Article
Oncology
Danna Sheinboim, Shivang Parikh, Paulee Manich, Irit Markus, Sapir Dahan, Roma Parikh, Elisa Stubbs, Gali Cohen, Valentina Zemser-Werner, Rachel E. Bell, Sara Arciniegas Ruiz, Ruth Percik, Ronen Brenner, Stav Leibou, Hananya Vaknine, Gali Arad, Yariv Gerber, Lital Keinan-Boker, Tal Shimony, Lior Bikovski, Nir Goldstein, Keren Constantini, Sapir Labes, Shimonov Mordechai, Hila Doron, Ariel Lonescu, Tamar Ziv, Eran Nizri, Guy Choshen, Hagit Eldar-Finkelman, Yuval Tabach, Aharon Helman, Shamgar Ben-Eliyahu, Neta Erez, Eran Perlson, Tamar Geiger, Danny Ben-Zvi, Mehdi Khaled, Yftach Gepner, Carmit Levy
Summary: Exercise induces metabolic reprogramming in internal organs, which increases nutrient demand and protects against cancer metastasis by limiting nutrient availability to tumor cells. Both mouse and human studies show that exercise can reduce the incidence and likelihood of metastatic cancer, and this protective effect is dependent on mTOR activity.
Article
Mathematics
Eugenio Giannelli, J. Miquel Martinez, A. A. Schaeffer Fry
Summary: This article investigates the relationship between the derived length of a defect group and the number of degrees of irreducible characters in a block, providing new evidence to support this statement.
JOURNAL OF ALGEBRA
(2022)
Article
Oncology
Qian Wang, Yi Fang Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Natasha Freidman, Lisa G. Horvath, Nigel Turner, Jeff Holst
Summary: Glutamine is a critical nutrient in cancer, especially in prostate cancer; and Guanosine monophosphate synthetase (GMPS) plays a significant role in de novo purine biosynthesis pathway. High expression of GMPS is associated with decreased survival rates in prostate cancer, and inhibition or knockdown of GMPS can significantly decrease cell growth in prostate cancer cells. These findings highlight the importance of glutamine metabolism and suggest GMPS as a potential therapeutic target in prostate cancer.
JOURNAL OF PATHOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Gregory R. Lumpkin, Robert D. Aughterson
Summary: This article provides perspectives on the phase transformations, stability fields, and order-disorder patterns of pyrochlore and defect fluorite type compounds, highlighting the relationship with factors such as ionic radius ratio and defect formation. Interestingly, despite differences in composition, the modulation effects are found to be similar in different compounds, suggesting that the A/B cation ratio and oxygen stoichiometry have minimal impact on the modulations.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Rekha R. Schnepf, M. Brooks Tellekamp, Theresa Saenz, John S. Mangum, Edwin Supple, Dennice M. Roberts, Craig L. Perkins, Karen N. Heinselman, Brian P. Gorman, Ann L. Greenaway, Eric S. Toberer, Adele C. Tamboli
Summary: This paper reports on the growth of epitaxial ZnGeP2 on Si and GaP substrates via reactive combinatorial sputtering in phosphine gas. The films on both GaP and Si showed high crystalline quality, but the films grown on Si exhibited higher threading dislocation densities and antiphase domains compared to those on GaP. The results suggest the potential for high-quality epitaxial ZnGeP2 growth with optimization of synthesis conditions and substrate preparation.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Nanoscience & Nanotechnology
Renlu Yuan, Yue Dong, Su Zhang, Xiaohong Chen, Huaihe Song
Summary: Designing dense carbon materials with high capacitance and good rate performance is crucial for future development of minimized and light-weight supercapacitors. The functionalized graphene block reported in this study shows high capacitances and good rate performance, demonstrating the importance of functionalization synergy in compact energy storage ability of carbon materials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jianfei Liu, Ji Wang, Yunlin Chen
Summary: In this study, the weak absorption and laser-induced damage in YCOB crystal were investigated using the one-dimensional quantum waveguide theory. The barrier strengths of precursor defects were calculated and the effect of crystal anisotropy on weak absorption was discussed. The damage thresholds of the crystals were determined and the contribution of mesoscopic clusters to the damage temperature was analyzed. The results provide insights into the mechanism of weak absorption and laser-induced damage in crystals.
Article
Chemistry, Multidisciplinary
Yukihiko Takagaki, Michael Hanke, Manfred Ramsteiner
Summary: The study investigates the sulfurization of InP(111) surfaces using vaporized Sb2S3 and Bi2S3, exploring the effects of temperature on the substitution of atoms and epitaxial growth orientation. It reveals that the coverage with Sb and Bi changes the surface free energy, leading to alterations in growth orientation. Additionally, the deposition of polycrystalline Sb2S3 films is facilitated by the thermally activated sticking of Sb2S3 species to the InP surfaces.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Yang Yue, Maosong Sun, Xu Li, Ting Liu, Yong Lu, Jie Chen, Yi Peng, Mudassar Maraj, Jicai Zhang, Wenhong Sun
Summary: This paper combined magnetron sputtering and high-temperature annealing technology to explore the thermal annealing of high-miscut-angle AlN films along different directions, achieving significant improvement in film quality by eliminating grain boundaries through annealing. This provides important reference for preparing high-quality deep ultraviolet emission devices.
Article
Multidisciplinary Sciences
Zaiwang Zhao, Yujuan Zhao, Runfeng Lin, Yuzhu Ma, Lipeng Wang, Liangliang Liu, Kun Lan, Jie Zhang, Hanxing Chen, Mengli Liu, Fanxing Bu, Pengfei Zhang, Liang Peng, Xingmiao Zhang, Yupu Liu, Chin-Te Hung, Angang Dong, Wei Li, Dongyuan Zhao
Summary: We report on the fabrication of three-dimensional hierarchical core-satellite SiO2@monomicelle spherical superstructures through a previously unexplored monomicelle interfacial super-assembly route. The ultrathin single layer of monomicelle subunits with hexagon-like regular discontinuous distribution on solid spherical interfaces can be achieved, and the number of monomicelles on colloidal SiO2 interfaces can be quantitatively controlled. This strategy provides a controllable way for building multiscale hierarchical regular micro- and/or macroscale materials and devices.
Article
Pharmacology & Pharmacy
Aya Yamamura, Md Junayed Nayeem, Hiroyuki Muramatsu, Kogenta Nakamura, Motohiko Sato
Summary: The study revealed that the VEGFR-3 signaling pathway plays a crucial role in the proliferation, migration, and tumor growth of androgen-independent/highly metastatic prostate cancer cells, highlighting its potential as a novel therapeutic target for prostate cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ashutosh Singh, Ankur Kumar, Prateek Kumar, Namyashree Nayak, Taniya Bhardwaj, Rajanish Giri, Neha Garg
Summary: c-Myc is a vital transcription factor that regulates gene expression and forms a heterodimer with MAX. L755507, a newly discovered small molecule, inhibits the formation of the c-Myc-MAX heterodimer and shows potential as an anti-tumor agent.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen
Summary: In HER2(+) breast cancer, overactivation of HER2 leads to aberrant G(i/o)-GPCR signaling, promoting cancer progression and resistance to HER2-targeted therapy. Pharmacologically deactivating GPCR signaling can block tumor growth and enhance therapeutic efficacy.
Article
Mathematics
Noelia Rizo, A. A. Schaeffer Fry, Carolina Vallejo
Summary: This study demonstrates that if the principal p-block of a finite group contains 5 irreducible characters, then the order of a Sylow p-subgroup can only be 5, 7, or isomorphic to a non-abelian 2-group of order 8.
JOURNAL OF ALGEBRA
(2021)
Article
Cell Biology
Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D. Longo
Summary: The study demonstrates that a fasting-mimicking diet activates starvation escape pathways in TNBC cells and reduces stemness markers in CSCs, leading to decreased cell numbers and improved mouse survival. Additionally, the diet activates different survival/growth pathways in differentiated cancer cells, which can be targeted by drugs to promote tumor regression.
