Article
Multidisciplinary Sciences
Shikha Nayar, Joshua K. Morrison, Mamta Giri, Kyle Gettler, Ling-Shiang Chuang, Laura A. Walker, Huaibin M. Ko, Ephraim Kenigsberg, Subra Kugathasan, Miriam Merad, Jaime Chu, Judy H. Cho
Summary: NOD2 deficiency contributes to fibrosis and stricturing complications in Crohn's disease through dysregulated homeostasis of activated fibroblasts and macrophages, which can be ameliorated by gp130 blockade. Carriers of NOD2 risk alleles exhibit dysregulated homeostasis of activated fibroblasts and macrophages, suggesting a potential role for gp130 blockade in rescuing the activated program caused by NOD2 mutations.
Editorial Material
Dermatology
Mariko Kochi, Tetsuya Higuchi
Summary: Langerhans cell histiocytosis (LCH) is a disease characterized by the proliferation of atypical histiocyte-like cells in various organs. In this study, a patient with LCH developed the disease after receiving adalimumab, a TNFa inhibitor, for treatment of Crohn's disease.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Robert D. Little, Adrian Swaine, Rebecca Reynolds, David J. Gibson, Mathilde Barrau, Francesca D'Errico, Rumneek Hampal, Miles P. Sparrow, Xavier Roblin, Peter M. Irving, Mark G. Ward
Summary: This retrospective study aimed to explore the association between adalimumab drug levels and Crohn's disease activity after dose-intensification. The results revealed that post-escalation drug levels were associated with subsequent CD remission.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Josefine Schardey, Sophie Zehl, Alina S. Kappenberger, Petra Zimmermann, Florian Beigel, Tobias S. Schiergens, Michael S. Kasparek, Florian Kuehn, Jens Werner, Ulrich Wirth
Summary: The study evaluated the role of NOD2 mutation status and other risk factors in postoperative complications after ileocolic resection for Crohn's disease. Independent risk factors for major postoperative complications were identified, but homozygosity for the NOD2 high-risk variant p.Leu1007fsX1008 did not increase postoperative morbidity.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Rheumatology
Zhiyan Wang, Mingdong Yang, Qunqun Zhang, Suhua Zhang, Haifang Sui, Jiane Liu, Qingrui Yang
Summary: Blau syndrome (BS) is a rare genetic immune disease commonly seen in childhood, with a high miss-rate of diagnosis and lack of effective clinical management. This case report presents a 54-year-old Chinese male patient with hand malformation, fever, skin rash, and joint pain, who was ultimately diagnosed through medical history and genetic analysis. The report aims to raise awareness among clinicians for accurate diagnosis and appropriate treatment of this rare clinical entity.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Infectious Diseases
Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Pawel Rogoz, Beata Weber-Dabrowska, Maciej Zaczek, Andrzej Gorski
Summary: Phage therapy may induce an immune response and production of neutralizing antibodies. The presence of these antibodies can affect the success of therapy, but it does not necessarily guarantee failure. On the other hand, phage-antibody complexes may cause tissue damage and late complications, highlighting the importance of monitoring antibody levels and discontinuing therapy if necessary.
Article
Biochemistry & Molecular Biology
Vincent W. Joustra, Andrew Y. F. Li Yim, Jessica R. de Bruyn, Marjolijn Duijvestein, Ishtu L. Hageman, Wouter J. de Jonge, Peter Henneman, Manon Wildenberg, Geert D'Haens
Summary: Prediction of endoscopic post-operative recurrence in CD patients following ICR using clinical risk factors alone has been inadequate. This study explored the association and predictive value of PBL DNA methylation in CD patients following ICR. Results showed limited differences in the genome-wide DNA methylome among CD patients with and without endoscopic POR, indicating that PBL DNA methylation is not a feasible predictive tool in post-operative CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Summary: Nguyen et al. used liver organoid cultures to study somatic mutations in stem cells from patients with liver diseases, finding that precancerous liver diseases do not lead to increased mutations or altered types in individual stem cells. This contrasts with mutational load in liver tumors, suggesting liver disease may drive tumorigenesis through indirect mechanisms.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Agata Krawczyk, Barbara Strzalka-Mrozik, Dominika Wcislo-Dziadecka, Magdalena Kimsa-Dudek, Celina Kruszniewska-Rajs, Joanna Gola
Summary: This study assessed the systemic effects of adalimumab in the treatment of psoriatic arthritis and found that the drug affects apoptosis, leading to improvement in the clinical condition of patients. The gene expression analysis of peripheral blood mononuclear cells indicated the potential systemic effects of adalimumab therapy.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Mohamed A. Abd El Aziz, Solafah Abdalla, Giacomo Calini, Hamadelneel Saeed, Anne-Lise D'Angelo, Kevin T. Behm, Sherief Shawki, Kellie L. Mathis, David W. Larson
Summary: This study retrospectively analyzed the safety of robotic redo ileocolonic resection in 98 patients with Crohn's disease. Patients who underwent redo ileocolonic resection had longer disease duration, more associated anoperineal disease, more previous lines of medical treatments, more frequent use of total parental nutrition before surgery for malnutrition correction, and longer adhesiolysis time. The risk of conversion to open ileocolonic resection was higher in the redo group. There were no significant differences in length of stay and 30-day morbidity between the two groups. No mortality or anastomotic leaks occurred in either group.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Michalis Liontos, Eleni Zografos, Panagiotis Zoumpourlis, Angeliki Andrikopoulou, Anna Svarna, Oraianthi Fiste, Elena Kunadis, Alkistis Maria Papatheodoridi, Maria Kaparelou, Konstantinos Koutsoukos, Nikoloas Thomakos, Dimitrios Haidopoulos, Alexandros Rodolakis, Meletios-Athanasios Dimopoulos, Flora Zagouri
Summary: The location of BRCA1/2 mutations in HGSOC patients does not significantly affect survival outcomes, but differences in PFS were detected among carriers with identical mutations in the same gene, suggesting the potential impact of other genetic abnormalities and co-contributing risk factors.
Article
Oncology
Chik Hong Kuick, Jia Ying Tan, Deborah Jasmine, Tohari Sumanty, Alvin Y. J. Ng, Byrrappa Venkatesh, Huiyi Chen, Eva Loh, Sudhanshi Jain, Wan Yi Seow, Eileen H. Q. Ng, Derrick W. Q. Lian, Shui Yen Soh, Kenneth T. E. Chang, Zhi Xiong Chen, Amos H. P. Loh
Summary: Our study found that mutations in chromosome 1 genes are common in 1p-intact neuroblastoma, but may not always disrupt the function of authentic 1p tumor suppressors. These findings suggest a complex interplay of 1p gene aberrations contributing to tumor suppressor inactivation in neuroblastoma.
Article
Cell Biology
Gemma L. Johnson, Morgan B. Glasser, Julia F. Charles, Jeffrey Duryea, Jessica A. Lehoczky
Summary: En1 and Lmx1b are re-expressed during mouse digit tip regeneration, but do not affect dorsal-ventral patterning. Genetic deletion of En1 or Lmx1b has a modest impact on bone regeneration in the digit tip.
Article
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan
Summary: This study suggests that patients with high titers of anti-drug antibodies to infliximab are as likely to respond to adalimumab therapy as those with low titers, indicating that high titers of antibodies are not predictive of treatment failure.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Maximilian Keck, Jutta Huebner, Jens Buentzel
Summary: Hearing impairment significantly affects communication between cancer patients and their oncologists. A questionnaire was developed with otorhinolaryngologists and hearing-impaired patients, analyzing the experiences, difficulties, wishes, and life satisfaction of 104 cancer survivors. The study found differences in conversation difficulties, physician-patient communication wishes, and psychological well-being between subjectively hearing-impaired and normal hearing participants.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
