Article
Chemistry, Physical
Elia Grueso, Rosa M. Giraldez-Perez, Edyta Kuliszewska, Jesus A. Guerrero, Rafael Prado-Gotor
Summary: A new method for detecting DNA and lysozyme biomolecules was developed using gold nanoparticles, with a practical and economical approach. The method showed high sensitivity and immediate results, avoiding issues with time delays seen in previous sensor designs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Spectroscopy
Changsheng Gan, Rong Cheng, Kunliang Cai, Xiaonan Wang, Chenkun Xie, Tiantian Xu, Chuanxun Yuan
Summary: The interactions between calf thymus DNA and a series of glucose-based cationic gemini surfactants with different spacer length were studied. The results showed that all the surfactants could efficiently interact with DNA, causing changes in its absorption intensity and conformation. Surfactant 1c exhibited the most significant effect, compacting the DNA molecules to a smaller size. These findings shed light on the potential applications of cationic gemini surfactants in gene delivery.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Xiao Deng, Muhammad Shahzad Kamal, Shirish Patil, Syed Muhammad Shakil Hussain, Xianmin Zhou, Mohamed Mahmoud
Summary: The study found that cationic gemini surfactants with different molecular structures have varying effects on wettability alteration in carbonate reservoirs, with the surfactant containing one phenyl group showing the best performance. The wettability alteration performance of surfactants is also influenced by factors such as bromine ions, and for low permeability carbonate rocks, it is an important parameter.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Olivia M. Singer, Jacob W. Campbell, Jacob G. Hoare, Jason D. Masuda, Gerrard Marangoni, Robert D. Singer
Summary: Gemini surfactants are composed of two hydrocarbon tails with corresponding polar headgroups, linked via a covalent spacer. The improved synthetic approach of these symmetrical gemini surfactants has led to their characterization of crystalline packing for the first time ever using X-ray crystallographic analysis.
Article
Chemistry, Multidisciplinary
Zheng Yue, Meihuan Yao, Guangyue Bai, Jiuxia Wang, Kelei Zhuo, Jianji Wang, Yujie Wang
Summary: This study investigated the impact of cationic gemini surfactants on the enzymatic activity and conformation of alpha-chymotrypsin (α-CT), finding that the surfactants led to superactivity of α-CT below the critical micelle concentration, and the charge density of headgroups was regulated through electrostatic interactions. Characterization using isothermal titration calorimetry (ITC) revealed an endothermic enthalpy change, indicating a change in conformation and enzymatic superactivity. Fluorescence spectroscopy, circular dichroism (CD), and differential scanning calorimetry (DSC) demonstrated that the gemini surfactants induced and regulated different protein structures. The findings are significant for understanding the activation and denaturation mechanisms of enzymes.
Article
Energy & Fuels
Shams Kalam, Sidqi A. Abu-Khamsin, Shirish Patil, Syed Muhammad Shakil Hussain, Mohamed Mahmoud, Muhammad Shahzad Kamal, Emad W. Al Shalabi
Summary: Surfactant adsorption is a significant challenge for cEOR techniques and it depends on the presence of silicate and clay minerals in carbonate outcrops. The higher the impurities, the higher the surfactant adsorption. The addition of a novel adsorption inhibitor, methylene blue, dramatically reduced the surfactant adsorption on carbonate outcrops. Curve fitting analysis showed that the Redlich-Peterson model described the adsorption isotherm well, while the pseudo-second-order model described the adsorption kinetics accurately.
Article
Energy & Fuels
Shams Kalam, Sidqi A. Abu-Khamsin, Shirish Patil, Syed Muhammad Shakil Hussain, Mohamed Mahmoud, Muhammad Shahzad Kamal, Emad W. Al Shalabi
Summary: Surfactant adsorption is a key factor affecting the efficiency of chemically enhanced oil recovery techniques. The presence of silicate and clay minerals increases the adsorption of surfactants on carbonate samples. High salinity and temperature decrease the adsorption. A new adsorption inhibitor, methylene blue, reduces the surfactant adsorption on carbonate samples significantly. The Redlich-Peterson and pseudo-second-order models provide the best fit for the adsorption isotherm and kinetics, respectively.
Article
Chemistry, Physical
Vicente Dominguez-Arca, Juan Sabin, Luis Garcia-Rio, Margarida Bastos, Pablo Taboada, Silvia Barbosa, Gerardo Prieto
Summary: A novel formulation of cationic liposomes was studied by mixing dipalmitoylphosphatidylcholine (DPPC) with tetradecyltrimethylammonium bromide gemini surfactants with different alkane spacer groups lengths attached to their ammonium head-groups. The physicochemical characterization of the cationic liposomes was obtained by combining experimental results with molecular dynamic simulations, in order to understand their structural configuration. The gemini surfactants partition into the lipid bilayer of DPPC liposomes, altering the colloidal stability and phase transition properties.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Xinwei Zhang, Jiao Ma, Kaide Ou, Xin Cong, Binbin Zhang, Qi Zhou, Yonggui Liao, Yajiang Yang, Hong Wang
Summary: A novel type of vesicles (VT/G) composed of Gemini cationic surfactant (G12-8-12) and TPE-2OH, an aggregation-induced emission (AIE) fluorescence probe, were prepared. The vesicles showed good binding and bactericidal effects on bacteria due to the compression of the interlayer and the generation of active substances. This new strategy has potential applications in bacteria detection and killing.
Article
Chemistry, Physical
Ahmed Abd-ElHamid, W. El-dougdoug, S. M. Syam, I. Aiad, Samy M. Shaban, Dong-Hwan Kim
Summary: Three gemini cationic surfactants with different hydrophobic tails were synthesized and confirmed spectroscopically. Surface tension measurements were conducted to examine their corrosion inhibition efficiency. It was found that the hydrophobicity and temperature affected their adsorption and micelle formation. The synthesized surfactants showed efficient affinity to mitigate steel corrosion, with GSBH exhibiting the highest inhibition efficiency of 94.5%. The adsorption of the inhibitors on C-steel was confirmed, and their behavior followed a modified Langmuir isotherm. The synthesized surfactants also showed affinity to mitigate sulfate reducing bacteria, with GSBO being the most effective.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Weiguang Yang, Yupeng Cao, Yakui Wang, Hongbin Ju, Yajie Jiang, Tao Geng
Summary: Four cationic amide Gemini surfactants were synthesized with unsaturated and saturated hydrophobic chains, showing different self-assembly behaviors in solution. The presence of unsaturated double bonds in the hydrophobic chains lowered the Krafft temperature and critical micelle concentration. Gemini surfactants based on oleamide preferentially formed worm-like micelles, while those based on stearate amide tended to form spherical aggregates in solution.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Chemistry, Physical
Azin Rashidy Ahmady, Pakshid Hosseinzadeh, Atefeh Solouk, Somaye Akbari, Adrianna M. Szulc, Bogumil E. Brycki
Summary: Gemini surfactants, composed of two cationic monomers linked together, have high surface activity and can decrease water surface tension due to their unique structure. They possess outstanding properties, such as antibacterial activity, unique aggregation behavior, and interaction with biomacromolecules. These properties can be tailored by adjusting the structure of the surfactant. Gemini surfactants demonstrate higher performance efficacy and lower toxicity compared to their monomeric counterparts. However, biocompatibility remains a limitation, leading researchers to develop alternative gemini surfactants based on amino acids and sugars.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Applied
Afreen Nishat, Naved Azum, Abdullah M. Asiri, Najam Sardar
Summary: Gemini surfactants show stronger interaction with the polymer compared to their conventional counterpart CTAB; viscosity studies indicate significant interaction between Gemini surfactants and the polymer; thermodynamic parameters support the feasibility of interaction between the polymer and surfactant.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2021)
Article
Chemistry, Applied
Sanbao Dong, Jiabao Fan, Hongmiao Lv, Taotao Qiang, Yue Ji, Weiwei Han
Summary: This study developed a foaming formula containing anionic, cationic, and zwitterionic surfactants, and optimized it through foaming ability and foam stability tests. The foaming formula exhibited excellent liquid unloading performance under high salinity, high condensate fraction, and high methanol fraction conditions.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2023)
Article
Chemistry, Multidisciplinary
Mange Ram Yadav, Mukesh Kumar, Prashant R. Murumkar
Summary: Gene therapy has the potential to address a wide range of health issues, but the lack of a suitable vector is a major obstacle. Gemini amphiphiles show promise in transfection efficiency, although they exhibit concentration-dependent toxicity in MTT assays.
Article
Chemistry, Physical
Rosa M. Giraldez-Perez, Elia Grueso, Said Lhamyani, Pilar Perez-Tejeda, Adriana-Mariel Gentile, Edyta Kuliszewska, J. Roman-Perez, Rajaa El Bekay
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Physical
Aila Jimenez-Ruiz, Rafael Prado-Gotor, Jose G. Fernandez-Bolanos, Alejandro Gonzalez-Benjumea, Jose Maria Carnerero
Summary: Stable oleuropein-coated gold nanoparticles were synthesized in aqueous media for the first time. The concentration of oleuropein in the reaction medium was found to significantly impact the outcome and stability of the resulting nanocolloid, with smaller particle sizes observed in more concentrated solutions. Self-assembled structures of oleuropein were identified at a specific concentration threshold, contributing to both increased stability and reduced particle size in concentrated solutions.
Article
Chemistry, Physical
Elia Grueso, Rosa M. Giraldez-Perez, Edyta Kuliszewska, Jesus A. Guerrero, Rafael Prado-Gotor
Summary: A new method for detecting DNA and lysozyme biomolecules was developed using gold nanoparticles, with a practical and economical approach. The method showed high sensitivity and immediate results, avoiding issues with time delays seen in previous sensor designs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Paula M. Castillo, Francisco J. Fernandez-Acejo, Jose M. Carnerero, Rafael Prado-Gotor, Aila Jimenez-Ruiz
Summary: The study utilizes the stabilizing effect of lysozymes to develop a quick naked-eye test for detecting urinary lysozyme concentrations over 57.2 μg/mL. By calculating color difference parameters, the test can reliably provide a positive colorimetric response in less than 15 minutes, making it useful for detecting disorders such as leukemia-associated lysozymurias.
Article
Pharmacology & Pharmacy
Rosa M. Giraldez-Perez, Elia Grueso, Inmaculada Dominguez, Nuria Pastor, Edyta Kuliszewska, Rafael Prado-Gotor, Francisco Requena-Domenech
Summary: The design and preparation of novel nanocarriers for transporting cancer drugs is crucial in chemotherapy research. By utilizing two new biocompatible gold nanosystems, a new 5-Fluorouracil (5-Fu) transporter was developed, enhancing efficacy, biocompatibility, and selectivity against lung cancer cells. Various techniques were used to study the physicochemical properties and uptake of the nanosystems, demonstrating the potential for improved cancer treatment strategies.
Article
Chemistry, Multidisciplinary
Axel Gomes, Jose M. Carnerero, Aila Jimenez-Ruiz, Elia Grueso, Rosa M. Giraldez-Perez, Rafael Prado-Gotor
Summary: This study investigated the adsorption of lysozyme onto gold nanoparticles and obtained the free energy of binding of the system for the first time. The interactions between lysozyme and AuNPs induce aggregation of citrate-stabilized AuNPs at low concentrations. The study also found that 10 nm AuNPs were the most appropriate for this interaction.
Article
Pharmacology & Pharmacy
Rosa M. Giraldez-Perez, Elia M. Grueso, Raquel Jimenez-Aguayo, Alfonso Carbonero, Marina Gonzalez-Bravo, Edyta Kuliszewska, Rafael Prado-Gotor
Summary: This study prepared new nanosystems for effective antibiotic delivery, exhibiting good antibacterial properties and internalization capacity in bacteria, making them suitable for medical applications.
Article
Biochemistry & Molecular Biology
Rosa M. Giraldez-Perez, Elia Grueso, Antonio J. Montero-Hidalgo, Raul M. Luque, Jose M. Carnerero, Edyta Kuliszewska, Rafael Prado-Gotor
Summary: In this study, different gold nanosystems were designed and synthesized for cancer therapy. It was found that gold nanoparticles can induce compaction of DNA-Doxo, enabling efficient drug delivery with high selectivity towards cancer cells. In vitro experiments showed that these compacted nanocomplexes exhibit strong therapeutic effects in cancer cell lines, while protecting non-tumor cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Chemistry, Multidisciplinary
Rafael Prado-Gotor
Article
Chemistry, Analytical
Elia Grueso, Rosa M. Giraldez-Perez, Rafael Prado-Gotor, Edyta Kuliszewska
Summary: Surfactant-capped gold nanoparticles were used to develop a colorimetric sensor based on plasmonic shift through the disaggregation mechanism. The sensor showed an instantaneous color change from blue to red with increasing biopolymer concentrations. The detection limit for DNA and Lysozyme sensing was in the nanomolar and picomolar range, respectively, and the sensor's response was immediate and highly dependent on the order of addition of reagents.
