Article
Hematology
Michael Pham, Giovanni Orsolini, Cynthia Crowson, Melissa Snyder, Rajiv Pruthi, Kevin Moder
Summary: This study aimed to validate the relationship between anti-phosphatidylserine prothrombin antibodies (aPSPT) and lupus anticoagulant (LAC), and determine their sensitivity and specificity in an all-comer population. The results showed that aPSPT had high specificity but lower sensitivity to LAC. These findings further support the potential of aPSPT as a clinical marker for LAC.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Ikhwan Rinaldi, Mondastri Korib Sudaryo, Nurhayati Adnan Prihartono
Summary: This study found that the prevalence of DIC in septic patients was 20.2%. Low albumin, respiratory infection, and antibiotic treatment >= 1 h were identified as risk factors for the development of DIC in septic patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Takeshi Wada, Satoshi Gando
Summary: The two phenotypes of disseminated intravascular coagulation (DIC) are thrombotic and fibrinolytic, characterized by thrombosis and hemorrhage respectively. Thrombotic DIC is caused by coagulation activation, insufficient anticoagulation, and inhibition of fibrinolysis, leading to microvascular fibrin thrombosis and organ dysfunction. Fibrinolytic DIC is characterized by extensive thrombin generation and systemic pathologic hyperfibrinolysis, resulting in severe bleeding.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Kyosuke Takahashi, Yutaka Umemura, Kazuma Yamakawa, Hiroshi Ogura, Takeshi Shimazu
Summary: The efficacy of anticoagulant therapies for septic DIC may be associated with patient age, with significantly lower mortality in younger age groups.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Hematology
Kasper Adelborg, Julie B. Larsen, Anne-Mette Hvas
Summary: Disseminated intravascular coagulation (DIC) is a systemic activation of the coagulation system, leading to microvascular thrombosis and hemorrhage. Underlying conditions like infection, cancer, or obstetrical complications initiate and propagate the DIC process. Timely and accurate diagnosis and treatment of DIC and its underlying causes are essential for prognosis.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese
Summary: The study found that um-PEA can reduce changes in coagulation markers and proinflammatory cytokine release caused by LPS, as well as prevent the formation of fibrin deposition and lung damage. Furthermore, um-PEA can also reduce the number of mast cells and the release of serine proteases, which are necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be a potential therapeutic approach in managing DIC and associated clinical implications of coagulopathy and lung dysfunction, such as COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Daniele Pastori, Danilo Menichelli, Vittoria Cammisotto, Pasquale Pignatelli
Summary: The use of DOACs in APS patients is controversial, with some guidelines suggesting consideration in specific situations. However, more high-quality studies are needed to determine the safety and efficacy of DOACs in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Romain Stammler, Yann Nguyen, Cecile Yelnik, Veronique Le Guern, Marc Lambert, Romain Paule, Eric Hachulla, Luc Mouthon, Anastasia Dupre, Felix Ackermann, Virginie Dufrost, Denis Wahl, Bertrand Godeau, Gaelle Leroux, Ygal Benhamou, Estibaliz Lazaro, Eric Daugas, Holy Bezanahary, Arsene Mekinian, Jean-Charles Piette, Nathalie Morel, Nathalie Costedoat-Chalumeau
Summary: This study analyzed the prevention of catastrophic antiphospholipid syndrome (CAPS), focusing on anticoagulation before CAPS episodes. The results indicated that the major precipitating factors of CAPS were infections, pregnancy, and surgery. Among patients with previous APS diagnosis, the proportion of using vitamin K antagonists (VKA) was low and many patients had a subtherapeutic international normalized ratio (INR) below 2, suggesting suboptimal anticoagulation management. These findings strongly suggest that inadequate anticoagulation can trigger CAPS.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Dermatology
Chun-Bing Chen, Tsun-Hao Hsu, Rosaline Chung-Yee Hui, Chun-Wei Lu, Wei-Ti Chen, Pin-Hsuan Chiang, Chuang-Wei Wang, Shiow-Shuh Chuang, Jui-Yung Yang, Shih-Yi Yang, Shu-Ying Chang, Yen-Chang Hsiao, Kuo-Chin Kao, Han-Chung Hu, Ting-Shu Wu, Chao-Wei Hsu, David Hui-Kang Ma, Shin-Yi Chen, Ya-Chung Tian, Chi-Yuan Cheng, Chi-Hua Chen, Min-Hui Chi, Ming-Ying Wu, Ren-Feng Liu, Chi-Hui Wang, Ya-Ching Chang, Jing-Yi Lin, Hsin-Chun Ho, Yang Yu-Wei Lin, Chee Jen Chang, Yu- Lin, Cheng-Lung Ku, Shuen-Iu Hung, Wen-Hung Chung
Summary: This study found that disseminated intravascular coagulation occurred in 21.3% of SJS/TEN patients, was associated with severe systemic complications, and had a higher mortality rate.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Al-Ameen Oredegbe, Fabiana Maria Santelises Robledo, Krishnakumar Hongalgi, Geovani Faddoul, Swati Mehta
Summary: Catastrophic anti-phospholipid syndrome (CAPS) is a rare and fatal complication of antiphospholipid syndrome (APS) characterized by microvascular thrombosis in multiple sites leading to multi-organ damage. We present a challenging case of CAPS in a patient who initially presented with bilateral adrenal hemorrhage, making the diagnosis difficult. This case highlights the importance of considering APS in patients with multi-organ failure and multiple thromboses and hemorrhage.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Immunology
Virginie Dufrost, Denis Wahl, Stephane Zuily
Summary: The findings regarding APS patients show that there is no increased risk of recurrent venous thromboembolism when using DOACs compared to warfarin, but there is a significantly heightened risk of recurrent arterial thrombosis. These results align with international guidelines recommending against the use of DOACs in APS patients with a history of arterial thrombosis.
AUTOIMMUNITY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhang, Congqing Wu, Lan Li, Ankit Pandeya, Guoying Zhang, Jian Cui, Daniel Kirchhofer, Jeremy P. Wood, Susan S. Smyth, Yinan Wei, Zhenyu Li
Summary: Histones can trigger coagulation activation, and lytic cell death is a novel mechanism of histone-induced coagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Malgorzata Skalska-Swistek, Hubert Huras, Andrzej Piotr Jaworowski, Rafal Swistek, Magdalena Kolak
Summary: Coagulopathies are important obstetric complications, and DIC syndrome is a severe and complex clotting disorder. Close monitoring of laboratory parameters of the coagulation system, fetal health, and timely delivery and initiation of intensive therapy are necessary.
Article
Hematology
Atsushi Murao, Takayuki Kato, Tetsunobu Yamane, Goichi Honda, Yutaka Eguchi
Summary: This study investigates the effect of recombinant human soluble thrombomodulin and antithrombin concentrate in the treatment of DIC through a post hoc analysis. The results show that combination therapy can significantly reduce 28-day mortality in patients with low platelet count and plasma AT level.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Article
Hematology
Juergen Grafeneder, Nina Buchtele, Daniel Egger, Michael Schwameis, Cihan Ay, Bernd Jilma, Christian Schoergenhofer
Summary: The DIC score from the International Society on Thrombosis and Haemostasis can predict 30-day mortality in patients with liver disease and low fibrinogen levels, suggesting its significance in the assessment of these patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Nicolas Gendron, Sara Zia Chahabi, Geraldine Poenou, Nadia Rivet, Tiphaine Belleville-Rolland, Pierre Lemaire, Antoine Escuret, Michele Ciaudo, Emmanuel Curis, Pascale Gaussem, Virginie Siguret, Luc Darnige
Letter
Hematology
Gonzalo De Luna, Luc Darnige, Stephane Roueff, Thierry Peyrard, Jacques Pouchot, Jean-Benoit Arlet
ANNALS OF HEMATOLOGY
(2020)
Article
Hematology
Georges Jourdi, Maxime Delrue, Alain Stepanian, Jessica Valaize, Geoffrey Foulon-Pinto, Julien Demagny, Jerome Duchemin, Fabienne Nedelec-Gac, Luc Darnige, Emmanuel Curis, Xavier Delavenne, Pascale Gaussem, Virginie Siguret, Isabelle Gouin-Thibault
THROMBOSIS RESEARCH
(2019)
Review
Rheumatology
Virginie Dufrost, Luc Darnige, Tatiana Reshetnyak, Maria Vorobyeva, Xin Jiang, Xin-Xin Yan, Grigorios Gerotziafas, Zhi-Cheng Jing, Ismael Elalamy, Denis Wahl, Stephane Zuily
CURRENT RHEUMATOLOGY REPORTS
(2020)
Article
Medical Laboratory Technology
Adeline Blandinieres, Jean-Benoit Arlet, Pascale Gaussem, Jacques Pouchot, Luc Darnige
ANNALES DE BIOLOGIE CLINIQUE
(2020)
Letter
Hematology
Chloe Friedrich, Juliette Gay, Anne-Sophie Alary, Jean-Benoit Arlet, Gerard Socie, Veronique Fremaux-Bacchi, Isabelle Radford Weiss, Olivier Kosmider, Luc Darnige
ANNALS OF HEMATOLOGY
(2020)
Letter
Hematology
Matthieu Mahevas, Guillaume Moulis, Emmanuel Andres, Etienne Riviere, Margaux Garzaro, Etienne Crickx, Vivien Guillotin, Marion Malphettes, Lionel Galicier, Nicolas Noel, Luc Darnige, Louis Terriou, Claire Guerveno, Mateo Sanchis-Borja, Thomas Moulinet, Benoit Meunier, Mikael Ebbo, Marc Michel, Bertrand Godeau
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Rheumatology
Paul Billoir, Adrien Michon, Luc Darnige
Summary: Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by recurrent thrombotic events and pregnancy morbidity, with persistently presence of antiphospholipid antibodies (aPL). This study reports three cases of central serous chorioretinopathy (CSC) associated with APS.
Editorial Material
Medical Laboratory Technology
Leila Ben Dhia, Laure Macraigne, Valentine Berti, Luc Darnige
ANNALES DE BIOLOGIE CLINIQUE
(2021)
Article
Rheumatology
Nicolas Gendron, Marie-Agnes Dragon-Durey, Richard Chocron, Luc Darnige, Georges Jourdi, Aurelien Philippe, Camille Chenevier-Gobeaux, Jerome Hadjadj, Jerome Duchemin, Lina Khider, Nader Yatim, Guillaume Goudot, Daphne Krzisch, Benjamin Debuc, Laetitia Mauge, Francoise Levavasseur, Frederic Pene, Jeremy Boussier, Elise Sourdeau, Julie Brichet, Nadege Ochat, Claire Goulvestre, Christophe Peronino, Tali-Anne Szwebel, Franck Pages, Pascale Gaussem, Charles-Marc Samama, Cherifa Cheurfa, Benjamin Planquette, Olivier Sanchez, Jean-Luc Diehl, Tristan Mirault, Michaela Fontenay, Benjamin Terrier, David M. Smadja
Summary: The prevalence of LAC positivity is significantly higher in COVID-19 patients compared to non-COVID-19 patients. However, LAC positivity at the time of hospital admission is not associated with the risk of VTE or in-hospital mortality.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Julie Carre, Georges Jourdi, Nicolas Gendron, Dominique Helley, Pascale Gaussem, Luc Darnige
Summary: DOACs have been increasingly prescribed for more than 10 years for the prevention and treatment of thrombotic events. However, their use in immunothrombotic disorders, such as HIT and APS, is still under investigation. HIT and APS share similarities in terms of autoimmune mechanism, multicellular activation, and platelet count decrease. DOACs have been included in guidelines for the treatment of HIT, but their use in APS is either subject to precautionary recommendations or not recommended in severe cases. Limited studies have been conducted on the use of DOACs in APS and HIT, with most being retrospective in nature. VITT, as a newly recognized immunothrombotic disorder, also has specific guidelines for anticoagulant strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Hematology
Lamisse Mansour-Hendili, Edouard Flamarion, Marc Michel, Caroline Morbieu, Christine Gameiro, Ivan Sloma, Bouchra Badaoui, Luc Darnige, Marion Camard, Ariane Lunati-Rozie, Abdelrazak Aissat, Sihem Tarfi, Chloe Friedrich, Veronique Picard, Loic Garcon, Nassera Abermil, Sophie Kaltenbach, Isabelle Radford-Weiss, Olivier Kosmider, Pascale Fanen, Pablo Bartolucci, Bertrand Godeau, Frederic Galacteros, Benoit Funalot
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Chloe Friedrich, Loria Zalmai, Juliette Gay, Marie Magdeleine Coude, Clotilde Bravetti, Romain Vazquez, Marie Temple, Eugenie Duroyon, Luc Darnige, Justine Decroocq, Anne Sophie Alary, Olivier Kosmider
Summary: This study developed a fragment analysis method (PCR-Fluo-ASXL1-FA) that can rapidly, accurately, and cost-effectively detect mutations in the ASXL1 gene. Compared to other methods, this approach can detect insertional mutations in the ASXL1 region and has high sensitivity. Through three practical cases, the feasibility of this technique has been demonstrated.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Hematology
Albain Chansavang, Aurelien Philippe, Ines Bozinovic, Khalil Ben Hadj Ali, David Smadja, Dominique Helley, Luc Darnige, Laetitia Mauge
Summary: This study evaluated the performance of a commercial ELISA method for detecting anti-FVIII IgG in patients with acquired hemophilia A. The results showed 100% sensitivity and specificity, and correlated with the traditional Bethesda assay. These data suggest the potential use of this method for both diagnosis and follow-up of AHA patients.
ANNALS OF HEMATOLOGY
(2022)
Letter
Hematology
Lina Khider, Marie Temple, Cecile Bally, Agathe Spaeth, Luc Darnige, Olivier Sanchez, Benjamin Planquette, Helene Mortelette, Emmanuel Messas, David M. Smadja, Joseph Emmerich, Tristan Mirault, Olivier Kosmider, Nicolas Gendron
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)