Review
Biochemistry & Molecular Biology
Mohammed E. Choudhury, Yuka Kigami, Junya Tanaka
Summary: With the increasing age of the population, the incidence of Parkinson's disease has grown significantly. Microglia play important roles in both the degeneration of dopaminergic neurons and the compensatory mechanisms in different regions of the basal ganglia, making it challenging to target them for PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Kelsey Barcomb, Christopher P. Ford
Summary: This review summarizes the previous work on the changes in neurotransmitter co-release and circuit dysfunction associated with the degeneration of midbrain dopamine neurons in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Behavioral Sciences
Marine Thomasson, Damien Benis, Philippe Voruz, Arnaud Saj, Marc Verin, Frederic Assal, Didier Grandjean, Julie Peron
Summary: There is growing evidence that both the basal ganglia and the cerebellum play functional roles in emotion processing, either directly or indirectly, through their connections with cortical and subcortical structures. However, the lateralization of this complex processing in emotion recognition remains unclear. This study investigated emotional prosody recognition in individuals with Parkinson's disease or cerebellar stroke patients, as well as in matched healthy controls. Results showed that a right hemispheric dysfunction was likely to induce greater deficits than a left one, and deficits following left hemispheric dysfunction were only observed in cerebellar stroke patients. Additional analyses revealed a worsening of performances in patients with predominantly right-sided lesions over time.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Review
Neurosciences
Monavareh Soti, Hoda Ranjbar, Kristi A. Kohlmeier, Mohammad Shabani
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Recent studies have shown that modulation of GABA and cannabinoid receptors can improve motor functions in Parkinson's disease patients. Therefore, investigating the changes of cannabinoid receptors in different stages of the disease and utilizing them in treatment could be significant for Parkinson's disease management.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Emil Warnberg, Arvind Kumar
Summary: This article discusses the role of midbrain dopaminergic neurons in the basal ganglia and how to explain how dopamine supports learning of continuous outputs instead of discrete action values. The authors propose a model and demonstrate its validity through a learning rule.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Dalton James Surmeier, Shenyu Zhai, Qiaoling Cui, DeNard V. Simmons
Summary: For the past 30 years, the prevailing belief has been that striatal dopamine depletion is the critical factor underlying the motor symptoms of Parkinson's disease. However, recent research has shown that the current network model fails to consider important aspects of the basal ganglia and that dopamine acts beyond the striatum. Studies using a progressive mouse model have demonstrated that striatal dopamine depletion alone is not enough to induce parkinsonism, and restoring dopamine signaling outside the striatum can alleviate motor deficits. Therefore, it is time to develop a new model for understanding the network determinants of motor disability in Parkinson's disease.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2023)
Article
Neurosciences
Rong Li, Ting Zou, Xuyang Wang, Hongyu Wang, Xiaofei Hu, Fangfang Xie, Li Meng, Huafu Chen
Summary: Parkinson's disease is a progressive neurodegenerative disease characterized by both motor and non-motor symptoms. Research suggests that as the disease progresses, gray matter atrophy in Parkinson's patients spreads from the basal ganglia to other brain regions, potentially playing a key role in motor and non-motor circuits.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Matthew J. D. Pilgrim, Zhen-Yi Andy Ou, Madeleine Sharp
Summary: Patients with Parkinson's disease may not utilize the reward value of stimuli when automatically allocating attention, and dopamine replacement therapy does not seem to modulate the effect of reward on automatic attention allocation.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Chunxiu Yu, Tony Tianlun Jiang, Charles T. Shoemaker, David Fan, Mark A. Rossi, Henry H. Yin
Summary: Unilateral dopamine depletion leads to asymmetric striatal output, resulting in turning behavior towards the side with lower output. The direction of turning is determined by the relative striatal outputs from the two cerebral hemispheres.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Aviv D. Mizrahi-Kliger, Lucia K. Feldmann, Andrea A. Kuehn, Hagai Bergman
Summary: Insomnia is a common and debilitating aspect of Parkinson's disease, perceived as a multifactorial entity with origins in disease symptoms, comorbidities, therapeutic strategies, and neural degeneration. Recent evidence has provided insights into the neural underpinnings of insomnia in PD, offering potential neuromodulation-based therapeutic avenues for treatment.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Liqiang Chen, Samuel Daniels, Yerim Kim, Hong-Yuan Chu
Summary: The intrinsic excitability of pyramidal tract neurons (PTNs) in the primary motor cortical layer was greatly decreased in parkinsonism, specifically affecting M1 PTNs but not intratelencephalic neurons (ITNs). The decreased excitability may be associated with impaired function of sodium channels and potassium channels, leading to abnormal firing patterns in parkinsonian state.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Mengya Wang, Huayuan Liu, Zegang Ma
Summary: Parkinson's disease is a neurodegenerative disease influenced by the cannabinoid system in the basal ganglia. Modulating the endogenous cannabinoid levels can have an anti-movement disorder effect, suggesting the development of drugs targeting the cannabinoid system as a novel strategy for Parkinson's disease treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Kristen Delevich, Benjamin Hoshal, Lexi Z. Zhou, Yuting Zhang, Satya Vedula, Wan Chen Lin, Juliana Chase, Anne G. E. Collins, Linda Wilbrecht
Summary: This study investigates the role of direct and indirect pathway spiny projection neurons (dSPNs and iSPNs) in choice rejection during learning. The results show that activation of iSPNs disrupts rejection of nonrewarded choices. These findings are important for designing interventions to enhance choice rejection in addiction or other conditions.
Article
Biochemistry & Molecular Biology
Arnaud L. Lalive, Mauro Congiu, Christopher Lewis, Dominik Groos, Joseph A. Clerke, Anna Tchenio, Yuan Ge, Fritjof Helmchen, Manuel Mameli
Summary: Through experiments with mice, it was found that the activity of lateral habenula neurons decreases with the decrease of reward-related stimuli, and this phenomenon can guide reward-driven behavior through synaptic inhibition.
Article
Substance Abuse
Amanda L. Persons, Brinda Desai Bradaric, Leo P. Kelly, Sharanya M. Kousik, Steven M. Graves, Bryan K. Yamamoto, T. Celeste Napier
Summary: The study suggests that self-administration of methamphetamine in rats leads to motor deficits and increased expression of GFAP and alpha-synuclein in brain and gut tissue, resembling features of prodromal and early-stage Parkinson's disease.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Clinical Neurology
Nacim Betrouni, Moussaoui Yasmina, Stephanie Bombois, Maud Petrault, Thibaut Dondaine, Cedrick Lachaud, Charlotte Laloux, Anne-Marie Mendyk, Hilde Henon, Regis Bordet
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Clinical Neurology
Renaud Lopes, Clement Bournonville, Gregory Kuchcinski, Thibaut Dondaine, Anne-Marie Mendyk, Romain Viard, Jean-Pierre Pruvo, Hilde Henon, Marios K. Georgakis, Marco Duering, Martin Dichgans, Charlotte Cordonnier, Xavier Leclerc, Regis Bordet
Summary: The study found that a machine learning model based on the PSCI network can accurately predict long-term cognitive outcomes after stroke, particularly in memory, attention, visuospatial, and language functions. The left superior frontal cortex was shown to be involved in these cognitive functions, and cortical thickness 6 months poststroke was found to be unrelated to cognitive function 36 months poststroke.
Article
Clinical Neurology
Audrey Riou, Jean-Francois Houvenaghel, Thibaut Dondaine, Sophie Drapier, Paul Sauleau, Dominique Drapier, Joan Duprez, Murielle Guillery, Florence Le Jeune, Marc Verin, Gabriel Robert
Summary: The study revealed the involvement of the cerebellum in nonmotor domains of PD, with differential but overlapping patterns of metabolic correlations, suggesting the involvement of cerebello-thalamo-striatal-cortical loops.
Article
Multidisciplinary Sciences
Leonardo Ceravolo, Sascha Fruhholz, Jordan Pierce, Didier Grandjean, Julie Peron
Summary: This study aimed to characterize the role of subcortical brain regions, such as the basal ganglia and cerebellum, in vocal emotion processing. The results indicate crucial contributions of the basal ganglia, especially the putamen, external globus pallidus, subthalamic nucleus, and various cerebellar lobules and nuclei, in efficiently decoding and responding to vocal emotions.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Melanie Genetti Gatfield, Julie Peron, Friedrich Medlin, Jean-Marie Annoni, Ettore A. Accolla
Summary: This study explores neurological evidence of compulsions without obsession in a patient following a stroke in the left subcortical regions, highlighting the significant role of compulsions in OCD pathology. Additionally, comprehensive neuropsychological findings revealed specific alterations in executive and emotional domains. MRI analyses further demonstrated a strong decrease in connectivity following the subcortical stroke, indicating large network alterations.
Article
Multidisciplinary Sciences
Philippe Voruz, Jordan Pierce, Kevin Ahrweiller, Claire Haegelen, Paul Sauleau, Sophie Drapier, Dominique Drapier, Marc Verin, Julie Peron
Summary: This study investigated the impact of motor symptom asymmetry in Parkinson's disease on cognitive performance and quality of life after deep brain stimulation (DBS). The results showed that patients with predominantly left-sided motor symptoms experienced a decline in cognitive performance post-DBS, while patients with predominantly right-sided motor symptoms maintained their cognitive performance, except for a verbal executive task.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Marine Thomasson, Damien Benis, Philippe Voruz, Arnaud Saj, Marc Verin, Frederic Assal, Didier Grandjean, Julie Peron
Summary: There is growing evidence that both the basal ganglia and the cerebellum play functional roles in emotion processing, either directly or indirectly, through their connections with cortical and subcortical structures. However, the lateralization of this complex processing in emotion recognition remains unclear. This study investigated emotional prosody recognition in individuals with Parkinson's disease or cerebellar stroke patients, as well as in matched healthy controls. Results showed that a right hemispheric dysfunction was likely to induce greater deficits than a left one, and deficits following left hemispheric dysfunction were only observed in cerebellar stroke patients. Additional analyses revealed a worsening of performances in patients with predominantly right-sided lesions over time.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Thibaut Dondaine, Florine Ruthmann, Fanny Vuotto, Louise Carton, Patrick Gele, Karine Faure, Dominique Deplanque, Regis Bordet
Summary: Cognitive and emotional disorders are common in patients recovering from COVID-19, with hypoxia potentially exacerbating these issues. Fatigue, anxiety, and depression are prevalent in all patients, while attentional and memory impairments are more severe in inpatients.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl O. Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Radek Ptak, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van De Ville, Frederic Assal, Julie A. Peron
Summary: The neuropsychological deficits and brain damage following SARS-CoV-2 infection have been investigated in this study. 116 patients with different disease severities were tested for neuropsychological performance, olfactory function, completed questionnaires, and underwent functional magnetic resonance imaging. Severe patients showed poorer verbal episodic memory, while moderate patients had reduced mental flexibility. Neuroimaging revealed different patterns of functional brain connectivity alterations. The severity of the infection in the acute phase predicted the neuropsychological performance six to nine months later. SARS-CoV-2 infection causes long-term memory and executive dysfunctions related to functional brain connectivity alterations.
HUMAN BRAIN MAPPING
(2023)
Article
Behavioral Sciences
Philippe Voruz, Ioana Medeleine Constantin, Julie Anne Peron
Summary: The longitudinal trajectories of cognitive-neuropsychiatric symptoms in Parkinson's disease vary depending on the motor symptom asymmetry at disease onset. Further investigation is needed to explore the relationship with biomarkers.
Review
Neurosciences
Jordan E. Pierce, Marine Thomasson, Philippe Voruz, Garance Selosse, Julie Peron
Summary: The role of the cerebellum in affective processing is important and involves both the lateral hemispheric lobules and the vermis. The activation of the cerebellum differs between explicit and implicit emotion tasks, with some overlapping clusters and some distinct clusters.
Article
Psychology, Clinical
P. Voruz, I. Jacot de Alcantara, A. Nuber-Champier, A. Cionca, G. Allali, L. Benzakour, P. H. Lalive, K-O Loevblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J-L Reny, J. Pugin, I Guessous, R. Ptak, B. N. Landis, F. Assal, J. A. Peron
Summary: The study shows that moderate and severe forms of COVID-19 cause greater long-term neuropsychological deficits compared to a normative population, indicating the long-term effects of SARS-CoV-2 on cognitive function independent of the severity of the initial infection.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Letter
Psychiatry
L. Benzakour, P. Voruz, F. Lador, I. Guerreiro, A. Kharat, F. Assal, J. A. Peron
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)
Article
Clinical Neurology
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Marine Thomasson, Patrice H. Lalive, Karl-Olof Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jerome Pugin, Idris Guessous, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van de Ville, Frederic Assal, Julie A. Peron
Summary: Lack of awareness of cognitive impairment, specifically anosognosia, plays a key role in distinguishing between different phenotypes of post-COVID-19 conditions. The prevalence of anosognosia for memory impairment varies based on the severity of the infection. Anosognosic patients show different cognitive and psychiatric profiles compared to nosognosic patients, and there are differences in brain functional connectivity between the two groups.
BRAIN COMMUNICATIONS
(2022)
Article
Neuroimaging
Marine Thomasson, Damien Benis, Arnaud Saj, Philippe Voruz, Roberta Ronchi, Didier Grandjean, Frederic Assal, Julie Peron
Summary: Recent studies have shown that the cerebellum plays a significant role in emotion processing, with cerebellar stroke patients demonstrating difficulties in emotional prosody recognition. Patients with right cerebellar lesions, especially for neutral or negative prosody, showed more misattributions, with emotional misattributions correlating with lesions in specific areas such as right Lobules VIIb and VIII and right Crus I and II. Acoustic features including pitch, loudness, and spectral aspects explained a significant proportion of variance in the misattribution of emotions. These findings suggest bilateral posterior cerebellar involvement in both sensory and cognitive processing of emotions.
NEUROIMAGE-CLINICAL
(2021)