Biophysical, biopharmaceutical and toxicological significance of biomedical nanoparticles

Abstract CT216: Phase I dose escalating study of 2B3-101, glutathione PEGylated liposomal doxorubicin, in patients with solid tumors and brain metastases or recurrent malignant glioma

(2015) Pieter J. Gaillard et al.   CANCER RESEARCH

Nanotechnologies in Drug Delivery - An Industrial Perspective

(2015) D.V. Bazile   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

(2014) Kvar C. L. Black et al.   ACS Nano

Cancer nanomedicine and the complement system activation paradigm: Anaphylaxis and tumour growth

(2014) S.M. Moghimi   JOURNAL OF CONTROLLED RELEASE

A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity

(2014) A. Maksimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro

(2014) Zhangjian Chen et al.   TOXICOLOGY LETTERS

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Unambiguous observation of shape effects on cellular fate of nanoparticles

(2014) Zhiqin Chu et al.   Scientific Reports

Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity

(2014) Kyle K. L. Phua et al.   Scientific Reports

Biological interactionsin vitroof zinc oxide nanoparticles of different characteristics

(2014) Sangeetha Aula et al.   Materials Research Express

Impact of Protein Modification on the Protein Corona on Nanoparticles and Nanoparticle–Cell Interactions

(2013) Lennart Treuel et al.   ACS Nano

PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles

(2013) Jinbin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanotheranostics for personalized medicine

(2013) Tae Hyung Kim et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement monitoring of Pluronic 127 gel and micelles: Suppression of copolymer-mediated complement activation by elevated serum levels of HDL, LDL, and apolipoproteins AI and B-100

(2013) Islam Hamad et al.   JOURNAL OF CONTROLLED RELEASE

Cytotoxic Effect of Nanocrystalline MgFe2O4Particles for Cancer Cure

(2013) S. Kanagesan et al.   Journal of Nanomaterials

Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance

(2013) Jinbin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology

(2013) Jinbin Liu et al.   Materials Today

Nanoparticles and the blood coagulation system. Part II: safety concerns

(2013) Anna N Ilinskaya et al.   Nanomedicine

Aptamer-conjugated gold nanoparticles for bioanalysis

(2013) Jiani Zhang et al.   Nanomedicine

Nanomedicine and the complement paradigm

(2013) S. Moein Moghimi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predictive Toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data

(2013) Limor Horev-Azaria et al.   Particle and Fibre Toxicology

The Immunogenicity of Polyethylene Glycol: Facts and Fiction

(2013) Huub Schellekens et al.   PHARMACEUTICAL RESEARCH

Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin

(2013) Noriyuki Yokomichi et al.   Human Cell

In Vitro Hematological and In Vivo Vasoactivity Assessment of Dextran Functionalized Graphene

(2013) Sayan Mullick Chowdhury et al.   Scientific Reports

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Reversible versus Irreversible Binding of Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona

(2012) Silvia Milani et al.   ACS Nano

MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets

(2012) Juan C. Stockert et al.   ACTA HISTOCHEMICA

Nanotheranostics for personalized medicine

(2012) Simona Mura et al.   ADVANCED DRUG DELIVERY REVIEWS

Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)

(2012) Vyom Sharma et al.   APOPTOSIS

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications

(2012) L. Harivardhan Reddy et al.   CHEMICAL REVIEWS

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study

(2012) Christoph Mamot et al.   LANCET ONCOLOGY

Effects of zinc oxide nanoparticles on gene expression profile in human keratinocytes

(2012) Seung Ho Lee et al.   Molecular & Cellular Toxicology

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

(2012) Thomas R. Downs et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Tracking T-cells in vivo with a new nano-sized MRI contrast agent

(2012) Li Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

(2012) Zhou J. Deng et al.   Nanotoxicology

Accelerated Blood Clearance of PEGylated PLGA Nanoparticles Following Repeated Injections: Effects of Polymer Dose, PEG Coating, and Encapsulated Anticancer Drug

(2012) Roonak Saadati et al.   PHARMACEUTICAL RESEARCH

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

(2012) Tingting Sun et al.   PLoS One

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

(2012) Rolando E. Yanes et al.   Small

Human cytosolic glutathione transferases: structure, function, and drug discovery

(2012) Baojian Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles

(2012) Sergey Ivanov et al.   Materials

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

(2012) Mi Kyung Yu et al.   Theranostics

Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration

(2012) Mohamed Abdelhalim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Squalene Based Nanocomposites: A New Platform for the Design of Multifunctional Pharmaceutical Theragnostics

(2011) José L. Arias et al.   ACS Nano

Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles

(2011) Boon Chin Heng et al.   ARCHIVES OF TOXICOLOGY

Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial

(2011) Charles Butts et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Nanotechnology for therapy and imaging of liver diseases

(2011) L. Harivardhan Reddy et al.   JOURNAL OF HEPATOLOGY

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanodetoxification: emerging role of nanomaterials in drug intoxication treatment

(2011) Lauren M Graham et al.   Nanomedicine

Superparamagnetic nanosystems based on iron oxide nanoparticles for biomedical imaging

(2011) Fujun Liu et al.   Nanomedicine

Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome

(2011) János Szebeni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineered nanoparticles for biomolecular imaging

(2011) Morteza Mahmoudi et al.   Nanoscale

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes

(2011) Hiromi Nabeshi et al.   Particle and Fibre Toxicology

Targeting kidney mesangium by nanoparticles of defined size

(2011) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo

(2011) Y. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive Toxicology of Cobalt Nanoparticles and Ions: Comparative In Vitro Study of Different Cellular Models Using Methods of Knowledge Discovery from Data

(2011) Limor Horev-Azaria et al.   TOXICOLOGICAL SCIENCES

Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells

(2011) Wei Kai et al.   Nanoscale Research Letters

Physiologically Based Pharmacokinetic Modeling of Nanoparticles

(2010) Mingguang Li et al.   ACS Nano

Toxicity and interaction of titanium dioxide nanoparticles with microtubule protein

(2010) Z. N. Gheshlaghi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Nanoparticle-based theranostic agents

(2010) Jin Xie et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives

(2010) Megan A. Hahn et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The kinetics of the tissue distribution of silver nanoparticles of different sizes

(2010) D.P.K. Lankveld et al.   BIOMATERIALS

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape

(2010) Sylvain Tollis et al.   BMC Systems Biology

Magnetic nanoparticle hyperthermia for prostate cancer

(2010) Manfred Johannsen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Nano meets bio at the interface

(2010) Jerzy Leszczynski   Nature Nanotechnology

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

The primary role of iron-mediated lipid peroxidation in the differential cytotoxicity caused by two varieties of talc nanoparticles on A549 cells and lipid peroxidation inhibitory effect exerted by ascorbic acid

(2010) Mohd Javed Akhtar et al.   TOXICOLOGY IN VITRO

Inorganic nanoparticle-based contrast agents for molecular imaging

(2010) Eun Chul Cho et al.   TRENDS IN MOLECULAR MEDICINE

Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors

(2009) W. T. Lim et al.   ANNALS OF ONCOLOGY

Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups

(2009) Carolina Salvador-Morales et al.   BIOMATERIALS

Anti-proliferative activity of silver nanoparticles

(2009) PV AshaRani et al.   BMC CELL BIOLOGY

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Development ofin vitrosystems for nanotoxicology: methodological considerations

(2009) Vicki Stone et al.   CRITICAL REVIEWS IN TOXICOLOGY

Physiologically based pharmacokinetics (PBPK)

(2009) Pascal Espié et al.   DRUG METABOLISM REVIEWS

A Rapid and Accurate Method for the Stem Cell Viability Evaluation: The Case of the Thawed Umbilical Cord Blood

(2009) Vassilios Katsares et al.   Labmedicine

Anticancer Efficacy of Squalenoyl Gemcitabine Nanomedicine on 60 Human Tumor Cell Panel and on Experimental Tumor

(2009) L. Harivardhan Reddy et al.   MOLECULAR PHARMACEUTICS

Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

(2009) Hyun A. Lee et al.   NANO LETTERS

Differential plasma protein binding to metal oxide nanoparticles

(2009) Zhou J Deng et al.   NANOTECHNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

(2009) Kunal Bhattacharya et al.   Particle and Fibre Toxicology

Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

(2009) Tsutomu Ishihara et al.   PHARMACEUTICAL RESEARCH

Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells

(2009) Baher Fahmy et al.   TOXICOLOGY IN VITRO

Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles

(2009) Chuan-Chin Huang et al.   TOXICOLOGY IN VITRO

Lung toxicity induced by intratracheal instillation of size-fractionated tire particles

(2009) Paride Mantecca et al.   TOXICOLOGY LETTERS

The Transport of Nanoparticles in Blood Vessels: The Effect of Vessel Permeability and Blood Rheology

(2008) Francesco Gentile et al.   ANNALS OF BIOMEDICAL ENGINEERING

Interaction of gold nanoparticles with protein: A spectroscopic study to monitor protein conformational changes

(2008) Nishima Wangoo et al.   APPLIED PHYSICS LETTERS

The influence of protein adsorption on nanoparticle association with cultured endothelial cells

(2008) Morton S. Ehrenberg et al.   BIOMATERIALS

Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro

(2008) William F. Vevers et al.   ECOTOXICOLOGY

Computational and Ultrastructural Toxicology of a Nanoparticle, Quantum Dot 705, in Mice

(2008) Pinpin Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Analysis of apoptosis by cytometry using TUNEL assay

(2008) Zbigniew Darzynkiewicz et al.   METHODS

Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover

(2008) Islam Hamad et al.   MOLECULAR IMMUNOLOGY

Pharmacokinetics and Biodistribution of Nanoparticles

(2008) Shyh-Dar Li et al.   MOLECULAR PHARMACEUTICS

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers

(2008) Robert Landsiedel et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Method for Analysis of Nanoparticle Hemolytic Properties in Vitro

(2008) Marina A. Dobrovolskaia et al.   NANO LETTERS

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Shape Induced Inhibition of Phagocytosis of Polymer Particles

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors affecting toxicity and efficacy of polymeric nanomedicines

(2008) Eiki Igarashi   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cellular responses induced by silver nanoparticles: In vitro studies

(2008) S. Arora et al.   TOXICOLOGY LETTERS