Review
Endocrinology & Metabolism
Jessica W. Y. Yuen, David D. Kim, Ric M. Procyshyn, William J. Panenka, William G. Honer, Alasdair M. Barr
Summary: Clozapine is the most effective pharmacotherapy for treatment-resistant psychosis, but its underutilization in clinical practice is due to serious metabolic side-effects. Patients treated with clozapine have a higher risk of developing metabolic syndrome, predisposing them to Type 2 diabetes and cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Kari A. Leibowitz, Lauren C. Howe, Alia J. Crum
Summary: Describing certain minor side effects as a sign the treatment is working can reduce patient anxiety and perception of threat, while also improving treatment experience and outcomes. A study on patients receiving oral immunotherapy for food allergies showed that this approach decreased the frequency of patients contacting providers with concerns about side effects and led to greater increases in a biomarker of allergic tolerance.
Editorial Material
Immunology
Jonathan Sprent, Cecile King
Summary: The side effects of SARS-CoV-2 vaccines may simply be a normal physiological response to contact with invading microorganisms, particularly the production of type I interferons.
SCIENCE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Armita Abolghasemi, Claudia Manca, Fabio A. Iannotti, Melissa Shen, Nadine Leblanc, Sebastien Lacroix, Cyril Martin, Nicolas Flamand, Vincenzo Di Marzo, Cristoforo Silvestri
Summary: The study indicates a complex interaction between vitamin D levels and atypical antipsychotic drugs on whole-body metabolism and gut microbiota in mice. Olanzapine, an atypical antipsychotic drug, exerts a protective effect against diet-induced obesity and insulin resistance independent of dietary vitamin D status. Changes in the endocannabinoidome and gut microbiota families might contribute to the inhibition of weight gain induced by olanzapine and vitamin D in mice on a high fat/high sucrose diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Valentina Palmieri, Flavio De Maio, Marco De Spirito, Massimiliano Papi
Summary: COVID-19 is a major challenge of the 21st century, recommended mask-wearing is crucial for pandemic control, nanotechnologies have brought innovation to mask production, but long-term effects should be carefully monitored.
Article
Chemistry, Physical
Veinardi Suendo, Yenni Lau, Ferdinand Hidayat, Muhammad Reza, Albaaqi Qadafi, Achmad Rochliadi
Summary: Polyaniline (PANI) is a conductive polymer synthesized by using ammonium persulfate as the oxidant in HCl solution. This study focuses on the conductivity alteration of PANI due to interchain interaction observed at different reaction temperatures. The synthesized PANI-ES at 0 degrees C shows promising results when applied as an electrocatalytic active layer in DSSC's counter-electrode.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Psychiatry
Beate Muschalla, Julia Mueller, Anja Grocholewski, Michael Linden
Summary: This study found that monitoring and discussing the side effects of therapy does not negatively affect the therapeutic alliance, but instead can improve it.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychology, Multidisciplinary
Carina Schlintl, Anne Schienle
Summary: The study showed that written information can influence the occurrence of reported placebo/nocebo side effects. Additionally, information about the provider's optimistic personality was associated with a lower frequency of reported adverse side effects.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M. Shokat, Dorit Ron
Summary: Alcohol Use Disorder (AUD) is a common issue with limited treatment options. Research suggests mTORC1 as a potential therapeutic target, but chronic use may lead to severe side effects. The study proposes a binary drug strategy, utilizing a combination of drugs to protect mTORC1 activity in the periphery and mitigate adverse effects.
NATURE COMMUNICATIONS
(2021)
Review
Food Science & Technology
William T. Festuccia
Summary: Evidence suggests that lipotoxicity and inflammation are key factors linking adipose tissue dysfunction to metabolic diseases, with mTOR playing a crucial role in regulating adipocyte and macrophage function. Studies reviewed here show that optimal levels of mTORC1 activity are necessary for lipogenic actions in adipocytes, while mTORC1 also regulates polarization in macrophages. On the other hand, mTORC2 promotes glucose uptake and lipogenesis in adipocytes while dampening macrophage inflammatory response.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kang Chen, Lai Yee Cheong, Yuan Gao, Yaming Zhang, Tianshi Feng, Qin Wang, Leigang Jin, Eric Honore, Karen S. L. Lam, Weiping Wang, Xiaoyan Hui, Aimin Xu
Summary: This study demonstrates that targeted delivery of thyroid hormone to adipose tissue with liposomes is a safe and efficient strategy for treating obesity and its related complications.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
John R. Kerr, Alexandra L. J. Freeman, Theresa M. Marteau, Sander van der Linden
Summary: Vaccines do not offer full immunity against COVID-19, and providing transparent communication about their effectiveness and uncertainty does not significantly impact decision-making or reduce willingness to be vaccinated. Transparent messages also do not decrease perceptions of vaccine efficacy or increase intentions to engage in protective behaviours post-vaccination.
Article
Environmental Sciences
Xuehui Zu, Jun Nan, Zhenbei Wang, Qiliang Xiao, Bohan Liu
Summary: An extended activated sludge model (E-ASM2d) was developed to accurately simulate the metabolic processes of side-stream P recovery under different COD:P conditions. Sensitivity analysis and simulation experiments showed that the fraction of P removal by tightly-bound EPS was improved by the side-stream operation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Environmental Sciences
Michal Jakl, Sanja Cavar Zeljkovic, Ishak Kovac, Katerina Belonoznikova, Jana Jaklova Dytrtova
Summary: The study revealed that triazolic fungicides can temporarily increase the weight of cherry tomato fruits but not sustainably. They also cause increased oxidative stress, decreased weight of thin stems and leaves, and lower chlorophyll content in leaves. The non-target impacts on plant biochemical processes were confirmed.
Article
Biotechnology & Applied Microbiology
Cheng Ren, Yibo Xu, Hongliang Liu, Zhimeng Wang, Teng Ma, Zhong Li, Liang Sun, Qiang Huang, Kun Zhang, Chengcheng Zhang, Yu Cui, Qian Wang, Yao Lu
Summary: This study found that RUNX2 is involved in the regulation of osteoblast autophagy and differentiation by mediating autophagy-related and osteoblast differentiation-related genes/proteins, as well as the p38MAPK signaling pathway.
Article
Endocrinology & Metabolism
Adam B. Salmon, Chad Lerner, Yuji Ikeno, Susan M. Motch Perrine, Roger McCarter, Christian Sell
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Multidisciplinary Sciences
JennaLynn Hunnicut, Yuhong Liu, Arlan Richardson, Adam B. Salmon
Article
Geriatrics & Gerontology
Adam B. Salmon, Jonathan Dorigatti, Hillary F. Huber, Cun Li, Peter W. Nathanielsz
Article
Cell Biology
Michal M. Masternak, Andrzej Bartke, Feiya Wang, Adam Spong, Adam Gesing, Yimin Fang, Adam B. Salmon, Larry F. Hughes, Teresa Liberati, Ravneet Boparai, John J. Kopchick, Reyhan Westbrook
Article
Multidisciplinary Sciences
Michael P. Siegel, Shane E. Kruse, Gary Knowels, Adam Salmon, Richard Beyer, Hui Xie, Holly Van Remmen, Steven R. Smith, David J. Marcinek
Article
Multidisciplinary Sciences
Wilson C. Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B. Salmon, Vivian Diaz, Martin Javors, William H. Wood, Yongqing Zhang, Kevin G. Becker, Viviana I. Perez, Arlan Richardson
Article
Zoology
Aubrey M. Sills, Joselyn M. Artavia, Brian D. DeRosa, Corinna N. Ross, Adam B. Salmon
AMERICAN JOURNAL OF PRIMATOLOGY
(2019)
Editorial Material
Geriatrics & Gerontology
Dudley W. Lamming, Adam B. Salmon
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Jonathan D. Dorigatti, Kevin M. Thyne, Brett C. Ginsburg, Adam B. Salmon
Summary: The study found that GPA intervention in young mice led to activation of the AMPK signaling pathway and various improvements in physiological parameters, while in old mice, although AMPK signaling activation was reduced, it still delayed age-related muscle tissue aging.
Review
Geriatrics & Gerontology
Michael Bene, Adam B. B. Salmon
Summary: A growing number of interventions have been found to extend the lifespan of laboratory animals. However, the extent to which these effects are conserved across species is unclear. This study analyzed published data on longevity interventions in Caenorhabditis and Drosophila, and found limited predictive value for identifying lifespan-extending compounds in mice. These results caution against assuming the translatability of lifespan-extending interventions across species, including humans.
Article
Geriatrics & Gerontology
Kevin M. Thyne, Adam B. Salmon
Summary: Methionine restriction (MR) can extend lifespan, but it is not affected by the absence of MsrA. MR can also improve resistance to oxidative stress and reduce the risk of age-related pathologies. However, the presence or absence of MsrA does not significantly affect the effects of MR on longevity and health span.
Article
Biochemistry & Molecular Biology
Jonathan D. Dorigatti, Kevin M. Thyne, Brett C. Ginsburg, Adam B. Salmon
Summary: Activation of AMP activated protein kinase (AMPK) signaling has been shown to extend lifespan and improve healthspan across multiple species. However, supplementing fruit flies with beta-guanidinopropionic acid (GPA) did not extend lifespan and may actually have detrimental effects on stress resistance and lifespan, highlighting the importance of replication studies in the field of aging.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Adam B. Salmon
Article
Geriatrics & Gerontology
Y Wang, AB Salmon, LG Harshman
EXPERIMENTAL GERONTOLOGY
(2001)
