Randomized clinical trial: inhibition of the TRPV1 system in patients with nonerosive gastroesophageal reflux disease and a partial response to PPI treatment is not associated with analgesia to esophageal experimental pain

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

(2011) A. L. Krarup et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Esophageal Multimodal Pain Model: Normal Values and Degree of Sensitization in Healthy Young Male Volunteers

(2011) Anne L. Krarup et al.   DIGESTIVE DISEASES AND SCIENCES

Diagnosis, novel mechanisms of disease and promising agents

(2011) Arne Kandulski et al.   Nature Reviews Gastroenterology & Hepatology

Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease

(2010) M. P. L. Guarino et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Analgesic Efficacy of Peripheral κ-Opioid Receptor Agonist CR665 Compared to Oxycodone in a Multi-modal, Multi-tissue Experimental Human Pain Model

(2009) Lars Arendt-Nielsen et al.   ANESTHESIOLOGY

Evoked Human Oesophageal Hyperalgesia: A Potential Tool for Analgesic Evaluation?

(2009) Anne Estrup Olesen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review

(2009) Camilla Staahl et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus

(2009) Christina Brock et al.   EUROPEAN JOURNAL OF PAIN

Management of heartburn not responding to proton pump inhibitors

(2009) R Fass et al.   GUT

An endoscopic method for thermal and chemical stimulation of the human oesophagus

(2009) s. s. olesen et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats

(2009) r. m. van den wijngaard et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Once is not enough: Improved efficacy following repeated dosing with a TRPV1 antagonist

(2009) A. D. Wickenden et al.   PAIN

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

(2008) Martin J. Gunthorpe et al.   DRUG DISCOVERY TODAY

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN