Journal
RSC ADVANCES
Volume 5, Issue 81, Pages 66104-66108Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra12529d
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Funding
- Ministry of Science and Technology of China [2012ZX09103101-042]
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Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.
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