Article
Immunology
Vijayashree Mysore, Suhail Tahir, Kazuhiro Furuhashi, Jatin Arora, Florencia Rosetti, Xavier Cullere, Pascal Yazbeck, Miroslav Sekulic, Madeleine E. Lemieux, Soumya Raychaudhuri, Bruce H. Horwitz, Tanya N. Mayadas
Summary: During inflammation, monocytes undergo changes in their cellular state. In glomerular inflammation, recruited CCR2(+)CX3CR1(+) double-positive monocytes acquire macrophage characteristics within renal blood vessels, a process that depends on CCR2 on monocytes and TNF-TNFR2-activated endothelial cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Michael Petermann, Zacharias Orfanos, Julie Sellau, Mohammad Gharaibeh, Hannelore Lotter, Bernhard Fleischer, Christian Keller
Summary: Our study investigated the role of CCR2 in a self-healing mouse model of O. tsutsugamushi infection, showing that CCR2 deficiency delayed disease onset, resolved symptoms, and resulted in higher concentrations of bacteria in the lung and impaired clearance. CCR2 drives blood monocytosis and the influx and activation of monocytes into the lung, accelerating bacterial replication and development of pulmonary inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Takeshi Zoshima, Tomohisa Baba, Yamato Tanabe, Yuko Ishida, Kimihiko Nakatani, Michio Nagata, Naofumi Mukaida, Mitsuhiro Kawano
Summary: The study reveals that CCR2 and CCR5 regulate glomerular macrophage infiltration and contribute to the development of glomerular endocapillary hypercellularity in LN. CCR5 inhibition can be a specific therapy for endocapillary hypercellularity without inducing wire-loop lesions.
Article
Chemistry, Medicinal
Robert J. Cherney, Prakash Anjanappa, Kumaravel Selvakumar, Douglas G. Batt, Gregory D. Brown, Anne Rose, Ragini Vuppugalla, Jing Chen, Jian Pang, Songmei Xu, Melissa Yarde, Andrew J. Tebben, Venkatram Reddy Paidi, Mary Ellen Cvijic, Arvind Mathur, Joel C. Barrish, Sandhya Mandlekar, Qihong Zhao, Percy H. Carter
Summary: Compound 3, identified as a potent and selective CCR2/5 dual antagonist, demonstrated excellent permeability and stability in vitro, as well as promising pharmacokinetic properties in animal studies, ultimately leading to its selection as a clinical candidate.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Stefan Wagner, Fernando de Moura Gatti, Daniel G. Silva, Natalia V. Ortiz Zacarias, Annelien J. M. Zweemer, Sven Hermann, Monica De Maria, Michael Koch, Christina Weiss, Dirk Schepmann, Laura H. Heitman, Nuska Tschammer, Klaus Kopka, Anna Junker
Summary: In this study, a series of highly selective CCR2 antagonists were designed and synthesized as F-18-labeled PET tracers. The most potent and selective candidate was applied in vivo in a biodistribution study, showing promising potential for further preclinical development. This compound represents the first potential nonpeptidic PET tracer for imaging of CCR2 receptors.
Article
Chemistry, Multidisciplinary
Lulu Zhang, Fang Du, Qiqi Jin, Li Sun, Boqian Wang, Ziyang Tan, Xinyu Meng, Baozhen Huang, Yifan Zhan, Wenqiong Su, Rui Song, Chunmei Wu, Luonan Chen, Xiaoxiang Chen, Xianting Ding
Summary: This study investigates the dysregulation of immune cells in SLE patients and finds that CD8(+)CD27(+)CXCR3(-) T cells increase in remission SLE, while they are overactive in active SLE. The functional dysregulation of these cells is positively associated with SLE activity. Additionally, a dynamic network biomarker model is developed to predict SLE remission and flares accurately.
Article
Rheumatology
Xiubo Fan, Chin Teck Ng, Dianyang Guo, Frances Lim, Jia Chi Tan, Annie Law, Lim Hee Goh, Zhi Yong Poon, Alice Cheung, Say Li Kong, Michelle Tan, Shang Li, Alwin Loh, Anne James, Tony Lim, Jinmiao Chen, Julian Thumboo, William Hwang, Andrea Low
Summary: This study demonstrates that administration of CXCL5 to lupus-prone mice can restore CXCL5 levels and improve survival. It also reduces disease activity and renal damage. The mechanism of action involves regulation of neutrophil activation and trafficking, as well as modulation of immune cell energy production and tissue fibrosis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Nathan Richoz, Zewen K. Tuong, Kevin W. Loudon, Eduardo Patino-Martinez, John R. Ferdinand, Anais Portet, Kathleen R. Bashant, Emeline Thevenon, Francesca Rucci, Thomas Hoyler, Tobias Junt, Mariana J. Kaplan, Richard M. Siegel, Menna R. Clatworthy
Summary: In lupus nephritis, kidney macrophages show distinct division of labor, with TrMacs orchestrating leukocyte recruitment and MoMacs responsible for uptake and presentation of IC antigen.
Article
Immunology
Valeria Erazo-Martinez, Gabriel J. Tobon, Carlos A. Canas
Summary: Cutaneous lupus erythematosus (CLE) can present as either a separate disease or as a manifestation of systemic lupus erythematosus (SLE). The pathophysiology of CLE involves complex interactions between genetic, environmental, and immune-mediated factors, leading to a self-amplification inflammatory cycle. Key cytokines and chemokines, such as IFNs, TNF-alpha, IL-6, IL-17, and CXCL10, play important roles in the inflammatory cascade and tissue damage seen in CLE. Understanding the role of these molecules is crucial for developing targeted therapies for CLE.
AUTOIMMUNITY REVIEWS
(2023)
Article
Microbiology
Bao-Zhu Li, Hua Wang, Xian-Bao Li, Qian-Ru Zhang, Rong-Gui Huang, Hong Wu, Yi-Yu Wang, Kai-Di Li, Xiu-Jie Chu, Nv-Wei Cao, Hao-Yue Zhou, Xin-Yu Fang, Rui-Xue Leng, Yin-Guang Fan, Jin-Hui Tao, Zong-Wen Shuai, Dong-Qing Ye
Summary: This study presents a pilot analysis of fungal microbiota in patients with systemic lupus erythematosus (SLE), showing significant differences in diversity and composition compared to other diseases and healthy controls. The composition of fungal and bacterial microbiota is imbalanced in SLE patients, and there is a complex relationship network between them.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Paolo Fagone, Katia Mangano, Roberto Di Marco, Zyanya Reyes-Castillo, Jose Francisco Munoz-Valle, Ferdinando Nicoletti
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by autoreactive B cells playing a role in disease pathogenesis. Recent studies suggest that the tetraspanin TSPAN32 may serve as a potential therapeutic target for autoimmune/immunoinflammatory disorders. It has been shown that B cell activation is associated with downregulation of TSPAN32, indicating its potential as a diagnostic marker and therapeutic target for humoral immune responses in chronic diseases like SLE.
Article
Medicine, General & Internal
Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clement Materne, Sophie Galier, Julien Haroche, Eric Frisdal, Alexis Mathian, Herve Durand, Micheline Pha, Miguel Hie, Anatol Kontush, Philippe Cluzel, Philippe Lesnik, Zahir Amoura, Maryse Guerin, Fleur Cohen Aubart, Wilfried Le Goff
Summary: This study uncovers the contribution of disturbed metabolism to the presence of coronary artery calcium and the associated risk of coronary heart disease in patients with systemic lupus erythematosus (SLE). Identification of novel lipid and metabolite biomarkers may help stratifying patients for reducing cardiovascular disease morbidity and mortality in SLE.
Article
Biochemistry & Molecular Biology
Krisztina Szabo, Ilona Jambor, Kitti Pazmandi, Nikolett Nagy, Gabor Papp, Tunde Tarr
Summary: This study analyzed the distribution of circulating T-FH and T-FR cells in SLE and their association with the disease. The results showed that the percentage of activated circulating T-FH and T-FR cells was increased in cutaneous lupus, but decreased in lupus nephritis. Moreover, the decreased proportion of T-FH17 cells was associated with low complement C4 levels and high disease activity scores.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Finny Monickaraj, Sreenivasa R. Oruganti, Paul McGuire, Arup Das
Summary: The study demonstrated that using a CCR2/CCR5 receptor inhibitor TAK-779 significantly reduced retinal vascular permeability in diabetic animals and decreased macrophage/microglia infiltration in the retina. Additionally, the drug treatment significantly reduced levels of SDF-1 and ICAM-1, increased the tight junction protein ZO-1 level, and decreased phospho-VE-Cad levels.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Veterinary Sciences
Alice A. Amudzi, Cesar Piedra-Mora, Diana Junyue Ma, Neil B. Wong, Clement N. David, Nicholas A. Robinson, Ramon M. Almela, Jillian M. Richmond
Summary: Cutaneous Lupus Erythematosus (CLE) is an autoimmune skin disease that can occur in dogs as well as humans. Transcriptomic analysis of skin biopsies in dogs with CLE can help understand the pathogenesis of this disease and provide insights for human treatment.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)