Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tatsuaki Watanabe, Satoshi Matsuo, Yui Watanabe, Takashi Hirama, Yasushi Matsuda, Masafumi Noda, Hiromichi Niikawa, Hisashi Oishi, Yamato Suzuki, Yutaka Ejima, Hiroaki Toyama, Yoshikatsu Saiki, Yoshinori Okada
Summary: This study examined the outcomes of bilateral lung transplantation (BLT) with pulmonary artery reconstruction (PAR) using donor aorta for pulmonary arterial hypertension (PAH) patients with a giant pulmonary arterial aneurysm (PAA). The study found that the operation time was longer in the PAR group, but the 90-day mortality and 5-year survival rates were comparable to the non-PAR group. This suggests that lung transplantation with PAR using donor aorta is a valid surgical option for PAH patients with a giant PAA.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Infectious Diseases
Li Wen-ting, Wu Chang-wei, Bian De-jian, Sha Wei
Summary: This study aimed to investigate the correlation between arterial blood gas parameters, inflammatory markers, and coagulation indicators with pulmonary artery systolic pressure (PASP) values in patients with active pulmonary tuberculosis (PTB). The results showed that arterial partial pressure of oxygen (PaO2) and procalcitonin were strongly correlated with PASP values in active PTB patients. The degree of hypoxia and severity of secondary respiratory bacterial infection may influence PASP value in active PTB.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos
Summary: Pulmonary artery denervation is a novel intervention aimed at reducing sympathetic activity in the pulmonary circulation for the treatment of pulmonary arterial hypertension. Despite some positive effects shown in pre-clinical studies and initial clinical trials, the technique's scope in current practice remains limited due to the lack of well-designed, large-scale, international randomized controlled clinical trials.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Wei-Fang Lan, Yan Deng, Bin Wei, Kai Huang, Ping Dai, Shan-Shan Xie, Dan-dan Wu
Summary: This study aimed to investigate the effect and clinical correlates of initial ambrisentan plus PDE5i combination therapy on echocardiographic right ventricular pulmonary artery coupling (RVPAC) in patients with severe pulmonary arterial hypertension (PAH). The results showed significant improvements in RVPAC ratios and functional status indices after 6 months of combination therapy. The study suggests that ambrisentan plus PDE5i combination therapy can lead to a significant improvement in RVPAC in severe PAH patients, with correlation to known prognostic markers of PAH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Liang Zhong, Shuang Leng, Samer Alabed, Ping Chai, Lynette Teo, Wen Ruan, Ting-Ting Low, James M. Wild, John C. Allen, Soo Teik Lim, Ju Le Tan, James Wei-Luen Yip, Andrew J. Swift, David G. Kiely, Ru-San Tan
Summary: This study evaluated pulmonary artery global longitudinal strain (GLS) as a prognostic marker in patients with pulmonary arterial hypertension (PAH) and found that GLS provides incremental prognostic utility over established risk scores.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Serkan Unlu, Stephanie Bezy, Marta Cvijic, Jurgen Duchenne, Marion Delcroix, Jens Uwe Voigt
Summary: RVFW LS/sPAP ratio as a new prognostic echocardiographic marker significantly predicts all-cause mortality and heart-lung transplantation in patients with pre-capillary PAH, and is superior to other well-established parameters, providing important value in understanding the relationship between RV function and afterload.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Zhang Xiao, Huangfu Zhao
Summary: This review discusses the risks associated with pregnant individuals with PAH and emphasizes the importance of contraception and reducing hemodynamic fluctuations in minimizing maternal mortality and improving pregnancy outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
David Poveda, Elie Fadel, William Lorenzi, Jean Baptiste Menager
Summary: This article presents a reconstruction strategy in a patient with a mismatch between the pulmonary artery and the donor aorta.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Peripheral Vascular Disease
Yusi Wu, Bingjie Pan, Zhen Zhang, Xiaohui Li, Yiping Leng, Yong Ji, Kun Sun, Alex F. Chen
Summary: The study reveals the critical role of caspase-4/11 in the pyroptosis pathway, which regulates pulmonary vascular dysfunction and accelerates the progression of pulmonary arterial hypertension (PAH). These findings provide a potential target for the diagnosis and treatment of PAH.
Article
Cardiac & Cardiovascular Systems
Jinzhi Lai, Jiuliang Zhao, Kaiwen Li, Xiaohan Qin, Hui Wang, Zhuang Tian, Qian Wang, Mengtao Li, Xiaoxiao Guo, Yongtai Liu, Xiaofeng Zeng
Summary: The study suggests that the ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP) accurately assesses the risk status and predicts prognosis in patients with systemic sclerosis-associated pulmonary arterial hypertension (PAH). A higher TAPSE/PASP ratio is associated with better overall survival.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Peter J. Kneuertz, Max S. Yudovich, Chiemezie C. Amadi, Elizabeth Bashian, Desmond M. D'Souza, Mahmoud Abdel-Rasoul, Robert E. Merritt
Summary: This study investigated the relationship between pulmonary artery diameter (PAD) measured by CT and outcomes following lobectomy. The results showed that the PAD on the surgical side was associated with major complications, unexpected ICU admission, and 30-day mortality. Adjusted analysis showed that surgical side PAD remained an independent factor associated with major complications. Therefore, evaluating the size of pulmonary artery on preoperative CT scans can help improve the assessment of operative risk.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valery Turner, Eva Maret, Juyong B. Kim, Marina Codari, Virginia Hinostroza, Domenico Mastrodicasa, Claire Watkins, William F. Fearon, Michael P. Fischbein, Francois Haddad, Martin J. Willemink, Dominik Fleischmann
Summary: This study found that pulmonary artery distensibility measured on preprocedural CTA is independently associated with persistent PH and two-year mortality in patients undergoing TAVR.
ACADEMIC RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yinghao Lim, Ting-Ting Low, Siew Pang Chan, Weiqin Lin, Ting Wei Teo, Jin-Hao Justin Jang, Ivandito Kuntjoro, Edgar Lik-Wui Tay, James Wei-Luen Yip
Summary: The study analyzed data from 102 patients with newly diagnosed PAH and found that a low PAPi was associated with mortality, with the low PAPi group having older age, lower pulmonary artery systolic pressure, and higher mean right atrial pressure. These findings suggest that PAPi may be a predictive marker for mortality in PAH.
Article
Engineering, Biomedical
Yuheng Wang, Hamidreza Gharahi, Marissa R. Grobbel, Akshay Rao, Sara Roccabianca, Seungik Baek
Summary: PAH is a condition associated with elevated pulmonary arterial pressure and poor prognosis, with a 15% mortality rate within 1 year. Previous studies have suggested the importance of wall shear stress in PAH progression, but doubts remain about its role. This study highlights the relevance of pressure-induced damage mechanism in human PAH and the need for large-animal experiments to validate disease mechanisms.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
