Article
Pharmacology & Pharmacy
Yuting Wu, Cheng Huang, Tianlu Shi, Jun Li
Summary: Alcohol-induced fatty liver development is a common early response to excessive alcohol consumption. In this study, NLRC5, a member of the NLR family, was found to play a crucial role in the development of alcoholic liver disease. The absence of NLRC5 prevented liver damage and steatosis caused by chronic and excessive ethanol use. NLRC5 also regulated the expression of key factors involved in lipid synthesis and metabolism, and its functional role in alcoholic liver disease was influenced by the autophagy pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Cell Biology
Xiaowen Ma, Hui Qian, Allen Chen, Hong-Min Ni, Wen-Xing Ding
Summary: Mitochondrion-ER and mitochondrion-LD contact sites play critical roles in regulating lipid metabolism in cells, with organelles communicating through membrane contact sites to maintain cellular homeostasis. Accumulation of lipid droplets in hepatocytes may indicate diseases such as NAFLD, highlighting the importance of proper inter-organelle communication.
Article
Gastroenterology & Hepatology
Young-Eun Cho, Do-Kyun Kim, Wonhyo Seo, Bin Gao, Seong-Ho Yoo, Byoung-Joon Song
Summary: The intake of fructose can lead to changes in gut microbiota, increased gut leakiness, hepatic inflammation/fibrosis, and elevated levels of nitroxidative stress markers in the small intestine and liver. This is likely due to decreased levels of intestinal tight junction and adherent junction proteins, which result in increased gut leakiness and endotoxemia.
Article
Multidisciplinary Sciences
Karissa E. Cottier, Devika Bhalerao, Candice Lewis, Jeannemarie Gaffney, Scott A. Heyward
Summary: Non-alcoholic fatty liver disease (NAFLD) is a prevalent and progressive disorder. The development of effective in vitro models for NAFLD is crucial for drug discovery. In this study, a micropatterned hepatocyte co-culture (MPCC) model was used to simulate liver steatosis. The MPCC model showed utility for compound screening, drug toxicity evaluation, and assessment of gene regulation.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Vitor de Miranda Ramos, Alicia J. Kowaltowski, Pamela A. Kakimoto
Summary: This study examines the relationship between autophagy and the development of fatty liver disease, but the exact role of autophagy in fatty liver disease development remains unclear. Research suggests that autophagy is necessary for the regulation of basic metabolism in hepatocytes and is closely linked to hepatic lipid metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Cao, Siping Xiong, Zhiyuan Wu, Lei Ding, Yebo Zhou, Haijian Sun, Mengyuan Zhu, Wei Thye Lee, Xiaowei Nie, Jin-Song Bian
Summary: Reduced NKA activity exacerbates Parkinson's disease, but the NKA-stabilizing monoclonal antibody DR5-12D can ameliorate this effect by accelerating alpha-synuclein degradation in neurons, ultimately improving tyrosine hydroxylase loss and behavioral deficits. The beneficial effects of DR5-12D involve activation of NKA alpha 1-dependent autophagy through increased AMPK/mTOR/ULK1 pathway signaling.
Article
Gastroenterology & Hepatology
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Ruelicke, Kurt Zatloukal, Hong-Min Ni, Wen -Xing Ding
Summary: Loss of SQSTM1/p62 leads to adipose tissue dysfunction and mature-onset obesity in mice. Loss of SQSTM1/p62 leads to brown adipose tissue maladaptation to alcohol consumption resulting in more severe liver injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Environmental Sciences
Cai-Yu Lian, Sheng Wei, Zi-Fa Li, Shu-Hui Zhang, Zhen-Yong Wang, Lin Wang
Summary: This study investigates the mechanisms of Glyphosate-induced hepatic steatosis using a rooster model and primary chicken embryo hepatocytes. The results show that Glyphosate exposure caused liver injury and disrupted lipid metabolism, leading to lipid accumulation. Transcriptomic analysis reveals the involvement of PPAR alpha and autophagy-related pathways in Glyphosate-induced hepatic lipid metabolism disorders.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Multidisciplinary
Yan Yin, Yisha Xie, Zhengli Wu, Qingfan Qian, Hao Yang, Shilan Li, Xinli Li
Summary: This study found that high-fat diet had a more significant effect on hepatic steatosis in aged mice compared to natural aging process. Apple polyphenol extract (APE) might be a promising dietary ingredient for alleviating hepatic steatosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Pengbo Wu, Tian Tian, Jinbo Zhao, Qi Song, Xiaoman Wu, Yitian Guo, Yuanjie Yu, Shiyun Tan, Hongmiao Xia
Summary: During the initial phase of hepatic steatosis, aggravated lipid accumulation, increased autophagy, and no alteration of apoptosis were observed under increased ER stress. The activation of the IRE1 alpha-JNK pathway during ER stress promoted cell survival by enhancing autophagy. Targeting this signaling pathway may offer new insights into preventive strategies for hepatic steatosis.
Article
Biochemistry & Molecular Biology
Qianyu Tang, Wenhui Liu, Xuefeng Yang, Yaying Tian, Jiacheng Chen, Yang Hu, Nian Fu
Summary: This study found that activating autophagy can improve hepatic steatosis by suppressing pyroptosis, potentially serving as a therapeutic strategy for pyroptosis-mediated MAFLD.
DNA AND CELL BIOLOGY
(2022)
Article
Plant Sciences
Pei-Pei Zhang, Bing-Yu Zhuo, Zi-Wei Duan, Song-Li Huang, Xin Li, Qian Cao, Ting Zhao, Sheng-Li Wei, Xiu-Hua Hub, Yuan Zhang
Summary: The study aimed to evaluate the lipid-lowering activity of Coreopsis tinctoria Nutt. (CT) through a mice model and a hepatoma cells model, and investigate its main components and mechanism. The study confirmed the lipid-lowering activity of CT extract and identified flavonoids as its main components. Among the main flavonoids, marein played a key role in promoting lipophagy by regulating the PI3K/AKT/mTOR pathway, resulting in a lipid-lowering effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abraham S. Meijnikman, Mark Davids, Hilde Herrema, Omrum Aydin, Valentina Tremaroli, Melany Rios-Morales, Han Levels, Sjoerd Bruin, Maurits de Brauw, Joanne Verheij, Marleen Kemper, Adriaan G. Holleboom, Maarten E. Tushuizen, Thue W. Schwartz, Jens Nielsen, Dees Brandjes, Eveline Dirinck, Jonas Weyler, An Verrijken, Christophe E. M. De Block, Luisa Vonghia, Sven Francque, Ulrich Beuers, Victor E. A. Gerdes, Fredrik Backhed, Albert K. Groen, Max Nieuwdorp
Summary: This study found that microbial ethanol might contribute to pathogenesis in some patients with nonalcoholic fatty liver disease. The research suggests that microbial ethanol could be considered in the pathogenesis of this highly prevalent liver disease.
Article
Biochemistry & Molecular Biology
Bikash Dangi, Nadezhda Y. Davydova, Marc A. Maldonado, Armina Abbasi, Nikita E. Vavilov, Victor G. Zgoda, Dmitri R. Davydov
Summary: The study found that the increase in CYP2E1 content significantly affects the metabolism rate of certain substrates and weakens homotropic cooperativity. Chronic alcohol exposure may impact the pharmacokinetics of drugs metabolized by CYP3A4.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Editorial Material
Cell Biology
Thuy T. P. Nguyen, Do-Young Kim, Seung-Soon Im, Tae-Il Jeon
Summary: Nonalcoholic fatty liver disease affects a quarter of the global population with its pathogenesis not completely understood. A recent study has shown that SREBF1/SREBP-1c contributes to hepatic lipid accumulation through increased lipid synthesis and decreased lipid degradation mediated by autophagic dysregulation.
Article
Oncology
Andreas Koch, Sven Arke Lang, Peter Johannes Wild, Susanne Gantner, Abdo Mahli, Gerrit Spanier, Mark Berneburg, Martina Mueller, Anja Katrin Bosserhoff, Claus Hellerbrand
Review
Physiology
Ralf Weiskirchen, Abdo Mahli, Sabine Weiskirchen, Claus Hellerbrand
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Gastroenterology & Hepatology
Abdo Mahli, Claus Hellerbrand
DIGESTIVE DISEASES
(2016)
Article
Oncology
Judith Sommer, Abdo Mahli, Kim Freese, Tobias S. Schiergens, Fulya Suzan Kuecuekoktay, Andreas Teufel, Wolfgang E. Thasler, Martina Mueller, Anja K. Bosserhoff, Claus Hellerbrand
Article
Gastroenterology & Hepatology
Abdo Mahli, Michael Saugspier, Andreas Koch, Judith Sommer, Peter Dietrich, Seren Lee, Reinhard Thasler, Jan Schulze-Luehrmann, Anja Luehrmann, Wolfgang Erwin Thasler, Martina Mueller, Anja Bosserhoff, Claus Hellerbrand
Article
Oncology
Peter Dietrich, Kim Freese, Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbrand, Anja Katrin Bosserhoff
Article
Toxicology
Seddik Hammad, Amnah Othman, Christoph Meyer, Ahmad Telfah, Joerg Lambert, Bedair Dewidar, Julia Werle, Zeribe Chike Nwosu, Abdo Mahli, Christof Dormann, Yan Gao, Kerry Gould, Mei Han, Xiaodong Yuan, Mikheil Gogiashvili, Roland Hergenroeder, Claus Hellerbrand, Maria Thomas, Matthias Philip Ebert, Salah Amasheh, Jan G. Hengstler, Steven Dooley
ARCHIVES OF TOXICOLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
A. Mahli, A. Koch, W. Thasler, C. Hellerbrand
JOURNAL OF HEPATOLOGY
(2018)
Article
Medicine, Research & Experimental
Abdo Mahli, Andreas Koch, Kim Fresse, Tobias Schiergens, Wolfgang Erwin Thasler, Christina Schoenberger, Ina Bergheim, Anja Bosserhoff, Claus Hellerbrand
LABORATORY INVESTIGATION
(2018)
Article
Pathology
Leandra Koletzko, Abdo Mahli, Claus Hellerbrand
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Toxicology
Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbrand
TOXICOLOGY MECHANISMS AND METHODS
(2019)
Article
Cell Biology
Abdo Mahli, Tatjana Seitz, Tobias Beckroege, Kim Freese, Wolfgang Erwin Thasler, Matthias Benkert, Peter Dietrich, Ralf Weiskirchen, Anja Bosserhoff, Claus Hellerbrand
Article
Cell Biology
Abdo Mahli, Tatjana Seitz, Kim Freese, Jan Frank, Ralf Weiskirchen, Mona Abdel-Tawab, Dariush Behnam, Claus Hellerbrand
Article
Oncology
Tatjana Seitz, Christina Hackl, Kim Freese, Peter Dietrich, Abdo Mahli, Reinhard Manfred Thasler, Wolfgang Erwin Thasler, Sven Arke Lang, Anja Katrin Bosserhoff, Claus Hellerbrand
Summary: The study demonstrates that xanthohumol inhibits melanoma metastasis and significantly reduces liver metastases in a mouse model, suggesting it as a promising novel treatment for patients with metastatic melanoma.
Article
Biochemistry & Molecular Biology
Rand Sayed Issa, Gohar Mushtaq, Aziz Unnisa, Abdo Mahli
Summary: This study discusses a case of concomitant leukemoid reaction and mucormycosis in a patient with severe COVID-19 infection. The patient's blood tests revealed the presence of leukemoid reaction, and skin biopsy showed characteristics of mucormycosis infection. The study suggests that severe COVID-19 infection may be associated with severe infections (bacterial or fungal) and other pathophysiological changes in the body.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)