☆ 4.0 Article

Synthesis of new chiral schiff bases from (+)-3-carene and their use in asymmetric oxidation of sulfides catalyzed by metal complexes

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (2009)

Journal

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Volume 45, Issue 6, Pages 815-824

Publisher

MAIK NAUKA/INTERPERIODICA/SPRINGER

DOI: 10.1134/S1070428009060037

Keywords

-

Categories

Chemistry, Organic

Funding

Russian Foundation for Basic Research [06-03-32 052]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

A number of new chiral Schiff bases were synthesized starting from accessible monoterpene (+)-3-carene, and the products were used as ligands in metal complex-catalyzed oxidation of sulfides to chiral sulfoxides. The optical purity and the sign of optical rotation of chiral sulfoxides were found to strongly depend on the oxidation temperature.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.0

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Chemistry, Multidisciplinary

Synthesis of Metal-Free Chiral Covalent Organic Framework for Visible-Light-Mediated Enantioselective Photooxidation in Water

Xuan Kan, Jian-Cheng Wang, Zhi Chen, Jia-Qi Du, Jing-Lan Kan, Wen-Yan Li, Yu-Bin Dong

Summary: In this study, a novel type of chiral covalent organic frameworks (CCOFs) was reported for the first time, which can achieve enantioselective photocatalytic reactions. The researchers successfully applied this framework to the photooxidation reaction of sulfides to sulfoxides and the synthesis of (R)-modafinil.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Cu(I)/Chiral Bisoxazoline-Catalyzed Enantioselective Doyle-Kirmse Reaction of Allenyl Sulfides with α-Diazoesters

Kang Wang, Shu-Sen Li, Jianbo Wang

Summary: In this study, a Cu(I)-catalyzed enantioselective Doyle-Kirmse reaction of allenyl sulfides and alpha-diazoesters was reported, providing a highly efficient synthetic route to enantio-enriched chiral tertiary homopropargylic sulfides. The reaction exhibited high enantioselectivities and good functional group tolerance, and alkyl substituted alpha-diazoesters were found to be efficient substrates as well. Mechanistic studies were conducted to gain insights into the reaction pathway, and the potential synthetic utility of this protocol was demonstrated.

CHEMISTRY-A EUROPEAN JOURNAL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Natural Sunlight Photocatalytic Synthesis of Benzoxazole-Bridged Covalent Organic Framework for Photocatalysis

Cheng-Juan Wu, Xin-Yu Li, Ting-Rui Li, Ming-Zhen Shao, Li-Jing Niu, Xiao-Fan Lu, Jing-Lan Kan, Yan Geng, Yu-Bin Dong

Summary: This study reports the first-ever synthesis of COF using natural sunlight and demonstrates its application as a reusable photocatalyst for promoting light-driven oxidation reactions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Cu(II) and Mn(II) Anchored on Functionalized Mesoporous Silica with Schiff Bases: Effects of Supports and Metal-Ligand Interactions on Catalytic Activity

Mihaela Mureseanu, Mihaela Filip, Irina Bleotu, Cezar Ionut Spinu, Alexandru Horia Marin, Iulia Matei, Viorica Parvulescu

Summary: A new series of Cu(II) and Mn(II) complexes with Schiff base ligands derived from 2-furylmethylketone (Met), 2-furaldehyde (Fur), and 2-hydroxyacetopheneone (Hyd) have been synthesized on functionalized SBA-15-NH2, MCM-48-NH2, and MCM-41-NH2 supports. The hybrid materials were characterized by various techniques and their catalytic performances in oxidation reactions were evaluated. The best catalytic activity was observed for the SBA-15-NH2-MetMn catalyst in the oxidation of cyclohexene, and no leaching was observed for Cu and Mn complexes.

NANOMATERIALS (2023)

Add to Collection

Article Chemistry, Organic

Stereogenic-at-Cobalt(III) Complex Catalyzed Halocyclization of Alkynes: Enantioselective Access to Axially Chiral ortho-Halo-C2-indoles

Chuan-Zhi Yao, Zu-Kui Xie, Jie-Yue Wang, Jia-Yu Zhang, Zi-Yuan Zhao, Qiankun Li, Jie Yu

Summary: Here, we present an anionic stereogenic-at-cobalt(III) complex catalysis strategy for the enantioselective halocyclization of ortho-alkynylanilines using N-halosuccinimide (NXS) as the halogen source. This method offers a distinct atroposelective approach to obtain axially chiral ortho-halo-C2-indole skeletons with excellent yields and good to high enantioselectivities (up to 99% yield, 99:1 er).

JOURNAL OF ORGANIC CHEMISTRY (2023)

Add to Collection

Article Chemistry, Organic

Rapid Photoracemization of Chiral Alkyl Aryl Sulfoxides

Kosho Makino, Kumi Tozawa, Yuki Tanaka, Akiko Inagaki, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi

Summary: The study revealed that the photoracemization reaction of chiral alkyl aryl sulfoxides is extremely fast and influenced by various substitution patterns. However, chiral sulfoxides with easily oxidizable functional groups are not suitable for this photo-isomerization.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Schiff bases derived from phloroglucinol carbonyl variants and their applications-A review

Maryam Bashir, Maryam Saifullah, Mubeshar Riaz, Muhammad Arshad, Ahmad Irfan, Sadia Iqbal, Zahoor H. Farooqi, Robina Begum

Summary: This mini review summarizes the potential applications of phloroglucinol derivatives in various fields. Different groups of scientists have explored various derivatives of phloroglucinol for a wide range of applications. The review focuses on the synthesis, structural, medicinal, catalytic, and enzyme inhibitory importance of phloroglucinol Schiff bases and their metal complexes.

INORGANIC CHEMISTRY COMMUNICATIONS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

Yu-Feng Zhang, Xiao-Yang Dong, Jiang-Tao Cheng, Ning-Yuan Yang, Li-Lei Wang, Fu-Li Wang, Cheng Luan, Juan Liu, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu

Summary: This study demonstrates the successful use of sulfoximines as ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides, achieving high yields and enantioselectivity. The obtained alpha-chiral primary amines can be converted to various synthetic building blocks, ligands, and drugs, highlighting the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Article Chemistry, Organic

Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

Takashi Mino, Yohei Fujisawa, Shizuki Yoshida, Mitsuru Hirama, Takumu Akiyama, Ryo Saito, Yasushi Yoshida, Yoshio Kasashima, Masami Sakamoto

Summary: By synthesizing cinnamoyl amide type chiral P,olefin ligand (S)-4, separable diastereomers of 4d were obtained successfully, and asymmetric allylic substitution reactions of indoles using (S,aS)-4d as a chiral ligand demonstrated high enantioselectivities (up to 98% ee).

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Deracemization of Chiral-at-Ruthenium Catalyst by Diastereoselective Dynamic Resolution

Dominik Baran, Sergei I. Ivlev, Eric Meggers

Summary: In this work, an auxiliary-mediated deracemization protocol was introduced for the synthesis of a non-C-2-symmetric chiral-at-ruthenium catalyst, which was then applied to an enantioselective ring-closing reaction.

ORGANOMETALLICS (2022)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Synthesis of amphiphilic chiral salen complexes and their conformational manipulation at the air-water interface

Shigehisa Akine, Keisuke Nomura, Mizuho Takahashi, Yoko Sakata, Taizo Mori, Waka Nakanishi, Katsuhiko Ariga

Summary: The number of hydrophilic triethylene glycol (TEG) chains and the structure of the hydrophobic pi-extended metallosalen core were found to influence the formation behavior and flexibility of the amphiphilic complexes at the air-water interface.

DALTON TRANSACTIONS (2023)

Add to Collection

Editorial Material Chemistry, Multidisciplinary

Asymmetric Rubottom-Type Oxidation Catalyzed by Chiral Calcium Phosphates

Hualing He, K. S. Satyanarayana Tummalapalli, Linfei Zhu, Minglei Chen, Suvratha Krishnamurthy, Jon C. C. Antilla

Summary: A highly efficient catalytic asymmetric Rubottom-type oxidation using m-CPBA as the oxidant and chiral calcium phosphate as the catalyst is described. The transformation enables direct hydroxylation of N-Boc oxindoles and beta-ketoesters in high yields(up to 99%) and with excellent enantioenriched fashion (up to >99% ee). The method was demonstrated by the synthesis of a pharmaceutically important 3-hydroxyoxindole with high enantiocontrol.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Asymmetric Rubottom-Type Oxidation Catalyzed by Chiral Calcium Phosphates

Hualing He, K. S. Satyanarayana Tummalapalli, Linfei Zhu, Minglei Chen, Suvratha Krishnamurthy, Jon C. Antilla

Summary: A highly efficient catalytic asymmetric Rubottom-type oxidation using m-CPBA as the oxidant and chiral calcium phosphate as the catalyst is described. The transformation enables direct hydroxylation of N-Boc oxindoles and beta-ketoesters in high yields (up to 99%) and with high enantioenrichment (up to >99% ee). The method was demonstrated by synthesizing a pharmaceutically important 3-hydroxyoxindole with excellent enantiocontrol.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Add to Collection

Article Chemistry, Organic

Ni-Catalyzed Decarboxylative Silylation of Alkynyl Carbonates: Access to Chiral Allenes via Enantiospecific Conversions

Kun Guo, Qian Zeng, Alba Villar-Yanez, Carles Bo, Arjan W. Kleij

Summary: A Ni-catalyzed decarboxylative silylation of alkynyl cyclic carbonates has been reported, which serves as versatile propargylic surrogates and affords a wide range of highly substituted 2,3- and 3,4-allenol products in good yields. The formal cross-coupling between a tentative intermediate Ni(allenyl) and the silyl reagent can be further extended to enantiospecific conversions providing access to chiral allene synthons. This study is of significance as it represents the first Ni-catalyzed propargylic silylation proceeding through an S(N)2' manifold.

ORGANIC LETTERS (2022)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Amalgamation, scrutinizing, and biological evaluation of the antimicrobial aptitude of thiosemicarbazide Schiff bases derivatives metal complexes

Muhammad Pervaiz, Anfal Munir, Aqsa Riaz, Zohaib Saeed, Umer Younas, Muhammad Imran, Sami Ullah, Rashida Bashir, Ayoub Rashid, Ahmad Adnan

Summary: Schiff base ligands and their metal complexes have gained significant attention due to their wide range of applications and unique structural features. They have been extensively used in various fields, including material science and biology, because of their broad-spectrum biological activities.

INORGANIC CHEMISTRY COMMUNICATIONS (2022)

Add to Collection

Article Chemistry, Organic

(1S,5R)-6,6-Dimethyl-4-(((1S,2S,5S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]heptan-2-yl)methyl)bicyclo[3.1.1]hept-3-en-2-one

Oleg V. Ardashov, Dina V. Korchagina, Irina Yu. Bagryanskaya, Konstantin P. Volcho, Nariman F. Salakhutdinov

Summary: A simple and convenient method for the gamma, beta-dimerization of verbenone was developed through aging with KOH without a solvent. The process involves the formation of the extended enolate of verbenone and its Michael addition to other molecules of verbenone, resulting in a product yield of 82% after purification.

MOLBANK (2022)

Add to Collection

Article Chemistry, Physical

Br?nsted acid catalyzed Prins-Ritter reaction for selective synthesis of terpenoid-derived 4-amidotetrahydropyran compounds

A. Yu Sidorenko, Yu M. Kurban, A. F. Peixoto, N. S. Li-Zhulanov, J. E. Sanchez-Velandia, A. Aho, J. Warna, Y. Gu, K. P. Volcho, N. F. Salakhutdinov, D. Yu Murzin, V. E. Agabekov

Summary: A range of SO3H-functionalized solids were studied as catalysts for the cascade Prins-Ritter reaction. The highest selectivity to the desired products was observed on biochar modified with chlorosulfonic acid. The addition of water significantly increased the reaction rate and selectivity.

APPLIED CATALYSIS A-GENERAL (2023)

Add to Collection

Article Biochemistry & Molecular Biology

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins

Sergey Kuranov, Mariya Marenina, Dmitriy Ivankin, Mikhail Blokhin, Sergey Borisov, Tatyana Khomenko, Olga Luzina, Mikhail Khvostov, Konstantin Volcho, Tatyana Tolstikova, Nariman Salakhutdinov

Summary: Natural and synthetic coumarins are important structures for developing hypoglycemic drugs. In this study, twenty monoterpene-substituted 7-hydroxycoumarins were synthesized and evaluated for their hypoglycemic activity in an oral glucose tolerance test. Two compounds showed in vivo hypoglycemic action and possible mechanism of action was proposed based on an in vitro test.

MOLECULES (2022)

Add to Collection

Article Virology

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage-Amide Derived Orthopox Virus Replication Inhibitors

Evgenii S. S. Mozhaitsev, Evgeniy V. V. Suslov, Daria A. A. Rastrepaeva, Olga I. I. Yarovaya, Sophia S. S. Borisevich, Edward M. M. Khamitov, Dmitry S. S. Kolybalov, Sergey G. G. Arkhipov, Nikolai I. I. Bormotov, Larisa N. N. Shishkina, Olga A. A. Serova, Roman V. V. Brunilin, Andrey A. A. Vernigora, Maxim B. B. Nawrozkij, Alexander P. P. Agafonov, Rinat A. A. Maksyutov, Konstantin P. P. Volcho, Nariman F. F. Salakhutdinov

Summary: Although the variola virus has been eradicated, the search for new small molecules with activity against orthopoxviruses is still important, especially due to recent outbreaks of monkeypox. A series of benzoic acid amide derivatives containing an adamantane fragment were obtained, most of which showed activity against vaccinia virus. The leader compound 18a exhibited a high selectivity index (SI = 18,214). The IC50 values of the compounds correlated with the binding energy to the assumed biological target, the p37 viral protein (R-2 = 0.60).

VIRUSES-BASEL (2023)

Add to Collection

Article Chemistry, Organic

(1R,2R,6S)-2(4-(4-Isopropylbenzyl)piperazin-1-yl)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-enol

Alexandra V. Podturkina, Nikolai S. Li-Zhulanov, Konstantin P. Volcho, Nariman F. Salakhutdinov

Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by movement dysfunction. A new Prottremin derivative was synthesized by opening the epoxide ring with 1-(4-isopropylbenzyl)piperazine, with a product yield of 48% after purification.

MOLBANK (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids

Yulia Aleksandrova, Aldar Munkuev, Evgenii Mozhaitsev, Evgenii Suslov, Dmitry Tsypyshev, Kirill Chaprov, Roman Begunov, Konstantin Volcho, Nariman Salakhutdinov, Margarita Neganova

Summary: Novel monoterpene-based hydroxamic acids were synthesized, consisting of compounds with a hydroxamate group directly bound to monoterpene scaffolds or connected through aliphatic or aromatic linkers. Some of these compounds showed powerful HDAC6 inhibitory activity, with a hexa- and heptamethylene linker and (-)-perill fragment exhibiting the most excellent activity. Moderate antiradical activity was also observed. Compounds with an aromatic linker based on para-substituted cinnamic acids demonstrated the ability to suppress aggregation of beta-amyloid peptide 1-42. The lead compound 35a showed neuroprotective effects on in vivo Alzheimer's disease models. This research suggests the potential use of monoterpene-derived hydroxamic acids in Alzheimer's disease treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

Dmitry I. Ivankin, Tatyana E. Kornienko, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Chigozie Achara, Johannes Reynisson, Victor M. Golyshev, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik

Summary: A novel series of 3,5-disubstituted thiazolidine-2,4-diones were synthesized and tested for their activity against TDP1. Compounds 20d and 21d showed the highest activity with IC50 values in the submicromolar range. However, these compounds did not exhibit cytotoxicity against HCT-116 (colon carcinoma) and MRC-5 (human lung fibroblasts) cell lines in the concentration range of 1-100 μM, and they also did not sensitize cancer cells to the cytotoxic effect of topotecan.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan

Tatyana M. M. Khomenko, Alexandra L. L. Zakharenko, Tatyana E. E. Kornienko, Arina A. A. Chepanova, Nadezhda S. S. Dyrkheeva, Anastasia O. O. Artemova, Dina V. V. Korchagina, Chigozie Achara, Anthony Curtis, Johannes Reynisson, Konstantin P. P. Volcho, Nariman F. F. Salakhutdinov, Olga I. I. Lavrik

Summary: A series of new 5-hydroxycoumarin derivatives containing monoterpene moieties were synthesized and shown to have high inhibitory properties against TDP1. The most potent inhibitor was a geraniol derivative 33a with an IC50 of 130 nM. Docking simulations indicated a good fit with TDP1 and blocking of the catalytic pocket. These derivatives sensitized cancer cells to the cytotoxic effect of topotecan.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

Konstantin P. Volcho, Olga I. Lavrik

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Infectious Diseases

Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity

Nikolai S. Li-Zhulanov, Nadezhda P. Zaikova, Suat Sari, Dolunay Gulmez, Suna Sabuncuoglu, Keriman Ozadali-Sari, Sevtap Arikan-Akdagli, Andrey A. Nefedov, Tatyana V. Rybalova, Konstantin P. Volcho, Nariman F. Salakhutdinov

Summary: Azole antifungals, including fluconazole, have long been the first-line agents against fungal infections. In response to drug-resistant strains, we synthesized novel monoterpene-containing azoles with high antifungal activity and low cytotoxicity. These compounds showed broad-spectrum activity against tested fungal strains and had lower minimum inhibitory concentrations (MICs) compared to fluconazole, suggesting their potential as antifungal agents.

ANTIBIOTICS-BASEL (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Identification and Study of the Action Mechanism of Small Compound That Inhibits Replication of Respiratory Syncytial Virus

Anna A. Shtro, Artem M. Klabukov, Anzhelika V. Garshinina, Anastasia V. Galochkina, Yulia V. Nikolaeva, Tatyana M. Khomenko, Danila E. Bobkov, Aleksey A. Lozhkov, Konstantin V. Sivak, Kirill S. Yakovlev, Andrey B. Komissarov, Sophia S. Borisevich, Konstantin P. Volcho, Nariman F. Salakhutdinov

Summary: This article discusses the mechanism of action of compound K142 against respiratory syncytial virus (RSV), showing that its interaction with RSV surface proteins is crucial for its antiviral activity. However, in vivo studies have indicated weak antiviral activity, suggesting the need for further modifications to enhance its efficacy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Hybrids of Sterically Hindered Phenols and Diaryl Ureas: Synthesis, Switch from Antioxidant Activity to ROS Generation and Induction of Apoptosis

Elmira Gibadullina, Margarita Neganova, Yulia Aleksandrova, Hoang Bao Tran Nguyen, Alexandra Voloshina, Mikhail Khrizanforov, Thi Thu Nguyen, Ekaterina Vinyukova, Konstantin Volcho, Dmitry Tsypyshev, Anna Lyubina, Syumbelya Amerhanova, Anna Strelnik, Julia Voronina, Daut Islamov, Rakhmetulla Zhapparbergenov, Nurbol Appazov, Beauty Chabuka, Kimberley Christopher, Alexander Burilov, Nariman Salakhutdinov, Oleg Sinyashin, Igor Alabugin

Summary: This study explores the biological activity of a family of new hybrid molecules that combine sterically hindered phenols (SHPs) with additional urea/thiourea fragments. It finds that these compounds exhibit cytotoxic activity against tumor cells and have dual properties of pronounced antioxidant activity and increased reactive oxygen species generation. Molecular docking analysis reveals a potential target for these compounds. The most promising compounds can induce apoptosis in cancer cells through the intrinsic mitochondrial pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Oncology

Hydroxamic Acids Containing a Bicyclic Pinane Backbone as Epigenetic and Metabolic Regulators: Synergizing Agents to Overcome Cisplatin Resistance

Yulia Aleksandrova, Aldar Munkuev, Evgenii Mozhaitsev, Evgeniy Suslov, Konstantin Volcho, Nariman Salakhutdinov, Margarita Neganova

Summary: Researchers have explored the use of hydroxamic acids with specific chemical structures to address the issue of multidrug resistance in chemotherapy. They found that one particular hydroxamic acid, 18c, can synergize with cisplatin to enhance its anticancer effect and overcome cisplatin resistance.

CANCERS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors

Jonathan P. Dolan, Sanaz Ahmadipour, Alice J. C. Wahart, Aisling Ni Cheallaigh, Suat Sari, Chatchakorn Eurtivong, Marcelo A. Lima, Mark A. Skidmore, Konstantin P. Volcho, Johannes Reynisson, Robert A. Field, Gavin J. Miller

Summary: This study used virtual screening and experimental validation to discover a new compound that can inhibit the synthesis of alginate in Pseudomonas aeruginosa. The compound showed stronger inhibition than existing inhibitors, offering a potential pathway for the development of new selective antibacterial drugs.

RSC CHEMICAL BIOLOGY (2023)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

Conjugates of an antimicrobial peptide and usnic acid derivatives targeting resistant cancer cells

Siobhan O'Flaherty, Ysaline Krier, Mihayl Varbanov, Olga A. Luzina, Mikhail A. Pokrovsky, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Andrey G. Pokrovsky, Olga I. Lavrik, Konstantin P. Volcho, Nariman F. Salakhutdinov, Marc Devocelle

JOURNAL OF PEPTIDE SCIENCE (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.