Article
Polymer Science
Cristina Vallecillo, Manuel Toledano-Osorio, Marta Vallecillo-Rivas, Manuel Toledano, Raquel Osorio
Summary: This study examines the degradation of three collagen matrices over time, with Fibro-Gide showing the highest resistance to degradation challenges. The bacterial collagenase solution was found to be the most aggressive test, with all matrices degrading before 14 days of storage.
Article
Materials Science, Multidisciplinary
Qiang Zhang, Fransiska M. Bossuyt, Naomi C. Adam, Byron Llerena Zambrano, Flurin Stauffer, Patrick Rennhard, Roman Gubler, Roland Kung, Sarah Abramovic, Vullnet Useini, Walter Herzog, Tim Leonard, Michael W. Scott, William R. Taylor, Colin R. Smith
Summary: This study developed a strain sensor system and applied it to musculoskeletal soft tissues, measuring strain patterns wirelessly. The results showed that the sensor system exhibited excellent stability and resolution, and was able to record strain patterns during dynamic movements.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Polymer Science
Cristina Vallecillo, Manuel Toledano-Osorio, Marta Vallecillo-Rivas, Manuel Toledano, Alberto Rodriguez-Archilla, Raquel Osorio
Summary: Soft tissues are essential for maintaining teeth and implants. Using collagen matrices as an alternative to autogenous tissue graft has shown effectiveness in improving soft tissue dimensions. While autogenous connective tissue graft achieves higher values, collagen matrices are also effective in enhancing keratinized tissue width and mucosal thickness.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David Lubin, Abtin Jafroodifar, Rahul Seth, Daniel Zaccarini
Summary: This case highlights a rare scenario where metastatic lung adenocarcinoma initially presented as a musculoskeletal soft tissue mass, with further imaging revealing the true origin of the malignancy in the lung. Soft tissue metastasis from lung adenocarcinoma, although less common, remains clinically significant.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Pingping Wang, Hai Li, Yu Hu, Xiaojing Peng, Xinhua Ye, Di Xu, Ao Li
Summary: This study found a moderate correlation between vascular density grade and Ki-67 LI in soft tissue sarcoma, with other ultrasound features showing no correlation. The optimal cut-off point for distinguishing low and high proliferation groups was determined to be grade II. The area under the ROC curve was 0.74, with a sensitivity of 60.6% and specificity of 78.6%.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Daniele De Santis, Umberto Luciano, Paola Pancera, Giacomo Castegnaro, Christian Alberti, Federico Gelpi
Summary: This article conducted a systematic review and meta-analysis to investigate the clinical efficacy of xenogeneic collagen matrix (XCM) in treating gingival recession. The results suggest that CAF + CTG remains the gold standard for root coverage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
Willem-Jan Metsemakers, Jolien Onsea, Thomas Fintan Moriarty, Nikoloz Pruidze, Lia Nadareishvili, Mariam Dadiani, Mzia Kutateladze
Summary: This article reviews the clinical history of bacteriophage therapy for human musculoskeletal and skin/soft tissue infections and provides current practice and ongoing clinical study data. Bacteriophage therapy is an alternative to conventional antibiotics, but its clinical application is limited by regulatory hurdles.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Biophysics
H. Khajehsaeid, M. Tehrani, N. Alaghehband
Summary: This study investigates the softening of esophageal and arterial tissues under directional cyclic loading to determine the evolution of material parameters through damage progress. A proposed evolution law predicts the mechanical behavior of tissues after excessive deformations. Different deformation measures are examined to determine the most appropriate one for general 3D loading.
JOURNAL OF BIOMECHANICS
(2021)
Review
Engineering, Biomedical
Jinchun Ye, Chang Xie, Canlong Wang, Jiayun Huang, Zi Yin, Boon Chin Heng, Xiao Chen, Weiliang Shen
Summary: Studies have shown that active modulation of immune cells, particularly macrophages, via biomaterials is an effective way to control immune response, promote tissue regeneration, and facilitate biomaterial integration.
BIOACTIVE MATERIALS
(2021)
Article
Orthopedics
Rui Guo, Zhe Ji, Shutao Gao, Aihaiti Aizezi, Yong Fan, Zhigang Wang, Kai Ning
Summary: This meta-analysis study found a correlation between COL5A1 gene polymorphisms and susceptibility to musculoskeletal soft tissue injuries (MSTIs). Specifically, the rs12722 polymorphism was associated with an increased susceptibility to ligament injury, especially in the Caucasian population. The rs13946 polymorphism increased the risk of tendon and ligament injuries. On the other hand, the rs71746744 and rs3196378 polymorphisms showed a tendency to increase the risk of MSTIs, while no relevance was found between the rs11103544 polymorphism and MSTIs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Abhinav Bansal, Surbhi Goyal, Ankur Goyal, Manisha Jana
Summary: The WHO classification of soft tissue tumors in its recent fifth edition introduces new entities based on biological behavior, genetics, and morphology, serving as diagnostic and prognostic markers. Although primarily within the realm of pathologists, radiologists must also stay informed to contribute to optimal diagnosis and management of soft tissue tumors. Advances in molecular genetics and their impact on diagnosis, treatment, and prognosis of soft tissue tumors are emphasized.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zvi Artzi, Uri Renert, Erez Netanely, Daniel S. Thoma, Marilena Vered
Summary: This study examined the composition of lining and masticatory mucosa at implant sites before and after tissue augmentation procedures using VCMX. The results showed that there were increases in mean RPL in both MM and LM areas following augmentation, but no significant differences in RP density or collagen fiber arrangements pre- and post-augmentation. Overall, the augmentation with VCMX did not alter the composition of lining and masticatory mucosa at implant sites.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Christian M. Schmitt, Patrick Brueckbauer, Karl A. Schlegel, Mayte Buchbender, Werner Adler, Ragai E. Matta
Summary: The study found that the early healing phase is associated with significant volume loss of soft tissues, and the SCTG shows insignificant superiority compared to the CM in terms of enhancement effect.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Review
Polymer Science
Lei Chen, Zhiyong Zeng, Wenbing Li
Summary: This review discusses the function and mechanism of poly(acrylic acid) (PAA) in regulating the mineralization of collagen, particularly intrafibrillar mineralization (IM). The differences between two mineralization patterns (extrafibrillar and intrafibrillar) in terms of microstructure, biodegradation, cytocompatibility, osteoinduction in vitro, and performance in vivo are systematically compared. The review also includes the mineralization of self-mineralizable collagen matrices and references regarding collagen/PAA interactions in other fields. Finally, future potential improvements in this field are discussed.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Review
Sport Sciences
Oliver J. Price, Nicola Sewry, Martin Schwellnus, Vibeke Backer, Tonje Reier-Nilsen, Valerie Bougault, Lars Pedersen, Bruno Chenuel, Kjell Larsson, James H. Hull
Summary: The prevalence of lower airway dysfunction in athletes is approximately 21.8%, with the highest rates seen in elite endurance athletes, aquatic athletes, and winter-based athletes. Further research is needed to understand the causality and develop preventative strategies.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Izaan de Jager, Martin Schwellnus, Carel Viljoen, Elzette Korkie, Nicola Sewry, Sonja Swanevelder, Esme Jordaan
Summary: This study aimed to compare the lifetime prevalence and clinical characteristics of exercise-associated muscle cramping (EAMC) between runners participating in a 21.1-km and a 56-km road race. Results showed that the prevalence of EAMC was higher in the 56-km race, with differences in muscle groups affected, timing of occurrence, and severity of EAMC between the two race distances. These findings suggest that risk factors for EAMC may differ among runners of different race distances.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Article
Sport Sciences
Javier Alvarez-Romero, Mary-Jessica N. Laguette, Kirsten Seale, Macsue Jacques, Sarah Voisin, Danielle Hiam, Julian A. Feller, Oren Tirosh, Eri Miyamoto-Mikami, Hiroshi Kumagai, Naoki Kikuchi, Nobuhiro Kamiya, Noriyuki Fuku, Malcolm Collins, Alison September, Nir Eynon
Summary: This study aims to investigate the association between the COL5A1 gene and anterior cruciate ligament (ACL) injury risk. The results suggest that a specific locus of the COL5A1 gene may be associated with ACL injury risk. However, further studies with larger cohorts are needed to validate these findings and explore the functional relevance to ligament and joint biomechanics.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Nceba Hene, Paola Wood, Martin Schwellnus, Esme Jordaan, Ria Laubscher
Summary: The study found that scientifically based social network lifestyle intervention programs are effective in reducing certain non-communicable disease risk factors, such as overweight and diabetes risk.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Primary Health Care
Stephan Brill, Martin Schwellnus, Nicola Sewry, Dina Christa Janse Van Rensburg, Audrey Jansen Van Rensburg, Marcel Jooste, Jordan Leppan, Jeremy Boulter, Ishen Seocharan, Esme Jordaan
Summary: This study investigated the prevalence of self-reported pre-race chronic medical conditions and allergies in ultramarathon race entrants and explored if they are associated with an increased risk of race-day medical encounters (MEs). The results showed that participants who reported chronic medical conditions and allergies were more likely to have race-day MEs.
PHYSICIAN AND SPORTSMEDICINE
(2023)
Article
Primary Health Care
Pieter-Henk Boer, Martin P. Schwellnus, Esme Jordaan
Summary: This study explores the risk factors predictive of a history of MTSS in distance runners. The results showed that multiple chronic diseases and a history of allergies are predictive factors for MTSS. This helps guide healthcare professionals in prevention and rehabilitation efforts.
PHYSICIAN AND SPORTSMEDICINE
(2023)
Article
Orthopedics
Mark R. Antrobus, Jon Brazier, Peter Callus, Adam J. Herbert, Georgina K. Stebbings, Stephen H. Day, Liam P. Kilduff, Mark A. Bennett, Robert M. Erskine, Stuart M. Raleigh, Malcolm Collins, Yannis P. Pitsiladis, Shane M. Heffernan, Alun G. Williams
Summary: This study investigated the association between elite rugby athlete status and concussion-associated risk polymorphisms. The findings showed that there were differences in the COMT rs4680 genotype, which could potentially affect stress resilience, behavioral traits, concussion risk, and recovery in elite rugby athletes. Evaluating the COMT rs4680 genotype may be beneficial for individualized management of concussion risk among athletes.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Sport Sciences
Jon Brazier, Mark R. Antrobus, Adam J. Herbert, Peter C. Callus, Georgina K. Stebbings, Stephen H. Day, Shane M. Heffernan, Liam P. Kilduff, Mark A. Bennett, Robert M. Erskine, Stuart M. Raleigh, Malcolm Collins, Yannis P. Pitsiladis, Alun G. Williams
Summary: There is growing evidence that genetics play a role in tendon and ligament pathologies. This study found that 13 gene polymorphisms associated with tendon/ligament injury were also associated with elite rugby athlete status. Elite rugby athletes may have an inherited advantage that contributes to their resistance to soft tissue injury.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Nicola Sewry, Tom Wiggers, Martin Schwellnus
Summary: This study investigated the incidence and nature of medical encounters during a mass participation running event in the Netherlands. The overall incidence of medical encounters was low compared to longer-distance races, but the incidence of serious/life-threatening encounters was higher, mostly attributed to heat illnesses.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Review
Sport Sciences
Kelly Kaulback, David B. Pyne, James H. Hull, Carolette Snyders, Nicola Sewry, Martin Schwellnus
Summary: Acute respiratory infections (ARinf) can have short-term and long-term effects on exercise and sports performance in athletes. Current research suggests that ARinf is associated with acute decrements in sports performance and pulmonary function, but minimal effects on cardiorespiratory endurance. Furthermore, long-term ARinf can have detrimental effects on sports performance, including training mileage, overall training load, standardized sports performance-dependent points, and match play. Future research should adopt a uniform approach to further explore the relationship between ARinf and exercise/sports performance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Senanile B. Dlamini, Colleen J. Saunders, Mary-Jessica N. Laguette, Andrea Gibbon, Junaid Gamieldien, Malcolm Collins, Alison V. September
Summary: We developed a Biomedical Knowledge Graph model that integrates knowledge from multiple domains in a graph database to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Through a case-control study, we found that the ITGB2 gene is associated with ACL rupture risk. This study highlights the efficiency of using prior knowledge-driven in silico approach and recommends a multistep approach for genomics technologies in musculoskeletal soft tissue injuries.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Editorial Material
Sport Sciences
Sharief Hendricks, Carolyn Emery, Ben Jones, James Craig Brown, Kathryn Dane, Stephen W. West, Keith A. Stokes, Richie Gray, Ross Tucker
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Danielle M. Salmon, Marelise Badenhorst, James Brown, Janelle Romanchuk, Zachary Yukio Kerr, Simon Walters, Amanda Clacy, Sierra Keung, S. John Sullivan, Johna Register-Mihalik, Chris Whatman
Summary: New Zealand Rugby's Community Concussion Initiative includes an interactive education session to increase peer recognition of concussions. This study found that the one-off education session did not significantly improve high school players' concussion knowledge and attitudes.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2023)
Article
Sport Sciences
Danielle M. Salmon, Jason Chua, James C. Brown, Amanda Clacy, Zachary Yukio Kerr, Simon Walters, Sierra Keung, S. John Sullivan, Johna Register-Mihalik, Chris Whatman, Gisela Sole, Marelise Badenhorst
Summary: This study explored the perceptions of key stakeholder groups within New Zealand's community rugby system regarding their responsibilities related to concussions. The findings highlight the importance of role clarity, communication, and task-shifting in injury management. Clear definitions and acceptance of responsibilities by each stakeholder group are needed for effective concussion management in real-world sports settings.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Review
Sport Sciences
Isla J. Shill, Stephen W. West, James Brown, Fiona Wilson, Debbie Palmer, Ian Pike, Sharief Hendricks, Keith A. Stokes, Brent E. Hagel, Carolyn A. Emery
Summary: Video analysis is a crucial tool for injury surveillance in youth rugby union, although there is a lack of research in this area. This narrative review examines the strengths and limitations of current video analysis literature, emphasizes the importance of player safety in youth rugby, and provides recommendations for using video analysis to enhance safety measures.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
