4.6 Article

Copper-catalyzed oxidative cyclization of arylamides and β-diketones: new synthesis of 2,4,5-trisubstituted oxazoles

Journal

RSC ADVANCES
Volume 5, Issue 11, Pages 8002-8005

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra14394a

Keywords

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Funding

  1. National Natural Science Foundation of China [21172185, 21372187]
  2. Hunan Provincial Innovative Foundation [CX2014B258]
  3. New Century Excellent Talents in University from Ministry of Education of China [NCET-11-0974]
  4. Research Fund for the Doctoral Program of Higher Education of China, Ministry of Education of China [20124301110005]

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A novel copper catalyzed approach to oxazoles via enamide intermediates was developed from benzamides and beta-diketones. The successive condensation and cyclization reactions afforded various 2,4,5-trisubstituted oxazoles in good yields.

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