel Janssen-Mueller, Alexander Sietmann, Ankita Das, Lukas F. B. Wilm, Matthias Freitag, Michael Seidl, Frank Glorius, Fabian Dielmann
Summary: This study reports the synthesis and properties of photoswitchable electron-rich phosphines containing N-heterocyclic imines. Heteronuclear NMR spectroscopy and UV/vis studies reveal reversible electrocyclic ring-closing and ring-opening reactions of the imine substituents upon exposure to UV and visible light. The photoisomerization alters the electron-donating ability of the phosphines by up to Delta TEP = 8 cm-1.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Tristan Wegner, Alexander Dombovski, Katrin Gesing, Alexander Koehrer, Matthias Elinkmann, Uwe Karst, Frank Glorius, Joachim Jose
Summary: The cell membrane is an important platform for modifying and manipulating cellular behavior. This study presents a method for functionalizing the bacterial membrane using lipid mimetics, allowing for a new type of cascade reaction.
