Article
Rheumatology
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wu, Sindhu R. Johnson, Paula Rochon, Lihi Eder
Summary: This study compared patterns of healthcare utilization between male and female patients with inflammatory arthritis (IA). The findings showed that female patients had higher healthcare utilization than male patients before and after diagnosis, possibly indicating biological differences in disease course or sociocultural differences in healthcare-seeking behavior.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Genetics & Heredity
Yixiao Zeng, Kaiqiong Zhao, Kathleen Oros Klein, Xiaojian Shao, Marvin J. Fritzler, Marie Hudson, Ines Colmegna, Tomi Pastinen, Sasha Bernatsky, Celia M. T. Greenwood
Summary: A replication study confirmed CpG sites showing differential methylation in individuals positive and negative for anti-citrullinated protein antibodies (ACPA), identifying thousands of ACPA-associated differentially methylated cytosines (DMCs) in whole blood. Moreover, differentially methylated regions (DMRs) overlapping with rheumatoid arthritis (RA) related loci were enriched in cell adhesion and immune-related pathways.
Article
Immunology
Namrata Anand, Jenny Lutshumba, Megan Whitlow, Mohamed H. Abdelaziz, Rajesh Mani, Yasuhiro Suzuki
Summary: The study examined the role of IDOL in controlling cerebral Toxoplasma gondii infection in genetically resistant and susceptible strains of mice. The results showed that IDO1 deficiency in genetically resistant mice was compensated by the upregulated expression of Gbp1 and NOS2 to control the growth of cerebral tachyzoites. In contrast, IDO1 did not significantly contribute to controlling cerebral tachyzoite growth in genetically susceptible mice due to its suppressed expression in infected cells.
MICROBES AND INFECTION
(2022)
Review
Rheumatology
Sanjana Tarannum, Ying-Ying Leung, Sindhu R. Johnson, Jessica Widdifield, Vibeke Strand, Paula Rochon, Lihi Eder
Summary: This narrative review focuses on the influence of sex and gender on psoriatic arthritis, covering disease progression and outcomes, underlying mechanisms, and response to therapies. It also discusses the disparities between male and female patients in terms of treatment response and differences in pathophysiological mechanisms including genetics, immune, and hormonal mechanisms. Furthermore, it outlines the association of psoriatic arthritis with fertility and pregnancy outcomes.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Rheumatology
Alexis Ogdie, Wesley Matthias, Richard J. Thielen, Daniel Chin, Christopher D. Saffore
Summary: The study found differences in the prevalence and treatment of PsA and AS in the USA based on race/ethnicity, insurance coverage, and sex, with Medicaid enrollees having lower prevalence. Patients with commercial insurance and Medicare coverage were more likely to receive better treatment and visit rheumatologists.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Obstetrics & Gynecology
Zoltan Nemeth, Nelli Farkas, Balint Farkas
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2017)
Article
Reproductive Biology
Balint Farkas, Ferenc Boldizsar, Noemi Bohonyi, Nelli Farkas, Saska Marczi, Gabor L. Kovacs, Jozsef Bodis, Miklos Koppan
JOURNAL OF OVARIAN RESEARCH
(2020)
Article
Obstetrics & Gynecology
Zoltan Nemeth, Nelli Farkas, Balint Farkas
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2020)
Article
Obstetrics & Gynecology
Sarolta Szalai, Nelli Farkas, Bela Veszpremi, Jozsef Bodis, Kalman Kovacs, Balint Farkas
Summary: The study analyzed the effects of increased ionizing radiation emitted by the Chernobyl nuclear disaster on maternal and fetal outcomes in Hungary. Trends showed increasing rates of spontaneous and voluntary abortions, while there was a decreasing trend in late pregnancy losses during the study period. Ultimately, the data suggested that the nuclear catastrophe in 1986 did not lead to significant increases in pregnancy loss or congenital malformations in Hungary.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Endre Sulyok, Balint Farkas, Bernadett Nagy, Akos Varnagy, Kalman Kovacs, Jozsef Bodis
Summary: This article discusses the risks of excessive sodium intake on the development of cardiovascular and renal diseases, as well as the storage and dissociation of sodium in the skin interstitium. It also explores the cellular response to increased tissue sodium concentration and the protective role of endothelial glycocalyx in sodium retention. Furthermore, it highlights the involvement of oxygen free radicals in sodium-induced tissue damage and mentions some clinical entities associated with sodium/volume retention and oxidative stress.
Article
Obstetrics & Gynecology
Zoltan Nemeth, Szilard Kolumban, Roxana Schmidt, Peter Gubas, Kalman Kovacs, Balint Farkas
Summary: This study investigates the effectiveness of using a cube pessary for daily self-management of symptomatic pelvic organ prolapse (POP) and finds that it is a safe and effective long-term treatment for improving symptoms and quality of life.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Marta Hock, Istvan Tiringer, Eszter Ambrus, Zoltan Nemeth, Balint Farkas
Summary: The Hungarian version of the self-administered Australian Pelvic Floor Questionnaire (APFQ) has been translated, culturally adapted and validated in this study. The results indicate that the Hungarian version of APFQ is a reliable and valid instrument for evaluating symptom severity and impact of pelvic floor dysfunction on the quality of life of Hungarian women.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Jozsef Bodis, Balint Farkas, Bernadett Nagy, Kalman Kovacs, Endre Sulyok
Summary: Accumulating evidence suggests that the l-arginine-nitric oxide (NO) system plays a crucial role in various stages of female reproduction. This review explores the expression and function of this system, as well as its association with in vitro fertilization (IVF) outcomes. The study highlights the importance of l-arginine uptake, NO synthesis, and the balance of NO generation in achieving successful IVF outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love
Summary: THEMIS plays a critical role in T cell development by inhibiting SHP1 activity, and this is regulated by binding to GRB2.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sandor Pentek, Akos Varnagy, Balint Farkas, Peter Mauchart, Krisztina Godony, Timea Varjas, Tamas Koszegi, Peter Kaltenecker, Rita Jakabfi-Csepregi, Kalman Kovacs, Jozsef Bodis, Endre Sulyok
Summary: This study aimed to investigate the relationship between telomere length, telomerase activity, and oxidative DNA damage in IVF patients. The study found that telomere lengths were similar in granulosa cells and follicular fluid, but telomerase activity was significantly reduced and 8-OHdG levels were significantly elevated in follicular fluid. Additionally, high levels of 8-OHdG were associated with negative outcomes in IVF success and clinical pregnancies.
Review
Biochemistry & Molecular Biology
Endre Sulyok, Balint Farkas, Jozsef Bodis
Summary: Based on epidemiological observations, Barker et al. proposed the hypothesis/concept that adverse intrauterine environment, including insufficient nutrient supply, chronic hypoxia, stress, and toxic substances, is a significant risk factor for the development of chronic diseases in adulthood. Fetus responds to the unfavorable environment with adaptive reactions, ensuring short-term survival, but initiating pathological processes leading to adult diseases. This review outlines major mechanisms, such as telomere dysfunction, epigenetic modifications, and cardiovascular-renal-endocrine-metabolic reactions, with a particular focus on the role of oxidative stress in fetal origin of adult diseases.
Meeting Abstract
Obstetrics & Gynecology
C. Goepel, B. Farkas
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2018)
Meeting Abstract
Obstetrics & Gynecology
Z. Nemeth, N. Farkas, B. Farkas
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2018)
Article
Immunology
Matyas Meggyes, Julia Szanto, Adrienn Lajko, Balint Farkas, Akos Varnagy, Peter Tamas, Eszter Hantosi, Eva Miko, Laszlo Szereday
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Meeting Abstract
Obstetrics & Gynecology
B. Farkas, P. Gal, J. Bodis, N. Farkas, Z. Nemeth
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2017)