Article
Biochemistry & Molecular Biology
Qian Liu, Zhenrong Tan, Dafeng Zheng, Xueqing Qiu
Summary: A magnetic delivery system for targeted drug was developed using aminated lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) to fabricate nano Fe3O4 with pH responsiveness. The system successfully loaded doxorubicin hydrochloride (DOX) and demonstrated controlled release of the drug. The particle size ranged from 79.9-169.9 nm under optimized conditions and exhibited excellent pH responsiveness. The drug-loaded particles showed significant growth inhibition on cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Qingqing Guo, Xin Wu, Yanhong Ji, Yufan Hao, Shuyu Liao, Zhenyu Cui, Jianxin Li, Mohammad Younas, Benqiao He
Summary: A novel pH-responsive NF membrane was synthesized via interfacial polymerization with a mixture of piperazine and chitosan as the aqueous phase and trimesoyl chloride in n-hexane as the organic phase. This NF membrane exhibited excellent separation performance at pH 12 and could be adjusted for different applications by changing the pH values.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Hamidreza Garshasbi, Saba Salehi, Seyed Morteza Naghib, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Injectable hydrogels have gained significant attention in the past decade for their functional properties in drug delivery, particularly in precise, non-invasive, and targeted tissue locations. The development of drug delivery systems that are responsive to hydrogel stimuli to release drugs under various external stimuli is a challenging task. Chitosan-based hydrogels, known for their biocompatibility, mucosal adhesion, and hemostatic activity, hold great potential for tissue engineering and drug delivery. However, managing the structure of stimuli-responsive chitosan hydrogels or incorporating additional crosslinking agents, such as those with dual pH and thermo-responsiveness, can be difficult. Therefore, it is crucial to create these hydrogels for medicinal applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Hessam Jafari, Gholam Reza Mahdavinia, Bagher Kazemi, Hermann Ehrlich, Yvonne Joseph, Mehdi Rahimi-Nasrabadi
Summary: This study developed novel smart drug delivery systems using magnetic hydroxypropyl methylcellulose and chitosan to create core-shell nano-carriers with high loading capacity and pH-sensitive drug release properties.
CARBOHYDRATE POLYMERS
(2021)
Article
Biophysics
Anton Turaev, Ekaterina A. Isaakova, Vjacheslav V. Severov, Alexandra N. Bogomazova, Timofei S. Zatsepin, Makar Sardushkin, Andrey Aralov, Maria A. Lagarkova, Galina E. Pozmogova, Anna M. Varizhuk
Summary: The design of robust sensors for measuring intracellular pH based on native DNA i-motifs offers a sensitive and fast-response approach without the need for additional modules. This 'genome-inspired' design can be used to monitor proton dynamics in the nucleus, suggesting it is a productive approach for the development of biocompatible molecular tools.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Applied
Min Mu, Xiaoyan Liang, Di Chuan, Shasha Zhao, Wei Yu, Rangrang Fan, Aiping Tong, Na Zhao, Bo Han, Gang Guo
Summary: The study successfully constructed a Cabazitaxel@MPN/CS delivery system, with good drug release and cellular internalization effects in melanoma therapy, providing a promising strategy for cancer treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Parinaz Jabbari, Gholam Reza Mahdavinia, Parisa Fathi Rezaei, Bagher Kazemi Heragh, Parisa Labib, Hessam Jafari, Shahrzad Javanshir
Summary: A nanocomposite carrier with double-responsive features was developed by integrating magnetic montmorillonite into a chitosan matrix and crosslinking it with citric acid. The carrier showed high sustained release and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Iratxe Zarandona, Daniela M. Correia, Joana Moreira, Carlos M. Costa, Senentxu Lanceros-Mendez, Pedro Guerrero, Koro de la Caba
Summary: Chitosan-pectin films containing Fe3O4 magnetic nanoparticles were prepared using solution casting method, creating biopolymer-based magnetically active materials. Physical interactions between the matrix and nanoparticles were confirmed by FTIR spectra and DSC results. The structure of the films was influenced by the interactions, leading to changes in mechanical properties. VSM and electrical analysis showed that the films exhibited ferrimagnetic behavior and increased dielectric constant with higher nanoparticle concentration. Additionally, the films demonstrated enhanced antimicrobial activity against both Gram-negative and Gram-positive bacteria. These findings highlight the potential of chitosan-pectin films with Fe3O4 magnetic nanoparticles in active and intelligent food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Runna He, Shuangqing Sun, Jianpeng Cui, Mingshuo Chi, Zhikun Wang, Songqing Hu
Summary: In this paper, a novel composite Pickering emulsifier with magnetic response recognition and pH responsiveness is reported. This emulsifier can stabilize the emulsion and achieve demulsification under specific magnetic field and pH conditions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Keliang Zhang, Jun Gao, Shangji Li, Ting Ma, Linhong Deng, Yong Kong
Summary: In this study, chitosan (CS) was used for surface functionalization of mesoporous silica nanoparticles (MSN) to form a hybrid of MSN and CS (MSN/CS) for controlled drug delivery with pH-sensitivity. The introduced CS acted as a gatekeeper to prevent premature drug release, leading to higher cumulative release rates, especially at pH 5.0.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Chongchong Liu, Panping Yang, Jingguo Li, Shaokui Cao, Jun Shi
Summary: In this study, a remotely multi-responsive chitosan hydrogel was prepared with near-infrared (NIR) responsiveness, pH response, and thermal responsiveness. It showed notable NIR-triggered photo-thermal effect and remotely controllable drug delivery properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Multidisciplinary
Han Liu, Feifan Wang, Wenyang Wu, Xufeng Dong, Lin Sang
Summary: This study proposes a promising magneto-responsive shape memory polymer (SMP) for 3D printing. The SMP exhibits robust mechanical properties and magnetic responsiveness. The research also demonstrates the rapid magnetic response and high recovery performance of the material, as well as its ability to change and recover shape under a contactless magnetic field. These findings have significant implications for applications in 3D printing.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Ying Fang, KangRui Wang, Qin Li, ChengHong Huang
Summary: Carboxylation of chitosan and ethyl vanillin led to the formation of EV-CMCS, which was then used to create EV-CMCS@GNRs nanocomposites for PTX loading and release. The presence of a broken Schiff base under acidic conditions increased the CMC of EV-CMCS@GNRs, offering a new approach for delivering paclitaxel for tumor therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Fangxuan Yi, Fanyun Hou, Shouqing Zhan, Lisha Song, Rongfei Zhang, Xiangbo Han, Xia Sun, Zhanli Liu
Summary: This study developed a novel pH-responsive smart film for monitoring the freshness of food. The addition of red radish anthocyanin improved the performance of the film, which exhibited strong water vapor and gas barrier capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Mo Xiao, Xiaoying Su, Congming Xiao
Summary: In this study, an intelligent polymer ICMIPN was tailor-made through modulating its components, showing controllable physical properties such as photoisomerization, pH-sensitivity, and thermal stability.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Article
Biochemistry & Molecular Biology
S. S. Chougule, S. T. Gurme, J. P. Jadhav, T. D. Dongale, A. P. Tiwari
Summary: This study successfully synthesized silver nanoparticles using leaf extract of Moringa oleifera with strong antimicrobial properties. The combination of AgNPs with low-density polyethylene films showed effective prevention of microbial contaminations, ensuring food safety. Additionally, the AgNPs exhibited high photocatalytic degradation of dyes, making them a promising technological innovation for various applications.
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Trishala R. Desai, Tukaram D. Dongale, Swapnil R. Patil, Arpita Pandey Tiwari, Pankaj K. Pawar, Rajanish K. Kamat, Tae Geun Kim
Summary: This study presents an organic memristive device based on trypsin, which can modulate the current and resistance by altering the frequency and magnitude of the applied signal. It exhibits an inverse memristive effect and mimics bio-synaptic properties, providing new insights for neuromorphic computing applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Pharmacology & Pharmacy
Arpita P. Tiwari, Nanasaheb D. Thorat, Sabrina Pricl, Rakesh M. Patil, Sonali Rohiwal, Helen Townley
Summary: Bioinks are crucial for the fabrication of artificial living-tissue constructs using 3D bioprinting technologies, with a significant application in cancer management. The ability to recreate tumor microenvironments using 3D bioprinting is a promising approach for drug development and in vitro cancer modeling.
DRUG DISCOVERY TODAY
(2021)
Review
Electrochemistry
Rajshri Kundlik Satvekar
Summary: Effective and efficient diagnosis of COVID-19 is crucial for expanding testing capabilities, with nucleic acid-based testing becoming the gold standard. Nano-enabled systems like electrochemical nanobiosensors are playing a significant role in advancing diagnostic technologies for COVID-19.
JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING
(2022)
Review
Chemistry, Inorganic & Nuclear
Tejaswini Patil, Rutuja Gambhir, Anuja Vibhute, Arpita Pandey Tiwari
Summary: Nanotechnology has wide applications in medicine and biomedical engineering. Gold nanoparticles are stable and have unique properties, making them useful in various biological applications. Biological synthesis methods reduce the use of toxic chemicals. Functionalized gold nanoparticles are used in bioimaging, biosensing, anticancer therapy, drug delivery, and antimicrobial activity. The study of gold nanoparticles opens up new possibilities in the field of biology.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemical Research Methods
Anuja Vibhute, Omkar Nille, Govind Kolekar, Sonali Rohiwal, Shubham Patil, Seunghyun Lee, Arpita Pandey Tiwari
Summary: This study demonstrates the synthesis of functionalized carbon quantum dots (CQDs) using the one-pot pyrolysis method. The synthesized PLLCQD exhibits excellent antibacterial activity, bio-imaging capability, and anti-angiogenic properties. Various physicochemical techniques were employed to confirm the successful formation of PLLCQD.
JOURNAL OF FLUORESCENCE
(2022)
Article
Materials Science, Multidisciplinary
Rutuja Prashant Gambhir, Arun Kumar Parthasarathy, Shimpa Sharma, Shital Kale, Vikas Vijay Magdum, Arpita Pandey Tiwari
Summary: The method of using glycine functionalized iron oxide nanoparticles shows efficient potential in SARS-CoV-2 RNA extraction with its pH responsive nature, achieving adsorption in acidic medium and elution in basic medium. It has been demonstrated to have outstanding properties over current existing extraction protocols.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
T. Patil, V Khot, A. Pandey-Tiwari
Summary: The widespread and irrational use of antibiotics has led to the development of antibiotic-resistant bacteria. This study reports a single-step antibiotic-mediated synthesis of antibiotic-conjugated gold nanoparticles as a potential solution. The synthesized nanoparticles showed broad-spectrum antibacterial activity against various bacterial strains, including those responsible for hospital-acquired infections.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Review
Cell & Tissue Engineering
Tejaswini Patil, Sonali S. Rohiwal, Arpita P. Tiwari
Summary: Cancer stem cells (CSCs) are transformed forms of normal stem cells with the ability to develop resistance against chemo and radiotherapy. They play a crucial role in cancer recurrence by activating self-renewal signaling pathways, DNA repair capacity, microenvironment, and expression of ABC transporters. Targeting these mechanisms can eliminate CSCs and reduce cancer recurrence.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemical Research Methods
Pranoti Kamble, Dhanaji Malavekar, Arpita Pandey Tiwari
Summary: In this study, a cost-effective and environmentally safe method was developed to synthesize carbon quantum dots (CQDs) using human hair as the carbon source without the need for chemicals. The synthesized CQDs were further functionalized with Poly-L-Lysine to form PLLCQDs, which exhibited strong fluorescence intensity, photostability, and water solubility. Various characterization techniques were used to confirm the successful formation of PLLCQDs, and their size was determined to be 3 nm. The optimized synthesis parameters, including method, temperature, time, and concentration, had a significant impact on the quality and quantity of PLLCQDs, as well as their properties and applications. The synthesized PLLCQDs demonstrated excellent photo and chemical stability under different pH and UV radiation conditions, and showed low cytotoxicity towards fibroblast cells.
JOURNAL OF FLUORESCENCE
(2023)
Article
Biochemical Research Methods
Anuja Vibhute, Tejaswini Patil, Dhanaji Malavekar, Shubham Patil, Seunghyun Lee, Arpita Pandey Tiwari
Summary: A hydrothermal method was used to synthesize green fluorescent carbon dots (GCDs) from Annona squamosa leaves. The synthesized GCDs were confirmed using microscopic and spectroscopic techniques. The GCDs showed various properties, including strong antibacterial activity and anti-inflammatory effects. Moreover, the GCDs were found to affect the angiogenesis process by decreasing blood vessel density.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Multidisciplinary
Rutuja Prashant Gambhir, Shital Kale, Tukaram Dongale, Snehal Patil, Dhanaji Malavekar, Arpita Pandey Tiwari
Summary: This study demonstrates the selective anti-cancer activity of poly-l-lysine-functionalized iron oxide nanoparticles (PLL@IONPs) against osteosarcoma cancer. The nanoparticles were synthesized from spinach leaf extract. In vitro experiments showed selective cytotoxicity of the synthesized nanoparticles against osteosarcoma cells, while normal fibroblast cells were less affected. The nanoparticles also exhibited free radical scavenging activity and inhibited reactive oxygen species (ROS) generation. In vivo, PLL@IONPs inhibited site-specific angiogenesis and could potentially be used as a therapeutic for osteosarcoma cancer as well as a measure for carcinogen degradation.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Physical
Tejaswini P. Patil, Anuja A. Vibhute, Snehal L. Patil, Tukaram D. Dongale, Arpita P. Tiwari
Summary: The researchers have successfully synthesized gold nanoparticles (Ca-AuNPs) using dried fruit extract of Capsicum annum as a reducing agent. The synthesized nanoparticles were found to be spherical in shape with a size range of 20-30nm and exhibited a UV absorption peak at 540nm. The Ca-AuNPs showed significant antiangiogenic and antioxidant activities, making them potentially useful in biomedical applications.
APPLIED SURFACE SCIENCE ADVANCES
(2023)
Article
Chemistry, Physical
Anuja Vibhute, Tejaswini Patil, Rutuja Gambhir, Arpita Pandey Tiwari
Summary: Carbon Quantum Dots (CQDs) are a type of carbon material with strong fluorescence, showing great potential in bioimaging and biomedical applications. Understanding synthesis methods and optical properties is crucial for commercializing CQDs-based bioimaging research. This review covers various synthesis methods, optical properties, and surface functionalization agents, discussing applications in bioimaging, biosensing, and drug delivery, as well as current challenges and future prospects.
APPLIED SURFACE SCIENCE ADVANCES
(2022)
Review
Chemistry, Physical
Rutuja Prashant Gambhir, Sonali S. Rohiwal, Arpita Pandey Tiwari
Summary: This review explores the extensive use of magnetic iron oxide nanoparticle-based multifunctional platforms in biomedical applications. The modifications and integrations of IONPs with various entities make them suitable for a wide range of biomedical fields. The review also covers recent advances in multifunctional IONPs, including biosensing, pathogen detection, MRI, gene therapy, chemotherapy, drug delivery, bioimaging, stem cell detection, tissue engineering, nano-vaccines, microbe targeting, and COVID-19 management.
APPLIED SURFACE SCIENCE ADVANCES
(2022)
