Article
Chemistry, Multidisciplinary
Huilin Xie, Zhenyu Bi, Junli Yin, Zeshun Li, Lianrui Hu, Chen Zhang, Jianquan Zhang, Jacky W. Y. Lam, Pengfei Zhang, Ryan T. K. Kwok, Kai Li, Ben Zhong Tang
Summary: Fluorescence-guided phototherapy is an emerging noninvasive cancer treatment strategy. Organic molecules, with their easy construction, simple modification, and good biocompatibility, have shown promise as theranostic agents. This study successfully developed a versatile theranostic platform based on an aggregation-induced emission luminogen, TPA-TBT, which exhibited near-infrared emission, high fluorescence quantum yield, robust reactive oxygen species production, and excellent photothermal conversion efficiency. In vivo studies demonstrated its outstanding efficacy in both photodynamic and photothermal therapies against tumors in a mouse model. This work provides a design strategy for developing all-in-one cancer theranostic agents by modulating and utilizing the relaxation energy of excitons.
Article
Chemistry, Multidisciplinary
Hiromasa Takahashi, Hiroyuki Watanabe, Shunichiro Ito, Kazuo Tanaka, Yoshiki Chujo
Summary: We synthesized new binuclear boron complexes based on pyrazine with ortho and para substitution patterns. The para-linked complexes showed a narrow energy gap between highest occupied and lowest unoccupied molecular orbitals, resulting in far-red to near-infrared emission properties. Meanwhile, the ortho-substituted complex exhibited orange emission. The theoretical study suggested that the para-substitution did not significantly perturb the characteristic HOMO distribution originating from pyrazine, unlike the ortho-substituted one.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Applied
Caiyun Liu, Shisheng Cui, Jiamin Qu, Linyu Wang, Yuanyuan Cheng, Zhengxu Cai, Bin Tong, Ruoyu Zhang, Yuping Dong, Jianbing Shi
Summary: In this study, an aggregation-induced emission dye was synthesized from multiarylpyrroles (MAPs) and its fluorescence intensity was continuously enhanced by coordinating with tris(pentafluorophenyl)borane (BCF). The coordination between MAPs and BCF improved the fluorescence quantum yields and restricted molecular motion, while also reducing the ability to produce reactive oxygen species.
Review
Chemistry, Multidisciplinary
Jia Yu, Guoyu Jiang, Jianguo Wang
Summary: In vivo fluorescence imaging has gained attention for its excellent biosafety, high sensitivity, real-time monitoring ability, and non-invasiveness. Aggregation-induced emission luminogens (AIEgens) with near-infrared (NIR) absorption and emission wavelengths are ideal for this imaging due to their large Stokes shift, high brightness, and photostability. This review summarizes the strategies for constructing high-performance NIR AIEgens and highlights the encapsulation strategies to increase their water solubility and biocompatibility. The challenges and prospects of fabricating NIR AIEgens for in vivo fluorescence imaging are also discussed.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ming-Yu Wu, Jong-Kai Leung, Chuen Kam, Tsu Yu Chou, Jia-Li Wang, Xueqian Zhao, Shun Feng, Sijie Chen
Summary: This study developed a near-infrared fluorescent probe named TBTCP for real-time imaging of phagocytosis. TBTCP could selectively label the cell plasma membrane and report the cell membrane statuses and macrophage phagocytosis through fluorescence lifetime changes. It provides a functional tool to study phagocytic function-related diseases.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qifei Shen, Kai Gao, Zhiqin Zhao, Anran Gao, Yanzi Xu, Heng Wang, Lingjie Meng, Mingming Zhang, Dongfeng Dang
Summary: Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state. DTPABT-MC-R-based nanoparticles also display excellent photo-stability, and impressive photosensitive characteristics, finally leading to applications in cellular imaging and photodynamic therapy (PDT).
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Xiaoye Wen, Fang Li, Furong Liu, Zhefeng Fan
Summary: In this paper, a D-pi-A near-infrared aggregation-induced fluorescent probe was developed for rapid and sensitive detection of SO2. The probe showed high sensitivity and low toxicity, making it potentially useful for monitoring SO2 in living cells and food analysis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Kunze Du, Bing Wang, Shujing Chen, Yan Cui, Shuangqi Wang, Chunxiao Liang, Ye Shang, Chenhong Wang, Shixin Hou, Jin Li, Xie-an Yu, Yanxu Chang
Summary: A novel strategy was designed for sensitive and specific detection of thrombin via integrated TPABDFN and polypeptide substrate. This method showed a linear response in detecting thrombin and has potential application in the diagnosis of certain diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Materials Science, Multidisciplinary
Yu-Xin Che, Xiao-Ni Qi, Qi Lin, Hong Yao, Wen-Juan Qu, Bingbing Shi, You-Ming Zhang, Tai-Bao Wei
Summary: This review comprehensively summarizes the significant progress in innovative design strategies, excellent properties, and promising applications of novel functionalized phenazine derivatives in the fields of optical sensing and electrochemistry.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Materials Science, Multidisciplinary
Xiaodie Zhang, Junyi Gong, Wei Tao, Xiujie Jiang, Cheng Chen, Peifa Wei
Summary: Deep-red and near-infrared luminogens have been widely used in various fields. However, their complicated structures make synthesis and crystallization difficult, hindering the understanding of the structure-emission relationship. This study successfully achieved multiple deep-red and near-infrared emission ranges through the polymorphism of a simple conjugated luminogen. The packing-dependent emission of the compound helped establish a clear relationship between packing and emission.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Applied
Hua Ye, Jiaji Yang, Kleitos Stavrou, Mengke Li, Fen Liu, Feiyun Li, Shi-Jian Su, Andrew P. Monkman
Summary: In this study, two pairs of asymmetric isomers based on electron-donor units and electron-deficient moieties were designed and synthesized. Their photophysical properties were finely modulated by changing the position and number of certain groups. The results showed that the asymmetric and isomeric molecular design is a potential strategy for promoting the development of highly efficient long-wavelength thermally activated delayed fluorescence materials.
Article
Chemistry, Applied
Gaobin Zhang, Jianli Yan, Fangjie Chen, Yujie Yang, Chengyuan Wang, Jiaxiang Yang
Summary: Developing red materials with bright near-infrared emission and excellent two-photon performance through a simple preparation process is a meaningful and challenging work. In this study, a series of nitro functionalized D-pi-A type alpha-cyanostilbene derivatives with different side chains were designed and synthesized. The fluorescent properties of the compounds were found to be enhanced in the aggregation state due to side chain induced molecular planarization and formation of unique aggregate structures. Furthermore, side chain modified compounds were employed for the preparation of a mitochondrial targeting probe, which exhibited high fluorescence and selective targeting of mitochondria in live cells and zebrafish, and enabled the observation of complex mitochondrial networks under STED nanoscopy.
Article
Chemistry, Applied
Jinjin Zhang, Qi Chen, Yiqi Fan, Huayu Qiu, Zhigang Ni, Yang Li, Shouchun Yin
Summary: The study introduces a novel NIR fluorescent material TTBE, which exhibits solvatochromism and aggregation-induced emission characteristics, demonstrating NIR emission in water through the construction of nanoparticles and showing excellent cytocompatibility.
Article
Engineering, Biomedical
Zhenyan He, Yuting Gao, Huimin Zhang, Ying Xue, Fanling Meng, Liang Luo
Summary: A donor-pi-acceptor photosensitizer with near infrared aggregation-induced emission (AIE) is designed and synthesized for imaging-guided two-photon photodynamic therapy (2P-PDT), demonstrating precise cancer treatment through two-photon excitation in the NIR-II window.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Li Wang, Sai Wang, Xiang Chang, Weiqiong Zheng, Hu Zhang, Xiangqin Gan, Jingwei Huang, Xiugang Wu, Caifa You, Weiguo Zhu
Summary: A NIR-emitting iridium complex was designed and synthesized, exhibiting a significantly red-shifted emission peak. The influence of the enlarging rigid coordinated core and peripheral shields on the emissive property was studied. Pure NIR electroluminescence was achieved in polymer light-emitting diodes.
