The link between HLA-B27 and SpA--new ideas on an old problem

Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis

(2011) P. Bowness et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: A twenty-four-week clinical trial

(2010) I.-H. Song et al.   ARTHRITIS AND RHEUMATISM

Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene

(2010) J J Pointon et al.   GENES AND IMMUNITY

Mutational Analysis Reveals a Complex Interplay of Peptide Binding and Multiple Biological Features of HLA-B27

(2010) Begoña Galocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

(2010) Patrick Danoy et al.   PLoS Genetics

The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD)

(2009) J. J. Pointon et al.   ANNALS OF THE RHEUMATIC DISEASES

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

(2009) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Investigating the genetic association between ERAP1 and ankylosing spondylitis

(2009) David Harvey et al.   HUMAN MOLECULAR GENETICS

Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial

(2009) Alice Gottlieb et al.   LANCET

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

(2009) Xue-Jun Zhang et al.   NATURE GENETICS

Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series

(2009) T. Karaderi et al.   RHEUMATOLOGY

Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis

(2009) Xinwei Wang et al.   RHEUMATOLOGY INTERNATIONAL

On the heritability of psoriatic arthritis. Disease concordance among monozygotic and dizygotic twins

(2008) O B Pedersen et al.   ANNALS OF THE RHEUMATIC DISEASES

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

(2008) B Rueda et al.   ANNALS OF THE RHEUMATIC DISEASES

Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins

(2008) Elena Merino et al.   ARTHRITIS AND RHEUMATISM

Folding of HLA–B27 subtypes is determined by the global effect of polymorphic residues and shows incomplete correspondence to ankylosing spondylitis

(2008) Begoña Galocha et al.   ARTHRITIS AND RHEUMATISM

Association of interleukin-23 receptor variants with ankylosing spondylitis

(2008) Proton Rahman et al.   ARTHRITIS AND RHEUMATISM

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

(2008) Camilla Jandus et al.   ARTHRITIS AND RHEUMATISM

Review: Immune cells and mediators of inflammatory arthritis

(2008) Georg Schett   AUTOIMMUNITY

The interleukin-23/interleukin-17 axis in spondyloarthritis

(2008) Gerlinde Layh-Schmitt et al.   CURRENT OPINION IN RHEUMATOLOGY

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells

(2008) Susana G Santos et al.   ARTHRITIS RESEARCH & THERAPY