Article
Immunology
Sheng-Li Zhang, Zhi-Han Chen, Dian-Tian Lin, Qing Yan, Fei Gao, He Lin
Summary: The study revealed that EGCG could inhibit inflammation and new bone formation in SpA mice, as well as decrease inflammatory factor expression and osteogenic differentiation in osteoblasts from SpA mice. Additionally, EGCG improved SpA by suppressing the activation of the Wnt/beta-Catenin/COX-2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Elise Descamps, Anna Molto, Didier Borderie, Rik Lories, Corinne Miceli Richard, Marion Pons, Christian Roux, Karine Briot
Summary: This study found that serum levels of BMP-7 and sclerostin in early axSpA patients significantly increased over time, while DKK-1 showed no significant changes. Furthermore, inflammation was associated with changes in serum BMP-7 levels.
Article
Rheumatology
Torsten Diekhoff, Denis Poddubnyy, Fabian Proft, Katharina Ziegeler, Dominik Deppe, Christoph Niedermeier, Kay Geert A. Hermann
Summary: By comparing CT and MRI scans of patients with axial SpA, it was found that joint space lesions show increased density and may contain calcified matrix, suggesting new bone formation. The proportion of calcified matrix gradually increases in type C lesions.
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yu Jeong Lee, Moon-Ju Kim, Sungsin Jo, So-Hee Jin, Pu-Reum Park, Kijeong Park, Ho-Chun Song, Jahae Kim, Ji-Young Kim, Seung Cheol Shim, Tae-Hwan Kim, Sung-Jong Hong, Hyundeok Kang, Tae-Jong Kim, Eun Jeong Won
Summary: Helminth infections and their components have the potential to modulate immune responses. Clonorchis sinensis-derived protein (CSp) was found to protect against ankylosing spondylitis (AS) by reducing inflammatory cytokine-producing cells and new bone formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Sohel M. Julovi, Aiken Dao, Katie Trinh, Alexandra K. O'Donohue, Cindy Shu, Susan Smith, Meena Shingde, Aaron Schindeler, Natasha M. Rogers, Christopher B. Little
Summary: This study developed a preclinical comorbid model of chronic kidney disease (CKD) and osteoarthritis (OA), and investigated the disease-modifying interactions between these two diseases. The findings demonstrated bidirectional disease-modifying interaction between CKD and OA.
Article
Biochemistry & Molecular Biology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amelie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D. Zajac, Rachel A. Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J. M. Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Summary: The anti-inflammatory protein A20 plays a critical role in inhibiting NF-kappa B signaling and inflammation. Deficiency of A20 can lead to osteoporosis without causing inflammatory arthritis. A20 regulates RANK-induced NF-kappa B signaling through its specific domains, controlling osteoclast differentiation and bone development.
Article
Rheumatology
Murat Torgutalp, Valeria Rios Rodriguez, Fabian Proft, Mikhail Protopopov, Maryna Verba, Judith Rademacher, Hildrun Haibel, Joachim Sieper, Martin Rudwaleit, Denis Poddubnyy
Summary: This study investigated the longitudinal association between treatment with tumor necrosis factor inhibitors (TNFi) and the progression of radiographic sacroiliitis in patients with early axial spondyloarthritis (SpA). The results showed that receiving TNFi treatment for at least 12 months in the previous 2-year period was associated with a significant decrease in sacroiliitis scores. This effect became evident 2 to 4 years after treatment initiation.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Otorhinolaryngology
Sungsin Jo, Seung Hoon Lee, Hye-Ryeong Jo, Subin Weon, Chanhyeok Jeon, Min Kyu Park, Tae-Hwan Kim, Seok Hyun Cho
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by chronic eosinophilic inflammation and new bone formation, and this study found that eosinophil-derived TGF beta 1 may mediate aberrant bone remodeling in CRSwNP. TGF beta 1 expression in sinus bone cells was correlated with CT scores in CRSwNP, and treatment with a TGF beta 1 inhibitor attenuated the TGF beta 1-induced ALP expression and bone formation.
Review
Immunology
Anja Saalbach, Manfred Kunz
Summary: Psoriasis is a chronic inflammatory disease associated with various comorbidities and has been linked to cardiovascular diseases. However, recent evidence suggests that it also impacts the development of osteoporosis. Routine bone metabolism examination is crucial for psoriatic patients to prevent long-term consequences.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Rosalinde Stal, Alexandre Sepriano, Floris Alexander van Gaalen, Xenofon Baraliakos, Rosaline van den Berg, Monique Reijnierse, Juergen Braun, Robert B. M. Landewe, Desiree van der Heijde
Summary: In radiographic axial spondyloarthritis (r-axSpA), the occurrence of bridging syndesmophytes influences the development of facet joint ankylosis (FJA), and the presence of baseline FJA affects the formation of new syndesmophytes.
Article
Rheumatology
Karina Ying Ying Lin, Cao Peng, Kam Ho Lee, Shirley Chiu Wai Chan, Ho Yin Chung
Summary: An MRI deep learning algorithm was developed for detection of inflammatory sacroiliitis in axial SpA. The sensitivity and specificity of the algorithms were comparable with the interpretation by a radiologist, but outperformed that of the rheumatologist.
Review
Medicine, General & Internal
Christopher Ritchlin, Iannis E. Adamopoulos
Summary: Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton associated with significant pain and disability. The discovery of the IL-23/IL-17 pathway led to the development of highly effective antibodies directed toward IL-17A for the treatment of axSpA. New agents with dual inhibition of IL-17A and F isoforms, along with oral small molecule agents targeting the Jak-STAT pathway, have also shown efficacy in treating axSpA.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli, Giustino Varrassi
Summary: In recent years, there have been interesting advancements in the understanding of the basis of osteoarthritis (OA). Research suggests that cartilage degeneration is preceded by subchondral bone lesions, indicating a key role of this mechanism in the pathogenesis and progression of OA. Chronic low-grade inflammation of the synovial lining, along with immunological and metabolic factors, is now considered crucial in driving inflammation and tissue destruction in OA. Additionally, the role of neuroinflammation and central sensitization mechanisms as underlying causes of chronic pain has been characterized.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Jianrui Zheng, Zhi Yao, Lixiang Xue, Deli Wang, Zhen Tan
Summary: Osteonecrosis is caused by the death of bone marrow cells, leading to abnormal immune function and chronic inflammation that interferes with bone regeneration and repair. Osteoimmunology explores the interactions between immune cells and bone cells, and understanding the chronic inflammatory environment regulated by abnormal osteoimmune function can help develop new treatments for osteonecrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Charlotte Houttekiet, Kurt de Vlam, Barbara Neerinckx, Rik Lories
Summary: This study assessed the role of CRP levels in interventional clinical trials for PsA. The findings revealed inconsistent use of CRP levels in these trials, which limits the generalizability of the data. Additionally, the use of composite scores such as ACR20 or DAS28-CRP is also affected by baseline CRP levels.
Article
Biochemistry & Molecular Biology
Mathias Vanmunster, Ana Victoria Rojo Garcia, Alexander Pacolet, Sebastiaan Dalle, Katrien Koppo, Ilse Jonkers, Rik Lories, Frank Suhr
Summary: This study reveals the mechanisms controlling muscle atrophy and their impact on molecular clocks and metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Orthopedics
S. Monteagudo, F. M. F. Cornelis, X. Wang, A. de Roover, T. Peeters, J. Quintiens, A. Sermon, R. C. de Almeida, I Meulenbelt, R. J. Lories
Summary: ANP32A is identified as a novel repressor of Wnt signaling in articular cartilage, and its loss leads to hyper-activation of Wnt signaling. ANP32A inhibits target gene expression by histone acetylation masking. The study also reveals the involvement of ANP32A in cardiac hypertrophy. These findings have significant implications for understanding the pathogenesis of osteoarthritis and cardiac diseases.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
S. A. Elahi, R. Castro-Vinuelas, P. Tanska, R. K. Korhonen, R. Lories, N. Famaey, I. Jonkers
Summary: In silico approach was used to study the main mechanisms of cartilage degeneration in osteoarthritis. Collagen degradation drives degenerative changes in intact and degenerated cartilage, while mechanical loading initially causes proteoglycans depletion in the presence of a focal cartilage defect.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
J. Quintiens, A. De Roover, F. M. F. Cornelis, A. Escribano-Nun, A. Sermon, S. Pazmino, S. Monteagudo, R. J. Lories
Summary: This study identified the hypoxia and Wnt signaling pathways as regulators of ANP32A expression. Hypoxia increased ANP32A levels, while Wnt hyper-activation decreased ANP32A levels. The modulation of the ATM gene by hypoxia and Wnt was also observed. Maintaining hypoxia and limiting Wnt activation are important for protecting against osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Jonas J. W. Kuiper, Joerg C. Prinz, Efstratios Stratikos, Piotr Kusnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Secil Vural, Ina Koetter, Marleen G. van de Sande, Ayse Boyvat, Joke H. de Boer, George Bertsias, Niek de Vries, Charlotte L. M. Krieckaert, Ines Leal, Natasa Vidovic Valentincic, Ilknur Tugal-Tutkun, Hanane el Khaldi Ahanach, Felicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Loetscher, Floor G. Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Boehm, Kees Bosman, Tony J. Kenna, Simon J. Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik J. U. Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G. McGonagle, Franktien Turkstra
Summary: The 'MHC-I-opathy' concept describes a group of inflammatory diseases with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. However, the understanding and treatment of these disorders is limited due to patient heterogeneity and lack of systematic investigation. Therefore, interdisciplinary collaboration is needed to decipher the underlying disease mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Reem Assi, Chahrazad Cherifi, Frederique M. F. Cornelis, Qiongfei Zhou, Lies Storms, Sofia Pazmino, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt, Rik J. J. Lories, Silvia Monteagudo
Summary: The methylation of H3K79me is reduced in osteoarthritis. Histone demethylase families, such as Jumonji-C and KDM2/7, can increase the levels of H3K79me and targeting KDM2/7 can protect joints against osteoarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Reem Assi, Jolien Quintiens, Silvia Monteagudo, Rik J. J. Lories
Summary: Osteoarthritis is a chronic joint disease characterized by progressive damage to the joints, causing pain and loss of function. Intra-articular drug therapy has emerged as a potential treatment option, with drugs being injected directly into affected joints to optimize drug bioavailability and reduce systemic toxicity. This review explores the current landscape of intra-articular drug therapies for osteoarthritis, including established approaches and those in clinical development. Despite challenges in defining outcome measures and optimizing clinical trial set-ups, advancements in drug development and clinical trial design hold promise for successful therapies for this important disease.
Article
Orthopedics
Stijn Arnaert, Paul Byttebier, Sam Van Rossom, Evie Vereecke, Ilse Jonkers, Edwin Oei, Sita M. A. Bierma-Zeinstra, Rik Lories, Marienke van Middelkoop, Stefan Clockaerts
Summary: This study investigates the characteristics of the anterior tibiotalar fat pad (ATFP) in the ankle joint after one year of an ankle sprain and its correlation with systemic factors and local articular pathology. The results suggest that age, body mass index (BMI), and sex are significantly associated with the T1 intensity of ATFP. Age, diffuse cartilage loss in the lateral talus, and Kellgren and Lawrence score in the tibiotalar joint are negatively associated with the area of ATFP. BMI is positively associated with the ATFP area.
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Mariia Dzhus, Lisa Ehlers, Marjon Wouters, Katrien Jansen, Rik Schrijvers, Lien De Somer, Steven Vanderschueren, Marco Baggio, Leen Moens, Benjamin Verhaaren, Rik Lories, Giorgia Bucciol, Isabelle Meyts
Summary: Deficiency of human adenosine deaminase type 2 (DADA2) is a rare autoimmune disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. Neurological manifestations, particularly strokes, are a significant feature of DADA2, with brain stem and deep gray matter being commonly affected. Other neurological involvements include neuropathies, focal deficits, ophthalmological findings, convulsions, and headaches. Recognizing the diverse neurological manifestations of DADA2 is crucial for accurate diagnosis and appropriate management.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Ennio Lubrano, Silvia Scriffignano, Kurt de Vlam, Mario Ronga, Fabio Massimo Perrotta, Rik Lories
Summary: Psoriatic arthritis (PsA) is a complex and chronic inflammatory disease that combines arthritis and psoriasis with other conditions and comorbidities. Non-pharmacological approaches such as diet modifications, improved sleep quality, and physical activity have been shown to improve the quality of life for PsA patients.
Article
Cell & Tissue Engineering
Jeremie Zappia, Qiao Tong, Renee Van der Cruyssen, Frederique M. F. Cornelis, Cecile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Summary: Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis. Osteomodulin (OMD), a proteoglycan, is associated with the sclerotic phenotype. This study found that OMD binds to RANKL and inhibits osteoclastogenesis, thus regulating bone remodeling and contributing to bone and cartilage homeostasis. Targeting OMD may be a promising personalized approach for osteoarthritis.
Article
Rheumatology
S. Louis Bridges, Steffen Gay
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Joshua F. Baker, Daniel G. Baker
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
William Neal Roberts Jr, Edward R. Lew, Matthew H. Liang
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Daniel A. Albert
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Virginia D. Steen, Thomas A. Medsger
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Patricia Woo, Ross E. Petty
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
H. James Williams, Grant W. Cannon, Daniel O. Clegg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Biographical-Item
Rheumatology
Daniel J. Wallace
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Ann K. Rosenthal, Mary E. Csuka, Paul Halverson
Summary: Dr. McCarty is a giant in the field of rheumatology. His clinical and scientific discoveries have had a major impact and benefited many patients. He has been an exceptional mentor and role model, influencing our clinical practice styles, the importance we place on clinical observation, and our approach to scientific questions.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Arthur Weinstein
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Marc C. Hochberg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Richard M. Silver
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Anthony M. Reginato, Michelle A. Petri, Jonathan Kay
Summary: Bauer and Ropes were influential figures in the field of rheumatology, making significant contributions through clinical observation and laboratory research. They were also exceptional mentors and leaders in the field.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Mary K. Crow, Josef S. Smolen
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
James S. Louie
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
