4.6 Article

Friedel-Crafts alkylation of heteroarenes and arenes with indolyl alcohols for construction of 3,3-disubstituted oxindoles

Journal

RSC ADVANCES
Volume 5, Issue 123, Pages 101713-101717

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra21919a

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Funding

  1. Talents of High Level Scientific Research Foundation of Qingdao Agricultural University [6631112323, 6631115015]

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An intriguing camphorsulfonic acid catalyzed Friedel-Crafts alkylation of heteroarenes and arenes with indolyl alcohols has been developed featuring mild reaction conditions, wide substrate scope and high yields. This reaction provides an efficient method to access biologically important heterocyclic oxindole derivatives.

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