Article
Rheumatology
Lily Watson, Conor Coyle, Caroline Whately-Smith, Melanie Brooke, Uta Kiltz, Ennio Lubrano, Ruben Queiro, David Trigos, Jan Brandt-Juergens, Ernest Choy, Salvatore D'Angelo, Andrea Delle Sedie, Emmanuelle Dernis, Sandrine Guis, Philip Helliwell, Pauline Ho, Axel Hueber, Beatriz Joven, Michaela Koehm, Carlos Montilla, Jon Packham, Jose Antonio Pinto Tasende, Felipe Julio Ramirez Garcia, Adeline Ruyssen-Witrand, Rossana Scrivo, Sarah Twigg, Martin Soubrier, Theo Wirth, Laure Gossec, Laura Coates
Summary: This study analyzed the prescribing practices and extent of shared decision-making (SDM) in Psoriatic arthritis (PsA) across Europe. The results showed higher disease activity and treatment escalation rates in the UK, and effective implementation of SDM in face-to-face PsA consultations. Moreover, treatment escalation was only observed in patients with mild disease activity and higher perceived collaboration.
Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Review
Pharmacology & Pharmacy
Frank Kolbinger, Franco Di Padova, Atul Deodhar, Jason E. Hawkes, Christine Huppertz, Torsten Kuiper, Iain B. McInnes, Christopher T. Ritchlin, David Rosmarin, Georg Schett, Jose M. Carballido, Peter Hausermann, Claudio Calonder, Beate Vogel, Jean-Michel Rondeau, Gerard Bruin
Summary: Psoriasis, psoriatic arthritis, and axial spondyloarthritis are systemic inflammatory diseases with varied symptoms and treatment responses. Secukinumab, a drug targeting IL-17A, has been used for over 6 years in the treatment of these diseases and has specific pharmacological properties.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Dermatology
Tamara W. Van Hal, Michelle L. M. Mulder, Mark H. Wenink, Marcel C. Pasch, Frank H. J. van den Hoogen, Juul M. P. A. van den Reek, Elke M. G. J. De Jong
Summary: This study aimed to determine the prevalence, characteristics, and disease burden of psoriatic arthritis in psoriasis patients. It found that a proportion of patients with active psoriatic arthritis were not receiving rheumatological care, often characterized by low disease burden and poor screening questionnaire results.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Immunology
Weize Gao, Zhan Wang, Wenshuai Li, Yongxin Li, Mingjun Liu
Summary: This review systematically demonstrates the research progress of psoriasis-related biomarkers and elaborates their related mechanisms in the pathological development of psoriasis and psoriatic arthritis. In addition, we summarize the development of biologic therapies for psoriasis and psoriatic arthritis in order to drive the broader discussion of psoriasis as an autoimmune-mediated inflammatory skin disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
William Tillett, Alexis Ogdie, Alun Passey, Patricia Gorecki
Summary: This study aimed to assess baseline differences between plaque psoriasis alone and concomitant PsA patients and to investigate the impact of these characteristics on ustekinumab (UST) persistence and outcomes. Results showed that patients with concomitant PsA had a greater comorbidity burden, including hypertension, diabetes, obesity, and depression, and a greater inability to work. PsA, female sex, and depression were associated with shorter UST persistence. These findings emphasize the need for patient-centric, multidisciplinary care in screening for and managing comorbidities in psoriasis and PsA treatment.
Article
Multidisciplinary Sciences
Hyung Jin Hahn, Sang Gyu Kwak, Dong-Kyu Kim, Jong-Yeup Kim
Summary: Research indicates that individuals with Behcet disease are more likely to develop psoriasis, with higher risk seen in male BD patients and older individuals. Additionally, Behcet disease patients are also more prone to developing psoriatic arthritis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Pelagia Katsimbri, Emmanouil Korakas, Aikaterini Kountouri, Ignatios Ikonomidis, Elias Tsougos, Dionysios Vlachos, Evangelia Papadavid, Athanasios Raptis, Vaia Lambadiari
Summary: Chronic inflammation and increased oxidative stress contribute to non-communicable diseases, with dietary nutrients playing a role in immune system activation. Obesity is a major risk factor for psoriasis, which may be improved with strict dietary interventions and weight management. Further research is needed on the effects of different nutritional patterns on chronic inflammation and immune response in psoriasis.
Article
Nursing
Laura Cano-Garcia, Natalia Mena-Vazquez, Sara Manrique Arija, Maria Dolores Hernandez-Sanchez, Rocio Segura-Ruiz, Carmen Dominguez-Quesada, Antonio Fernandez-Nebro
Summary: This study investigated mood and sleep disorders as well as positive psychological factors in patients with AxSp and PsA, finding that insomnia might be associated with other mood disorders, quality of life, and inflammatory activity.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Salvatore D'Angelo, Enrico Tirri, Angela Maria Giardino, Marco Mattucci-Cerinic, Lorenzo Dagna, Leonardo Santo, Francesco Ciccia, Bruno Frediani, Marcello Govoni, Francesca Bobbio Pallavicini, Rosa Daniela Grembiale, Andrea Delle Sedie, Rita Mule, Francesco Paolo Cantatore, Rosario Foti, Elisa Gremese, Paola Conigliaro, Fausto Salaffi, Ombretta Viapiana, Alberto Cauli, Roberto Giacomelli, Luisa Arcarese, Giuliana Guggino, Romualdo Russo, Amy Puenpatom, Domenico Capocotta, Francesca Nacci, Maria Grazia Anelli, Valentina Picerno, Corrado Binetti, Florenzo Iannone
Summary: This prospective observational study collected data from rheumatology clinics in Italy and found that golimumab (GLM) as a second anti-TNF drug is effective in the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). GLM improved disease activity and quality of life in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
